Clinical trials: Epidural, open to volunteers
Spinal Cord Injuries
Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury
The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord…
- Trial name
- MC-PP-3 (NCT04879862)
- Testing
- Epidural stimulation + Stand Training, Epidural stimulation + Step Training, Epidural stimulation + Bladder Capacity Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Claudia Angeli
Radiculopathy
Interest of the Virtual Reality as an Analgesic Support and in the Management the Pre-procedural Anxiety in Rheumatology
As a part of the current rheumatological practice skills, epidural injections through the sacrococcygeal hiatus take part in the strategy for managing radicular diseases.
- Trial name
- REAVIR (NCT05289999)
- Testing
- Virtual reality headset for first injection, Virtual reality headset for second injection
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier le Mans
Organ Dysfunction, Organ Support
Thoracic Epidural Analgesia for Acute Pancreatitis With Early Organ Dysfunction
Acute pancreatitis may cause early respiratory, cardiovascular, or renal dysfunction and may require intensive care and organ support.
- Conditions
- Organ Dysfunction, Organ Support, Acute Pancreatitis (AP)
- Trial name
- TEA-APOD (NCT07697690)
- Testing
- Thoracic Epidural Analgesia With Ropivacaine, conventional analgesia
- Volunteers
- 150 people
- Sponsor
- First People's Hospital of Chenzhou
Intervertebral Disc Displacement, Low Back Pain
Exercise Therapy After Caudal Epidural Steroid Injection
Brief Summary Lumbar radicular pain arising from intervertebral disc herniation is commonly managed with a caudal epidural steroid injection (CESI), a minimally invasive procedure that delivers anti-inflammatory medication to the…
- Conditions
- Intervertebral Disc Displacement, Low Back Pain, Radiculopathy
- Trial name
- CAPER (NCT06956664)
- Testing
- Conventional Physiotherapy, Aerobic Exercise Programme, Core-Stabilization Exercise Programme
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Çankırı Karatekin University
Epidural Hematoma, Decompressive Craniectomy
Prospective, Observational Real-world Treatments of AEDH in Large-scale Surgical Cases
This is a multicenter, prospective, and observational real-world study aimed at investigating the current situation of surgical treatments and prognosis for acute epidural hematoma in China, and analyzing the optimization of…
- Conditions
- Epidural Hematoma, Decompressive Craniectomy, Craniotomy
- Trial name
- PORTALS-AEDH (NCT04229966)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- RenJi Hospital
Lumbosacral Radicular Pain, Lumbar Radiculopathy
Determination of Sensitivity and Specificity of Straight Leg Raise Test Via Transforaminal Nerve Root Block
This study aims to evaluate the diagnostic accuracy of the straight leg raise test in patients with suspected lumbosacral radicular pain.
- Conditions
- Lumbosacral Radicular Pain, Lumbar Radiculopathy, Straight Leg Raise
- Trial name
- NCT07696312
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Marmara University
Duodenal Neoplasm, Pancreatic Neoplasm
Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy
This phase II trial compares the effect of rectus sheath block with liposomal bupivacaine to thoracic epidural analgesia (TEA) on pain control in patients following surgical removal of all or part of the pancreas and duodenectomy…
- Trial name
- NCT06411795
- Testing
- Bupivacaine, Hydromorphone, Iopamidol
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Spinal Stenosis, Ligamentum Flavum Hypertrophy
Cytokines, Neuroplasticity Modulators, and Biomarkers in Spinal Canal Stenosis and Endoscopic Decompression
Research Rationale and Study Design Lumbar spinal stenosis (LSS) is a common degenerative musculoskeletal disorder characterized by narrowing of the spinal canal, often leading to pain and disability.
- Trial name
- NCT07232836
- Testing
- Endoscopic Spinal Canal Decompression
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Poznan University of Physical Education
Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H)
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Introduction: Major abdominal surgery encompasses a broad range of surgical procedures in heterogeneous patient populations.Management of postoperative pain has received keen attention in recent years with considerable concurrent…
- Conditions
- Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H), Colectomy Left/Right/Total Under Laparotomy, Hepatectomy
- Trial name
- NCT07901582
- Testing
- Epidural administered opioid
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- National and Kapodistrian University of Athens
Breakthrough Pain
Programmed Intermittent Epidural Bolus Compared With Continuous Infusion in Multiparous Women
The goal of this randomized controlled trial is to examine the impact of programmed intermittent bolus epidural analgesia technique on the incidence of breakthrough pain during labor in multiparous women compared to continuous…
- Trial name
- NCT06580327
- Testing
- programmed intermittent Bolus epidural analgesia, continuous epidural infusion
- Where
- Israel
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Anesthesia, Analgesia
Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural
As the dural puncture epidural (DPE) is increasing in popularity for labor analgesia, it is important to understand how it impacts outcomes in parturients.
- Trial name
- NCT05514431
- Testing
- Epidural, Dural Puncture Epidural (DPE) technique, Combined Spinal-Epidural (CSE) technique
- Where
- 2 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Ventral Hernia, Ventral Hernia Repair
Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release
This study is comparing two ways to manage pain after a major hernia repair surgery called "transversus abdominis release." One method uses an epidural, a small tube placed in the back that delivers pain medicine directly around…
- Conditions
- Ventral Hernia, Ventral Hernia Repair, Postoperative Pain
- Trial name
- EASE-TAR (NCT07840183)
- Testing
- Bupivicaine, Fentanyl, Thoracic epidural analgesia
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Needle Phobia
Lidocaine Patch for Epidural Placement Pain in Laboring Women
Needle phobia can negatively affect the patient experience and may contribute to anxiety during labor procedures. During epidural placement, a standard intradermal lidocaine skin wheal is administered before Tuohy needle…
- Trial name
- NCT07700108
- Testing
- Lidocaine patch 4%, 1% Lidocaine Skin Wheal
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Ohio State University
EpiDural Hematoma, Traumatic Brain Injury
Acute EpiDural Hematoma Treated With Middle Meningeal Artery Embolization: a Randomized Trial (AEDH-MT)
A prospective, multicenter, randomized controlled, open-label, blinded endpoint evaluation study.
- Trial name
- AEDH-MT (NCT06292585)
- Testing
- MMA embolization plus medical therapy, Medical therapy alone
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Changhai Hospital
Postpartum Recovery, Mother-infant Bonding
Labor Epidural Analgesia and Mother-Infant Bonding After Vaginal Delivery
This prospective observational cohort study aims to evaluate the association between postpartum recovery quality and mother-infant bonding in women undergoing vaginal delivery.
- Conditions
- Postpartum Recovery, Mother-infant Bonding, Labor Pain
- Trial name
- NCT07582289
- Testing
- Labor Epidural Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ataturk University
Anesthesia, Epidural
Using the CompuFlo® CathCheck™ System to Check Epidural Catheter Function Before Tubal Ligation: A Pilot Study
This pilot study evaluates the use of the CompuFlo® CathCheck™ System to assess labor epidural catheter function before reactivation for postpartum tubal ligation.
- Trial name
- NCT07720908
- Testing
- CompuFlo® CathCheck™ System Assessment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University
Labor Analgesia, Labor Pain
Effect of Dural Puncture Epidural Analgesia on Oxytocin in Early vs Late Labor
Oxytocin is a key hormone that regulates uterine contractions during labor. Dural Puncture Epidural Analgesia (DPEA) is a modern technique for labor pain relief that provides faster onset and more reliable analgesia than standard…
- Conditions
- Labor Analgesia, Labor Pain, Oxytocin
- Trial name
- DPEA-OXY (NCT07873814)
- Testing
- Dural Puncture Epidural Analgesia (DPEA)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Laparotomy
Influence of Analgesic Technique on Post Operative Rehabilitation After Median Laparotomy
Randomized controlled trial (1:1) in two parallel groups, multicentric, open-label, comparing two locoregional anesthesia (LRA) techniques as integral parts of multimodal analgesia: the control group will benefit from epidural…
- Trial name
- QORRECTCATH (NCT04985695)
- Testing
- Epidural analgesia, Bilateral rectus sheath block, Laparotomy
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Spinal Cord Injuries
Epidural Electrical Stimulation for Spinal Cord Injury Patients and Corticospinal Motor Circuit Improvement
The study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.
- Trial name
- NCT06455137
- Testing
- Epidural Stimulator
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Obstetric Pain, Anesthesia, Local
The Use of Electrical Stimulation for Determination of Epidural Catheter Placement
The aim of this study is to address the problem of epidural failure. The investigators theorize epidural failure can be due to inappropriate catheter movement and this may be related to the length of which the epidural catheter…
- Trial name
- NCT06055686
- Testing
- Electrical Epidural Stimulation Test
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University