Clinical trials: Endovascular Treatment
Endovascular Thrombectomy, Large Vessel Occlusion
Triage of Patients Presenting Beyond 24 Hours With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late)
The objective of this study is to create a comprehensive, multi-center, TRACK-LVO registry-linked cohort of consecutive patients with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO) and presenting to each…
- Conditions
- Endovascular Thrombectomy, Large Vessel Occlusion, Acute Ischemic Stroke
- Trial name
- TRACK-LVO Late (NCT06200753)
- Testing
- Mechanical Thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Huanhu Hospital
Middle Cerebral Artery Aneurysm
Prospective, Multicenter Cohort Study on the Safety and Efficacy of Treatment for Middle Cerebral Artery Aneurysms
Intracranial aneurysm is one of the most common cerebrovascular diseases, with a prevalence of about 3.2%. With the aging of the population and the further popularization of MRA and other examination methods, the prevalence of…
- Trial name
- NCT04927520
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Submassive Pulmonary Embolism
The RESCUE II Study. The Bashir™ Endovascular Catheter (BEC),
To demonstrate the efficacy and safety of the Bashir™ Endovascular Catheter for the administration of pharmaco-mechanical catheter directed therapy using pulse spray of r-tPA for the treatment of acute submassive pulmonary…
- Trial name
- NCT06120179
- Testing
- The Bashir™ Endovascular Catheter (BEC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Temple University
Unruptured Intracranial Aneurysm, Intracranial Bifurcation Aneurysm
Early Complications After Flow Diverter Versus Stent-Assisted Coiling for Unruptured Wide-Neck Intracranial Bifurcation Aneurysms
This prospective real-world cohort study aims to compare early postoperative complications between flow diverter treatment and stent-assisted coiling in patients with unruptured wide-neck intracranial bifurcation aneurysms.
- Conditions
- Unruptured Intracranial Aneurysm, Intracranial Bifurcation Aneurysm, Wide-Neck Aneurysm
- Trial name
- FD-SAC BAS (NCT07754188)
- Testing
- Flow Diverter, Stent-Assisted Coiling
- Where
- 3 sites in China
- Volunteers
- 274 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Myocardial Infarction, Myocardial Reperfusion Injury
Efficacy of Endovascular Catheter Cooling Combined With Cold Saline for the Treatment of Acute Myocardial Infarction
The purpose of this study is to determine whether treatment of patients suffering from ST-elevation myocardial infarction (STEMI) with 1-2 liters of cold saline and central venous catheter cooling with Philips InnerCool RTx…
- Conditions
- Myocardial Infarction, Myocardial Reperfusion Injury, Anterior Wall Myocardial Infarction, Inferior Wall Myocardial Infarction
- Trial name
- CHILL-MI (NCT01379261)
- Testing
- Cooling
- Where
- 10 sites in Austria, Denmark and 2 more
- Volunteers
- 120 people
- Sponsor
- Region Skane
Acute Ischemic Stroke
Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)
Though intravenous thrombolysis has been shown to improve symptoms in acute ischemic stroke patients, the recanalization rate remains low (22.6%) and only around 30% of patients benefit from the treatment.
- Trial name
- NCT06677970
- Testing
- BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
- Where
- South Korea
- Volunteers
- 176 people
- Sponsor
- Yonsei University
Arterial Occlusive Diseases
A Prospective Study: the Value of Using iFlow and PBV in the Endovascular Treatment of Infrapopliteal Arterial Occlusive Diseases
Color coded blood flow and blood perfusion techniques are applied to the endovascular treatment of infrapopliteal arterial occlusion,to establish a method of quantitative evaluation of blood flow and tissue perfusion,to improve…
- Trial name
- NCT03248323
- Testing
- dyna-pbv
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Superior Cave Syndrome
Title Endovascular Treatment of Superior Cave Syndromes Reaching the Trifurcation: a Single-Center Case Series
Superior vena cava syndrome (SCS) is caused by obstruction of blood flow in the superior vena cava, which allows venous return from the upper half of the body to the heart.
- Trial name
- TESC-Tri (NCT06680999)
- Testing
- Data collection
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Peripheral Arterial Disease
Effectiveness of Medical Therapy, Endovascular Therapy, and Surgery for Peripheral Arterial Disease
This study is designed to develop a clinical registry of Peripheral Arterial Disease (PAD) patients undergoing lower extremity revascularization to describe the population and assess comparative effectiveness of endovascular…
- Trial name
- PAD (NCT01588067)
- Where
- 2 sites in United States
- Volunteers
- 271 people
- Sponsor
- Kaiser Permanente
Intracranial Aneurysm
Intelligent Microcatheter Shaping for Intracranial Aneurysm Coil Embolization
This prospective, multicenter, observational registry study will evaluate the real-world safety, effectiveness, and clinical value of artificial intelligence (AI)-assisted microcatheter shaping during coil embolization of…
- Trial name
- NCT07749404
- Testing
- Physician-Experience Microcatheter Shaping, AI-Assisted Microcatheter Shaping Simulation Technology
- Where
- China
- Volunteers
- 1,438 people
- Sponsor
- Xuanwu Hospital, Beijing
Cerebral Aneurysm
Goal-directed Therapy in Endovascular Coiling of Cerebral Aneurysm Patients
Goal directed therapy (GDT) is a technique, which employs a non-invasive cardiac output monitoring (NICOM) device to guide management of circulating blood volume and blood pressure during procedures.
- Trial name
- NCT02507999
- Testing
- Flotrac
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Acute Ischemic Stroke
EnDovascular Therapy Plus Best Medical Treatment (BMT) Versus BMT Alone for MedIum VeSsel Occlusion sTroke
Acute ischemic stroke (AIS) is one of the main causes of disability and loss of quality adjusted life years. This study is to analyze whether endovascular therapy (EVT) in addition to best medical treatment (BMT) reduces the…
- Trial name
- DISTAL (NCT05029414)
- Testing
- Endovascular Therapy
- Where
- 56 sites in Belgium, Finland and 9 more
- Volunteers
- 543 people
- Sponsor
- University Hospital, Basel, Switzerland
Peripheral Arterial Disease, Critical Limb Ischemia
Exercise Rehabilitation for Patients With Critical Limb Ischemia After Revascularization
Peripheral arterial disease (PAD) affects more than 200 million people worldwide. This disease occurs with narrowing and occlusion of arteries supplying oxygenated blood to the organs and limbs.
- Trial name
- NCT03839953
- Testing
- Supervised Exercise Program, Best Medical Therapy
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Acute Ischemic Stroke
Study of Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core
Endovascular therapy (EVT) was recommended as the primary treatment for patients with acute large vascular occlusion (LVO) in anterior circulation.
- Trial name
- ANGEL-ASPECT (NCT04551664)
- Testing
- Best medical management, Endovascular therapy
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Beijing Tiantan Hospital
Intracranial Aneurysm
International Registry of Intra-arterial and Endosaccular Flow Diverters (IRF)
This multicenter retrospective cohort study aims to evaluate and compare the technical performance, safety, and clinical outcomes of intracranial aneurysms treated with flow diverter stents and endosaccular flow disruptors.
- Trial name
- IRF (NCT06174727)
- Where
- 13 sites in United States, Canada
- Volunteers
- 5,000 people
- Sponsor
- Montefiore Medical Center
Stroke, Acute
Endovascular Acute Stroke Intervention Trial - the EASI Trial
Stroke constitutes the primary cause of acquired disability in adults and the second cause of dementia following Alzheimer disease.
- Trial name
- EASI (NCT02157532)
- Testing
- mechanical thrombectomy, Best standard treatment
- Where
- 2 sites in Canada
- Volunteers
- 480 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Intracranial Aneurysm
A Single-arm Trial of the Flow Diverter (Tonbridge) For Endovascular Treatment of Intracranial Aneurysms
The purpose of this study is to assess the effectiveness and safety of the Flow Diverter (Tonbridge) by collecting data from subjects who receive endovascular treatment of intracranial aneurysms.
- Trial name
- NCT04918420
- Testing
- Flow Diverter (Tonbridge)
- Where
- 7 sites in China
- Volunteers
- 142 people
- Sponsor
- Ton-Bridge Medical Tech. Co., Ltd
Pulmonary Embolism
A Prospective Study for the Treatment of Severe Pulmonary Embolism With Pharmacodynamic Thrombectomy
The mortality of severe pulmonary embolisms admitted to the resuscitation department for circulatory failure remains in the range of 30-40% at the acute phase. Hemodynamic failure is the leading cause of death.
- Trial name
- RESPIRE (NCT04318782)
- Testing
- Pharmacodynamic thrombectomy
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Basilar Artery Occlusion, Acute Cerebrovascular Accident
Endovascular Treatment for Acute Basilar Artery Occlusion
Rationale: Recently, two prospective multicenter RCT reported a potential beneficial effect of endovascular thrombectomy (EVT) in patients with an acute symptomatic basilar artery occlusion (BAO).
- Conditions
- Basilar Artery Occlusion, Acute Cerebrovascular Accident, Stroke Due to Basilar Artery Occlusion
- Trial name
- NCT04751708
- Testing
- endovascular treatment, best medical management
- Where
- China
- Volunteers
- 340 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Pulmonary Embolism
First - In - Man Study to Assess the Safety and Feasibility of The Bashir™ Endovascular Catheter for the Treatment of Acute Pulmonary Embolism
The Bashir™ Endovascular Catheter is a device intended for the localized infusion of therapeutic agents into the pulmonary artery and peripheral vasculature.
- Trial name
- NCT03927508
- Testing
- r-tPA, The Bashir™ Endovascular Catheter
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- Thrombolex, Inc.