Clinical trials: Enlarged Heart
Chronic Kidney Disease, Hypertrophy, Left Ventricular
Effects of a Reduction in Renal Function on Cardiovascular Structure and Function
Chronic kidney disease (CKD) is present in 1 in 7 of the population and confers a high risk of cardiovascular disease. The pathophysiology of cardiovascular disease in CKD is poorly understood because CKD is always accompanied by…
- Conditions
- Chronic Kidney Disease, Hypertrophy, Left Ventricular, Hypertension
- Trial name
- CRIB-DONOR II (NCT02973607)
- Testing
- Nephrectomy
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Hypertension; Hypertrophy, Left Ventricular
Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy
This study will evaluate the safety and efficacy of amlodipine plus valsartan in patients with hypertension and left ventricular hypertrophy
- Trial name
- NCT00446563
- Testing
- Valsartan, Amlodipine, Hydrochlorothiazide
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Novartis
Cardiac Hypertrophy, Immunosuppression
Cardiac Allograft Remodeling and Effects of Sirolimus
Cardiac allograft remodeling causes poor quality of life, allograft failure and increased mortality after heart transplantation.
- Trial name
- CAR (NCT01889992)
- Testing
- Cardiac MRI, Coronary angiography with IVUS, Cardiac Allograft Remodeling
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Nebraska
Dilated Cardiomyopathy, Primary Prevention of Sudden Cardiac Death
Electrophysiologic and Morphologic Assessment of the Substrate to Guide Implantation of Defibrillators in Dilated Cardiomyopathy
With the present study the investigators intend to identify the morphologic and electrophysiologic substrate markers of increased arrhythmic risk in patients with dilated cardiomyopathy undergoing implantation of a defibrillator…
- Conditions
- Dilated Cardiomyopathy, Primary Prevention of Sudden Cardiac Death, Implantable Cardioverter Defibrillator
- Trial name
- EMOSIDD (NCT01378572)
- Where
- 3 sites in United States, Italy
- Volunteers
- 200 people
- Sponsor
- Catholic University of the Sacred Heart
End-stage Renal Disease
Effects of Strict Volume Control in Hypertensive Hemodialysis Patients on Cardiac Structure and Chronic Inflammation
This study aims mainly to investigate the effects of two approaches to control blood pressure in hypertensive hemodialysis patients; using antihypertensive drugs versus strict volume control (by strict dietary salt restriction…
- Trial name
- NCT00307463
- Testing
- strict volume control policy, antihypertensive drugs administration
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 258 people
- Sponsor
- Ege University
Cardiomyopathy, Hypertrophic
Long-Term Results of DDD Pacing in Obstructive Hypertrophic Cardiomyopathy
DDD pacing improves symptoms and relieves LV outflow tract (LVOT) obstruction in most patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00001530
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension, Left Ventricular Hypertrophy
Hypertension in Hemodialysis
How high blood pressure in hemodialysis patients should be diagnosed and treated using medications or without medications is the purpose of this study.
- Trial name
- NCT00067665
- Testing
- Ultrafiltration
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Dilated Cardiomyopathy
Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy
This study describes a controlled randomized clinical trial to evaluate the efficacy of bone marrow derived stem-cell implants by minithoracotomy in patients with dilated cardiomyopathy and cardiac failure class III or NYHA.
- Trial name
- SDILCM (NCT00743639)
- Testing
- intramyocardial bone marrow stem cells implantation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Laminopathies, Emery Dreifuss Muscular Dystrophy 2
Modifying Factors in Striated Muscle Laminopathies
Mutations in the LMNA gene, which codes for lamins A and C, proteins of the nuclear lamina, are responsible for a wide spectrum of pathologies, including a group specifically affecting striated skeletal and cardiac muscles, with…
- Conditions
- Laminopathies, Emery Dreifuss Muscular Dystrophy 2, LMNA-Related Congenital Muscular Dystrophy, Dilated Cardiomyopathy-1A
- Trial name
- LMNAModifier (NCT05394506)
- Testing
- Skin Biopsy, Muscle biopsy
- Where
- 8 sites in France
- Volunteers
- 40 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Lv Hypertrophy, Heart Failure, Diastolic
Prevention of Cardiovascular Stiffening With Aging and Hypertensive Heart Disease
The purpose of this study is to determine whether vigorous exercise training 4-5 days/week for one year in sedentary middle aged (ages 40-64) individuals at high risk for future development of heart failure will improve cardiac…
- Conditions
- Lv Hypertrophy, Heart Failure, Diastolic, Stiffness, Vascular
- Trial name
- LVH (NCT03476785)
- Testing
- High intensity exercise, Yoga
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Marfan Syndrome
Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome
Marfan syndrome is a hereditary connective tissue disorder. Many individuals with this condition die because of the associated heart and blood vessel abnormalities.
- Trial name
- NCT00429364
- Testing
- Losartan Potassium, Atenolol
- Where
- 26 sites in United States, Belgium and 1 more
- Volunteers
- 608 people
- Sponsor
- Carelon Research
Myocardial Infarction, Stroke
My Research Legacy Pilot Study
The My Research Legacy Pilot Study will establish a participant registry that collects self-reported health data and answers to online survey questions about individual daily choices, diets, and exercise; data from wearable…
- Conditions
- Myocardial Infarction, Stroke, Cardiomyopathy, Dilated, Systolic Heart Failure
- Trial name
- NCT02958098
- Volunteers
- 2,267 people
- Sponsor
- American Heart Association
Hypertrophy, Left Ventricular
Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart Failure
This study will assess the efficacy of mirabegron, a new beta3-adrenergic receptor in the prevention of heart failure. This is a two armed, prospective, randomized, placebo-controlled, multi-centric european phase IIb trial with…
- Trial name
- Beta3_LVH (NCT02599480)
- Testing
- mirabegron, Echocardiography, Cardiac MRI
- Where
- 10 sites in Belgium, France and 6 more
- Volunteers
- 296 people
- Sponsor
- Jean-Luc Balligand
Hypertrophic Cardiomyopathy
Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem
This is a pilot clinical trial to assess whether the administration of diltiazem may be able to decrease the development or progression of hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00319982
- Testing
- Diltiazem
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Brigham and Women's Hospital
Aortic Valve Stenosis, Left Ventricular Hypertrophy
Effect of Angiotensin II Receptor Blockers (ARB) on Left Ventricular Reverse Remodelling After Aortic Valve Replacement in Severe Valvular Aortic Stenosis
The consequence of aortic valve stenosis (AVS) is increased pressure load on the left ventricle which causes left ventricular (LV) hypertrophy, and myocardial stretch will cause activation of cardiac peptides and activation of…
- Conditions
- Aortic Valve Stenosis, Left Ventricular Hypertrophy, Atrial Fibrillation
- Trial name
- NCT00294775
- Testing
- Candesartan
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
Cardiovascular Diseases, Heart Diseases
Mortality Surveillance of MRFIT Screenees
To ascertain the sixteen year mortality status of the 361,662 middle-aged men screened in 1973-1975 for the Multiple Risk Factor Intervention Trial (MRFIT).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Cerebrovascular Accident, Coronary Disease
- Trial name
- NCT00005156
- Sponsor
- University of Minnesota
Dilated Cardiomyopathy (DCM), Heart Failure
Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy
This study aims to evaluate the safety and preliminary efficacy of a second administration of fibroblast activation protein (FAP)-targeted immunosuppressive chimeric antigen receptor dendritic cells (CAR-DC) in patients with…
- Trial name
- NCT07516288
- Testing
- FAP immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiomyopathy, Congestive, Pulmonary Hypertension
Characterization of the Liver Parenchyma Using Parametric T1 and T2 Magnetic Resonance Relaxometry
To determine normal T1 and T2 values of the liver, and to assess the impact of age and gender To determine the relation between markers of right heart decompensation and T1/T2 values of the liver in patients with pulmonary…
- Conditions
- Cardiomyopathy, Congestive, Pulmonary Hypertension, Constrictive Pericarditis, Cardiomyopathy, Dilated
- Trial name
- NCT04623528
- Testing
- T1 and T2 relaxometry of the liver parenchyma
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dilated Cardiomyopathy (DCM)
Evaluating the Prognostic Impact of Anti-β1AR Antibodies and Anti-L-CaC Antibodies in Patients With Dilated Cardiomyopathy
Background of the study The etiology of dilated cardiomyopathy (DCM) is complex and involves a variety of genetic, environmental, and immunologic factors.
- Trial name
- NCT06741995
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Left Ventricular Hypertrophy
Point-of-care Ultrasound and Treatment Disparities for Left Ventricular Hypertrophy
The objective of the proposed project is to quantify the prevalence and disparities of undiagnosed left ventricular hypertrophy (LVH) in Emergency Department (ED) patients with persistently elevated asymptomatic BP, and to…
- Trial name
- NCT05730309
- Testing
- Customized discharge and expedited referral instructions
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Yale University