Clinical trials: Epigenetic
Colorectal Cancer, Colorectal Cancer Metastatic
Comprehensive Genomic Profiling of Colorectal Cancer Patients With Isolated Liver Metastases to Understand Response & Resistance to Cancer Therapy
This is a prospective study investigating the disease course of patients with colorectal cancer that have had their cancer spread to their liver.
- Conditions
- Colorectal Cancer, Colorectal Cancer Metastatic, Hepatic Metastases
- Trial name
- COMPARISON (NCT03364621)
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- University Health Network, Toronto
Full Term Infants, Environmental Exposures
Epigenetic and Developmental Effects of In Utero Exposure to Environmental Toxicants
Metabolic diseases such as obesity and diabetes are modern day epidemics. Early life exposure to an adverse developmental environment, including environmental toxins, are linked to increased susceptibility to obesity, metabolic…
- Conditions
- Full Term Infants, Environmental Exposures, Adiposity
- Trial name
- NCT01815385
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Stunting, Development, Child
Methylation, mIcrobiome, NUtritional sTatus, and dEvelopment of Stunted Children
The investigators will conduct a case-control study among under-two children in Lombok Timur, West Nusa Tenggara, Indonesia. The power required to detect changes in epigenetic markers may not be sufficient in the cohort study.
- Conditions
- Stunting, Development, Child, DNA Methylation, Epigenetics
- Trial name
- MINUTES (NCT05779904)
- Where
- Indonesia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Gestational Diabetes Mellitus (GDM)
Imprinting in Metabolic Diseases - Identifying Epigenetic Mechanisms in Human Gestational Diabetes Through Cell-free DNA
This clinical trials aims to investigate the impact of parental metabolism during pregnancy on fetal epigenetic signatures. The metabolic profiles of both parents will be evaluated through a blood sample collected from the father…
- Trial name
- Epi_GDM (NCT07436195)
- Testing
- Metabolic and epigenetic characterization of parents ans fetuses
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Coronary Artery Disease, Acute Coronary Syndrome
DNA Methylation Analysis in Acute Coronary Syndrome and Atrial Fibrillation: DIANA Clinical Trial
Although epigenetics has been identified as one of the most relevant pathophysiological components in the development of cardiovascular diseases, there is still considerable difficulty in finding markers of epigenetic damage…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Atrial Fibrillation
- Trial name
- NCT04371809
- Testing
- DNA methylome
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Acute Kidney Injury, Renal Transplantation
Detection of Plasma DNA of Renal Origin in Kidney Transplant Patients
Donor-derived cell-free DNA (dd-cfDNA) has been proposed as a potential diagnostic tool to monitor the rejection status of the kidney transplant.
- Trial name
- DART-REIN (NCT06026592)
- Testing
- determination of circulating biomarkers of renal origin circulating biomarkers of renal origin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma, Children
Early Risk of Asthma in Children Exposed to In-utero Maternal Obesity
This study seeks a better understanding of the pathogenesis of asthma in early life. The aim of this project is to determine whether the offspring of obese mothers at 3 years of life have increased the risk of asthma compared to…
- Conditions
- Asthma, Children, Obesity, Maternal
- Trial name
- NCT02903134
- Volunteers
- 240 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Cannabis Use
Cannabis Use and Epigenetic Alterations in Human Male Sperm Cells
This is a follow-up project to a proof-of-concept study to determine if Cannabis use in male humans is associated with changes in deoxyribonucleic acid (DNA) methylation profile of sperm.
- Trial name
- NCT03614637
- Testing
- Cannabis use abstinence for 11 weeks
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy
Effect of a Multivitamin/Multimineral/Phytochemical Dietary Supplement on Indices of Human Health
This is a global transcriptomics and epigenetic pilot study designed to identify changes in gene expression and DNA methylation patterns following the consumption of an MVM/phytochemical supplement in a small group of healthy…
- Trial name
- NCT03146312
- Testing
- MVM/phytochemical supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- USANA Health Sciences
Infertility
Epigenetic Safety of Assisted Reproductive Technology
The primary purpose of the study is to investigate the relationship between different protocols of assisted reproductive technology and the epigenetic safety of the offspring.
- Trial name
- NCT04065945
- Testing
- Completion questionnaires/providing biological samples
- Where
- China
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Obesity
Dietary Intervention and Assessment of Obesity-related Gene Methylation Levels in Overweight Women
The clinical study aimed to study the effect of an intervention with foods containing folate and hazelnut oil to assess whether this diet could modulate the methylation levels of two obesity-related genes, LEP and POMC, in…
- Trial name
- NCT04523532
- Testing
- Dietary folate and hazelnut oil
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Thamires Ribeiro Chaves
Type 2 Diabetes, Obesity
Long-term Effects of Lifestyle Intervention During Pregnancy in High Risk Women and in Their Offspring - Role of Environmental, Genetic and Epigenetic Factors
SUBJECTS: All participants in the RADIEL-study (2008-2011) who delivered (n=535), will be invited to this follow-up study, with their children (age 3-5 years) and the father.
- Conditions
- Type 2 Diabetes, Obesity, Metabolic Syndrome
- Trial name
- NCT02048839
- Where
- Finland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Taurine, Aging, Biological
Effects Of Daily Taurine Intake For 6 Months On Biological Age and Body Metabolism Indicators As Well As Physical Fitness In 55-75-year-old Women And Men
The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months.
- Conditions
- Taurine, Aging, Biological, Physical Activity, Metabolic Health
- Trial name
- TauAge (NCT06613542)
- Testing
- 4g of taurine daily
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Heart Rate, Heart Rate Variability
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
In this study, the pills formulated are being used to try to ameliorate the effect of air pollution on epigenetic changes, specifically DNA methylation, potentially linked with particulate matter air pollution inhalation and…
- Conditions
- Heart Rate, Heart Rate Variability, Inflammation
- Trial name
- EPI-Air (NCT01864824)
- Testing
- methyl donor
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Ischemic Stroke, Acute, Acute Hemiparesis
Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia
The aim of this study is to demonstrate the effect of routine exercise program on neuroplasticity through histone acetylation and gene expression changes in acute stroke survivors from an epigenetic perspective and to investigate…
- Trial name
- NCT06726941
- Testing
- Physiotherapy and Rehabilitation Practices
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Afyonkarahisar Health Sciences University
Vagina Disease, Diagnosis
Feasibility of the Oricol™ Sampling Device to Retrieve Vagina Mucus (Wall) Samples for Genomic & Epigenetic Analysis.
Primary Objective The primary objective is to explore the feasibility of collecting a vaginal sample using the OriCol™ Sampling Device. Secondary Objectives The study has secondary objectives to assess: 1.
- Trial name
- Ellele-01 (NCT05709119)
- Testing
- Quantification of human DNA retrieved and DNA fragmentation profile.
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Origin Sciences
Healthy
National Survey to Understand Ethical, Legal and Social Issues in Communicating to the Public About Epigenetics
Few people realize that environmental pollution and some behaviors like physical activity and tobacco smoking can affect their health by "turning on" or "turning off" certain genes through a process called "epigenetic…
- Trial name
- NCT07020234
- Testing
- Epigenetics Video, Nanotechnology Video
- Where
- United States
- Volunteers
- 2,040 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pain, Postoperative, Excavatum, Pectus
Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery
This will be a prospective observational study to determine the association between specific genotypes, epigenetics, behavioral, social and biological factors, with the phenotypes, defined by pain perception, postoperative pain…
- Conditions
- Pain, Postoperative, Excavatum, Pectus, Scoliosis Idiopathic
- Trial name
- NCT04031716
- Testing
- Meditation
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Non-Alcoholic Fatty Liver Disease
Lysosomal Acid Lipase Activity in Nonalcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease affecting a quarter of the world population. Pathological accumulation of fat, into the hepatocytes, is the first hit and is due to altered hepatic and…
- Trial name
- NAFLD LAL (NCT05419765)
- Testing
- Peripheral blood withdrawn
- Where
- Italy
- Volunteers
- 316 people
- Sponsor
- University of Roma La Sapienza
Chronic Beryllium Disease
Exposure in Epigenetic Regulation of Immune Response in Chronic Beryllium Disease (CBD)
This study will provide important results for each aim, while also providing an integrative transcriptional and epigenomic profile of CBD.
- Trial name
- BeEpiGen (NCT02604693)
- Testing
- Nothing
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- National Jewish Health