Clinical trials: Endothelium
Portal Hypertension, Cirrhosis
A Pilot Study: Defining Peripheral Endothelial Function in Portal Hypertensive Cirrhotic Patients
Rationale for the study: To try and define PEF in cirrhotic patients with CSPH, and maybe to try to find a correlation between HVPG ( hepatic vein pressure gradient ) result and PEF result in a way that the result of the PEF test…
- Trial name
- NCT02356250
- Sponsor
- Eyal Ashkenazi
Infant, Premature, Diseases
Serum Vascular Endothelial Growth Factor in Infants With Intravitreal Ranibizumab
To determine the serum concentrations of ranibizumab and vascular endothelial growth factor (VEGF) in infants with retinopathy of prematurity (ROP) who received intravitreal ranibizumab
- Trial name
- NCT03115255
- Testing
- intravitreal ranibizumab
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Type 2-diabetes
Effects of Linagliptin on Renal Endothelium Function in Patients With Type 2 Diabetes.
Diabetes mellitus is a metabolic disease with a growing prevalence worldwide, affecting 171 million people in 2000 and an expected 366 million people in 2030 (1) and therefore diabetic nephropathy is rapidly increasing in the…
- Trial name
- NCT01835678
- Testing
- Linagliptin
- Where
- 2 sites in Germany
- Volunteers
- 65 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Retinal Vein Occlusion
Vascular Endothelial Growth Factor (VEGF) Levels in Retinal Vein Occlusion (RVO) During Anti-VEGF Treatment
The purpose of this study is to treat patients with retinal vein occlusion with standard of care anti-vascular endothelial growth factor therapy and to correlate levels of vascular endothelial growth factor in the anterior…
- Trial name
- NCT04707625
- Testing
- Aflibercept Ophthalmic
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Wake Forest University Health Sciences
Vascular Endothelial Growth Factor Overexpression
Differential Regulation of VEGF, Cadherin, Angiopietin 2 by Trigger Oocyte Maturation With GnRHa vs hCG in Donors
Introduction OHSS still remains a complication of assisted reproduction treatments. hCG administration to trigger final oocyte maturation will release vascular mediators, being VEGF and other proteins such as VE-Cadherin or…
- Trial name
- NCT00848185
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Diabetes Mellitus, Endothelial Dysfunction
Aldosterone and Vascular Disease in Diabetes Mellitus
Specific aims for this proposal are to determine in patients with diabetes mellitus the effects of an aldosterone receptor antagonist on: 1. Coronary microvascular function assessed by MRI perfusion reserve, 2.
- Conditions
- Diabetes Mellitus, Endothelial Dysfunction, Albuminuria
- Trial name
- NCT00214825
- Testing
- eplerenone, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Brigham and Women's Hospital
Proteinuric Renal Disease, Proteinuric Kidney Disease
Sparsentan for the Treatment of VEGF Signaling Pathway Inhibitor-Associated Proteinuria
Single-center, open-label, two-stage pilot study examining the efficacy and safety of sparsentan for reducing high-grade proteinuria among patients with cancer who receive vascular endothelial growth factor inhibitors
- Conditions
- Proteinuric Renal Disease, Proteinuric Kidney Disease, Proteinuria, Proteinuria in Nephrotic Range
- Trial name
- NCT07224776
- Testing
- sparsentan, No sparsentan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Type 2 Diabetes
Effect of a Simulated Flight in Patients With Type 2 Diabetes and Healthy Volunteers
Diabetes is an increasingly common condition which affects millions of people in the United Kingdom. Patients with type 2 diabetes are at increased risk to develop severe heart disease and vascular complications and these can…
- Trial name
- FlyBar (NCT04031417)
- Testing
- Hypoxia, Low Humidity
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Healthy Subjects
Endothelial Dysfunction Induced by Postprandial Lipemia
Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.
- Trial name
- NCT00660491
- Testing
- exercise training
- Where
- Norway
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Primary Open-angle Glaucoma, Glaucoma
Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma
The glycocalyx is a fibrillary lining structure that covers the inner surface of blood vessels. Composed of glycoproteins and polysaccharides, it is an essential determinant of vascular endothelial physiology: it limits…
- Trial name
- GLAUCALYX (NCT05264818)
- Testing
- Glycocheck, Ophthalmological examinations
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cardiovascular Diseases, Endothelial Dysfunction
Effect of Propionic Acid Supplementation on Endothelial Function
Coronary Artery Disease (CAD) remains a leading cause of morbidity and mortality worldwide despite improved mitigation of traditional risk factors.
- Trial name
- NCT05135702
- Testing
- Sodium Propionate
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Chronic Obstructive Pulmonary Disease
Cardiovascular Effects of Pulmonary Rehabilitation in COPD
Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction, which is clinically manifested by dyspnea and leads the patient to a vicious cycle of sedentary lifestyle.
- Trial name
- NCT03943030
- Testing
- Pulmonary rehabilitation
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Evaluate the Correlation Between the Level of ESM-1 and the Prognosis of the Patients With ARDS
Endothelial Cell Specific Molecule-1 (ESM-1): a Novel Biomarker for ARDS Endothelial Injury
To observe the changes of plasma ESM-1 levels in patients with ARDS, and to explore its clinical significance.
- Trial name
- NCT03296761
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Jingyuan,Xu
Kidney Injury, Proteinuria
Isosorbide Mononitrate For Anti-Vascular Endothelial Growth Factor (VEGF) Induced Kidney Injury
The purpose of this study is to test the hypothesis that isosorbide mononitrate prevents deterioration of renal function in patients receiving anti-angiogenic therapies that target vascular endothelial growth factor (VEGF).
- Conditions
- Kidney Injury, Proteinuria, Hypertension
- Trial name
- NCT04051957
- Testing
- Isosorbide Mononitrate
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The University of Texas Health Science Center, Houston
Stable Angina
Comparison of the Vasomotor Function and Myocardial Flow in Patients Treated With Bioresorbable and Metallic Stents at 1 Year
Background: A total of 25-50% of patients with stable coronary atherosclerosis treated with metallic stent implantation remain with effort angina despite optimal medical treatment and absence of stent restenosis at 1 year.
- Trial name
- BVS-Flow (NCT02738658)
- Testing
- Bioresorbable vascular scaffold, Everolimus-eluting stent
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Type 2 Diabetes Mellitus
Molecular Mechanisms of Type 2 Diabetes Mellitus
This project is designed to evaluate the molecular mechanisms involved in the early development of endothelial dysfunction in type 2 diabetic patients.
- Trial name
- NCT00816218
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 2 Diabetes, Peripheral Arterial Disease
Liraglutide and Peripheral Artery Disease
STARDUST is an open-label, two-arm randomized controlled trial, aimed at evaluating the effects of liraglutide on peripheral perfusion, as compared with the aggressive treatment of cardio-metabolic risk factors, in people with…
- Trial name
- STARDUST (NCT04881110)
- Testing
- Liraglutide, Control
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Campania Luigi Vanvitelli
Neovacular Age-related Macular Degeneration
UNcovering the Difference Between Ranibizumab and Aflibercept, Focusing on Systemic Anti-vascular Endothelial Growth Factor (VEGF) Effects in Patients With neovascuLar Age-related Macular Degeneration (AMD)
This study assessed systemic vascular endothelial growth factor (VEGF) level in patients with neovascular Age-related Macular Degeneration following treatment with Ranibizumab or Aflibercept.
- Trial name
- UNRAVEL (NCT01988662)
- Testing
- Neovascular Age-related Macular Degeneration
- Where
- 24 sites in Israel, Malaysia and 5 more
- Volunteers
- 205 people
- Sponsor
- Novartis Pharmaceuticals
Atherosclerosis, Endothelial Dysfunction
Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis
A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment on endothelial dysfunction parameters in subjects with peri-implantitis/peri-implant mucositis…
- Conditions
- Atherosclerosis, Endothelial Dysfunction, Peri-Implantitis, Peri-implant Mucositis
- Trial name
- NCT05906810
- Testing
- Non-surgical periodontal treatment
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Catania
Malignant Solid Tumour
Combination of Bevacizumab and Allogeneic NK Immunotherapy for Metastatic Solid Tumors
The aim of this study is the safety and efficacy of Bevacizumab plus allogeneic natural killer (NK) immunotherapy to many kinds of recurrent solid tumors.
- Trial name
- NCT02857920
- Testing
- Bevacizumab, NK immunotherapy
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou