Clinical trials: Eosinophilic Gastroenteritis
Food Allergy, Asthma
Assessing Risk of Food Insecurity Within Households of Children With Food Allergy
Our central hypothesis is that dietary limitations introduced by food allergy will contribute to increased food insecurity in households with food allergic children when compared to food insecure households without food allergic…
- Conditions
- Food Allergy, Asthma, Allergic Rhinitis, Atopic Dermatitis
- Trial name
- NCT01897506
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Eosinophilic Esophagitis
The Efficacy and Tolerability of 12-weeks Treatment With Almond and Buckwheat Based Formula in Pediatric Patients With Active EoE
Eosinophilic esophagitis (EoE) is a chronic, relapsing, immune-mediated esophageal disease. Clinical manifestations in infants and toddlers generally include vomiting, food refusal, choking with meals and, less commonly, failure…
- Trial name
- NCT05622214
- Testing
- Else nutrition formula
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Eosinophilic Gastrointestinal Disease Eosinophilic Inflammatory Disease, Food Allergy
Data and Sample Collection Study to Elucidate the Mechanisms of Eosinophilic Disorders
The purpose of this study is to elucidate the mechanisms underlying eosinophil growth, survival, migration, and function and to investigate and further characterize the pathophysiology of, clinical manifestations of, and spectrum…
- Trial name
- NCT00267501
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Eosinophilic Esophagitis, EoE
The Immune Directed Individualized Elimination Therapy (iDIET) Study
This is a randomized, double blind, sham-controlled, pilot/feasibility trial of individualized dietary elimination treatment.
- Trial name
- iDIET (NCT05543512)
- Testing
- Algorithm to diagnose food allergens
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of North Carolina, Chapel Hill
Barrett's Esophagus, Eosinophilic Esophagitis
Study to Image the Esophagus Using the OFDI Capsule
The main purpose of this research is to test the feasibility and tolerability of the tethered capsule Optical Frequency Domain Imaging (OFDI)
- Trial name
- NCT02204150
- Testing
- OFDI Capsule
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Eosinophilic Gastritis, Eosinophilic Duodenitis
A Study to Assess Subcutaneous AK002 in Eosinophilic Gastritis and/or Eosinophilic Duodenitis
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy, safety, tolerability, and pharmacodynamic effect of subcutaneous lirentelimab (AK002), given monthly for 6 doses, in…
- Trial name
- ENIGMA-SC (NCT05152563)
- Testing
- AK002
- Where
- 76 sites in United States
- Sponsor
- Allakos Inc.
Eosinophilic Esophagitis, Dysphagia
Eosinophilic Esophagitis Treatment: Montelukast vs Fluticasone
This study will compare response to treatment of Eosinophilic Esophagitis with montelukast vs standard therapy fluticasone. Investigators hypothesize that montelukast is equally effective in treating symptoms and histology of EoE…
- Trial name
- NCT01702701
- Testing
- Montelukast, Fluticasone
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Gastroesophageal Reflux Disease, Eosinophilic Esophagitis
Predictors of Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis
The investigators will determine the prevalence of gastroesophageal reflux disease (GERD) in Eosinophilic Esophagitis (EoE) and importantly determine the predictors of response to Proton Pump Inhibitor (PPI) therapy in EoE.
- Conditions
- Gastroesophageal Reflux Disease, Eosinophilic Esophagitis, Dysphagia
- Trial name
- NCT01479231
- Testing
- dexlansoprazole
- Sponsor
- Mayo Clinic
Eosinophilic Esophagitis, Esophageal Stenosis
Eosinophilic Esophagitis: Influence of Dilation on Dysphagia and Inflammation
A database analysis and review of histological slides (retrospective) and a patient questionnaire analysis (prospective) will be conducted in Bern (Switzerland) to evaluate the efficacy and safety of esophageal dilation and its…
- Conditions
- Eosinophilic Esophagitis, Esophageal Stenosis, Esophageal Dilation, Esophageal Dilatation
- Trial name
- NCT00667524
- Where
- Switzerland
- Volunteers
- 207 people
- Sponsor
- University of Bern
Eosinophilic Esophagitis
Natural History of Eosinophilic Esophagitis
Researchers are trying to understand the course of Eosinophilic Esophagitis (EoE), its progression and effects of treatments.
- Trial name
- EoE (NCT03290482)
- Testing
- Barium Esophagram, EsophaCap, Physical Examination and Questionnaires
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Mayo Clinic
Eosinophilic Esophagitis (EoE)
Comparison of Eohilia With Dupixent on Esophagus Diameter in Patients With Eosinophilic Esophagitis.
The purpose of this study is to compare Eosinophilic Esophagitis treatments Eohilia with Dupixent in their effects on diameter and scarring of the esophagus.
- Trial name
- NCT07358234
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT], budesonide oral suspension
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Eosinophilic Esophagitis
Open-Label Extension Study of Reslizumab in Pediatric Subjects With Eosinophilic Esophagitis
This study is an open-label study where all subjects will receive active drug, reslizumab. Subjects are able to enter this trial only through completion of study Res-05-0002 (NCT00538434).
- Trial name
- NCT00635089
- Testing
- reslizumab
- Where
- 36 sites in United States, Canada
- Volunteers
- 190 people
- Sponsor
- Ception Therapeutics
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease
The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
The primary aim of this study was to determine the proportion of patients with esophageal eosinophilic infiltration that have objective (measurable) evidence of gastroesophageal reflux disease (GERD).
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease, EE, GERD
- Trial name
- NCT00728481
- Testing
- Esomeprazole, Budesonide
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Mayo Clinic
Eosinophilic Esophagitis, Respiratory Allergy
Survey About the Relationship Beetween Allergic Rhinitis and Seasonal EOE Exacerbations
Eosinophilic esophagitis (EoE) is a chronic inflammatory esophagus disease that is presented in patients with a history of recurrent dysphagia.
- Trial name
- NCT05755477
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Nucera Eleonora
Eosinophilic Esophagitis
Topical Steroid Treatment for Eosinophilic Esophagitis
This was a randomized controlled trial of swallowed fluticasone vs. placebo for eosinophilic esophagitis. Eosinophilic esophagitis is an inflammatory condition in which the wall of the esophagus becomes filled with large numbers…
- Trial name
- NCT00275561
- Testing
- Fluticasone
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Mayo Clinic
Eosinophilic Esophagitis
Cow's Milk Elimination for Treatment of Eosinophilic Esophagitis
The investigators seek to assess the efficacy of removing cow's milk from an EoE patient's diet. This will be determined by esophageal inflammation and clinical and histological response to the milk elimination treatment.
- Trial name
- NCT05083156
- Testing
- Diet Change
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Eosinophilic Gastritis, Eosinophilic Duodenitis
An Extension Study of Lirentelimab in Eosinophilic Gastritis and/or Eosinophilic Duodenitis (Formerly Referred to as Eosinophilic Gastroenteritis)
This is a Phase 3, open-label, extension study to assess the long term efficacy and safety of lirentelimab given monthly.
- Trial name
- NCT04620811
- Testing
- lirentelimab
- Where
- 38 sites in United States
- Volunteers
- 159 people
- Sponsor
- Allakos Inc.
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Eosinophilic Esophagitis, EoE
Diagnosis and Monitoring of Eosinophilic Esophagitis Using the Cytosponge
The current endoscopic methods for diagnosing and monitoring treatment response in Eosinophilic Esophagitis (EoE) are costly, inconvenient, and risky.
- Trial name
- NCT02114606
- Testing
- Cytosponge™ Cell Collection Device
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- University of North Carolina, Chapel Hill
Eosinophilic Esophagitis
Topical Budesonide Treatment for Eosinophilic Esophagitis (EoE)
The purpose of this study is to conduct a clinical trial of two formulations of budesonide (nebulized/swallowed versus viscous/swallowed) in patients with EoE to determine if medication contact time and distribution in the…
- Trial name
- NCT00961233
- Testing
- inhaled/swallowed budesonide, viscous/swallowed budesonide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill