Clinical trials: Enteric Infections
Enterobacteriaceae Infections
The Burden and Genetic Variability of Extended-Spectrum ß-Lactamase (ESBL) - Producing Pathogens in Swiss Children
Objectives: The aim of the study is to determine the molecular epidemiology and genetic variability of ESBL-producing enterobacteriaceae (E-ESBL) among children in Switzerland and to estimate the associated clinical burden of…
- Trial name
- NCT00894036
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Sepsis
Effect of Enteral Genistein Supplementation in Sepsis
To evaluate effects of genistein supplementation to enteral nutrition on inflammatory cytokines and morbidity in patients with sepsis
- Trial name
- NCT02796794
- Testing
- Genistein, enteral nutrition only
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- TC Erciyes University
Sepsis, Immune System Disorder
The Th17/Treg Cells and IL-23/IL-17 Axis and Early Enteral Nutrition in Sepsis
The investigators aim to evaluate the roles of Th17/Treg cells and IL-23/IL-17 axis in the mechanisms of early enteral nutrition (EEN) correcting immune imbalance of sepsis by means of improving the intestinal flora disturbance.
- Conditions
- Sepsis, Immune System Disorder, Enteral Feeding
- Trial name
- NCT03385850
- Testing
- enteral nutrition
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Gastrointestinal Infection, Respiratory Viral Infection
Wells and Enteric Disease Transmission Trial (WET - Trial)
Approximately 40 million people in the US are served by private wells, many of which are untreated. The investigators estimate that 1.29 million cases of gastrointestinal illness (GI) per year are attributed to consuming water…
- Trial name
- NCT04258059
- Testing
- Active household UV water treatment device, Inactive household UV water treatment device
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Temple University
Malnutrition Pregnancy, Malnutrition in Children
Early Life Malnutrition, Environmental Enteric Dysfunction and Microbiome Trajectories
Malnutrition in women of reproductive age remains a public health concern in Sub-Saharan Africa (SSA). Malnutrition during pregnancy affects foetal growth with a tendency of the exposed infants to also develop it.
- Conditions
- Malnutrition Pregnancy, Malnutrition in Children, Malnutrition (Calorie), Environmental Enteric Dysfunction
- Trial name
- UZBCS-2 (NCT07195006)
- Testing
- Malnutrition in pregnancy as exposure, Poor WASH living conditions as exposure
- Where
- Zimbabwe
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Zimbabwe
Critical Illness, Sepsis
Enteral Glutamine in Critical Illness
Glutamine is an amino acid which is rapidly depleted in critical illness. It is used as energy by cells that line the gut, vital for immune system function, and works as an anti-oxidant.
- Conditions
- Critical Illness, Sepsis, Respiratory Insufficiency
- Trial name
- NCT00318331
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christiana Care Health Services
Typhoid Fever, Paratyphoid Fever
Investigating Enteric Fever - Salmonella Typhi and Paratyphi Challenge Study
Enteric fever, an infection characterised by diarrhoea and rash, is most often caused by a bacteria called Salmonella enterica. After ingesting contaminated food or drink, the Salmonellae travel first to the gut, then the…
- Trial name
- NCT02192008
- Testing
- Salmonella Typhi, Salmonella Paratyphi
- Where
- United Kingdom
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Sepsis, Critical Illness
Methionine Metabolism in Enterally Fed Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Protein synthesis is increased mainly in the form of immune and signaling proteins, while muscle and structural protein synthesis…
- Trial name
- NCT01889264
- Testing
- Observational
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Enteric Fever, Acute Febrile Illness
Transcriptomic Responses for the Identification of Pathogens
Acute undifferentiated febrile infection (AUFI) is a common presenting syndrome in low-resource settings and better diagnostics are urgently needed to improve patient management and guide disease prevention interventions.
- Conditions
- Enteric Fever, Acute Febrile Illness, Typhoid, Paratyphoid Fever
- Trial name
- TRiP (NCT04878549)
- Testing
- 5-gene transcription signature
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Water-Related Diseases, Enteric Pathogens
Rural Appalachia Pilot Water Treatment Trial
Consumption of unsafe drinking water is associated with a substantial burden of disease globally. In the USA, the burden of disease associated with consumption of contaminated drinking water from non-regulated private wells and…
- Conditions
- Water-Related Diseases, Enteric Pathogens, Exposure to Chemical Pollution
- Trial name
- NCT06120985
- Testing
- Countertop pitcher water filter
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Diarrhea
Meatsafe Food Storage and Diarrhea Prevention Trial in Urban Bangladesh
The goal of this clinical trial was to evaluate whether a simple household food storage cabinet called a "meatsafe" could reduce bacterial contamination of complementary foods and decrease diarrhea among children aged 6 to 24…
- Trial name
- NCT07332078
- Testing
- Meatsafe Food Storage Cabinet
- Where
- Bangladesh
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Pneumonia
Pharmacokinetic Evaluation of Moxifloxacin IV to Enteral Switch Therapy in Intensive Care Patients
In the Intensive Care (IC)-unit moxifloxacin treatment is often started with intravenous administrations. As moxifloxacin is known to have a high oral bioavailability in healthy volunteers, patients are switched to oral or…
- Trial name
- NCT00458900
- Testing
- IV and enteral administration of moxifloxacin
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
HIV Infections
Comparison of Two Anti-HIV Regimens That Include One of Two Forms of Didanosine (ddI)
Didanosine is an effective anti-HIV drug, but it can cause stomach upset. This study tests a new form of didanosine, ddI EC, a coated pill that passes through the stomach more easily and hopefully will prevent stomach upset.
- Trial name
- NCT00002224
- Testing
- Nelfinavir mesylate, Stavudine, Didanosine
- Where
- 24 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- Bristol-Myers Squibb
Humoral Primary Immunodeficiencies (PIDs), Secondary Form of Humoral Immunodeficiencies
Study of Populations at Risk of Developing Chronic Hepatitis Linked to Chronic Enteric Virus Infection in Patients With Primary Immunodeficiency and Secondary Humoral Deficiency
Dysimmune and specially hepatic immuno-pathological processes are frequent in patients with PIDs (primary immune deficiencies), particularly but not exclusively in patients with humoral defects.
- Conditions
- Humoral Primary Immunodeficiencies (PIDs), Secondary Form of Humoral Immunodeficiencies, Combined Immunodeficiency (CID), Severe Combined Immunodeficiency (SCID)
- Trial name
- EVAH (NCT06659588)
- Testing
- Plasma, urine and stool collection
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness, Infection Complication
A Trial of Enteral Colostrum on Clinical Outcomes in Critically Ill Patients
Enteral administration of immune-modulating nutrients such as glutamine, omega-3 fatty acids, selenium, and antioxidants has been suggested to reduce infections and improve recovery from critical illness.
- Conditions
- Critical Illness, Infection Complication, Multiple Organ Dysfunction Syndrome
- Trial name
- NCT03019250
- Testing
- Colostrum, Maltodextrin
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- National Nutrition and Food Technology Institute
Urinary Tract Infection(UTI)
Antibiotic Therapies for Urinary Tract Infections and Their Impact on the Gut Microbiota
A urinary tract infection requires antibiotic treatment. While this treatment is intended to eliminate bacteria from the urine, it may also facilitate the development of resistant strains in the digestive tract.
- Trial name
- ABIME (NCT07424989)
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Rouen
Typhoid, Paratyphoid Fever
Evaluation of the Vi Polysaccharide Vaccine Against Typhoid Fever
This study is part of the International Vaccine Institute's (IVI's) typhoid Vi demonstration project that aims to accelerate the rational introduction of Vi vaccines in typhoid endemic countries.
- Trial name
- NCT00125008
- Testing
- Typhoid Vi vaccine, Hepatitis A vaccine
- Where
- India
- Volunteers
- 37,673 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Septic Shock
A Randomized Controlled Study of Enteral Nutrition in Septic Shock
There is a paucity of data on the timing and role of enteral nutrition in septic shock. The primary aim of this study is to conduct a phase III single-center pilot randomized controlled trial comparing early trophic enteral…
- Trial name
- NCT02025127
- Testing
- Enteral nutrition
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Medical College of Wisconsin
Diarrhea
Dose Escalating Study of a Prototype CS6 Subunit Vaccine With a Modified Heat-labile Enterotoxin From Enterotoxigenic Escherichia Coli (ETEC)
This study will evaluate the safety of a prototype Coli surface antigen 6 (CS6) subunit vaccine (CssBA) alone or in combination with Escherichia coli double mutant heat labile toxin (dmLT) given by intramuscular (IM) injection.
- Trial name
- NCT03404674
- Testing
- CssBA, dmLT
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PATH
Sepsis, Critical Illness
Evaluation of the Effect of Immune Modulating Enteral Nutrition Formula
The aim is to compare the efficacy and tolerability of an immune modulating enteral nutrition formula versus the regular formula on the outcomes of critically ill septic patients by assessment of clinical outcomes, immune…
- Trial name
- NCT05186480
- Testing
- Neo Mune
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- NewGiza University