Clinical trials: Endovascular Thrombectomy
Acute Ischemic Stroke
Endovascular Stroke Treatment Only (ESTO) Trial
The specific aims of this study are to: 1. Determine whether the endovascular treatment (mechanical thrombectomy) alone without using intravenous (IV) recombinant tissue plasminogen activator (rt-PA) in acute ischemic stroke…
- Trial name
- NCT04240470
- Testing
- Thrombectomy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Missouri-Columbia
Acute Ischemic Stroke
Comparison of Perioperative Conscious Sedation During Endovascular Thrombectomy in Acute Ischemic Stroke
This study aims to conduct a multicenter, prospective, randomized clinical trial to scientifically evaluate the safety and efficacy of different perioperative sedation methods during endovascular thrombectomy in acute ischemic…
- Trial name
- PEACE (NCT06139692)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 4 sites in China
- Volunteers
- 810 people
- Sponsor
- Jinling Hospital, China
Stroke, Acute, Ischemic Stroke, Acute
Endovascular Therapy for Large Core Patients With Uncertain Response to Thrombectomy
The purpose of this study is to assess the safety and efficacy of endovascular thrombectomy in both an early and extended time window in patients with large strokes due to large artery occlusion.
- Trial name
- OUTER LIMITS (NCT06961487)
- Testing
- EndovascularThrombectomy, Endovascular thrombectomy with any FDA-approved device
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Stroke, Stroke Acute
Mechanical Thrombectomy in the Middle East and North Africa: Interim Results from the MEMENTO Registry
The MEMENTO (MEchanical thrMobectomy NETwork for MENA TOgether) Registry is a multicenter, prospective observational study aiming to evaluate the effectiveness, safety, and cost-effectiveness of mechanical thrombectomy (MT) in…
- Conditions
- Stroke, Stroke Acute, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- MEMENTO Regist (NCT06702787)
- Where
- Egypt
- Volunteers
- 1,500 people
- Sponsor
- Middle East North Africa Stroke and Interventional Neurotherapies Organization
Mesenteric Artery Ischemia, Thromboembolism
Endovascular thromBectomy of Acute Mesentery Vessels Occlusion Hybrid With Emergent Laparoscopic Surgery
Acute mesenteric artery thromboembolism(AMT) is one of the important causes of acute abdomen and intestinal necrosis. If the intestinal blood supply is not restore in time, the prognosis of the disease is often poor and even…
- Trial name
- BOWEL (NCT04686981)
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Acute Ischemic Stroke
SELECT2: A Randomized Controlled Trial to Optimize Patient's Selection for Endovascular Treatment in Acute Ischemic Stroke
SELECT 2 evaluates the efficacy and safety of endovascular thrombectomy compared to medical management alone in acute ischemic stroke patients due to a large vessel occlusion in the distal ICA and MCA M1 who have large core on…
- Trial name
- SELECT2 (NCT03876457)
- Testing
- Endovascular Thrombectomy, Medical Management
- Where
- 31 sites in United States, Australia and 4 more
- Volunteers
- 352 people
- Sponsor
- University Hospitals Cleveland Medical Center
Cerebrovascular Stroke, Thrombolytic Therapy
Thromboelastometry and Ischemic Stroke (ThromboPredict)
In ischemic stroke, the recanalization rate after intravenous thrombolysis has been estimated to be less than 50% in patients with proximal intracranial artery occlusion; this rate is greater than 80% after endovascular…
- Conditions
- Cerebrovascular Stroke, Thrombolytic Therapy, Mechanical Thrombectomy
- Trial name
- NCT04870684
- Testing
- thromboelastometry test
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Ischemic Stroke
Evaluation of the Safety and Performance of Magneto Microcatheter
A prospective, open label single arm feasibility study to evaluate the safety and performance of the Magneto Microcatheter in patients diagnosed with acute ischemic stroke and planned for thrombectomy procedure.
- Trial name
- NCT04466033
- Testing
- Magneto Microcatheter
- Where
- 3 sites in Hungary, Israel
- Volunteers
- 4 people
- Sponsor
- Magneto Thrombectomy Solutions
Pulmonary Embolism and Thrombosis
Compative Study of PE in Thrombosed AVF After Balloon Thrombectomy Vs. Thromboaspiration.
The goal of this multicentric clinical trial is to compare the incidence of pulmonary thromboembolism (PTE), assessed through AngioCT, in the endovascular treatment of acute thrombosis in native and prosthetic arteriovenous…
- Trial name
- NCT06051032
- Testing
- Balloon thrombectomy, Thromboaspiration system
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Ischemic Stroke, Acute, Thrombectomy
CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke
Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process.
- Conditions
- Ischemic Stroke, Acute, Thrombectomy, Anesthesia, General, Cerebrovascular Circulation
- Trial name
- COMET-AIS (NCT05051397)
- Testing
- HYPERCAPNIA, NORMOCAPNIA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Stroke, Ischemic, Intravascular Thrombosis
Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET)
To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who received recanalization operation.
- Conditions
- Stroke, Ischemic, Intravascular Thrombosis, Mechanical Thrombectomy
- Trial name
- NCT04664933
- Testing
- Intra-arterial administration of neuroprotective agents
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Hui-Sheng Chen
Acute Lower Limb Arterial Occlusion
The ArtixASCEND Study
This study is a post-market, prospective, multicenter, single-arm study to evaluate the safety and effectiveness of the Artix Thrombectomy System in patients with acute lower extremity arterial occlusions.
- Trial name
- NCT07135895
- Testing
- Artix Thrombectomy System
- Where
- 23 sites in United States
- Volunteers
- 250 people
- Sponsor
- Inari Medical
Ischemic Stroke, Anesthesia
The Effect of Sedoanalgesia and General Anaesthesia on Early Neurological Recovery in Acute Ischaemic Stroke Patients Undergoing Endovascular Thrombectomy
The hypothesis of this study is that sedoanalgesia will provide better early neurological recovery than general anaesthesia in acute ischaemic stroke patients undergoing endovascular thrombectomy and to investigate the…
- Conditions
- Ischemic Stroke, Anesthesia, Neurologic Symptoms
- Trial name
- NCT06183567
- Testing
- Sedoanalgesia, general anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Umraniye Education and Research Hospital
Acute Stroke
New York City Mobile Interventional Stroke Team
Endovascular treatment has recently become the recommended therapy for acute stroke after the publication of five randomized trials (MR CLEAN1, ESCAPE2, EXTEND IA3, SWIFT PRIME4, REVASCAT5) in 2015 that demonstrate its efficacy.
- Trial name
- NYC MIST (NCT03048292)
- Testing
- Acute Endovascular Stroke Treatment
- Where
- 4 sites in United States
- Volunteers
- 191 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Deep Vein Thrombosis
Comparison Of Different Mechanical Thrombectomy Devices in Endovascular Treatment of Acute Iliofemoral Venous Thrombosis
A head-to-head comparison of two different types of percutaneous mechanical thrombectomy (PMT) - ClotTriever System versus aspiration thrombectomy (including rheolytic thrombectomy) - in patients with acute iliofemoral deep vein…
- Trial name
- NCT07622212
- Testing
- Percutaneous mechanical thrombectomy by ClotTriever System, Percutaneous mechanical thrombectomy by aspiration or rheolytic thrombectomy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
Stroke, Ischemic
RCT of Ghrelin in Stroke Patients
About half of the patients with acute ischemic stroke treated with endovascular thrombectomy (EVT) remain dependent on the help of others or die in the first 90 days.
- Trial name
- MR GENTLE (NCT05726240)
- Testing
- Ghrelin
- Where
- 3 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Rijnstate Hospital
Stroke, Acute, Cerebral Stroke
Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window
TENSION (Efficacy and safety of ThrombEctomy iN Stroke with extended leSION and extended time window) is a prospective, open label, blinded endpoint (PROBE), European two-arm, randomized, controlled, post-market study to compare…
- Conditions
- Stroke, Acute, Cerebral Stroke, Cerebrovascular Stroke, Apoplexy; Brain
- Trial name
- Tension (NCT03094715)
- Testing
- Thrombectomy, Best medical care
- Where
- 42 sites in Austria, Canada and 8 more
- Volunteers
- 253 people
- Sponsor
- University Hospital Heidelberg
Acute Ischemic Stroke
Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy
1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2.
- Trial name
- NOTICE-1 (NCT07049692)
- Testing
- Hyperbaric Oxygen Therapy, Conventional therapy group
- Where
- 2 sites in China
- Volunteers
- 424 people
- Sponsor
- Beijing Chao Yang Hospital
Arterial Ischemic Stroke
A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS)
The primary study objective is to assess the safety of afamelanotide while the secondary objective is to assess whether the therapy affects the size of the penumbra, by increasing blood flow, restoring oxygen supply to the brain…
- Trial name
- NCT04962503
- Testing
- Afamelanotide
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Clinuvel Pharmaceuticals Limited
Acute Ischemic Stroke, Endovascular Thrombectomy
Effects of Post-Operative Sedation for Endovascular Thrombectomy
Studies from our lab indicated that long-term sedation is protective in mice with midbrain infarct. To assess whether post-operative sedation has protective effects on clinical outcomes in patients with ischemic stroke undergoing…
- Trial name
- POSET (NCT04517383)
- Testing
- post-operative sedation, routine recovery
- Where
- China
- Volunteers
- 1,286 people
- Sponsor
- RenJi Hospital