Clinical trials: Enlarged Heart
Dilated Cardiomyopathy with Conduction Defect, Left Bundle-Branch Block
Conduction System Pacing Versus Biventricular Pacing for Cardiac ResYNChronization
Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV) is the cornerstone treatment for heart failure patients with ventricular dyssynchrony.
- Conditions
- Dilated Cardiomyopathy with Conduction Defect, Left Bundle-Branch Block, Heart Failure, Resynchronization Therapy
- Trial name
- CSP-SYNC (NCT05155865)
- Testing
- Resynchronization with conduction system pacing, Cardiac resynchronization therapy with biventricular stimulation
- Where
- Slovenia
- Volunteers
- 62 people
- Sponsor
- University Medical Centre Ljubljana
Cardiomyopathy, Dilated, Prognosis
Cardiac Magnetic Resonance-Clinical Prediction Model-Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is a common and serious heart disease characterized by left ventricular enlargement and impaired pumping function, with adverse prognosis (including heart failure, arrhythmia, heart-related…
- Conditions
- Cardiomyopathy, Dilated, Prognosis, Magnetic Resonance Imaging, Cardiac, Death, Sudden, Cardiac
- Trial name
- MPS-CMR-DCM (NCT07527715)
- Testing
- left ventricular ejection fraction
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital
Heart Failure
Optoelectronic Pletysmography and Diaphragmatic Thickness in Heart Failure Patients
The investigators aimed to evaluate the effects of cardiomegaly associated with inspiratory muscle weakness on tricompartmental distribution of chest wall volumes, on the thickness of the right hemidiaphragm and on the…
- Trial name
- NCT02481388
- Testing
- Maximal exercise ramp test
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal de Pernambuco
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Dilated Cardiomyopathy
Danish ICD Study in Patients With Dilated Cardiomyopathy
The primary objective of this study is to determine the efficacy of ICD therapy compared with control on the endpoint of death from any cause in patients with heart failure of non-ischemic oetiology.
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Reduced LVEF
- Trial name
- DANISH (NCT00542945)
- Testing
- ICD, Optimal medical treatment
- Where
- Denmark
- Volunteers
- 1,116 people
- Sponsor
- Danish Study Group
Cardiomyopathy, Dilated, Cardiomyopathies, Secondary
Characterization of Irreversible Myocardial Injury in Cardiomyopathies by Contrast-enhanced CMR
Different studies have shown that fibrosis of the heart increases the risk for a sudden death from e.g. arrhythmias. Magnetic Resonance Imaging (CMR) can easily identify even small areas of fibrosis in the heart muscle after…
- Trial name
- NCT00549861
- Testing
- Cardiac Magnetic Resonance study
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Oliver Strohm
Dilated Cardiomyopathy
Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is a poorly understood cause of systolic heart failure and is the most common indication for heart transplantation worldwide.
- Trial name
- NCT01917149
- Testing
- Benazepril, Valsartan, Metoprolol
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Xijing Hospital
Ventricular Ejection Fraction, LVF
AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor
This prospective, multicenter, cluster-randomized controlled study aims to evaluate the accuracy of an investigational artificial intelligence (AI) Software as a Medical Device (SaMD) designed to compute ejection fraction (EF)…
- Conditions
- Ventricular Ejection Fraction, LVF, LV Dysfunction, Atrial Enlargement
- Trial name
- EFACT (NCT06699056)
- Testing
- 15-minutes of sitting during COR ECG Acquistion
- Where
- 8 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Hypertensive Left Ventricular Hypertrophy
Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy
The primary objective of this study is to determine which treatment will be more effective to reduce left ventricular mass in hypertensive patients with left ventricular hypertrophy comparing aliskiren and eplerenone.
- Trial name
- EARTH (NCT01893788)
- Testing
- Aliskiren, Eplerenone
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Nagoya University
Dilated Cardiomyopathy
Simvastatin Therapy in Patients With Dilated Cardiomyopathy.
Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with significant early morbidity and mortality. About half of patients die or require heart transplantation within 5 years of diagnosis.
- Trial name
- SavDCM (NCT03775070)
- Testing
- Simvastatin
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital
Dilated Cardiomyopathies, Hypertrophic Cardiomyopathy
Sahlgrenska Cardiomyopathy Project
This is a joint project by Sahlgrenska University Hospital: Sahlgrenska, Östra and Mölndal. Our objective is to diagnose and map patients with well phenotyped cardiomyopathies (CMP) including in depth clinical and molecular…
- Conditions
- Dilated Cardiomyopathies, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy
- Trial name
- NCT03527342
- Where
- Sweden
- Volunteers
- 3,000 people
- Sponsor
- Göteborg University
Long QT Syndrome, Brugada Syndrome
Physical Activity in Children With Inherited Cardiac Diseases
Use lay language. Current guidelines regarding physical activity in patients with inherited arrhythmia and cardiomyopathy are mostly dedicated to adult patients, with a special focus on sports competition.
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Hypertrophic Cardiomyopathy
- Trial name
- NCT04650009
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Dilated Cardiomyopathy, Heart Failure
Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy (REMEDIUM)
The goal of REMEDIUM project is to develop personalized stem cell therapy for patients with chronic heart failure due to dilated cardiomyopathy (DCM).
- Trial name
- REMEDIUM (NCT02248532)
- Testing
- Stem cell therapy
- Where
- Slovenia
- Volunteers
- 66 people
- Sponsor
- University Medical Centre Ljubljana
Dilated Cardiomyopathy, Obstructive Sleep Apnea
Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea
The aim of this randomized controlled study is to investigate the effect of continues positive airway pressure (CPAP) treatment in patients with dilated cardiomyopathy (DCM) and concomitant obstructive sleep apnea (OSA).
- Trial name
- RIDA (NCT02989181)
- Testing
- Continues Positive Airway Pressure (CPAP)
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- Göteborg University
Hypertension, Left Ventricular Hypertrophy
Effect of Valsartan on Left Ventricular Myocardial Functions in Hypertensive Patients With Left Ventricular Hypertrophy
The study hypothesis: Valsartan as an angiotensin II receptor blocker treatment has beneficial effects on both midwall mechanics and myocardial functions in hypertensive patients with Left ventricular hypertrophy.
- Trial name
- NCT01425411
- Testing
- valsartan
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Mustafa Kemal University
Cardiomyopathies, Dilated Cardiomyopathy
Pediatric Cardiomyopathy Mutation Analysis
The goal of this protocol is to obtain information from individuals with cardiomyopathy and from their families in order to elucidate the molecular genetics of this disorder.
- Conditions
- Cardiomyopathies, Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Restrictive Cardiomyopathy
- Trial name
- NCT02432092
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Dilated Cardiomyopathy, Chronic Heart Failure
Training Study to Evaluate the Benefit of Exercise for Patients With Chronic Heart Failure
The study investigates the safety and effectiveness of a 12 week endurance training program for patients with chronic heart failure
- Trial name
- CHF (NCT00934609)
- Testing
- Endurance training
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Universität des Saarlandes
Atrial Fibrillation
Effects of Dronedarone on Cardiac Geometry and Function in Patients With Atrial Fibrillation and Left Atrial Enlargement
Primary Objective: Evaluate the effect of dronedarone versus placebo (standard therapy) in slowing the progression of adverse left atrial remodeling in patients with atrial fibrillation (AF) following 12 months of treatment.
- Trial name
- ODYSSEUS (NCT01198873)
- Testing
- Dronedarone
- Where
- 57 sites in United States, Canada
- Volunteers
- 76 people
- Sponsor
- Sanofi
Cardiopulmonary Failure, Myocardial Infarction (MI)
COR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable
The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using…
- Conditions
- Cardiopulmonary Failure, Myocardial Infarction (MI), Heart Decompensation, Heart Failure
- Trial name
- COR-INSIGHT (NCT06763549)
- Testing
- SUBPROTOCOL A, SUBPROTOCOL B, SUBPROTOCOL C
- Where
- United States
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Obstructive Coronary Artery Disease, Left Ventricular Hypertrophy
Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study
To evaluate the ability of exercise ECG to discriminate between hypertensive heart disease-related and CAD-related abnormalities
- Trial name
- HYSTERESIS (NCT07847463)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pisa