Clinical trials: Epidural
Pregnancy, Pain
A Trial Comparing Combined Spinal- Epidural Dosing Strategies for External Cephalic Version
We plan to conduct a prospective, single blinded, randomized clinical trial to assess the impact of combined spinal-epidural dosing on the success rate of, and patient satisfaction during, external version for breech fetal…
- Trial name
- NCT01991743
- Testing
- Group 2.5, Group 5, Group 7.5
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Northwestern University
Tubal Ligation, Bilateral Tubal Ligation
Continuous Labor Epidural Catheter for Tubal Ligation Study
This study is to study the success rate of using the epidural catheter that was placed during the labor for the surgical anesthesia to perform a postpartum tubal ligation.
- Trial name
- NCT00898443
- Testing
- Epidural anesthetic, Spinal anesthetic
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Alabama at Birmingham
Ketamine Adverse Reaction, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?
Pain control after cesarean delivery is associated with improved breastfeeding and infant rooming-in times. In addition, inadequate analgesia leads to elevated plasma catecholamine concentrations, which negatively affect every…
- Conditions
- Ketamine Adverse Reaction, Effects of; Anesthesia, Spinal and Epidural, in Pregnancy, Complication of Labor and/or Delivery
- Trial name
- NCT00486902
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Northwestern University
Spinal Cord Injury
Neuromodulation Techniques After SCI
Spinal cord injury (SCI) leads to several health-related consequences often linked to reduced levels of physical activity. Direct stimulation of the spinal cord, either through implanted devices or surface stimulation, has been…
- Trial name
- NCT04241250
- Testing
- EAW+SCES (exoskelton and spinal cord epidural stimulation), EAW+TS (exoskelton and transspinal stimulation)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Cervical Radiculitis, Pain
CESI With Low Dose Lidocaine and Transient Weakness
Cervical radicular pain is relatively common, often treated with epidural steroid injection (ESI), when conservative treatments like oral analgesics, physical therapy and activity modification have failed.
- Trial name
- NCT03127137
- Testing
- Experimental Group 1 triamcinolone and lidocaine, Experimental Group 2 triamcinolone and saline
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Northwestern University
Labor
Do Peanut Shaped Birthing Balls Reduce the Length of Labor in Patients With Epidural Analgesia?
Labor patients who meet inclusion and exclusion criteria will be consented to be participate in this study to determine if the use of a peanut shaped birthing ball reduces the length of labor and reduces the incidence of cesarean…
- Trial name
- NCT02539563
- Testing
- peanut shaped birthing ball
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Wake Forest University Health Sciences
Pain, Postoperative, Major Abdominal Surgery
Bilateral Transversus Abdominis Plane Block With Exparel Verus Continuous Epidural Analgesia With Bupivacaine
Comparison of Bilateral Transversus Abdominis Plane Block with Exparel versus Continuous Epidural Analgesia With Bupivacaine
- Trial name
- NCT02996227
- Testing
- TAP block, Epidural analgesia, EXPAREL
- Where
- 2 sites in United States
- Volunteers
- 514 people
- Sponsor
- The Cleveland Clinic
Pain, Radiating
Surgery Prevention by Transforaminal Injection of Epidural Steroids for Cervical Radicular Pain
Cervical radicular pain is a common cause of disability and pain in the upper extremity and neck with an annual incidence of 83.2/100,000 (1).
- Trial name
- SPIES (NCT02226159)
- Testing
- Lidocaine, Lidocaine with Dexamethasone
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Spinal Cord Injury
Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury
We propose to demonstrate that epidural stimulation (ES) can be used to recover significant levels of autonomic control of cardiovascular and respiratory function as well as the ability to voluntarily control leg movements below…
- Trial name
- NCT02037620
- Testing
- 5-6-5 Specify electrode, Restore Advance Pulse Generator
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Louisville
Pain Following Thoracotomy Surgery
Study of Exparel Versus Epidural for Pain Control After Thoracotomy
Unilateral intercostal nerve blocks provide pain control as effectively as a continuous thoracic epidural, and will a lower incidence of side effects.
- Trial name
- NCT02178553
- Testing
- Epidural, Intercostal Bupivicaine (Exparel)
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Mayo Clinic
Osteoarthritis
Analgesia After Total Hip Arthroplasty: Peri-Articular Injection Versus Epidural Patient Controlled Analgesia (PCA)
The best way to provide analgesia after total hip arthroplasty is hotly debated. There are two protocols in use at Hospital for Special Surgery(HSS).
- Trial name
- PAI Hip (NCT01658072)
- Testing
- Peri-Articular Injection, Epidural Patient Controlled Analgesia (Epidural PCA)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Hospital for Special Surgery, New York
Spinal Cord Injuries, Paraplegia
Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury
A study to compare electrophysiologic activity of epidural stimulation and dorsal root ganglion stimulation, as well as quantify changes in motor performance with both types of stimulation over the course of 10 rehabilitation…
- Conditions
- Spinal Cord Injuries, Paraplegia, Tetraplegia, Paralysis
- Trial name
- NCT04736849
- Testing
- Percutaneous epidural and dorsal root stimulation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Peter J. Grahn, Ph.D.
Labor, Analgesia, Epidural
Effect of Timing on Efficacy of Morphine Analgesia After 2-chloroprocaine Anesthesia
Epidural chloroprocaine is often used in obstetrical anesthesia because of its fast onset and short duration. These properties make it an ideal drug to use for epidural anesthesia in patients undergoing postpartum tubal ligation.
- Trial name
- NCT00487084
- Testing
- Morphine-CP-saline (MCS), saline-2CP-morphine (SCM), saline-lidocaine-morphine (SLM)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Pain Relief
Comparison of Loss of Resistance Techniques
The purpose of this study is to determine whether there is a difference in success outcome of the combined spinal epidural labor analgesia between air versus saline when used to identify the epidural space.
- Trial name
- NCT00638274
- Testing
- Air, Saline
- Where
- United States
- Volunteers
- 356 people
- Sponsor
- Wake Forest University Health Sciences
Epidural Spinal Tumors, Cancer
Study of Combined Decompressive Spine Radiosurgery and Pembrolizumab
The purpose of this research study is to find out what effects (good and bad) Pembrolizumab and radiosurgery have on participants with high-grade epidural disease of the spine.
- Trial name
- NCT05204290
- Testing
- Pembrolizumab, Stereotactic Body Radiation Therapy, Blood draws
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Wake Forest University Health Sciences
Anesthesia, Epidural, Hypotension
Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
The purpose of this pilot trial is to examine the feasibility and ease of use of monitoring by ClearSight in laboring and delivering patients with the intent to compare time-to-treatment of hypotension between conventionally…
- Trial name
- NCT05906368
- Testing
- ClearSight HPI Monitoring system, Standard of Care Blood Pressure Monitoring
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Anesthesia
Loss of Resistance, w/wo Stimulation, For Epidural Placement
The purpose of this randomized, observer-blinded, investigative trial is to determine if the use of electrical stimulation, compared to the traditional loss of resistance technique alone, improves the success rate of epidural…
- Trial name
- NCT03087604
- Testing
- Thoracic epidural block, Electrical Nerve stimulation, Solution For Thoracic epidural block
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wake Forest University Health Sciences
Anesthesia, Caudal
A Prospective Observational Study of Epidural Pressures During Caudal Epidural in the Pediatric Population
This study is a prospective study of epidural pressure changes when local anesthetic is injected from the caudal route. All patients will receive the same weight based volume dose of local anesthetic after induction of general…
- Trial name
- NCT02233309
- Testing
- Monitoring of pressures during caudal anesthesia
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Jessica Goeller
Lumbar Spine Disc Herniation, Lumbar Radiculitis
Dexamethasone Versus Depo Medrol in Lumbar Epidurals
Comparison of Dexamethasone versus Depo Medrol when used in lumbar epidural injections will be conducted on subjects that have not had previous injections or have not had an injection in the last 12 months.
- Conditions
- Lumbar Spine Disc Herniation, Lumbar Radiculitis, Lumbar Back Pain
- Trial name
- NCT01397552
- Testing
- Dexamethasone, methylprednisolone acetate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- State University of New York - Upstate Medical University
Postdural Puncture Headache
Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache
The purpose of this study is to compare a pain block in the midface, versus the traditional, more invasive, therapeutic epidural patch for the treatment of headaches
- Trial name
- NCT03112720
- Testing
- Epidural Blood Patch, Sphenopalatine Ganglion Block
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey