Clinical trials: Epidural/Anesthesia, open to volunteers
Chronic Neck Pain, Cervical Radiculopathy
Cervical Epidural Block in Chronic Neck Pain
Chronic neck pain can negatively affect daily activities, work ability, and quality of life. Cervical epidural block is commonly used to reduce pain and inflammation, while exercise and physical therapy aim to improve muscle…
- Trial name
- CNP-TREAT (NCT07787741)
- Testing
- Cervical Epidural Steroid Injection, Cervical Stabilization Exercise Program, Physical Therapy Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Alİ Eman, MD
Labor Pain
Changes in Velocimetric Indices of Uterine and Umbilical Arteries Before and After Combined Spinal-epidural Analgesia in Laboring Women (PART II)
Combined spinal-epidural (CSE) for labor analgesia has been used for many years and is practiced commonly at our institution, especially when the patient requests immediate pain relief.
- Trial name
- NCT06655675
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Urinary Retention
Evaluation of the Efficacy of the Addition of Magnesium Sulfate to Morphine on the Occurrence of Acute Urinary Retention Following Epidural Anesthesia for Cesarean Section.
Peri-medullary anesthesia is the preferred anesthetic technique for Caesarean surgery. Compared with general anesthesia, it reduces maternal and fetal morbidity and mortality, as well as postoperative pain.
- Trial name
- EPIMAG (NCT06442995)
- Testing
- Injection of 500 mg magnesium sulfate + 2 mg morphine into the epidural space, Injection of Isotonic saline + 2 mg morphine into the epidural space
- Where
- France
- Volunteers
- 290 people
- Sponsor
- CHU de Reims
Obstetric Labor
Carbohydrate-Optimized Nutritional Solution Versus Electrolyte Hydration in Labor
This is a pilot randomized, triple-blind clinical trial (pilot RCT) evaluating the preliminary effects of energy supplementation with carbohydrate-rich sports gels compared to a low-sugar sports drink during labor in low-risk…
- Trial name
- NCT07742748
- Testing
- High carbohydrate sports gel, Low carbohydrate hydrogel
- Where
- Spain
- Volunteers
- 147 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Parturients, Accidental Puncture of Dura During Anaesthesia
Epidural Hydroxyethyl Starch for Post-Dural Puncture Headache in Parturients
The incidence of accidental dural puncture (ADP) among parturients receiving neuraxial labor analgesia has been reported to range from 1% to 1.5%.
- Conditions
- Parturients, Accidental Puncture of Dura During Anaesthesia, Epidural Filling, Hydroxyethyl Starch
- Trial name
- NCT07914790
- Testing
- Epidural hydroxyethyl starch, No epidural hydroxyethyl starch
- Where
- 4 sites in China
- Volunteers
- 410 people
- Sponsor
- Peking University First Hospital
Labour Analgesia
Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia
Epidural analgesia is the gold standard for controlling labour pain. However, labour pain happens during neuraxial analgesia, due to anaesthetic, obstetric, maternal factors.
- Trial name
- DIANA (NCT07614516)
- Testing
- Machine-learning prediction model
- Where
- Italy
- Volunteers
- 12,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ultrasonographic Evaluation of Epidural Depth in Infants
Evaluation of Skin-to-Epidural Distance at Different Vertebral Levels by Ultrasonography in Infants: A Prospective Observational Study
The goal of this observational study is to learn about the distance between the skin and the epidural space in infants younger than 12 months.
- Trial name
- NCT07847762
- Testing
- Ultrasonographic Assessment of Skin-to-Epidural Distance, Epidural Catheter Placement for Clinical Indications
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
Maternal Hypotension, Labor Epidural Analgesia
Maternal and Fetal Clinical Significance of Hypotension Following Labor Epidural Analgesia
The goal of this study is to learn how often blood pressure drops after an epidural for labor and how these drops may affect the parent and the baby.
- Conditions
- Maternal Hypotension, Labor Epidural Analgesia, Fetal Heart Rate Abnormalities
- Trial name
- NCT07272018
- Testing
- Epidural Analgesia (Standard Clinical Care)
- Volunteers
- 480 people
- Sponsor
- The Chaim Sheba Medical Center
Anesthesia
Poke and a Placebo
To discover if a positive description of the procedure for an epidural can reduce the overall pain score associated with the procedure.
- Trial name
- NCT04497220
- Testing
- Negative Connotation Langauge, Positive Connotation Language
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Subcostal, Lateral
Combined Subcostal and Lateral Transversus Abdominis Plane Block for Postoperative Analgesia Versus Thoracic Epidural Analgesia in Patients Undergoing Major Abdominal Cancer Surgery
This study aims to evaluate the safety and efficacy of combined subcostal and lateral transversus abdominis plane (TAP) for postoperative analgesia versus thoracic epidural anesthesia (TEA) in patients undergoing major abdominal…
- Conditions
- Subcostal, Lateral, Transversus Abdominis Plane Block, Postoperative Analgesia
- Trial name
- NCT07273136
- Testing
- Subcostal and lateral transversus abdominis plane block, Thoracic epidural anesthesia
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Thoracal Epidural Block, Echocardiography
Effect of Thoracic Epidural Anesthesia on Left Ventricular Functions: A Strain Echocardiography Study
Post-thoracic surgery pain management thoracic epidural catheter is the most commonly used method. Thoracic epidural anesthesia, in which cardiac sympathetic nerves (T1-T5) are involved in neural blockade, is the focus of our…
- Trial name
- TEA-strain (NCT06770790)
- Testing
- strain echocardiography
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Percutaneous Internal Ring Suturing, Pain Management
Comparison of the Postoperative Analgesic Effects of RSB and CEB in Pediatric Patients Scheduled for Percutaneous Internal Ring Suturing
Inguinal hernia is one of the most common surgical pathologies in children, and the minimally invasive percutaneous internal ring suturing (PIRS) technique is widely preferred.
- Trial name
- NCT07147062
- Testing
- Rectus Sheath Block, Caudal Epidural Block
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Postoperative Pain Management
Postoperative Analgesia in Thoracic Surgery
Analgesic management in thoracic surgery presents a particular challenge for the anesthesiologist, given the intensity of postoperative pain associated with thoracotomy, a surgical procedure that can impact respiratory function…
- Trial name
- ARP-TS (NCT07694141)
- Testing
- Postoperative pain through Visual analogue scale, Postoperative complications
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Epidural Analgesia, Ultrasound Assistance
Impact of Ultrasound Guidance on Central Neuraxial Block Success in Patients With Non-Palpable Vertebral Anatomy
Patients scheduled to undergo general surgery with planned epidural catheter placement will be evaluated by comparing two different techniques routinely used in anesthesia practice for catheter insertion.
- Trial name
- NCT07269184
- Testing
- epidural catheter, ultrasonography, anatomic landmark, epidural cateterisation
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Cesarean Section
Sensory Block Onset: Epidural vs Dural Puncture Epidural in Cesarean Section
The goal of this clinical trial is to compare the onset of sensory block between epidural anesthesia and dural puncture epidural (DPE) in patients undergoing elective cesarean delivery.
- Trial name
- NCT07349082
- Testing
- Dural Puncture Epidural (DPE) Anesthesia, epidural anesthesia
- Where
- 2 sites in Indonesia
- Volunteers
- 72 people
- Sponsor
- Gadjah Mada University
Epidural Catheterization
Ultrasound Predictors of Difficulty in Performing Epidural Anesthesia for Labor in Pregnant Patients.
This is a prospective observational study conducted at the University Hospital of Padua. The goal is to identify ultrasound markers that can help predict whether placing an epidural catheter during labor will be difficult.
- Trial name
- NCT07056166
- Testing
- epidural catheter, spine ultrasonography
- Where
- Italy
- Volunteers
- 563 people
- Sponsor
- University of Padova
Labor Epidural Analgesia, Perfusion Index
Perfusion Index Variability During Epidural Labor Analgesia
This prospective, single-centre observational study evaluates changes in the peripheral Perfusion Index (PI) - a non-invasive parameter derived from the pulse-oximetry photoplethysmographic waveform - in women receiving epidural…
- Conditions
- Labor Epidural Analgesia, Perfusion Index, Pain
- Trial name
- NCT07831967
- Testing
- Epidural (or opioid-only combined spinal-epidural) labor analgesia
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Gdansk
Obstetric Pain, Anesthesia, Local
Electrical Epidural Stimulation Test for Detecting Epidural Catheter Reactivation in Obstetric Population
Following labor, epidural or combined spinal-epidural (CSE) catheters are kept in place and deactivated. However, many women opt for procedures such as tubal ligation, which may require epidural anesthesia as a method of pain…
- Trial name
- NCT04983511
- Testing
- Electrical Epidural Stimulation Test (EST)
- Volunteers
- 40 people
- Sponsor
- Stanford University
Regional Anaesthesia, Cesarean Section
Dose-response Study of Spinally Administered Ropivacaine for Caesarean Section in Tall Parturients
The main goal is to determine the optimum dose of ropivacaine, a local anaesthetic, that provides regional anaesthesia with no or minimum adverse effects (i.e.
- Trial name
- NCT03936790
- Testing
- Ropivacaine, Fentanyl
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paraskevi Matsota
Postoperative Pain After Total Knee Arthroplasty, Postoperative Pain
Postoperative Pain and Analgesic Use After Total Knee Arthroplasty
This prospective observational study evaluates postoperative pain intensity and analgesic consumption in patients undergoing total knee arthroplasty (TKA) under different anesthesia techniques.
- Conditions
- Postoperative Pain After Total Knee Arthroplasty, Postoperative Pain, Analgesic Consumption
- Trial name
- NCT07457814
- Where
- Czechia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic