Clinical trials: Entropy
General Anaesthesia, Depth of Anaesthesia
Epileptiform EEG Patterns During Induction of General Anaesthesia With Sevoflurane Compared to Those With Propofol
The aim of the study was to assess the influence of volatile induction of general anaesthesia with sevoflurane using two different techniques and intravenous anaesthesia with propofol on the possible presence of epileptiform…
- Conditions
- General Anaesthesia, Depth of Anaesthesia, Intraoperative Awareness, Seizures
- Trial name
- EEG (NCT03209323)
- Testing
- electroencephalography (EEG), bispectral index (BIS), response and state entropy (RE and SE)
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Silesia
Fetal Heart Rate Variability
Fetal Evaluation at Term Using Statistical ECG Signal Processing (FETUSES)
Background The fetal heart rate (FHR) is commonly monitored during labor to detect early fetal acidosis. FHR variability is traditionally investigated using Fourier transform, however, fetal conditions differ from adults (higher…
- Trial name
- FETUSES (NCT02835417)
- Volunteers
- 3,563 people
- Sponsor
- Hospices Civils de Lyon
Endoscopic Sinus Surgery
SPI-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the utility of Surgical Pleth Index (SPI) for monitoring pain perception intraoperatively and its influence on intraoperative blood loss, quality of surgical field using Boezaart…
- Trial name
- FESSSPI (NCT03417180)
- Testing
- Remifentanil, surgical pleth index
- Where
- 2 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Silesia
Cognitive Dysfunction
Effect of Usage of Electroencephalogram (EEG) Entropy on the Incidence of Postoperative Cognitive Dysfunction in Geriatric Patients
To determine if the usage of EEG Entropy helps to reduces the incidence of POCD in elderly patients after general anesthesia.
- Trial name
- NCT00700674
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Khaled Eye Specialist Hospital
Burst Suppression, EEG With Abnormally Slow Frequencies
Reduction of Intraoperative EEG Burst Suppression
Burst suppression (BS) is a not physiological pattern in the electroencephalogram (EEG). BS during general anesthesia is mainly seen as a sign for too deep hypnosis and may increase the risk of postoperative delirium (POD), a…
- Conditions
- Burst Suppression, EEG With Abnormally Slow Frequencies, Postoperative Delirium
- Trial name
- BsR (NCT03775356)
- Testing
- Treatment of hypotension and/or reduction of anesthetics
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- Technical University of Munich
Brain Injury, Craniocerebral Trauma
Study of the Approximate Entropy of Adrenocorticotropic Hormone and Cortisol Secretion in Patients With Head Injury
OBJECTIVES: I. Determine the randomness of adrenocorticotropic hormone (ACTH) and cortisol secretion using approximate entropy in patients who have sustained a head injury. II.
- Trial name
- NCT00006270
- Testing
- cosyntropin, metyrapone
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- National Center for Research Resources (NCRR)
Carotid Artery Stenoses
SPI-guided Analgesia During CEA Under RA
The aim of this randomized prospective trial is to assess the utility of Adequacy of Anaesthesia technique (Response Entropy and Surgical Pleth Index) for monitoring pain perception intraoperatively, maintainance of hemodynamic…
- Trial name
- CEA (NCT04500249)
- Testing
- infiltration rescue intraoperative analgesia, rescue IA, rescue antyhypertensive medication
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Silesia
Head and Neck Surgery, Maxillofacial Surgery
Impact of Nociception Level (NOL)-Guided Remifentanil Infusion on Intraoperative Arterial Pressure and Vasopressor Necessity
The aim of this study is to determine if Nociception Level (NOL)-guided Remifentanil analgesia, combined with Entropy-guided Propofol anesthesia, has a significant beneficial effect on the incidence of intraoperative hypotension…
- Trial name
- NCT04963036
- Testing
- Entropy and NOL-Guided Goal Directed Anesthesia, Standard of Care Group (Entropy and blinded NOL)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Anesthesia, General
The Effect of Frontal Electromyogram (F-EMG) Activity on the Entropy Index Behavior During General Anesthesia
This study evaluates the effect of frontal EMG activity on Entropy index in burst suppression level of propofol anesthesia and surgery
- Trial name
- NCT03366662
- Testing
- Monitoring of frontal electrical muscle activity
- Where
- Finland
- Sponsor
- Tampere University Hospital
Neuromuscular Blockade
Electromyographic Calibration Guided by Depth of Anesthesia
The goal of the CELESTE study is to evaluate whether calibration of EMG is needed for reliable interpretation of neuromuscular function and if so, to identify the minimal necessary depth of anesthesia.
- Trial name
- CELESTE (NCT04911088)
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- University Hospital Ulm
Electrophysiological Randomness, Entropy
Decreased EEG Complexity in Schizophrenia
Aim was to detect EEG complexity in a specific group of patients to contribute to the discussion whether schizophrenia is associated with increased or decreased complexity.
- Trial name
- NCT02187835
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uskudar University
Lumbar Disc Disease
SPI-directed Analgesia for Lumbar Discectomy
The aim of this randomized trial is to assess the efficacy of analgesia for lumbar discectomy and compare Numerical Rating Scale (NRS) with Surgical Pleth Index (SPI) for monitoring pain perception postoperatively.
- Trial name
- SPI (NCT02971540)
- Testing
- Metamizol, Tramadol, Bupivacaine
- Where
- Poland
- Volunteers
- 132 people
- Sponsor
- Medical University of Silesia
Endoscopic Sinus Surgery
SPI-guided vs PRD-guided Analgesia During FESS for Intraoperative Blood Loss
The aim of this randomized trial is to assess the efficacy of analgesia , compare the utility of Pupillary Dilatation Reflex (PRD), Surgical Pleth Index (SPI) for monitoring pain perception intraoperatively and their influence on…
- Trial name
- NCT03389763
- Testing
- Remifentanil
- Where
- Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Silesia
Propofol, Child
Time to Peak Effect of Propofol in Children
In order to determine the speed of onset of the anaesthetic propofol in children, investigators will compare the two age groups 1-6 years vs 8-13 years.
- Trial name
- TPEPC (NCT03426462)
- Testing
- Propofol
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Anaesthesia, Surgery
Comparison of Two Electroencephalogram (EEG)-Derived Indices With Electroencephalogram Signals
Bispectral Index (BIS) and Entropy indices will be compared with each other, and to raw EEG signals in patients receiving sevoflurane anaesthesia.
- Trial name
- NCT01077674
- Where
- Finland
- Volunteers
- 65 people
- Sponsor
- Arvi Yli-Hankala
Anesthesia, General
Monitoring of Anesthetic Depth and EEG Band Power Using PLE (Phase Lag Entropy) During Propofol Anesthesia
The evaluation of the anesthetic depth monitoring using PLE (Phase Lag Entropy) during propofol anesthesia
- Trial name
- PLE (NCT03299621)
- Testing
- PLE (Phase Lag Entropy), Muscle Relaxant
- Where
- 2 sites in South Korea
- Volunteers
- 35 people
- Sponsor
- Korea University Anam Hospital
Anaesthesia
Aminophylline and Cognitive Function After Sevoflurane Anaesthesia
Early postoperative recovery of neurologic and cognitive functions is especially advantageous after fast-tracking ambulatory procedures to hasten home discharge after surgery.1 It is well known that volatile anaesthetic agents…
- Trial name
- NCT01022151
- Testing
- 0.2 mL/kg of aminophylline 10 mg/mL [group A2], 0.2 mL/kg of aminophylline 15 mg/mL [group A3], 0.2 mL/kg of aminophylline 20 mg/mL [group A4]
- Where
- Saudi Arabia
- Volunteers
- 180 people
- Sponsor
- King Faisal University
Anaesthesia
Electromyographic (EMG) on the Anaesthesia Monitor
Intubation may induce electromyographic (EMG) activity, causing depth of anaesthesia monitors to show misleadingly high values. The investigators want to investigate whether this EMG activity can be visually seen on the…
- Trial name
- NCT01142635
- Testing
- Rocuronium bromide
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Tampere University Hospital
COPD
Complexity of the Airflow in COPD
Recently, there has been a growing interest in the study of nonlinear dynamics as a methodology for complementary analysis to characterize the respiratory pattern. These methods are well established in studies of heart rate.
- Trial name
- NCT01888705
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Pain
BIS and Entropy Nociception Monitoring
Reports have been appearing in literature over the past years of various nociception-antinociception monitors, introduced and promoted from major manufactures.
- Trial name
- BIS4 (NCT02585466)
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz