Clinical trials: Epigenetic Changes
BDNF, DNA Methylation, Suicide, Drug Responses.
Epigenetic Regulation of BDNF in Schizophrenia
In this proposal, we will (1) detect the associations between BDNF and Trk B gene DNA methylation, histone modification, psychotic symptoms, obesity, suicide and antipsychotic drug responses in Taiwanese patients (2) discuss the…
- Trial name
- NCT01021449
- Where
- Taiwan
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Atrial Fibrillation
Antiorbital Calcium in Chronic Conditions
The purpose of this study is to determine the mechanistic effects of an ionic calcium supplement in adults with atrial fibrillation, osteoarthritis, and hypertension.
- Trial name
- AntiAFib (NCT05302713)
- Testing
- Ionic Calcium, Calcium Carbonate
- Where
- United States
- Sponsor
- National University of Natural Medicine
Preterm, Neurodevelopmental Disorder
Biomarkers, Neurodevelopment and Preterm Infants
Approximately 2% of neonates in the US are born very preterm. Preterm births are associated with impaired cognitive, language and motor function, and increased risk for autism spectrum disorders.
- Conditions
- Preterm, Neurodevelopmental Disorder, Epigenetic Changes
- Trial name
- NCT02557191
- Testing
- Observational study
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Osteoporosis，Neurological Disorders
Beijing Osteoporosis With Neurological Disorders in Epigenetic Changes Study
Epigenetic modification refers to the change of heritable gene expression occurring in the case of unchanged DNA sequence, including DNA methylation, epigenetic modification, RNAS, chromatin modification, etc.
- Trial name
- BONE (NCT03401619)
- Testing
- Exercise，Nutrition，Bisphosphonates，Statins，Calcitonin,Vitamin D，et al.
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Obesity, Periodontitis
Periodontal Inflammation and Epigenetics in Obese Individuals
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis.
- Trial name
- NCT07610902
- Testing
- Non-surgical periodontal therapy will be administered
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Breast Neoplasms
Reversing Therapy Resistance With Epigenetic-Immune Modification
The investigators propose a randomized two arm trial, using Simon's 2-stage design, in ER+ patients with therapy resistant breast cancer to test the optimal sequence and dosing of epigenetic immune priming in hormone therapy…
- Trial name
- NCT02395627
- Testing
- Tamoxifen, Vorinostat, Pembrolizumab
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, San Francisco
Overweight and Obesity, Body Weight Changes
FatMax Training on Metabolic and Epigenetic Parameters
Exercise is an essential pillar for the health of all individuals, as it contributes to physical, mental, and emotional well-being.
- Trial name
- NCT06553482
- Testing
- FatMAx training intervention, FatMax and physical endurance exercise intervention, Control
- Where
- Mexico
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Fat Mass, Risk Factors Cardiovascular Disease
Follow up Study of Varapodio Trial: Effect of Longevity and Fasting Mimicking Diet on Risk Factors Age Correlated and Biomarkers of Aging
A large ongoing randomized, open-label trial aimed at evaluating the effects of two different dietary interventions, FMD and LD, on body composition and cardiovascular (CV) biomarkers in a real word population (NCT05698654) is…
- Conditions
- Fat Mass, Risk Factors Cardiovascular Disease, Epigenetic Aging, Metabolism Changes
- Trial name
- NCT07255300
- Testing
- fasting mimicking diet
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Fondazione Valter Longo
Age Over 50 Years
The Impact of Exercise Intervention on Biological and Functional Aging Through the Lens of Epigenetic Clocks
This study investigated the effects of a structured 6-month high-intensity interval training (HIIT) program on blood DNA methylation-based measures of biological ageing, physical fitness, cardiovascular function, body…
- Trial name
- NCT07799103
- Testing
- Exercise - Relative High-Intensity Interval Training (HIIT)
- Where
- Hungary
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hungarian University of Sports Science
Hospitalism
Psychological, Neurological and Immunological Changes Following a Meeting With a Chaplain Coupled With Biblical Readings
The aim of the "HEALING" " (Hospital-based Ecumenical And Linguistic Immuno-NeuroloGic) Study was to examine immunological and neurological changes in hospitalized participants after meeting a chaplain and Biblical listenings, in…
- Trial name
- HEALING (NCT04112121)
- Testing
- Meeting with a Chaplain coupled with Biblical Readings
- Where
- Hungary
- Volunteers
- 57 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Hypertension
Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change
Bisphenol A(BPA) is an endocrine disrupting chemical, which mimics the action of estrogen. Previous studies reported that BPA exposure is associated with increased risk of cardiovascular diseases.
- Trial name
- NCT02096991
- Testing
- Can 1, Can 2, Glass
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Liver Cirrhosis, Hepatitis C, Chronic
Prolonged Release Pirfenidone for Advanced Residual Liver Fibrosis (MINERVA).
Prolonged-Release Pirfenidone (PR-PFD) is an anti-fibrogenic and anti-inflammatory molecule used for the treatment of idiopathic pulmonary fibrosis (approved by FDA) and liver fibrosis (approved in Mexico by COFEPRIS).
- Conditions
- Liver Cirrhosis, Hepatitis C, Chronic, Epigenetic Disorder
- Trial name
- NCT05542615
- Testing
- Prolonged-Release Pirfenidone
- Where
- 2 sites in Mexico
- Volunteers
- 60 people
- Sponsor
- University of Guadalajara
Low Back Pain, Modic Changes Type I or II Seen on MRI
Antibiotics In Modic Changes
Low-back pain (LBP) is the single leading cause for disability worldwide, affects all age groups and has increased from 58 million years lived with disability (YLDs) in 1990 to 83 million YLDs in 2010.
- Trial name
- AIM (NCT02323412)
- Testing
- Amoxicillin (Amoksicillintrihydrat)
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Autism Disorders and Maternal Stress, Development Delay
Perinatal Autism Genetics and Epigenetics Study
The University of Iowa's Center for Disabilities and Development is researching how pregnancy, early childhood experiences, and genetic factors influence child development, with a focus on autism spectrum disorder (ASD).
- Conditions
- Autism Disorders and Maternal Stress, Development Delay, Prenatal Stress, Social Behavior
- Trial name
- PAGES (NCT07738003)
- Testing
- Change in child's DNA methylation, Perinatal stress, Early social experience
- Where
- United States
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Obesity, Pre-diabetes
Valued EpiGenetic Glycemic ImprovEments Through Weight Loss
This randomized controlled clinical trial will use methylomic and transcriptomic profiling to examine the effects of a weight loss intervention on the cholesterol metabolism gene network in monocytes and adipocytes and…
- Trial name
- VEGGIE (NCT02869659)
- Testing
- Weight Loss Group, Delayed Weight Loss
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Wake Forest University Health Sciences
Metastatic Melanoma
Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat
The purpose of this study is to treat metastatic melanoma with a combination of standard chemotherapy (decitabine and Temozolomide in a dose escalation scheme) with an study drug called panobinostat.
- Trial name
- NCT00925132
- Testing
- Temozolomide, Decitabine, Panobinostat
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Iowa
Non Small Cell Lung Cancer, Pancreatic Cancer
Feasibility Study to Investigate Rectal Mucus in Aero-Digestive Tract Cancer.
The aim of the study is to assess the feasibility of genomic and epigenetic analysis of rectal mucus to detect non-colorectal cancers of the aero- digestive tract using samples collected by the OriCol™ Sampling Device.
- Conditions
- Non Small Cell Lung Cancer, Pancreatic Cancer, Bladder Cancer, Colorectal Cancer
- Trial name
- ORI-EGI-03 (NCT05102110)
- Testing
- Oricol Test
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- Origin Sciences
Insulin Resistance, Decreased Pulmonary Function
Associations of Exposure to Phthalates With Insulin Resistance and Epigenetic Change
Phthalate is an endocrine disrupting chemical, which works as an anti-androgenic agent. Phthalate is mainly used as PVC plasticizer and easily found in commonly used products such as electronic device, paint, lubricant…
- Trial name
- NCT02284477
- Testing
- non- PVC containing packing materials, PVC containing packing materials
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Itch
Identification of the Mechanism of Non-histaminergic Itch Inducing Epigenetic Changes
Itch is defined as an unpleasant sensation that evokes the desire to scratch. Chronic itch, defined as itch persisting for more that 6 weeks, is a key symptom in many diseases severely affects the quality of life of the affected…
- Trial name
- NCT06997926
- Testing
- blood sampling
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Adenosquamous Carcinoma of the Pancreas
Superenhancer Inhibitor Minnelide in Advanced Refractory Adenosquamous Carcinoma of the Pancreas (ASCP)
Background: Pancreatic cancer is one of the most lethal types of cancer. American Society for Clinical Pathology (ASCP) is a highly aggressive type of pancreatic cancer. It is very rare.
- Trial name
- NCT04896073
- Testing
- Minnelide, ECG, CT/MRI
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)