Clinical trials: Endovascular Thrombectomy
Acute Ischemic Stroke, Endovascular Thrombectomy
Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP)
Acute ischemic stroke (AIS) is a leading cause of mortality and long-term disability worldwide. Among these, stroke caused by large vessel occlusion (LVO) are associated with particularly poor outcomes.
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Minocycline, Posterior Circulation
- Trial name
- NCT07594301
- Testing
- Minocycline hydrochloride capsule
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Xiang Luo
Stroke, Acute Ischemic Stroke
Mobilisation After Endovascular Stroke Treatment
The goal of this observational study is to learn how the timing of mobilisation after endovascular thrombectomy (EVT) affects complications in patients with acute ischaemic stroke.
- Conditions
- Stroke, Acute Ischemic Stroke, Acute Ischemic Stroke AIS, Endovascular Thrombectomy
- Trial name
- MAESTRO (NCT07860333)
- Testing
- Mobilisation
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Large Vessel Occlusion, Stroke
Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)
Endovascular thrombectomy (EVT), also known as clot retrieval, is a procedure that improves recovery for people who suffer a stroke by removing blood clots from large blood vessels in the brain.
- Conditions
- Large Vessel Occlusion, Stroke, Ischemic Stroke
- Trial name
- HoBIT (NCT07367633)
- Testing
- Head of bed position of 0-degrees, Head of bed position of 30-degrees or greater
- Where
- 2 sites in Canada
- Volunteers
- 2,240 people
- Sponsor
- Population Health Research Institute
Acute Ischemic Stroke (AIS)
Study of the Safety and Neuroprotective Capacity of Scp776 in Acute Ischemic Stroke
A Randomized, Placebo-Controlled, Double-Blind, Multicenter Study of the Safety and Neuroprotective Capacity of Scp776 in Subjects Undergoing Endovascular Thrombectomy for Acute Ischemic Stroke
- Trial name
- ARPEGGIO (NCT05585606)
- Testing
- scp776 (1.9 mg/kg), scp776 (3.8 mg/kg), scp776 (4.8 mg/kg)
- Where
- 22 sites in United States
- Volunteers
- 120 people
- Sponsor
- Silver Creek Pharmaceuticals
Stroke, Acute, Ischemic
PeRfusiOn Post tHrombEcTomy (PROPHET)
Endovascular mechanical thrombectomy is the standard of care for treating patients with a large-vessel occlusion acute ischemic stroke.
- Trial name
- PROPHET (NCT06691230)
- Where
- 2 sites in Switzerland
- Volunteers
- 279 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ischemic Stroke
Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke
The purpose of the study is to understand whether a new treatment of stroke - endovascular clot removal - can be added to the current standard of care to improve patient outcomes.
- Trial name
- ESCAPE (NCT01778335)
- Testing
- Endovascular thrombectomy/thrombolysis
- Where
- Canada
- Volunteers
- 316 people
- Sponsor
- University of Calgary
Pulmonary Embolism
Evaluation of the Magneto eTrieve™ PE Kit for Endovascular Thrombectomy in Subjects With Acute Pulmonary Embolism
Prospective, multi-center, open-label, single-arm clinical study of the safety and effectiveness of the eTrieve™ in subjects presenting with signs and symptoms of acute intermediate-risk pulmonary embolism
- Trial name
- eTrieve II (NCT05821426)
- Testing
- eTrieve PE Kit
- Volunteers
- 130 people
- Sponsor
- Magneto Thrombectomy Solutions
Acute Ischemic Stroke
Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime)
Stroke is a common cause of disability. The most common type of stroke, an ischemic stroke, is caused by a blood vessel in the brain getting blocked by a clot.
- Trial name
- CoPrime (NCT06638151)
- Testing
- aspirin + clopidogrel, Aspirin
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of Alberta
Acute Ischemic Stroke Patients, Acute Ischemic Stroke
Guiding Catheters in Endovascular Stroke Therapy - Are Balloon Guided Catheters Superior?
The BEST study is an academically initiated, single-center, prospective, randomized controlled clinical trial investigating the potential advantages and disadvantages of using a guide catheter with or without a balloon in the…
- Conditions
- Acute Ischemic Stroke Patients, Acute Ischemic Stroke, Acute Ischemic Stroke AIS
- Trial name
- BEST (NCT07478042)
- Testing
- Ballon guide catheter, Guide catheter without balloon
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University Hospital Heidelberg
Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation
Sodium Sivelestat With Mechanical Thrombectomy for Acute Stroke: A Pilot Study
Stroke remains a major global health burden, with acute ischemic stroke (AIS) accounting for more than 65% of all cases. Endovascular thrombectomy (EVT) has been established as the standard treatment for large vessel occlusion…
- Conditions
- Acute Ischemic Stroke, Neutrophil Extracellular Traps Formation, Large Vessel Occlusion, Thrombectomy
- Trial name
- NCT07196605
- Testing
- Sodium Sivelestat
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke, Endovascular Thrombectomy
A Predictive Model and Scoring System for Severe Complications After Endovascular Thrombectomy
To establish a predictive model and scoring system for predicting severe complications after thrombectomy. This scoring system can be used to identify high-risk patients after endovascular thrombectomy, guide the early use of…
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Symptomatic Intracranial Hemorrhage, Malignant Cerebral Edema
- Trial name
- NCT06290076
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke
SUPERSTAR: Aspiration vs. Stent Retriever in Anterior Circulation LVO
This is a multicenter, open-label, blinded-endpoint, randomized controlled trial comparing super large bore catheter aspiration versus stent retriever thrombectomy as the first-line technique for anterior circulation large vessel…
- Trial name
- SUPERSTAR (NCT07555977)
- Testing
- Super Large Bore Catheter, Stent Retriever Thrombectomy
- Where
- China
- Volunteers
- 708 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Stroke, Ischemic, Cerebral Edema
Early Prophylactic Decompressive Hemicraniectomy Following Endovascular Therapy in Large Hemispheric Infarct Trial
Early Decompressive Hemicraniectomy for High-Risk Large Ischemic Core Stroke Post-EVTAcute Ischemic Stroke (AIS), particularly Anterior Circulation Large Vessel Occlusion (LVO), is a major cause of global disability and death.
- Trial name
- NCT07118345
- Testing
- Early prophylactic decompressive hemicraniectomy
- Where
- 2 sites in China
- Volunteers
- 380 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Ischemic Stroke AIS, Stroke Acute
ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
This domain has a prospective, randomized, controlled, open-label, parallel group with blinded endpoint assessment (PROBE) design.
- Conditions
- Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic
- Trial name
- ACT-WHEN (NCT06320431)
- Testing
- Tenecteplase
- Where
- 24 sites in Australia, Canada
- Volunteers
- 4,000 people
- Sponsor
- University of Calgary
Acute Ischemic Stroke
Efficacy and Safety of Butylphthalide for Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis or Endovascular Treatment
Butylphthalide, as a well-known neuroprotective medication, is a family of compounds initially isolated from the seeds of Apium graveolens Linn, of which active ingredient is dl-3-N-butylphthalide (dl-NBP).
- Trial name
- BAST (NCT03539445)
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke, Hypothermia
Safety and Efficacy of Selective Intra-Arterial Cooling Infusion Combined With EVT in Acute Ischemic Stroke
This is a multicenter, randomized, controlled, subject- and assessor-blinded clinical trial. The research objective is to evaluate the safety and efficacy of selective intra-arterial cooling infusion combined with endovascular…
- Trial name
- FOCUS (NCT06485427)
- Testing
- Selective Intra-arterial Cooling Infusion (IA-SCI)
- Where
- 12 sites in China
- Volunteers
- 258 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Stroke, Vascular Occlusion
REperfusion Therapy for Acute Ischemic STrOke Due to Large aRtEry Occlusion
The aim of the study was to establish a clinical and advanced imaging database of acute ischemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion of anterior circulation within 24 hours from…
- Conditions
- Stroke, Vascular Occlusion, Endovascular Treatment, Mechanical Thrombectomy
- Trial name
- RESTORE (NCT05311605)
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke
Outcome in Patients Treated with Intraarterial Thrombectomy - OptiMAL Blood Pressure Control (OPTIMAL-BP)
Recent endovascular thrombectomy (EVT) trial have proven the effectiveness of intraarterial revascularization in patients with larger cerebral artery occlusion.
- Trial name
- NCT04205305
- Testing
- conventional blood pressure control (labetalol, nicardipine), intensive blood pressure control (labetalol, nicardipine)
- Where
- South Korea
- Volunteers
- 306 people
- Sponsor
- Yonsei University
Acute Ischemic Stroke, Basilar Artery Occlusion
Endovascular Therapy for Acute Basilar Artery Occlusion With Large Ischemic Core
Acute basilar artery occlusion is associated with high mortality and severe disability. Previous randomized trials have demonstrated the benefit of endovascular therapy in selected patients with basilar artery occlusion; however…
- Conditions
- Acute Ischemic Stroke, Basilar Artery Occlusion, Large Ischemic Core
- Trial name
- NCT07672795
- Testing
- Endovascular Therapy, Best Medical Management
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Acute Stroke, Mechanical Thrombectomy
BraiN20® Monitoring in Acute Stroke Undergoing Thrombectomy
N20 somatosensory evoked potential (SEP) response shows high predictive accuracy of functional recovery in patients with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT).
- Trial name
- PROMISE20 (NCT06149754)
- Testing
- BraiN20(R) monitoring of N20 somatosensory evoked potential
- Where
- 3 sites in Spain
- Volunteers
- 65 people
- Sponsor
- Fundació Institut Germans Trias i Pujol