Clinical trials: Endothelium
Vascular Stiffness, Endothelial Dysfunction
Targeting Inflammation to Treat Cardiovascular Aging
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States with older age being a primary risk factor.
- Conditions
- Vascular Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- TIVA (NCT01775865)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Oxidative Stress, Endothelial Dysfunction
Genes, Fibrinolysis and Endothelial Dysfunction- Dialysis Aim 3
The purpose of the study is to see how two classes of blood pressure medications,angiotensin-converting enzyme inhibitors (Ace inhibitors) and angiotensin receptor blockers (ARBs), differ in their long term effects on certain…
- Trial name
- NCT00878969
- Testing
- valsartan (ARB), ramipril (ACE inhibitor)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Corneal Edema Secondary to Corneal Endothelial Dystrophy
Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty
The purpose of this study is to report the early clinical outcomes in patients undergoing Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) for corneal edema secondary to corneal endothelial cell dysfunction, and to…
- Trial name
- DSAEK (NCT00744796)
- Testing
- DSAEK, Anterior Segment Optical Coherence Topography (OCT), Best Spectacle Corrected Visual Acuity (BSCVA)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hyperlipidemia
Endothelial Hyperpolarization in Humans
The purpose of this study is to elucidate the role Endothelium-Derived Hyperpolarizing Factor (EDHF) plays in dilating blood vessels and whether it differs between healthy people and those with high cholesterol.
- Trial name
- NCT00166166
- Testing
- Tetraethylammonium (TEA), L-NG-monomethyl Arginine (L-NMMA), Bradykinin
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Emory University
Atherosclerosis
Inflammation and Vascular Function in Atherosclerosis
The purpose of this study is to determine whether reducing inflammation in blood vessels with an aspirin-like drug called salsalate will improve blood vessel function.
- Trial name
- NCT00760019
- Testing
- salsalate
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Arterial Stiffening, Aging
Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss.
- Conditions
- Arterial Stiffening, Aging, Menopause
- Trial name
- SHAPE (NCT00608062)
- Testing
- GnRHant - Ganirelix acetate, Transdermal estradiol patch
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Ametropia
Endothelial Bleb Response With Toric Lenses
Evaluate the short-term corneal response of oxygen deprivation when using toric contact lenses. The response will be noted by endothelial bleb formation in both open eye and closed eye state.
- Trial name
- NCT00630305
- Testing
- alphafilcon A toric, lotrafilcon B toric, senofilcon A toric
- Where
- Australia
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Obstructive Sleep Apnea
Study to Assess the Changes in Blood Clotting Factors and Blood Vessel Wall Function in Obstructive Sleep Apnea
Obstructive sleep apnea is a condition in which people have decreased breathing during their sleep. Untreated sleep apnea has been linked to increased risk for cardiovascular diseases.
- Trial name
- NCT00936481
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Insulin Resistance
The Effects of Altering Physical Activity on Cardiometabolic Health
The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular…
- Trial name
- PIA (NCT01879059)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Insulin Sensitivity, Cardiovascular Risk
Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women
Birth control pills are the most commonly used method of birth control. The purpose of this research study is to examine whether birth control pills change heart disease risk and how the body handles blood sugar when given to…
- Conditions
- Insulin Sensitivity, Cardiovascular Risk, Perimenopausal Disorder
- Trial name
- NCT01475513
- Testing
- Ortho Cyclen®
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Obesity, Endothelial Dysfunction
Effects of Body Mass Index on the Hyperemic Response to Regadenoson
We will test the hypothesis that a single dose of Regadenoson will produce equivalent degrees of coronary hyperemia in patients of widely different body size.
- Conditions
- Obesity, Endothelial Dysfunction, Decreased Vascular Flow
- Trial name
- NCT00859833
- Testing
- Adenosine, Regadenoson
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Tinea Pedis
Nitric Oxide Releasing Solution (NORS) Footbath to Treat Athlete's Foot
The purpose of this study is to determine the fungicidal efficacy of nitric oxide releasing solution footbath and it's effect on the clinical signs and symptoms associated with Tinea Pedis
- Trial name
- NCT02871011
- Testing
- Nitric Oxide, Water
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Nitric Solutions Inc.
Chronic Kidney Disease, Hypertension
Alpha-Adrenoceptor Vascular Function In Chronic Kidney Disease Focus On The Role Of Endothelial Nitric Oxide
The purpose of this study is to learn more about why most patients with early stages of kidney disease have high blood pressure.
- Trial name
- NCT00356265
- Testing
- Procedure: Regional phenylephrine arterial infusion
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Periodontitis
Periodontal Infection and Endothelial Dysfunction
The purpose of this study is to determine the effect of periodontal therapy on endothelial function and other biomarkers of cardiovascular disease
- Trial name
- NCT00681564
- Testing
- One-Stage Full-Mouth Disinfection, Periodontal care
- Where
- 2 sites in Colombia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Type 2 Diabetes Mellitus, Coronary Artery Disease
Effects of Agonists of Glucagon Like Peptide - 1 Receptors (GLP-1R) on Arterial Stiffness, Endothelial Glycocalyx and Coronary Flow Reserve in Patients With Coronary Artery Disease and Patients With Diabetes Mellitus
Arterial stiffness is associated with increased risk for cardiovascular disease. Moreover, the integrity of endothelial glycocalyx plays a vital role in vascular permeability, inflammation and elasticity.
- Trial name
- NCT03010683
- Testing
- Liraglutide, Metformin
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Phenylketonuria
Phenylketonuria, Oxidative Stress, and BH4
The purpose of this study is to see how tetrahydrobiopterin therapy (BH4; also known as sapropterin dihydrochloride or Kuvan) affects measures of oxidative stress and endothelial function in patients with Phenylketonuria (PKU).
- Trial name
- NCT01395394
- Testing
- Kuvan, Meal Challenge
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Atherosclerosis
Arterial Function and Atherosclerosis in Essential Thrombocythemia
The aim of the study is to examine (a) whether patients with JAK2 V617F positive ET in comparison to age-and sex-matched, apparently healthy control subjects show more advanced progression of arterial stiffness, pulse-wave…
- Trial name
- NCT03828422
- Testing
- imaging
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Obesity
Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation
T-PA release is impaired in obese subjects. In order to have a better mechanistic understanding of t-PA release, we will compare t-PA release to Flow Mediated Vasodilation, Radial Artery Tonometry, and other markers of…
- Trial name
- P1A3B (NCT00780481)
- Testing
- Bradykinin
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Hypertension, Diabetes
Free Fatty Acids-Induced Hypertension in Obese Subjects (Aim #2)
The purpose of this study is to see if salsalate, an Nuclear factor-kappaB (NF-κB) mediated inflammation inhibitor, or carvedilol, an α- and β-blocker, will protect against free fatty acid induced hypertension, insulin…
- Trial name
- FFAADA (NCT02406586)
- Testing
- Salsalate, Carvedilol, Intralipid 20%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetes Type 2
The Effect of Aliskiren on Endothelial Function in Pre-Diabetes and Diabetes
The purpose of this research is to study and determine the effects of Aliskiren on blood vessels and blood flow. The primary hypothesis is that Aliskiren will increase endothelial function by 30% or more in comparison to the…
- Trial name
- NCT01165983
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center