Clinical trials: Enteral Nutrition Feeding
Sepsis, Length of Stay
Limited Versus Extended Trophic Feeding (LET-FEED) Trial
Study Hypothesis/Question In infants born very preterm, advancing enteral feeds after 24 hours from birth (limited trophic feeds) versus after 72 hours (extended trophic feeds) reduces the risk of all-cause late onset sepsis…
- Conditions
- Sepsis, Length of Stay, Mortality, Neurodevelopmental Delay
- Trial name
- LET-FEED (NCT06893939)
- Testing
- Limited Trophic Feeds (1 day of trophic feeds), Extended Trophic Feeds (3 days of trophics)
- Where
- 6 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Washington
Critical Illness, Enteral Nutrition
TAK-954 in Critically Ill Participants With Enteral Feeding Intolerance (EFI)
The purpose of this study is to assess the treatment effect of intravenous TAK-954 in improving the average daily protein adequacy received through enteral nutrition in critically-ill participants developing EFI.
- Conditions
- Critical Illness, Enteral Nutrition, Enteral Feeding Intolerance
- Trial name
- NCT03477903
- Testing
- TAK-954, Metoclopramide, Normal Saline
- Where
- 44 sites in United States, Australia and 2 more
- Volunteers
- 1 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Congenital Heart Disease
Impact of Early Enteral Feeding on Splanchnic Blood Flow After Surgery for Critical Heart Disease in the Newborn
The objective of this study is to determine the impact of early post-operative feeding on splanchnic blood flow, cardiac output and end organ perfusion, and the patients overall clinical outcomes.
- Trial name
- NCT00919945
- Testing
- Continuous feeding at time 1 and NPO at time 2, NPO at time 1 and continuous feeding at time 2
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- The Hospital for Sick Children
Gastrostomy, Tracheostomy
No DIET Trial: Dogmatic Interruption of Enteral nuTrition
There is currently limited guidance on when to hold nutritional supplementation through for patients, who are receiving tube feeding, undergoing surgical procedures.
- Trial name
- NCT06431048
- Testing
- Naso-enteral nutrition will be stopped when the patient is called to the OR for scheduled procedure., Naso-enteral nutrition will be stopped 2 hours before the scheduled procedure.
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Jeffrey Coughenour
Feeding Patterns, Sleep
The Impact of Overnight Nutrition Support on Sleep and Circadian Rhythm Disruption in the ICU
The purpose of this study is to determine whether modifying the timing of nutrition support from overnight to daytime enhances sleep quality, preserves circadian rhythms, and improves overall inflammation and cardiometabolic…
- Conditions
- Feeding Patterns, Sleep, Glucose Intolerance
- Trial name
- NCT04737200
- Testing
- Time-of-day of enteral nutrition provision (daytime first), Time-of-day of enteral nutrition provision (nighttime first)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Critical Illness, Feeding Intolerance
JLU_Nutr_FI Registry: A Prospective Registry of Feeding Intolerance in Critically Ill Patients
This prospective observational cohort study aims to characterize feeding intolerance in critically ill adult patients and to identify clinical, physiological, laboratory, electrophysiological, and imaging factors associated with…
- Trial name
- NCT07844538
- Volunteers
- 2,000 people
- Sponsor
- The First Hospital of Jilin University
Enteral Nutrition, Cancer
2kcal Tube Feed Study
The primary aim of this study is to investigate the effects of a plant-based, high energy, high protein tube feed with and without inclusion of fibre on gastrointestinal tolerance in adult patients who require nutritional support…
- Trial name
- NCT05411848
- Testing
- 2kcal HP PlantBased
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Nutricia UK Ltd
Constipation
Fiber Formula Study Among Radiation Oncology Patients
During radiation treatment for head and neck cancer a large percentage of patients at Mayo Clinic Rochester develop the need for tube feeding to meet nutrition and hydration needs.
- Trial name
- NCT00888147
- Testing
- Fiber containing tube feeding formula
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Trauma to the Abdomen
Enteral Feeding in the Post-Injury Open Abdomen
The purpose of this study is to determine if Enteral Feeding (EN) in patients with a traumatic bowel injury requiring an open abdomen impacts outcomes.
- Trial name
- NCT01853735
- Where
- United States
- Volunteers
- 515 people
- Sponsor
- Denver Health and Hospital Authority
Nutrition
Pilot: Feasibility of Intermittent Enteral Feeding in Ventilated MICU Patients
Specific Aims: Aim 1: Evaluate the feasibility of intermittent feeding in intensive care unit patients who are mechanically ventilated.
- Trial name
- NCT04164108
- Testing
- Intermittent Enteral Nutrition Protocol
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Enteral Feeding Intolerance, ICU
Transcutaneous Auricular Stimulation Targeting Enteral Feeding Intolerance
This study will test whether electrical stimulation applied to the outer ear can improve tolerance of tube feeding in critically ill adults in the intensive care unit (ICU).
- Trial name
- TASTE-FI (NCT07854236)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Traumatic Brain Injury
The Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- NCT06248970
- Testing
- Rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zeng Changhao
Gastroparesis
Evaluation of Single Doses of GSK962040 in Critically Ill Patients With Enteral Feed Intolerance
The aims of MOT112571 are to assess the pharmacodynamic effects, safety, tolerability, pharmacokinetics, and potential therapeutic benefit of single doses of GSK962040 in critically ill patients with delayed gastric emptying and…
- Trial name
- NCT01039805
- Testing
- GSK962040 (50 mg), GSK962040 (75 mg)
- Where
- Australia
- Volunteers
- 34 people
- Sponsor
- GlaxoSmithKline
Gastroenterology Surgery, Tube Feeding
Efficacy of a Novel Prototype Gastrostomy Tube Anchor Dressing
This is a single-center prospective study evaluating the efficacy of a prototype gastrostomy anchor dressing for use with button gastrostomy tubes.
- Trial name
- Tube Anchor (NCT07115134)
- Testing
- Bearables Gastrostomy Tube Dressing
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Children's National Research Institute
Pain, Stress
The Effect of Feeding Positions During Tube Feeding on Stress, Pain Level and Feeding Tolerance of Preterm Infants
Premature infants have a need for an orogastric or nasogastric feeding tube because of the immaturity of coordination between suck-swallow and breathing. Tube feeding could cause feeding intolerance and stress.
- Conditions
- Pain, Stress, Enteral Feeding Intolerance
- Trial name
- NCT04156529
- Testing
- ESU position, ESRL position
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Sibel Serap Ceylan
Enteral Feeding Intolerance
Enteral Nutrition Tolerance and the Gut Microbiome Study
The current study will enroll patients who are going to require enteral nutrition support for at least 4 weeks and randomize them to standard polymeric formulas or blenderized tube feeding.
- Trial name
- NCT03795870
- Testing
- Polymeric Tube Feeds, Blenderized Tube Feeds
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Preterm, Feeding Behavior
Feeding Readiness and Oral Feeding Success in Preterm Infants
To examine the effects of sensorimotor interventions applied to in preterm infants on readiness for feeding and oral feeding success.
- Conditions
- Preterm, Feeding Behavior, Enteral Feeding Intolerance
- Trial name
- NCT04946045
- Testing
- Sensorimotor Interventions (Tactile/Kinesthetic Stimulation+Nonnutritive Sucking)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Enteral Nutrition, Enteral Feeding
Bolus Versus Continuous Feeding Regimens Post Gastrostomy Tube Placement
The purpose of this study is to determine the best way to feed children after they have a gastrostomy tube placed. The study compares bolus feeding to continuous feeding.
- Conditions
- Enteral Nutrition, Enteral Feeding, Gastrostomy Tube
- Trial name
- NCT02006953
- Testing
- Bolus feeding schedule following gastrostomy tube placement, Continuous chimney feeds following gastrostomy tube placement
- Where
- 2 sites in United States
- Volunteers
- 97 people
- Sponsor
- University of Michigan
Preterm Infants
Early Administration of Bifidobacterium to Very Low Birth Weight Infants
To evaluate the effects of early administration of probiotics on acceleration of enteral feeding, and on growth of very low birth weight infants, newborn infants with birth weight less than 1500g are administered Bifidobacterium…
- Trial name
- NCT01330095
- Testing
- Administration of Bifidobacterium bifidum
- Where
- Japan
- Volunteers
- 36 people
- Sponsor
- Tokyo Women's Medical University
Enteral Feeding, Neonate
Safety and Effectiveness of Early Feeding After Bowel Anastomosis in Neonates or Infants
The study is primary designed to evaluate the safety and effectiveness of early feeding after bowel anastomosis, and observe the effect of early postoperative feeding on promoting postoperative rehabilitation and reducing…
- Conditions
- Enteral Feeding, Neonate, Infant, Intestinal Anastomosis Complication
- Trial name
- NCT04464057
- Testing
- early oral feeding or early enteral nurtrion
- Where
- 2 sites in China
- Volunteers
- 947 people
- Sponsor
- Weibing Tang