Clinical trials: Eosinophils
Asthma, Asthma in Children
Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma
Asthma is characterised by episodic symptoms (attacks) caused by airway inflammation and decreased airflow to the lungs. It affects 10% of the Canadian population and is the most common chronic disease in childhood.
- Conditions
- Asthma, Asthma in Children, Diagnosis, Inflammation
- Trial name
- DIVE (NCT05992519)
- Testing
- ¸FeNO
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Université de Sherbrooke
Asthma in Children
Airway Microbiota Based Treatment of Asthma in Preschool Children
Airway microbiota pattern may related the preschool asthma exacerbation. This is a single-center, randomized-controlled trial, the study will compare the management of preschool wheeze determined by airway microbiota phenotype…
- Trial name
- AMBT (NCT04527016)
- Testing
- Microbiota and eosinophils based therapy, Clinical guidelines based therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Children's Hospital of Fudan University
Asthma Childhood
This Study Aims to Compare Asthma Control in Children Monitored With FeNO Against a Historical Cohort Without FeNO. Secondary Objectives Include Evaluating Associations Between FeNO Levels, ACT/C-ACT Scores, Eosinophil Counts, FEV1%, ICS Adherence, and Exacerbation Frequency.
This study aims to evaluate whether incorporating FeNO monitoring into routine pediatric asthma care improves clinical outcomes relative to a historical cohort managed without FeNO
- Trial name
- NCT07788534
- Testing
- FENO, PFT
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Asthma
Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Subjects With Severe Uncontrolled Refractory Asthma
This study will evaluate two dose regimens of mepolizumab [75mg intravenous (i.v.) or 100mg subcutaneous (SC) every 4 weeks] compared with placebo over a 32 week treatment period in subjects with severe refractory asthma with…
- Trial name
- NCT01691521
- Testing
- Mepolizumab IV, Mepolizumab SC
- Where
- 134 sites in United States, Argentina and 14 more
- Volunteers
- 580 people
- Sponsor
- GlaxoSmithKline
Eosinophilic Esophagitis
Proton Pump Inhibitor (PPI) Response in Eosinophilic Esophagitis Assessed by Transnasal Endoscopy (TNE)
This study will enroll participants who have been diagnosed with Eosinophilic Esophagitis (EoE). Upon study enrollment, the participant will begin a proton pump inhibitor (PPI), Omeprazole 20mg twice daily.
- Trial name
- NCT04149470
- Testing
- Omeprazole 20mg BID
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Colorado, Denver
Preoperative Anxiety, Preoperative Evaluation
Association Between Preoperative Anxiety and Blood Eosinophil Levels
In the studies, the presence of preoperative anxiety has been evaluated and reported with anxiety scales. The presence of anxiety and allergic diseases has also been examined in a limited study with the analysis of neuroendocrine…
- Conditions
- Preoperative Anxiety, Preoperative Evaluation, STAI, Eosinophil Blood Count
- Trial name
- NCT06837415
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Naime Yalçın
Allergic Asthma
Changes in Eosinophil Cationic Protein and Sputum Eosinophils Following Allergen Immunotherapy
Asthma is a chronic heterogeneous inflammatory airway disease affecting millions worldwide and remains a major global health burden.
- Trial name
- NCT07694947
- Testing
- Allergen Immunotherapy Extract
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University Hospital
Asthma
Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
This study is researching a drug called dupilumab. The study is focused on patients who have uncontrolled asthma. Asthma is a condition where the airways narrow and swell, making it difficult to breathe.
- Trial name
- AIM4:Next Step (NCT06572228)
- Testing
- dupilumab, ICS/LABA
- Where
- 77 sites in United States, Canada and 4 more
- Volunteers
- 120 people
- Sponsor
- Regeneron Pharmaceuticals
COPD, Inhaled Corticosteroid
Eosinophil-guided Reduction of Inhaled Corticosteroids
Clinical trial on eosinophil-guided time-updated person-specific reduction of inhaled corticosteroid (ICS) therapy and prophylactic azithromycin therapy in patients with severe or very severe chronic obstructive pulmonary disease…
- Conditions
- COPD, Inhaled Corticosteroid, Azithromycin, COPD Exacerbation
- Trial name
- COPERNICOS (NCT04481555)
- Testing
- Azithromycin, ICS
- Where
- 9 sites in Denmark
- Volunteers
- 444 people
- Sponsor
- Chronic Obstructive Pulmonary Disease Trial Network, Denmark
Eosinophilic Esophagitis
A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis
Study CC-93538-EE-001 is a Phase 3, multicenter, multinational, randomized, double-blind, placebo-controlled induction and maintenance study to evaluate the efficacy and safety of CC- 93538 in adult and adolescent participants…
- Trial name
- NCT04753697
- Testing
- CC-93538
- Where
- 212 sites in United States, Argentina and 13 more
- Volunteers
- 430 people
- Sponsor
- Celgene
Nasal Lavage Fluid, Eosinophils
Nasal Lavage Study: Comparing Single Versus Multi Sample Lavages
Nasal lavage could be an integral component of assessing airway inflammation. Research into the reproducibility of cell counts is key to understanding the value of lavage results.
- Conditions
- Nasal Lavage Fluid, Eosinophils, Reproducibility of Results
- Trial name
- NCT00229190
- Testing
- Nasal lavage, Allergy skin testing, Peak nasal inspiratory flow
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Asthma, Healthy
Minimally Invasive Biomarker for Asthma Disease Severity
Can a clinical test be developed that could help manage asthma symptoms?
- Trial name
- NCT02225678
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Asthma, Asthma; Eosinophilic
Effects of Anti-IL5 Biological Treatments on Blood IgE Levels in Severe Asthmatic Patients
Real-life, observational, retrospective, multicenter study to evaluate the effects of anti-IL5 biological treatments on blood total IgE Levels in atopic patients with severe eosinophilic asthma.
- Trial name
- BIONIGE (NCT04181190)
- Testing
- Total IgE, Blood cell counts, Asthma control assessment
- Where
- 8 sites in Italy
- Volunteers
- 130 people
- Sponsor
- Università degli Studi di Ferrara
Asthma
Dupilumab on Airway Hyper-responsiveness and Ventilation Heterogeneity in Patients With Asthma.
In asthmatics with airway hyperresponsiveness and a "T2 immune signature" (type 2), Dupilumab will suppress airway hyperresponsiveness (assessed by methacholine PC20 ≤ 4 mg/mL (PC20: provocative concentration causing a 20% fall…
- Trial name
- NCT03884842
- Testing
- Dupilumab/Dupixent
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Asthma, Asthma, Bronchial
Mechanistic Study of Anti-inflammatory Effects of Fevipiprant in Patients With Eosinophilic Asthma.
This is an exploratory, randomized, subject- and investigator-blinded, placebo-controlled mode-of-action study to demonstrate the anti-inflammatory effects of fevipiprant compared to placebo after 12 weeks of treatment in 48…
- Conditions
- Asthma, Asthma, Bronchial, Bronchial Asthma, Eosinophilia
- Trial name
- NCT03989635
- Testing
- QAW039
- Sponsor
- Novartis Pharmaceuticals
Allergic Asthma
Pemirolast in Allergen Challenge (PEMAG)
The purpose of this study is to establish the influence of the non-steroidal candidate-drug pemirolast on allergen-induced airway obstruction and inflammation in allergic subjects with asthma.
- Trial name
- PEMAG (NCT03119714)
- Testing
- Pemirolast
- Where
- Sweden
- Volunteers
- 1 people
- Sponsor
- Karolinska University Hospital
Severe Asthma, Asthma Control Level
Remission in Adults With Severe Asthma in Thailand
The goal of this observational study is to determine the prevalence of remission among adults with severe asthma, as well as the factors associated with remission in Thailand.
- Trial name
- NCT07328035
- Testing
- Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires, Spirometry, Fractional exhaled nitric oxide (FeNO) test
- Where
- Thailand
- Volunteers
- 230 people
- Sponsor
- Thammasat University
Healthy
Effect of Smoking and Time of Day on Eosinophils
The study investigates the effect of acute smoking and time of day on blood eosinophils in chronic smokers. Chronic cigarette smokers without chronic respiratory diseases smoking at least 8 cigarettes per day and never-smoking…
- Trial name
- NCT07625111
- Testing
- Smoking for 4 hours
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Marek Lommatzsch
Asthma
A Phase 3a, Repeat Dose, Open-label, Long-term Safety Study of Mepolizumab in Asthmatic Subjects
This is a multi-center, open-label, long-term study of subcutaneously (SC) administered mepolizumab 100mg in addition to standard of care (SOC), in subjects with severe eosinophilic asthma.
- Trial name
- NCT02135692
- Testing
- Mepolizumab, SOC
- Where
- 114 sites in United States, Argentina and 16 more
- Volunteers
- 339 people
- Sponsor
- GlaxoSmithKline
Asthma
An Imaging Study Using PET/CT to Characterize the Effect of Intravenous Reslizumab on Airway Inflammation
This is an exploratory study with the following primary objectives: 1) to establish that PET/CT of the lung can reliably distinguish healthy, non-asthmatic participants from participants with severe asthma and an eosinophilic…
- Trial name
- DEAR (NCT02937168)
- Testing
- Reslizumab, Fludeoxyglucose F 18 (FDG)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.