Clinical trials: Enlarged Heart
Hypertrophic, Ischemic
Coronary Artery Disease and Coronary Microvascular Disease in Cardiomyopathies Registry
Long-term prognostic value of macrovascular and microvascular coronary artery stenoses in each type of cardiomyopathy.
- Conditions
- Hypertrophic, Ischemic, Restrictive Cardiomyopathy, Dilated Cardiomyopathies
- Trial name
- 3CRegistry (NCT03479580)
- Testing
- Patients with a cardiomyopathy
- Where
- France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Grenoble
Consolidation, Lung Injury
Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna Trial
This study aims to evaluate whether the use of AI as a physician support tool is associated with an increase in the detection rate of chest radiographic findings in adults with respiratory complaints, compared to diagnosis…
- Conditions
- Consolidation, Lung Injury, Pleural Effusion, Pneumothorax
- Trial name
- NCT06686251
- Testing
- App LuAna
- Where
- Brazil
- Volunteers
- 2,400 people
- Sponsor
- Hospital Israelita Albert Einstein
Hypertension Arterial, Hypokinetic
Etiological DiagnOsis of caRdiac Diseases Based on echoCardiograpHIc Images and Clinical Data.
Research hypothesis - Recent studies have shown that high-dimensional descriptors of the cardiac function can be efficiently exploited to characterize targeted pathologies.
- Conditions
- Hypertension Arterial, Hypokinetic, Cardiomyopathies, Left Ventricular Hypertrophy
- Trial name
- ORCHID (NCT05942729)
- Testing
- Determine the etiology of hypokinetic and hypertrophic heart disease on transthoracic echocardiography data alone
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Chronic Systolic Heart Failure (Dilated Cardiomyopathy)
NORDIC: Nitric Oxide-Derived Oxidants and Regional Endothelial and Diastolic Dysfunction in Dilated Cardiomyopathy
The principal aim is to investigate the safety and efficacy of rosiglitazone in patients with chronic systolic heart (Dilated cardiomyopathy).
- Trial name
- NORDIC (NCT00293137)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Pneumothorax, Pulmonary Nodule, Solitary
Multi-Reader Retrospective Study Examining Carebot AI CXR 2.0.21-v2.01 Implementation in Everyday Radiology Clinical Practice
The primary objective is to evaluate the performance parameters of the proposed DLAD (Carebot AI CXR) in comparison to individual radiologists.
- Conditions
- Pneumothorax, Pulmonary Nodule, Solitary, Atelectasis, Subcutaneous Emphysema
- Trial name
- NCT05963945
- Testing
- Carebot AI CXR
- Where
- Czechia
- Volunteers
- 956 people
- Sponsor
- Carebot s.r.o.
Chronic Heart Failure
Metabolic Manipulation in Chronic Heart Failure
Conventional measures used for the treatment of chronic heart failure act predominantly by reducing the work performed by the heart.
- Trial name
- NCT00841139
- Testing
- Perhexiline
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Dilated Cardiomyopathy, Ischemic Cardiomyopathy
Optimized Biventricular Pacing Allograft Recipients
This study tests optimization of biventricular pacing (BiVP) in patients with dilated cardiomyopathy (DCM) or ischemic cardiomyopathy (ICM) during cardiac transplantation in patients with advanced cardiac failure.
- Trial name
- BiBET (NCT01290822)
- Testing
- BiVP, AAI Pacing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Henry M. Spotnitz
Atrial Fibrillation, Persistent
Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation
Persistent atrial fibrillation (PerAF) can induce right atrial (RA) enlargement. Our previous study demonstrated patients with PerAF and RA enlargment may benefit from adjunctive RA ablation.
- Trial name
- NCT05883722
- Testing
- Catheter ablation
- Volunteers
- 200 people
- Sponsor
- Xu Liu
Cardiomyopathy, Dilated, Tachycardia, Ventricular
The Leiden Nonischemic Cardiomyopathy Study
Rationale: Sudden cardiac death, mainly caused by ventricular arrhythmias (VA), is a major cause of morbidity and mortality in non-ischemic cardiomyopathy (NICM). Therapies that effectively prevent VA are lacking.
- Conditions
- Cardiomyopathy, Dilated, Tachycardia, Ventricular, Ventricular Fibrillation
- Trial name
- NCT01940081
- Testing
- Transthoracic echocardiography, Exercise test, 24-hour Holter electrocardiogram
- Where
- Netherlands
- Volunteers
- 148 people
- Sponsor
- Leiden University Medical Center
Heart Failure, Cardiomyopathy, Dilated
Role of Left Ventricular Pacing Site
Cardiac resynchronization therapy has been shown to be effective in reducing symptoms and mortality in heart failure patients. However, very few is known about the importance of the left ventricular pacing site.
- Conditions
- Heart Failure, Cardiomyopathy, Dilated, Coronary Disease
- Trial name
- NCT00221780
- Testing
- left ventricular pacing
- Where
- France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Bordeaux
Patients With Idiopathic Dilated Cardiomyopathy
18F-deoxyglucose (FDG) PET-CMD
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) may have application in a promising tool for identification of myocardial inflammation in patients with dilated cardiomyopathy (DCM).Therefore, the purpose of the…
- Trial name
- NCT02078141
- Testing
- 18F-deoxyglucose (FDG)
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Healthy Adults (Full Study and Extension Phase), Hypertrophic Cardiomyopathy or Dilated Cardiomyopathy
A Pilot Project Exploring the Impact of Whole Genome Sequencing in Healthcare
The MedSeq™ Project seeks to explore the impact of incorporating information from a patient's whole genome sequence into the practice of clinical medicine.
- Trial name
- NCT01736566
- Testing
- Family History + Whole Genome Sequencing, Family History Only
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Heart Diseases, Cardiomyopathy, Congestive
Idiopathic Dilated Cardiomyopathy
To determine the familial occurrence and pathogenesis of idiopathic dilated cardiomyopathy.
- Trial name
- NCT00005201
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy
Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR)
This is a multicenter, prospective, open-label, randomized, investigator-initiated trial evaluating whether angiotensin receptor blocker (ARB) therapy improves clinical outcomes in patients with severe aortic stenosis (AS) and…
- Conditions
- Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy, Severe Aortic Stenosis
- Trial name
- ARBITAR (NCT07735130)
- Testing
- Angiotensin Receptor Blocker (ARB)
- Where
- South Korea
- Volunteers
- 632 people
- Sponsor
- Seoul National University Hospital
Cardiomyopathy, Dilated
Cell Therapy in Dilated Cardiomyopathy: Observational Study
Using bone marrow mononuclear cell in 24 patients with Idiopathic dilated cardiomyopathy
- Trial name
- NCT00612911
- Testing
- Cell therapy
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- Ministry of Health, Brazil
Dilated Cardiomyopathy
Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy
The purpose of this study is to determine the safety and clinical effectiveness of umbilical cord mesenchymal cells transplanted by intravenous infusion in patients with heart failure.
- Trial name
- RIMECARD (NCT01739777)
- Testing
- ucMSC, Controls
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad de los Andes, Chile
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated
Individualized Early Risk Assessment for Heart Diseases
Heart failure (HF) is the common end-stage of different medical conditions. It is the only growing cardiovascular disease and its prognosis remains worse than that of many malignancies.
- Trial name
- IndivuHeart (NCT02417311)
- Testing
- Skin biopsy, genotyping and disease phenotyping
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Connective Tissue Diseases, Right Ventricular Hypertrophy
Early Detection of Cardiac Impairment and Prediction of RV Hypertrophy in Patients With CTD
There have been reports suggesting that progressive RV failure and death in connective tissue disease (CTD) are related to right ventricular hypertrophy (RVH) and dilation, irrespective of pulmonary arterial hypertension (PAH).
- Trial name
- EARLY-MYO-CTD (NCT04297371)
- Testing
- CMR examination
- Where
- China
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Heart Disease Structural Disorder, Ventricular Tachycardia
Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia
Sudden cardiac death (SCD) due to recurrent ventricular tachycardia (VT) is an important clinical sequela in patients with structural heart disease.
- Conditions
- Heart Disease Structural Disorder, Ventricular Tachycardia, Cardiomyopathy, Dilated, Sarcoidosis
- Trial name
- CAAD-VT (NCT05524077)
- Testing
- Ablation, Anti-arrhythmic Drugs (AADs)
- Where
- 9 sites in Australia
- Volunteers
- 162 people
- Sponsor
- Western Sydney Local Health District
Dilated Cardiomyopathy
Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy
A randomised, double-blind, placebo-controlled trial to evaluate the role of intracoronary injection of progenitor cells compared to placebo injection in patients with Dilated Cardiomyopathy who have been pre-treated with G-CSF…
- Trial name
- REGEN-DCM (NCT01302171)
- Testing
- granulocyte colony stimulating factor (GCSF), bone marrow mononuclear cells
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Barts & The London NHS Trust