Clinical trials: Energy and Cognition
Aging, Cognitive Decline
Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition
Extended bouts of periodic mastication and intermittent energy restriction (IER) may improve cognitive performance in the context of adult hippocampal neurogenesis in an ageing population.
- Trial name
- ChANgE (NCT03457870)
- Testing
- Intermittent Energy Restriction, Chewing, Chewing + Intermittent Energy Restriction
- Where
- United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- King's College London
Quality of Life, Cognitive Decline
Health and Energy Through Active Living Every Day After Cancer Intervention for Cancer Survivors
The purpose of the Health and Energy through Active Living Every Day (HEALED) intervention, is to examine the effect of a web-based intervention on changes in device-measured physical activity (light and moderate-to-vigorous…
- Conditions
- Quality of Life, Cognitive Decline, Fatigue, Sleep
- Trial name
- HEALED (NCT05356988)
- Testing
- Physical activity experiment, Balance and flexibility control
- Where
- United States
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- American Cancer Society, Inc.
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Tavua, Fiji
Ambient air temperatures in Fiji are increasing due to climate change. Solutions are needed to build heat resilience in communities and adapt.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- NCT07592117
- Testing
- Cool roof
- Where
- Fiji
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Metabolism - Cerebral Energy
The Efficient Brain Study
Cerebral energy metabolism declines with advanced aging, and is implicated in age-related cognitive decline, Alzheimer's disease (AD), and other forms of neurodegenerative disease (Parkinson's disease).
- Trial name
- NCT02771366
- Testing
- Fermented Papaya Preparation, Granulated Sugar
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Physical Performance, Exercise Performance
The Acute Effects of Liquid IV's Pre-Workout Supplement on Muscle Endurance & Strength, Energy, and Cognition
The goal of this study is to learn if a new pre-workout supplement can improve exercise performance in healthy adults. It will also look at how the supplement affects mood and energy levels.
- Conditions
- Physical Performance, Exercise Performance, Endurance Exercise, Perceived Exertion
- Trial name
- NCT07225608
- Testing
- proprietary pre-workout supplement
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Exercise Performance Impairment, Cognitive Function Decline
Effects of Energy Drink on Repeated Sprint Performance and Cognitive Function in Athletes
Energy drinks are often used by athletes before competitions to enhance their performance. Recent research has pointed out that the performance effects of select ingredients have been studied individually but not in combination…
- Conditions
- Exercise Performance Impairment, Cognitive Function Decline, Fatigue
- Trial name
- NCT07104188
- Testing
- Caffeine, Energy Drink
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Chien-Wen Hou
Mild Cognitive Impairment
Proof of Mechanism of a New Ketogenic Supplement Using Dual Tracer PET (Positron Emission Tomography)
A six month, placebo-controlled, parallel group project in which MCI participants will receive 30 g/day of a custom-made MCT-based ketogenic supplement or a matching placebo.
- Trial name
- BENEFIC (NCT02551419)
- Testing
- ketogenic drink
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Université de Sherbrooke
Endurance Cycling Performance
The Effect of Diet Composition on Performance, Expenditure, Blood Lipids, and Appetite Hormones in Highly Trained Cyclists
This study employs a crossover design to evaluate the effect of two different diets (high carbohydrate vs. ketogenic) and corresponding test meals on endurance exercise performance, energy expenditure including resting metabolic…
- Trial name
- DCAP (NCT04097171)
- Testing
- Diet
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Caffeine
The Effects of e+Shots Energy Beverage on Mental Energy
The aim of the research project is to determine the changes in motivation to perform mental and physical tasks, feelings of vigor and fatigue, mental task vigilance and fine motor function after consumption of a commercially…
- Trial name
- NCT03850275
- Testing
- Intervention/treatment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clarkson University
Huntington's Disease
Creatine Therapy for Huntington's Disease
This study, CREST-HD, will examine the safety and tolerability of 8 grams of creatine in subjects affected by Huntington's disease (HD).
- Trial name
- NCT00026988
- Testing
- Creatine
- Where
- 4 sites in United States
- Volunteers
- 64 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico
Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06834893)
- Testing
- Cool roof
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Mild Cognitive Impairment, Metabolic Syndrome
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
The study explores whether selective memory complaints (SMC), mild cognitive impairment (MCI) and the comorbidity of Metabolic Syndrome symptomatic of peripheral and cerebral hypo-metabolism with corresponding epigenetic shifts…
- Trial name
- NCT03319173
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Bristlecone Health, Inc.
Cognition, Appetite
Acute Effects of Paraxanthine on Energy and Focus
This study aims to evaluate the effects of paraxanthine (200 mg and 300 mg) on energy, focus, appetite, and cognitive performance in healthy adults.
- Conditions
- Cognition, Appetite, Mental Energy, Dietary Supplement
- Trial name
- PXN (NCT06628596)
- Testing
- Paraxanthine 200mg and 300mg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Iovate Health Sciences International Inc
Cognitive Change
Semaglutide and Cognition in Healthy Volunteers
Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1RA). It is a safe medication approved for use in type-2 diabetes mellitus (T2DM) and obesity.
- Trial name
- OxSENSE (NCT06363487)
- Testing
- Semaglutide, 0.5 mg/mL
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Resistance Exercise Performance, Cognitive Functions
Dose-Response Effects of Short-Term Ashwagandha on Anaerobic Exercise and Cognitive Function in Resistance-Trained Athletes
Ashwagandha (ASH) is an herbal supplement derived from the Withania somnifera plant. It is commonly described as an adaptogen, a substance thought to help the body cope with physical and psychological stress.
- Conditions
- Resistance Exercise Performance, Cognitive Functions, Anaerobic Performance, Dietary Supplementation Athletic Performance
- Trial name
- ASH (NCT07853274)
- Testing
- Low-dose Ashwagandha Supplement, High-dose Ashwagandha Supplement
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Jacksonville State University
Overweight, Obesity
The Effects of Including Almonds in a Weight Loss Trial
The purpose of this study is to determine whether inclusion of almonds in a weight loss regimen will augment the rate of weight loss, promote a greater fat mass/fat-free mass ratio of weight loss, improve blood pressure and…
- Trial name
- NCT02360787
- Testing
- Energy restriction, Almonds (15% kcal/day)
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Purdue University
Obesity
Low Energy Ketogenic Diet in Obese Subjects - the Impact on Whole Organism
The study evaluates the timeline of changes of body composition, physical and psychological performance, and biochemical markers of metabolism and inflammation responses to low energy ketogenic diet for loosing weight in obese…
- Trial name
- KETO (NCT03338452)
- Testing
- Low energy ketogenic diet
- Where
- Slovenia
- Volunteers
- 38 people
- Sponsor
- University of Primorska
Hypothyroidism
Hypothyroidism, Metabolism and Quality of Life - Focus on QOL, REE, Cognitive Function and Body Composition
This project has the following primary aims: The main objective is to delineate the association between changes in Resting energy expenditure (REE) and QOL in hypothyroid patients before and after one year of L-T4 treatment.
- Trial name
- HYMAQ (NCT02891668)
- Testing
- Levothyroxine treatment
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Herlev Hospital
Mild Cognitive Impairment
Energy Metabolism and Cognitive Aging
Participants 60 and older with and without Parkinson's disease who have mild cognitive decline will be randomized to either a standard higher carbohydrate diet or a carbohydrate-restricted ketogenic diet for 8 weeks.
- Trial name
- NCT00777010
- Testing
- Ketogenic diet, Healthy high carbohydrate diet
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Cincinnati