Clinical trials: Endothelium, Vascular
Ovarian Hyperstimulation Syndrome, GnRH Antagonist
Preventive Application of GnRH Antagonist on Early OHSS
Ovarian hyperstimulation syndrome is an iatrogenic complication of controlled ovarian stimulation. Ovarian hyperstimulation syndrome prevention is a multistage process and more important than treatment.Preventive administration…
- Conditions
- Ovarian Hyperstimulation Syndrome, GnRH Antagonist, Aspirin, Vascular Endothelial Growth Factor
- Trial name
- NCT03188471
- Testing
- GnRH antagonist, aspirin
- Where
- China
- Volunteers
- 175 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Atherosclerosis, Type 2 Diabetes Mellitus
Omacor for the Treatment of Vascular Dysfunction in Patients With Type 2 Diabetes Mellitus
The purpose of the study is to determine whether a 6-week treatment with 4 g Omacor/day improves the baseline and postprandial endothelial function (after a high-fat meal) in patients with type 2 diabetes mellitus.
- Trial name
- NCT00328536
- Testing
- Omacor
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Ruhr University of Bochum
Migraine With Aura, Stroke
Induction of Migraine Aura With Cilostazol
In a double blind placebo-controlled cross-over study the effect of cilostazol on aura induction and endothelial response is tested in patient with migraine with aura.
- Trial name
- NCT02253004
- Testing
- Cilostazol
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Herlev Hospital
Neovascular Age-related Macular Edema, Diabetic Macular Edema
Anti-VEGF in Real-world
Anti-vascular endothelial growth factor therapy is the major intervention for treating ischemic retina diseases. According to FDA and China Food and Drug Administration, Ranibizumab, Aflibercept, and Conbercept are major types of…
- Conditions
- Neovascular Age-related Macular Edema, Diabetic Macular Edema, Choroidal Neovascular Membrane, Non-proliferative Diabetic Retinopathy
- Trial name
- NCT05222633
- Testing
- Ranibizumab, Aflibercept, Conbercept
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Wenbin Wei
Aging, Blood Pressure
Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise
High blood pressure (BP) is the major modifiable risk factor for cardiovascular diseases (CVD) and related health conditions, particularly among postmenopausal (PM) women.
- Conditions
- Aging, Blood Pressure, Endothelial Dysfunction, Hypertension
- Trial name
- NCT05000515
- Testing
- High-resistance inspiratory muscle strength training, Aerobic exercise
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Coronary Heart Disease
Efficacy of Enhanced External Counterpulsation on Ventricular Function
The purpose of this study is to investigate the efficacy of Enhanced External Counterpulsation (EECP) therapy on ventricular function in patients with coronary heart disease
- Trial name
- EECPVF (NCT03106116)
- Testing
- Experimental: Enhanced External Counterpulsation, Standard medical therapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Hemolytic Uremic Syndrome
Study of 'Vascular Competence' Profile and Endothelial Activation in the Hemolytic Uremic Syndrome in Children and Adults
The Hemolytic Uremic Syndrome (HUS) is a rare thrombotic microangiopathy (TMA), affecting both children and adults. HUS is characterized by the abnormal occurrence of diffuse thrombosis in the microcirculation resulting in the…
- Trial name
- SHU (NCT02904863)
- Testing
- Extra blood draw samples
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Coronary Artery Disease
Effects of Different Doses of Ticagrelor on Platelet Aggregation and Endothelial Function in Diabetic Patients With Stable Coronary Artery Disease
Ticagrelor is an oral, reversibly-binding, direct-acting P2Y12 receptor antagonist used clinically for the prevention of atherothrombotic events in patients with acute coronary syndromes (ACS).
- Trial name
- NCT02889549
- Testing
- ticagrelor, clopidogrel
- Where
- 2 sites in United States, China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Coronary Artery Disease
Ivabradine to Improve Endothelial Function in Patients With Coronary Artery Disease
This study evaluates the effect of ivabradine on endothelial function in patients with coronary artery disease (CAD) after complete revascularization with percutaneous coronary angioplasty (PCI).
- Trial name
- RIVENDEL (NCT02681978)
- Testing
- Ivabradine, Standard medical therapy
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Campus Bio-Medico University
Diabetes Type 2, Diabetic Nephropathy
Ramipril and Clopidogrel in Oxidative Stress, Vascular Inflammation and Endothelial Dysfunction in Type 2 Diabetes and Diabetic Nephropathy
The purpose of this study is to determine whether the combination with ramipril and clopidogrel leads to further improvement of endothelial function, reduction of oxidative stress and reduction of vascular inflammation, compared…
- Conditions
- Diabetes Type 2, Diabetic Nephropathy, Vascular Disease
- Trial name
- NCT01743014
- Testing
- Ramipril, Clopidogrel
- Where
- 2 sites in Greece
- Volunteers
- 60 people
- Sponsor
- AHEPA University Hospital
Macular Degeneration
Evaluation of Physician and Patient Knowledge of Safety and Safe Use Information for Aflibercept
The study will be an observational, cross-sectional study of knowledge, understanding, and self-reported behavior among a sample of physicians and patients with recent aflibercept experience in a total of up to five European…
- Trial name
- NCT02615496
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- 5 sites in France, Germany and 3 more
- Volunteers
- 716 people
- Sponsor
- Bayer
Diabetic Macular Edema (DME)
Early Combined Use of Dexamethasone Intravitreal Implant and Anti-VEGF in the Treatment of DME.
The goal of this clinical trial is to learn if the efficacy of dexamethasone implant combined with anti-VEGF superior to anti-VEGF monotherapy in the treatment of DME in Chinese patients.
- Trial name
- NCT06846073
- Testing
- The combination of intravitreal anti-VEGF and dexamethasone implants injections.
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer, Vascular Disease，Peripheral
Onco-Vascular Exer-Study
In Chile, in the year 2022, the main causes of death were diseases of the circulatory system (31,606) and cancer (with 28,453 deaths).
- Conditions
- Breast Cancer, Vascular Disease，Peripheral, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- NCT06766903
- Testing
- Exercise training
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Cristian Alvarez
Coronary Artery Disease, Endothelial Function
Effect of Ticagrelor on Endothelial Function
This study is to assess the function of blood vessels while being treated with different types of blood thinners to determine the effect of these medications on blood vessels.
- Trial name
- NCT01805596
- Testing
- clopidogrel, Ticagrelor
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Non-Small Cell Lung Cancer, Chronic Obstructive Pulmonary Disease
Detection of Circulating Endothelial Progenitors Cells (EPCs) in Non-small Cell Lung Cancer (NSCLC)
Bone-marrow-derived progenitor cells (EPCS) play an important role in neovascularization and tumor growth. In lung cancer, angiogenesis is an important event in mechanisms of tumor proliferation and metastasis.
- Trial name
- CBNPC:PCE (NCT00826683)
- Testing
- Enumeration of endothelial cell progenitor in peripheral blood by flow cytometry, Endothelial cell progenitor characterization by primary cell cultures
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Coronary Artery Disease, Type 2 Diabetes Mellitus
Arginase Inhibition in Ischemia-reperfusion Injury
The present project is designed to test the hypothesis that arginase contributes to endothelial dysfunction induced by ischemia-reperfusion in patients with coronary artery disease.
- Trial name
- NCT02009527
- Testing
- N-hydroxy-nor-arginine, NaCl
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska Institutet
Endothelial Dysfunction
Centella Asiatica in Older Adults
The purpose of this study is to determine the effects of a dietary supplement containing centella asiatica on on vascular endothelial function in older adults.
- Trial name
- NCT06472791
- Testing
- Centella Asiatica
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Perimenopause
Hemodynamics After Resistance Training
Women's blood vessel health gets worse after menopause, or "the change of life". Some women exercise less during menopause. Exercise can improve blood vessel health.
- Trial name
- HeART (NCT07022340)
- Testing
- Resistance Training Intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Michigan
Angina, Coronary Artery Disease
Exercise-training Before Coronary Artery Bypass Graft (CABG)
The aim is to evaluate the effect of exercise training upon endothelial function in the mammary artery of patients who are scheduled for CABG, as well as study the functional properties of single cells isolated from a small…
- Trial name
- NCT00218985
- Testing
- Exercise training
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Hypertension, Diabetes
Aliskiren vs Hydrochlorothiazide in Hypertensive Type II Diabetic Patients on Resistance Arteries
This study will be performed only at the Jewish General Hospital. It will investigate the effect of treatment with aliskiren, an inhibitor of renin, a substance produced by the kidney that constricts arteries and raises blood…
- Trial name
- NCT01480791
- Testing
- Aliskiren vs. hydrochlorothiazide, Hydrochlorothiazide
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
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