Clinical trials: Endotoxemia
Obesity, Endotoxemia
Dietary Green Tea Confection For Resolving Gut Permeability-Induced Metabolic Endotoxemia In Obese Adults
This study is focused on assessing gastrointestinal-level improvements by which green tea limits metabolic endotoxemia. It is completed in two phases.
- Conditions
- Obesity, Endotoxemia, Inflammation
- Trial name
- NCT03413735
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Cardiovascular Disease
Fenofibrate and Omega-3 Fatty Acid Modulation of Endotoxemia
The purpose of this study is to better understand the anti-inflammatory benefits of two prescription medicines that are currently used to help people with cholesterol problems.
- Trial name
- FFAME (NCT01048502)
- Testing
- Fenofibrate (Tricor) tablets, Lovaza
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy Volunteers
Vorapaxar in the Human Endotoxemia Model
Vorapaxar is a recently approved protease activated receptor - 1 (PAR-1) inhibitor. Platelet inhibition may also exert positive results on coagulation activation and may beneficially influence the inflammatory response.
- Trial name
- NCT02875028
- Testing
- Vorapaxar, LPS
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dysbiosis, Endotoxemia
Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome
This study evaluates dietary green tea extract to improve gut health and inflammation in persons with metabolic syndrome and healthy adults.
- Conditions
- Dysbiosis, Endotoxemia, Metabolic Syndrome, Inflammation
- Trial name
- NCT03973996
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthy Volunteers
The Genetics of Evoked Responses to Niacin and Endotoxemia: The GENE Study
The purpose of this study is to determine genetic factors that affect responses to niacin therapy and endotoxemia in healthy volunteers.
- Trial name
- GENE (NCT00953667)
- Testing
- Immediate Release Niacin, Extended Release Niacin, Endotoxin
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Inflammatory Responses
Effects of a Prescription Omega-3 Fatty Acid Concentrate on Induced Inflammation
The purpose of this study is to assess whether the marine omega-3 fatty acids can attenuate inflammatory responses to endotoxin challenge.
- Trial name
- PRONOVA (NCT01813110)
- Testing
- 4 g prescription omega-3 concentrate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Penn State University
Healthy Volunteers, Endotoxemia
Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide
Defibrotide is an anti-inflammatory and anti-coagulatory agent approved for treatment of veno-occlusive disease. Although it has been in clinical use for almost 30 years, the exact mechanism of action has never been fully…
- Trial name
- LPS_DF (NCT02876601)
- Testing
- Defibrotide, Lipopolysaccharide
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bernd Jilma