Clinical trials: Eosinophilic Enteritis
Eosinophilic Esophagitis
The Efficacy and Tolerability of 12-weeks Treatment With Almond and Buckwheat Based Formula in Pediatric Patients With Active EoE
Eosinophilic esophagitis (EoE) is a chronic, relapsing, immune-mediated esophageal disease. Clinical manifestations in infants and toddlers generally include vomiting, food refusal, choking with meals and, less commonly, failure…
- Trial name
- NCT05622214
- Testing
- Else nutrition formula
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Eosinophilic Esophagitis, EoE
Dupilumab for Eosinophilic Esophagitis With Severe Strictures
The purpose of this research study is to determine how well an FDA-approved drug, dupilumab, works to treat patients with severe strictures and active Eosinophilic Esophagitis (EoE).
- Trial name
- DESTRICT (NCT06352073)
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of North Carolina, Chapel Hill
Eosinophilic Esophagitis
Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoE
The goal of this clinical trial is to [primary purpose: e.g., learn if intervention or health behavior can treat, prevent, diagnose etc.] in [describe participant population/primary condition; could include any of the following…
- Trial name
- DeTECTS (NCT06705387)
- Testing
- Dupilumab, Fluticasone
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
Esophagitis, Eosinophilic
The Potential Role of Compounds Derived From Ultra-processed Foods in Pathogenesis of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic antigen-mediated inflammatory disease of the esophagus that affects both children and adults.
- Trial name
- NCT06093204
- Testing
- Dietary evaluation
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Eosinophilic Gastritis, Eosinophilic Duodenitis
A Study to Assess Subcutaneous AK002 in Eosinophilic Gastritis and/or Eosinophilic Duodenitis
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, tolerability, and pharmacodynamic effect of subcutaneous lirentelimab (AK002), given monthly for 6 doses, in…
- Trial name
- ENIGMA-SC (NCT05152563)
- Testing
- AK002
- Where
- 76 sites in United States
- Sponsor
- Allakos Inc.
Eosinophilic Esophagitis
San Raffaele EoE Biobank
Eosinophilic Esophagitis (EoE) is a immuno-mediated disease, characterised by a Th-2 food-antigen driven chronic inflammatory response of the esophagus.
- Trial name
- EoEBiobank (NCT05896891)
- Testing
- esophagogastroduodenoscopy (EGD), buccal swab, blood withdrawal
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
Deglutition Disorders, Esophageal Diseases
Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index
Eosinophilic Esophagitis (EoE) is a chronic inflammatory disease of the esophagus affecting children and adults. The most frequent symptoms are swallowing difficulties and thoracic pain.
- Conditions
- Deglutition Disorders, Esophageal Diseases, Eosinophilia
- Trial name
- EEsAI (NCT00939263)
- Testing
- assessment of disease activity using the EEsAI
- Where
- 25 sites in United States, Canada and 2 more
- Volunteers
- 650 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Eosinophilic Esophagitis
Evaluating Adrenal Insufficiency in Adults With Eosinophilic Esophagitis on Chronic Swallowed Topical Steroids
Eosinophilic esophagitis (EoE), a chronic inflammatory disease of the esophagus, is a clinical and financial burden to patients if left untreated.
- Trial name
- NCT05246085
- Testing
- Cortisol level
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Eosinophilic Esophagitis
An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)
The purpose of this study is to test the safety and effectiveness of Losartan potassium in subjects with eosinophilic esophagitis (EoE) including those with a connective tissue disorder (CTD) and those without a CTD.
- Trial name
- NCT03029091
- Testing
- Losartan Potassium
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Dysphagia
Routine Screening for Eosinophilic Esophagitis in Patients Presenting With Dysphagia
The purpose of this study is to identify the prevalence of pathologic eosinophilic esophagitis (EoE) in the cohort of adult patients who present for specialty care in the gastroenterology clinics with complaint of difficulty…
- Trial name
- NCT01028235
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- San Antonio Uniformed Services Health Education Consortium
Eosinophilic Esophagitis
Efficacy and Safety of Three Doses of Florence Oral Suspension in Adults With Eosinophilic Esophagitis
The purpose of this study is to evaluate the efficacy of three doses of Florence oral suspension on changes of eosinophilic infiltration in esophageal biopsies.
- Trial name
- NCT02873468
- Testing
- Florence 30 μg/mL, Florence 60 μg/mL, Florence 90 μg/mL
- Where
- Brazil
- Volunteers
- 116 people
- Sponsor
- EMS
Eosinophilic Esophagitis
Eosinophilic Oesophagitis Assessment With String Testing
Eosinophilic oesophagitis (EoE) is an inflammatory condition of the oesophagus (food pipe) that can lead to difficulty swallowing and to food to getting stuck and has become increasingly common over the past 40 years.
- Trial name
- EoEAST (NCT06159218)
- Testing
- CEST - coiled oesophageal string test
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Eosinophilic Esophagitis
Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus
The goal of this study is to test the feasibility and the tolerability of a tethered spectrally encoded confocal microscopy (SECM) capsule and to use it to image the esophagus.
- Trial name
- NCT02202590
- Testing
- SECM Capsule
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Eosinophilic Esophagitis
CEGIR 7808: Use of Unsedated Transnasal Esophagoscopy (TNE) to Monitor Dietary Management of Eosinophilic Esophagitis in Children
The purpose of this study is to test the effectiveness of utilizing Transnasal Esophagoscopy as a means of monitoring Eosinophilic Esophagitis patients.
- Trial name
- NCT03342391
- Testing
- Transnasal esophagoscopy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Eosinophilic Esophagitis
Fluticasone Versus Esomeprazole to Treat Eosinophilic Esophagitis
The purpose of this study is to assess the clinical efficacy of proton pump inhibitors in comparison to aerosolized swallowed steroids for the treatment of eosinophilic esophagitis (EE).
- Trial name
- NCT00895817
- Testing
- Swallowed fluticasone, Esomeprazole
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Walter Reed Army Medical Center
Abdominal Pain, Inflammatory Bowel Diseases
Examining the Effect of Ondansetron on Bowel Prep Success
This is a pilot randomized-controlled trial assessing the utility of ondansetron for improving pediatric pre-colonoscopy bowel prep outcomes using the boston bowel preparation score, as well as assessing the impact on patient…
- Conditions
- Abdominal Pain, Inflammatory Bowel Diseases, Eosinophilic Gastroenteritis, Diarrhea
- Trial name
- NCT05439772
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- State University of New York - Downstate Medical Center
Eosinophilic Gastrointestinal Disease Eosinophilic Inflammatory Disease, Food Allergy
Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders
The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further characterize the pathophysiology of, clinical manifestations of, and spectrum…
- Trial name
- NCT00267501
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
EoE, Eosinophilic Esophagitis
A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis
The goal of this study is to find out if a medication called upadacitinib can help treat a condition called Eosinophilic Esophagitis (EoE).
- Conditions
- EoE, Eosinophilic Esophagitis, Eosinophilic Esophagitis (EoE)
- Trial name
- ATUNE (NCT07588568)
- Testing
- Upadacitinib 30mg Dose
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of North Carolina, Chapel Hill
Eosinophilic Esophagitis
A Study to Investigate the Efficacy and Tolerability of ESO-101 in Patients With Eosinophilic Esophagitis
This is a randomized, placebo-controlled, double-blind trial to evaluate the efficacy, tolerability, and safety of ESO-101 in adult patients with active eosinophilic esophagitis (EoE).
- Trial name
- NCT04849390
- Testing
- ESO-101
- Where
- 17 sites in Germany, Netherlands and 3 more
- Volunteers
- 43 people
- Sponsor
- EsoCap AG
Eosinophilic Esophagitis
Natural History of Eosinophilic Esophagitis
Researchers are trying to understand the course of Eosinophilic Esophagitis (EoE), its progression and effects of treatments.
- Trial name
- EoE (NCT03290482)
- Testing
- Barium Esophagram, EsophaCap, Physical Examination and Questionnaires
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Mayo Clinic