Clinical trials: Enlarged Heart
Cardiomyopathy, Dilated
Effect of Sildenafil on Left Ventricular Function in Pediatric With Primary Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and impaired contraction that is not explained by abnormal loading conditions.(1) Both inherited predisposition and…
- Trial name
- AssiutU (NCT07536880)
- Volunteers
- 70 people
- Sponsor
- Assiut University
Cardiomyopathy
Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
The objective of this study is to collect information on patients with cardiomyopathy (CM) due to mutations in the MYBPC3 gene, to evaluate their disease course, burden of illness, risk factors for this disease, and the quality…
- Trial name
- MyCLIMB (NCT05112237)
- Where
- 29 sites in United States, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- Tenaya Therapeutics
Dilated Cardiomyopathy
The Arrhythmogenic Potential of Midwall Septal Fibrosis in Dilated Cardiomyopathy
Midwall septal fibrosis (MSF) is a common structural abnormality in non-ischaemic dilated cardiomyopathy (DCM). Its presence is believed to increase the risk of malignant ventricular arrhythmias (VA), but the mechanism of…
- Trial name
- DCM-MSF (NCT05026112)
- Testing
- ECG-Imaging, Cardiac MRI scan
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Heart Failure
Stem Cells and Resynchronization Cardiac
Same patients with dilated myocardiopathies with large areas of fibrosis has not been as successful after Cardiac Resynchronization Therapy, for Heart Failure patients in functional class III or IV.
- Trial name
- RCT and SCT (NCT00800657)
- Testing
- Pacing and Stem Cells Implantations., Pacing and Stem Cells Implantation
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto de Molestias Cardiovasculares
Dilated Cardiomyopathy
PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors
This is a multicentre European double-blind,randomized and controlled trial with 2 parallel groups (1 study medication, 1 placebo) in order to analyse the impact of ACE inhibitors (ACEi) in subjects who carry a mutation but have…
- Trial name
- PRECARDIA (NCT01583114)
- Testing
- perindopril
- Where
- 7 sites in Denmark, France and 5 more
- Volunteers
- 6 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Fabry Disease
Therapeutic Implications of CMR Low Native T1 in Non-treated Non-hypertrophic Females With Fabry Disease (FD)
Females with Fabry disease are characterized by variable phenotypes regarding time of onset, severity of symptoms and progression of disease due to the random inactivation of X chromosome leading to a cellular mosaic of mutated…
- Trial name
- NATI-Fab (NCT07872852)
- Testing
- Decision tree for initiating treatment
- Where
- 12 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Atrial Fibrillation
Prevalence of Sub-Clinical Atrial Fibrillation Using an Implantable Cardiac Monitor
The primary objective of the study is to determine the rate of detection of sub-clinical atrial fibrillation (≥ 5 minutes)within an average of 12 months following implant of the St.
- Trial name
- ASSERT-II (NCT01694394)
- Testing
- Implantable Cardiac Monitor (Confirm ICM model 2102)
- Where
- 19 sites in Canada, Netherlands
- Volunteers
- 256 people
- Sponsor
- Population Health Research Institute
Dilated Cardiomyopathy
Respiratory Muscles Training in Patients With Dilated Cardiomyopathy
The aim of this study was to determine the effects of respiratory muscles training on cardiopulmonary parameters and quality of life in patients with dilated cardiomyopathy (DCM).
- Trial name
- NCT04307823
- Testing
- Treadmill training, Treadmill protocol and Respiratory training
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Heart Failure With Normal Ejection Fraction, Left Ventricular Hypertrophy
Imaging Histone Deacetylase in the Heart
The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.
- Conditions
- Heart Failure With Normal Ejection Fraction, Left Ventricular Hypertrophy, Aortic Valve Stenosis, Diabetes
- Trial name
- NCT03549559
- Testing
- 11C-Martinostat, PET-MRI
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cardiomyopathy, Hypertrophic
Prognosis of Subjects With Unexplainable Precordial Deep T-wave Inversion Without Wall Thickness> 15mm
The investigators sought to evaluate the morphological and functional changes and prognosis of participants with unexplainable precordial deep T-wave inversion on ECG and with apical thickness less than 15mm.
- Trial name
- NCT02692508
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Dilated Cardiomyopathy
Outcome-targeted Therapy: Principle and Outcome Evaluation: Clinical Study and Phenotype-genotype Correlation
Brief Summary(Use lay language. Include a statement of the study hypothesis.): Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with significant early morbidity and mortality.
- Trial name
- NCT06632834
- Testing
- simvastatin therapy
- Where
- Taiwan
- Volunteers
- 230 people
- Sponsor
- National Taiwan University Hospital
Hypertension, Arteriosclerosis
The Effects of Lowering Dialysate Sodium in Hypertensive Hemodialysis Patients
Unfavorably high sodium intakes remain prevalent around the world. A negative sodium gradient in hemodialysis treatment results in absolute sodium removal via diffusive transport of sodium from the blood to the dialysate, and it…
- Conditions
- Hypertension, Arteriosclerosis, Left Ventricular Hypertrophy
- Trial name
- NCT01455974
- Testing
- Decreasing dialysate sodium from 138 mmol/L to 136 mmol/L
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Capital Medical University
Chronic Kidney Disease, Secondary Hyperparathyroidism
Active Vitamin D Effect on Left Ventricular Hypertrophy
Left ventricular hypertrophy (LVH) predicts mortality at start of dialysis. Prevention of of LVH is important. It is not known whether secondary hyperparathyroidism might induce LVH.
- Conditions
- Chronic Kidney Disease, Secondary Hyperparathyroidism, Left Ventricular Hypertrophy
- Trial name
- NCT00175149
- Testing
- Alfacalcidiol
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Per Ivarsen
Ventricular Arrythmia
China Structural Ventricular Arrhythmias Registry
This is an observational, prospective, multi-center registry ,aiming at building a risk stratification for malignant structural ventricular arrhythmias.
- Trial name
- NCT03821051
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Heart Failure, Cardiomyopathy, Dilated
Early Feasibility Study of the AccuCinch® Ventricular Restoration System in Patients With Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation
This is a non-randomized, prospective, multi-center Early Feasibility Study of the AccuCinch® Ventricular Restoration System in Patients with Prior Mitral Valve Intervention (PMVI) and Recurrent Mitral Regurgitation.
- Trial name
- CorCinch-PMVI (NCT03560167)
- Testing
- AccuCinch® Ventricular Restoration System
- Where
- 19 sites in United States
- Volunteers
- 5 people
- Sponsor
- Ancora Heart, Inc.
Heart Failure
Feasibility Study of Radiofrequency Heating of Cardiac Infarction Scar to Treat Heart Failure
The purpose of this study is to examine the safety and potential effectiveness of a new surgical procedure for treating heart failure.
- Trial name
- RECOVER (NCT00881777)
- Testing
- Radiofrequency heating of the myocardial infarct scar, Coronary Artery Bypass Grafting (CABG) surgery
- Where
- 3 sites in Paraguay, Poland
- Volunteers
- 3 people
- Sponsor
- CoRepair, Inc.
Acute Myocarditis
MyocarditIRM-Génétique - Genetic Sub-study of the French Cohort of Acute Myocarditis Cases Diagnosed by MRI
The aim of this retrospective, non-interventional study is to assess the prevalence and describe the genetic variants found in a cohort of patients with acute myocarditis confirmed by MRI.
- Trial name
- MyocarditIRM-G (NCT07717073)
- Where
- France
- Volunteers
- 602 people
- Sponsor
- French Cardiology Society
Essential Hypertension, Left Ventricular Hypertrophy
Candesartan and Candesartan/ Hydrochlorothiazide in the Treatment of Patients With Hypertension and LVH
The CandLE study with at maximum daily dose of 32 mg candesartan or 16/12.5 mg candesartan/hydrochlorothiazide has the objective to evaluate under naturalistic conditions, i.e.
- Trial name
- CandLE (NCT00607633)
- Volunteers
- 686 people
- Sponsor
- AstraZeneca
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Non-Invasive Evaluation of Myocardial Stiffness by Elastography in Pediatric Cardiology (Elasto-Pédiatrie)
First, investigators must determine the physiological standards across age classes of myocardial stiffness estimated by Elastography in ultrafast (estimated right ventricular stiffness [VD] and left ventricular [LV]).
- Trial name
- NCT02619825
- Testing
- Echography, Elastography
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University