Clinical trials: Endothelium, Vascular
Microalbuminuria, Endothelial Dysfunction
Microalbuminuria as a Cardiovascular Risk Factor (PRECISED Substudy)
Microalbuminuria (MA) is an independent cardiovascular risk factor in diabetic and non-diabetic subjects. However, in the setting of type 2 diabetes, microalbuminuria could be a marker of either early diabetic nephropathy or…
- Conditions
- Microalbuminuria, Endothelial Dysfunction, Diabetic Nephropathy, Diabetic Retinopathy
- Trial name
- NCT02409511
- Testing
- non intervention
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Poor Sleep Quality
Effects of Daily Avocado Consumption on Sleep and Skin Health in Postmenopausal Females
Poor sleep quality and accelerated skin aging are common in postmenopausal women and may be linked, in part, through impaired vascular function.
- Trial name
- SAVER (NCT07880444)
- Testing
- Hass Avocado, Safflower Oil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure
Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure
The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.
- Conditions
- Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure, Male, Female
- Trial name
- NCT06735599
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgia State University
Macular Polypoidal Choroidal Vasculopathy (PCV)
Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy
This study is a 60-week, two-arm, randomized, open-label, active-controlled, multi-center study in patients with Polypoidal choroidal vasculopathy (PCV) who have not previously received anti-Vascular endothelial growth factor…
- Trial name
- PROUD (NCT05666804)
- Testing
- Brolucizumab 6mg
- Where
- 15 sites in South Korea
- Volunteers
- 148 people
- Sponsor
- Novartis Pharmaceuticals
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Insulin Resistance
The Effect of 12-week Circuit Training on Insulin Sensitivity and Endothelial Function in Women With Insulin Resistance
During the last 10 years many studies concerning the impact of physical training on whole-body insulin sensitivity have been published, but there is a lack of an extended investigation on the potential clinical benefits of novel…
- Trial name
- NCT04528693
- Testing
- Circuit training (combination of strength and endurance exercises)
- Where
- Poland
- Volunteers
- 49 people
- Sponsor
- Poznan University of Physical Education
Intermittent Claudication, Cardiovascular Diseases
Acute Responses to Arm-Crank Exercise on Cardiovascular Function of Patients With Peripheral Artery Disease
The aim of this study is to analyze acute responses of arm-cranking exercise on cardiovascular function of peripheral arterial disease patients and compare it to the main exercise recommendation, walking exercise.
- Conditions
- Intermittent Claudication, Cardiovascular Diseases, Blood Pressure, Endothelial Dysfunction
- Trial name
- NCT05611021
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 17 people
- Sponsor
- University of Nove de Julho
Improve Endothelial Function and Decrease Vascular Stenosis
Phosphodiesterase Type 5 Inhibition to Improve Endothelial Function and Vascular Remodeling in Chronic Kidney Disease and End Stage Renal Disease Patients Requiring New Arteriovenous Fistula
Patients with stage IV and V chronic kidney disease and end stage renal disease requiring hemodialysis at University of Alabama at Birmingham (UAB) Dialysis Clinics will be recruited from the UAB Vascular Access Clinic, which has…
- Trial name
- NCT02414204
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Alabama at Birmingham
Coronary Artery Disease, Diabetes Mellitus
Role of Endothelial Biomarkers in Patients With Coronary Artery Disease
Coronary artery disease is a contraction of the coronary arteries that prevent adequate blood supply to the heart muscle is called CAD.
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Cytomegalovirus Infections
- Trial name
- NCT03146208
- Volunteers
- 54 people
- Sponsor
- Assiut University
Coronary Artery Disease, Endothelial Function
Offset of Ticagrelor's Effect on Endothelial Function as Assessed With Peripheral Arterial Tonometry (EndoPAT Assay)
Ticagrelor administration, whose molecule resembles to adenosine, led to reduction in overall mortality and thrombotic cardiovascular (CV) events when directly compared to clopidogrel in the PLATO trial, implicating possible…
- Trial name
- NCT01957527
- Testing
- Peripheral arterial tonometry (EndoPAT)
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Patras
Atherosclerosis, Endothelial Dysfunction
Predictive Medicine Research
To establish normal values by age, race, and gender of novel markers of risk in healthy subjects necessary to predict precise risk of cardiovascular disease in an individual
- Trial name
- NCT00384761
- Where
- United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- Emory University
Lung Neoplasms
Impact of Endostar Combined With Chemotherapy on the Angiogenesis of Advanced Non-small Cell Lung Cancer (NSCLC)
To study the impact of endostar combined with docetaxel and cisplatin on the angiogenesis of non-small cell lung cancer, patients will be randomly assigned to the group one (endostar combined with docetaxel and cisplatin) and…
- Trial name
- NCT00657423
- Testing
- Treated by endostar combined with docetaxel and cisplatin, Treated by docetaxel and cisplatin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Carcinoma
A Study of RO4929097 in Patients With Advanced Renal Cell Carcinoma That Have Failed Vascular Endothelial Growth Factor (VEGF)/Vascular Endothelial Growth Factor Receptor (VEGFR) Therapy
The purpose of this study is to evaluate the activity of RO4929097 in renal cell carcinoma patients that have failed therapy with VEGF/VEGFR directed agents.
- Conditions
- Clear Cell Renal Cell Carcinoma, Recurrent Renal Cell Carcinoma, Stage IV Renal Cell Cancer
- Trial name
- NCT01141569
- Testing
- Gamma-Secretase Inhibitor RO4929097, Laboratory Biomarker Analysis
- Where
- 4 sites in Canada
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Arterial Hypertension, Postmenopausal; Menorrhagia
Effects of Resistance Training Intensity on Cardiovascular Parameters of Hypertensive Women
The goal of this clinical trial is to understand about the effects of resistance training (RT) intensity on cardiovascular parameters in postmenopausal women with systemic arterial hypertension (SAH).
- Conditions
- Arterial Hypertension, Postmenopausal; Menorrhagia, Cardiovascular Diseases
- Trial name
- NCT06538454
- Testing
- Resistance training
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Diabetic Macular Edema
Treatment for CI-DME in Eyes With Very Good VA Study
Although multiple studies have clearly demonstrated that ranibizumab therapy is more effective than laser alone for vision gain and avoiding vision loss in patients with central-involved Diabetic Macular Edema (DME), only eyes…
- Trial name
- Protocol V (NCT01909791)
- Testing
- Prompt Laser, Prompt aflibercept, Deferred laser
- Where
- 103 sites in United States, Canada
- Volunteers
- 702 people
- Sponsor
- Jaeb Center for Health Research
Coronary Artery Disease, Coronary Artery Stenosis
Absorb IV Randomized Controlled Trial
ABSORB IV is a prospective, randomized (1:1, Absorb BVS to XIENCE), single-blind, multi-center study, registering approximately 2610 subjects from approximately 140 sites in the United States and outside the United States.
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Coronary Disease, Coronary Stenosis
- Trial name
- NCT02173379
- Testing
- Absorb BVS, XIENCE
- Where
- 120 sites in United States, Australia and 3 more
- Volunteers
- 2,604 people
- Sponsor
- Abbott Medical Devices
Primary Aldosteronism
The Effect of SAAE on Vascular Endothelial Function in PA Patients
The study aims to assess the effect of superselective adrenal arterial embolization on vascular endothelial function in patients with primary aldosteronism based on brachial artery flow-mediated relaxation
- Trial name
- NCT05561361
- Testing
- Super selective adrenal artery embolization, Spironolactone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Atherosclerosis
Effects of PA-1 Transcriptional Regulation on Monocyte Function
Researching genetic differences in people with no prior medical conditions for better understanding of cardiac diseases through genetic research.
- Trial name
- NCT00512369
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Pulmonary Hypertension
Endothelial Function in Patients With Scleroderma or Cirrhosis With and Without Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is a condition characterized by an increased pulmonary vascular resistance that can lead to right heart failure and death.
- Trial name
- NCT01729611
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The Cleveland Clinic
Diabetic Retinopathy, Retinal Neovascularisation
Ranibizumab in Diabetic Vitrectomy. A Prospective, Randomised Controlled Trial of Ranibizumab Pre-treatment in Diabetic Vitrectomy - a Pilot Study
This study will evaluate the effect of ranibizumab on patients undergoing vitrectomy surgery for the complications of diabetic retinopathy.
- Trial name
- RaDiVit (NCT01306981)
- Testing
- Ranibizumab, Saline
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
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