Clinical trials: Epigenetic
Periimplantitis
The Role of Functional Epigenetic Modifications in Peri-Implantitis
The aim of this pilot, exploratory, single blind clinical trial is to evaluate the epigenetic changes associated with peri-implantitis.
- Trial name
- NCT03753464
- Testing
- Gingival biopsy and blood sample collection
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- NYU College of Dentistry
Lung Cancer With Mediastinal Lymph Node Involvement
Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging
A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by…
- Trial name
- NCT01653002
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Essen
Exercise-induced Inflammation
Effect of Combined Fatty Acid Supplementation and Eccentric Exercise Training on Exercise Performance
The aim of the study is to determine whether fish oil (specifically omega-3 long chain polyunsaturated fatty acids [EPA-DHA]) supplementation can enhance eccentric resistance exercise performance when combined with a resistance…
- Trial name
- FAT (NCT03259412)
- Testing
- Fish Oil
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Age Over 50 Years
The Impact of Exercise Intervention on Biological and Functional Aging Through the Lens of Epigenetic Clocks
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body…
- Trial name
- NCT07799103
- Testing
- Exercise - Relative High-Intensity Interval Training (HIIT)
- Where
- Hungary
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hungarian University of Sports Science
Sedentary Behavior
Impact of 4 Months of Exercise Changes of Heart Health-related Epigenetic Markers in Healthy, Sedentary Individuals
We aim to analyze the impact of a single acute exercise intervention (ergometry) on the expression pattern of specific heart health related miRNAs in healthy, previously sedentary participants, and how this pattern will be…
- Trial name
- miR-4-heart (NCT04791306)
- Testing
- supervised exercise training, home-based exercise training
- Where
- Austria
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Paracelsus Medical University
Colorectal Cancer
A Study of Enhancing Response to MK-3475 in Advanced Colorectal Cancer
This study is being done to test the safety and effectiveness of the combination of intravenous (IV) romidepsin and/or oral 5-azacitidine with IV MK-3475 in people with microsatellite stable (MSS) advanced colorectal cancer.
- Trial name
- NCT02512172
- Testing
- Oral CC-486, Romidepsin, MK-3475
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Weight Gain, Anemia, Iron Deficiency
Egg Intervention During Pregnancy in Indonesia
The study consists of two arms: 1) intervention group using eggs as supplementary food given from 2nd trimester of pregnancy to birth, and 2) observational group of pregnant mothers.
- Conditions
- Weight Gain, Anemia, Iron Deficiency, Birth Weight, Birth Length
- Trial name
- PRECODE (NCT04694235)
- Testing
- Egg intervention
- Where
- Indonesia
- Volunteers
- 702 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Acute Myeloblastic Leukemia
Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients
The main objective of this study is to identify epigenetic markers specific to abnormal myeloid cells in patients with acute myeloid leukemia (AML) by analyzing the methylation of circulating cell-free DNA in plasma.
- Trial name
- LAMME (NCT07250217)
- Testing
- Epigenetic markers
- Where
- 2 sites in France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier de la Region de Mulhouse et Sud Alsace
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
High-risk Prostate Cancer
A Platform Study of Epigenetic Therapy Before Prostatectomy in Men With Prostate Cancer
This is an open-label, non-randomized, exploratory platform protocol designed to assess the safety and antitumor activity of epigenetic therapies in participants with localized prostate cancer who are undergoing radical…
- Trial name
- NCT06888102
- Testing
- Neoadjuvant Epigenetic Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Edwin Posadas, MD
Prenatal Stress
Measuring Outcomes of Maternal COVID-19-related Prenatal Exposure
The rapidly spreading coronavirus Covid-19 pandemic is a major concern worldwide and Italy is at the forefront of this emergency.
- Trial name
- MOM-COPE (NCT04540029)
- Testing
- Maternal stress
- Where
- Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cystic Fibrosis
DNA Methylation and Lung Disease in Cystic Fibrosis
Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease-modifier genes and environmental exposure.
- Trial name
- METHYLCF (NCT02884622)
- Testing
- nasal epithelial, Blood sampling
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Anemia and Pregnancy, Metabolism and Foetal Growth
Foetal Exposure and Epidemiological Transition: Role of Anaemia in Early Life for Non-communicable Diseases Later
Study Hypotheses: 1. Anaemia, which is frequent before conception as well as during early pregnancy, affects metabolism and foetal growth trajectories, influencing the risk of NCDs in the offspring. 2.
- Conditions
- Anemia and Pregnancy, Metabolism and Foetal Growth, Epigenetics
- Trial name
- FOETALforNCD (NCT02191683)
- Where
- Tanzania
- Volunteers
- 1,748 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Asthma, Pulmonary Function
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring.
- Conditions
- Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
- Trial name
- VCSIP (NCT06106646)
- Testing
- No active intervention in this protocol (previously randomized to Vitamin C)
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- Oregon Health and Science University
Long COVID-19 Syndrome, Long COVID Symptoms
Epigenetic Changes in Long COVID Patients
The goal of this observational study is to improve the understanding of the biological mechanisms underlying long COVID and to identify molecular biomarkers that may support its diagnosis, prognosis, and future precision medicine…
- Trial name
- ECLIPSE (NCT07757620)
- Where
- 3 sites in Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Hepato Cellular Carcinoma (HCC)
Hepatocellular Carcinoma Identification Using Delta-HLD
HIDE (Hepatocellular Carcinoma Identification via Delta-HLD) is a proof-of-concept case-control study designed to evaluate the performance of delta-HLD, Epiliquid's proprietary liquid biopsy technology, in detecting…
- Trial name
- HIDE (NCT07148310)
- Where
- Argentina
- Volunteers
- 200 people
- Sponsor
- Epiliquid Holding, Inc
Immune System Diseases, Infections
Epigenetic Memory of Vitamin D Supplementation
The investigators will study the mechanistic details of dietary programming of the epigenome at the example of epigenetic programming of primary human immune cells with the micronutrient vitamin D3.
- Conditions
- Immune System Diseases, Infections, Healthy Lifestyle
- Trial name
- VitDPAS (NCT06104111)
- Testing
- Vitamin D3
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Polish Academy of Sciences
Healthy
The Molecular Basis for a Broad Range of Phenotypes Related to hTAS2R38
This single-site, within-subject, experimental study is designed to test the hypothesis that individuals express taste receptors differently and have different sensitivities to bitter taste samples, which results from uneven…
- Trial name
- NCT01399944
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Autism Spectrum Disorder, Developmental Delay
A Salivary miRNA Diagnostic Test for Autism
The goal of this study is to validate a panel of miRNAs that distinguish children with autism spectrum disorder (ASD) from their non-ASD peers with a positive MCHAT-R.
- Trial name
- NCT02832557
- Testing
- Salivary collection, Vineland Adaptive Behavior Scale-III Assessment, Medical history questionaire
- Where
- United States
- Volunteers
- 998 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Healthy
Effect of Exercise Intensity on Epigenetic Response in Healthy Young Adult
Aerobic exercise has been shown to trigger a variety of body responses which then trigger physiological adaptations. One of the physiological adaptations that occur is an increase in mitochondrial biogenesis.
- Trial name
- NCT04985006
- Testing
- running at moderate intensity, running at high intensity
- Where
- Indonesia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Rahmaningsih Mara Sabirin