Clinical trials: Endovascular Treatment
Endovascular Thrombectomy, Ischemic Cerebrovascular Accident
A Trial to Assess the Efficacy and Safety of OTR4132-MD in Patients With Acute Ischemic Stroke
The MaTRISS 2 study is a phase 2 randomized, double-blinded and placebo-controlled trial aimed at recruiting 60 subjects (30 placebo and 30 active) from 15 stroke centers in France.
- Trial name
- MATRISS-II (NCT06700824)
- Testing
- OTR4132
- Where
- 15 sites in France
- Volunteers
- 60 people
- Sponsor
- Organ, Tissue, Regeneration, Repair and Replacement
Endovascular Therapy, Acute Ischaemic Stroke
Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke
The RESCUE-BP is a multi-centered, prospective, randomized, open label, blinded endpoint (PROBE) phase III trial. In patients with acute ischemic stroke who have undergone endovascular treatment and achieved successful…
- Conditions
- Endovascular Therapy, Acute Ischaemic Stroke, Collateral Circulation, Blood Pressure Management
- Trial name
- RESCUE-BP (NCT07527013)
- Testing
- Stratified Blood Pressure Management
- Where
- China
- Volunteers
- 544 people
- Sponsor
- Beijing Tiantan Hospital
Postimplantation Syndrome, Myocardial Injury
Steroid Treatment to Prevent Thoracic Endovascular Aortic Repair Postimplantation Syndrome
Postimplantation syndrome (PIS) is a common and clinically important complication following thoracic endovascular aortic repair (TEVAR).
- Conditions
- Postimplantation Syndrome, Myocardial Injury, MACE, Mortality
- Trial name
- STOP TEVAR PIS (NCT07328906)
- Testing
- Methylprednisolone (MP)
- Where
- Serbia
- Volunteers
- 174 people
- Sponsor
- University of Belgrade
Ischemic Stroke
Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe
A phase III, randomized, multi-center, investigational, open label clinical trial that will examine whether treatment with endovascular thrombectomy is superior to standard medical therapy alone in patients who suffer a Distal…
- Trial name
- DUSK (NCT05983757)
- Testing
- Experimental: endovascular thrombectomy in patients who suffer a distal medium vessel occlusion, Standard medical management
- Where
- 4 sites in United States
- Volunteers
- 584 people
- Sponsor
- Raul Nogueira
Iliac Vein Obstruction, May-Thurner Syndrome
Iliac Vein Stenting in Advanced Chronic Venous Insufficiency
About 90 % of vascular symptoms affecting the lower limbs consist of venous diseases. Its highest incidence occurs from the second decade of life, affecting significantly the economically active population.
- Conditions
- Iliac Vein Obstruction, May-Thurner Syndrome, Cockett Syndrome
- Trial name
- NCT02149212
- Testing
- Phlebotonic, Stent, Limb elastic compression support
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Acute Ischemic Stroke, Large Vessel Occlusion
Sevoflurane vs. Propofol for General Anesthesia in Patients With Acute Ischemic Stroke Treated With Endovascular Therapy
Acute ischemic stroke occurs when a blood clot blocks blood flow to part of the brain. Patients with this condition may require endovascular therapy, a procedure used to remove the clot and restore blood flow.
- Trial name
- SAVE (NCT07902791)
- Testing
- Sevoflurane, propofol (drug)
- Where
- Spain
- Volunteers
- 314 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Dissection of the Superior Mesenteric Artery
Dissection of the Superior Mesenteric Artery
This study aims to evaluate the prognosis of patients with spontaneous solitary dissection of superior mesenteric artery (SIDSMA) who have been treated with stents.
- Trial name
- NCT05171842
- Testing
- Observe the prognosis after stent implantation
- Where
- China
- Volunteers
- 136 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Acute Ischemic Stroke
Randomized Study of Bailout Intracranial Angioplasty Following Thrombectomy for Acute Large Vessel Occlusion
Unfavorable outcomes were associated with failed thrombectomy of acute large vessel occlusions (LVO). The failed thrombectomy rate was 12-41% reported in multiple randomized controlled trials (RCT).
- Trial name
- ANGEL-REBOOT (NCT05122286)
- Testing
- Bailout angioplasty, Standard therapy
- Where
- China
- Volunteers
- 348 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
Butylphthalide for Brain Edema After Endovascular Treatment
This is a prospective, multicenter, randomized controlled clinical study aimed at evaluating the efficacy of butylphthalide in improving the severity of cerebral edema and prognosis in patients with acute anterior circulation…
- Trial name
- NCT07528456
- Testing
- Butylphthalide
- Where
- 10 sites in China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Ischemic Stroke
COOLing of the Ischemic PENumbra in Patients With Acute Ischemic Stroke.
This study will develop and validate a novel, active/conductive combined head and neck cooling system to selectively cool the ischemic penumbra during the acute phase of stroke, reducing neuronal damage and improving stroke…
- Trial name
- PEN-Cool (NCT07844096)
- Testing
- PEN-Cool Conductive Head-and-Neck Cooling System, Standard Reperfusion Therapy / Routine Care
- Where
- 5 sites in India
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Christian Medical College and Hospital, Ludhiana, India
Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke
Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)
Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor…
- Conditions
- Anterior Cerebral Artery Syndrome, Anterior Cerebral Artery Stroke, Acute Ischemic Stroke, Cardioembolic Stroke
- Trial name
- NCT07013396
- Testing
- Transcranial Doppler (TCD) examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Subarachnoid Hemorrhage, Aneurysmal, Cerebral Vasospasm After Subarachnoid Hemorrhage
Endovascular Therapy for Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Cerebral vasospasm is a common and serious complication after aneurysmal subarachnoid hemorrhage and is an important cause of delayed cerebral ischemia and poor neurological outcomes.
- Trial name
- RESCUE-CV (NCT07643922)
- Testing
- Intra-arterial and Intravenous Milrinone Therapy, Standardized Medical Management
- Where
- 2 sites in China
- Volunteers
- 306 people
- Sponsor
- Beijing Tiantan Hospital
Acute Ischemic Stroke
EmboTrap ® II Revascularization Device (Neuravi) in Acute Ischemic Stroke
The primary aim of Registrap study is to assess the safety and effectiveness of the EmboTrap®II Clot Retriever device (Neuravi) in patients with acute ischemic stroke from large vessel occlusion.
- Trial name
- NCT03601702
- Testing
- Mechanical thrombectomy with EmboTrap ® II Device
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Niguarda Hospital
Intracranial Aneurysms
Efficacy Trial of Intracranial Aneurysm Treatment Using Two Different Endovascular Techniques
To date the standard non-surgical treatment strategy for treating un-ruptured intracranial aneurysms is the use of either coils or self-expandable stents.
- Trial name
- NCT01084681
- Testing
- Endovascular treatment of intracranial aneurysms, Endovascular treatment of intracranial aneurysm with coils
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- Balt International
Intracranial Aneurysm
Flow Diverter Stent for Endovascular Treatment of Unruptured Saccular Wide-necked Intracranial Aneurysms
Unruptured saccular intracranial aneurysms larger than 7 mm can be treated with endovascular occlusion using detachable coils, with or without expendable stent assistance.
- Trial name
- EVIDENCE (NCT01811134)
- Testing
- PIPELINE flow diverter stent, Coils, with or without expendable stent
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Hospices Civils de Lyon
Deep Venous Thrombosis
Second Line Endovascular Treatment in Acute DVT
The goal of this study is to fill the paucity of second line endovascular treatment for acute deep venous thrombus (DVT) by using catheter-directed thrombolysis (CDT) and mechanical thrombectomy (MT) as adjunctive second-line…
- Trial name
- NCT06486181
- Testing
- Thrombolysis/Thrombectomy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Intracranial Artery Stenosis, Stent
Wingspan Stent System for Intracranial Artery Stenosis
The primary objective of this trial is to evaluate the safety and efficacy of Wingspan Stent System in \"real world\" patients with intracranial atherosclerotic stenosis.
- Conditions
- Intracranial Artery Stenosis, Stent, Endovascular Therapy
- Trial name
- NCT06618222
- Testing
- Wingspan stent system
- Where
- China
- Volunteers
- 43 people
- Sponsor
- The First People's Hospital of Changzhou
Venous Stenosis, Venous Occlusion
The Merit WRAPSODY AV Access Efficacy Study (WAVE)
The purpose of the study is to demonstrate the safety and efficacy of the Merit WRAPSODY Endovascular Stent Graft for treatment of stenosis or occlusion within the dialysis access outflow circuit
- Trial name
- WAVE (NCT04540302)
- Testing
- Merit WRAPSODY Endovascular Stent Graft, PTA
- Where
- 43 sites in United States, Brazil and 2 more
- Volunteers
- 357 people
- Sponsor
- Merit Medical Systems, Inc.
Distal Aortic Dissection
A Multi-center Trial of Single-Branched Stent Graft System to Treat Aortic Dissection
Aim:Castor is a novel single-branched stent graft system for endovascular repair of aortic arch dissection. This is a prospective, one-arm, open, multi-center, pre-market study of Castor stent to evaluate its efficacy and safety…
- Trial name
- NCT01914237
- Testing
- Castor Stent Graft
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Changhai Hospital
Aneurysm, Aortic Aneurysm
Longitudinal Registry of Endovascular Thoracoabdominal Aneurysms
The purpose of this study is to evaluate the long-term safety and performance of complex endovascular aneurysm repair by inclusion in a longitudinal registry
- Trial name
- LoRETA (NCT03499431)
- Testing
- Endovascular Thoracoabdominal Aneurysm Repair
- Volunteers
- 1,000 people
- Sponsor
- Tara Mastracci