Clinical trials: Epigenetic Disorder
Down Syndrome
Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome
Heterokaryotypic monozygotic twins discordant for Down syndrome (DS) are very rare, with an incidence estimated to be less than 1 over 7,000,000 pregnancy in the general population.
- Trial name
- Colibri (NCT05767216)
- Testing
- Biological sampling
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Institut Jerome Lejeune
Bipolar Disorder (BD)
Epigenetic and Neurochemical Correlates of Bipolar Disorder
Aim of Study: To assess DNA methylation of the IL1-B gene in individuals with BD compared to healthy controls. To evaluate the expression of 5-hydroxytryptamine (serotonin) receptors in BD and shed more light into its role into…
- Trial name
- NCT06829316
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Assiut University
Myelodysplastic Syndromes
An Observational Study for Dacogen Long-Term Treatment in Patients With Myelodysplastic Syndrome
The purpose of this study is to investigate the overall response rate (ORR) and safety when treating patients with myelodysplastic syndrome with decitabine.
- Trial name
- NCT01400633
- Testing
- decitabine injection
- Where
- 16 sites in South Korea
- Volunteers
- 156 people
- Sponsor
- Janssen Korea, Ltd., Korea
Cystic Fibrosis
DNA Methylation and Lung Disease in Cystic Fibrosis
Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease-modifier genes and environmental exposure.
- Trial name
- METHYLCF (NCT02884622)
- Testing
- nasal epithelial, Blood sampling
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Stroke Rehabilitation
Post Stroke Intensive Rehabilitation
Prospective observational cohort study, with 6 months follow up, to identify clinical, instrumental and genetic predictors of functional recovery in hospitalized patients undergoing intensive rehabilitation after stroke.
- Trial name
- PSR (NCT03866057)
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Childhood Obesity, Epigenetics
Early Childhood Obesity Programming by Intrauterine Growth Restriction
The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from…
- Trial name
- NCT03402139
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Schizophrenia
Quetiapine and the Dopaminergic Epigenetic Control
BACKGROUND: Epigenetic modifications such as DNA-methylation and histone acetylation are known to be involved in the pathophysiology of schizophrenia. Aim of the present study is to investigate 1.
- Trial name
- NCT00370500
- Testing
- Quetiapine fumarate
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hepatocarcinoma
Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches
This is a national, observational, retrospective, cross-sectional, non-profit study focused on patients with HCC. The study aims to characterize the expression and function of novel noncoding regulatory transcripts, including…
- Trial name
- DELIVER (NCT07432347)
- Testing
- Collection of tumor tissue (Fresh or/and archival FFPE), blood samples
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- Niguarda Hospital
Muscular Dystrophy, Facioscapulohumeral
Clinical, Genetic and Epigenetic Characterization of Patients With FSHD Type 1 and FSHD Type 2
The aim of the study was to compare the severity of illness between groups of patients (Facio-Scapulo-Humeral Dystrophy = FHSD1, FSHD2 and patients both FSHD1 and FSHD2).
- Trial name
- NCT01970735
- Testing
- Blood test
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
PCOS, Offspring, Adult
Offspring Born to Mothers With Polycystic Ovary Syndrome in Guangzhou Cohort Study
The Offspring Born to Mothers with Polycystic Ovary Syndrome in Guangzhou Cohort study (PCOS-BIG) was established to investigate the short- and long-term effects of intrauterine exposure to maternal PCOS on the health of…
- Conditions
- PCOS, Offspring, Adult, Hyperandrogenism, Epigenetics
- Trial name
- PCOS-BIG (NCT03742011)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Atrial Fibrillation
Biomarkers and Epigenetic Markers Associated With Pain in Patients With Symptomatic Atrial Fibrillation
Atrial fibrillation (AF) is the most common sustained arrhythmia and the number of patients with AF is expected to increase substantially in the coming decades.
- Trial name
- PAIN (NCT05201989)
- Where
- Sweden
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Fetal Alcohol Spectrum Disorders
Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder
The objective of the study is to validate epigenetic changes as biomarkers in a prospective sampling of newborn blood samples collected at birth (umbilical cord blood) and during routine screening (heel stick blood) in newborns…
- Trial name
- NCT03494738
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- CAMC Health System
Breast Cancer
Biomarkers for Breast Cancer Risk in African American Women
Background: At present, women do not have very accurate tests to inform of them of their personal risk of developing breast cancer.
- Trial name
- NCT01736306
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- National Cancer Institute (NCI)
Peripheral T Cell Lymphoma, Epigenetic Repression
Chidamide in Combination With Azacitidine, Liposomal Mitoxantrone, and Prednisone (CAMP Regimen) for the Treatment of Previously Untreated Nodal TFH Cell Lymphoma
This study is investigating the effectiveness (specifically the objective response rate - ORR) of a new combination therapy called CAMP (chidamide, azacitidine, liposomal mitoxantrone, and prednisone) for previously untreated…
- Trial name
- NCT05958719
- Testing
- Chidamide, Azacitidine, liposomal mitoxantrone
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Obstructive Sleep Apnea, Morbid Obesity
Epigenetics Modifications in Morbid Obesity and Obstructive Sleep Apnea Patients: The EPIMOOSA Study
This study evaluates epigenetics in morbid obese patients who are waiting for bariatric surgery. A home cardiopulmonary polygraphy is performed to evaluate for the presence of sleep-disordered breathing.
- Conditions
- Obstructive Sleep Apnea, Morbid Obesity, Epigenetic Disorder
- Trial name
- EPIMOOSA (NCT03995836)
- Testing
- CPAP, Bariatric Surgery
- Volunteers
- 70 people
- Sponsor
- Aragon Institute of Health Sciences
Cow Milk Allergy
Epigenetic Effects in Children With Cow's Milk Allergy Treated With Different Formulas
Lactobacillus GG (LGG) is able to exert long lasting effects in children with atopic disorders. Nutramigen LGG accelerates tolerance acquisition in infants with cow's milk allergy.
- Trial name
- EPICMA II (NCT04184700)
- Testing
- EHCF+LGG, RHF, SF
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Federico II University
Lung Cancer
Developing Novel Circulating Epigenetic Biomarkers for Early Detection of Lung Cancer
The investigators aim to identify novel circulating methylated biomarkers for early lung cancer detection as well as to develop new technologies that are clinically applicable with high sensitivity and specificity.
- Trial name
- NCT04814407
- Testing
- Blood-derived DNA methylation detection
- Where
- Taiwan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Metastatic Melanoma
Study to Determine Efficacy and Safety of CC-486 With Nab-Paclitaxel Versus Nab-Paclitaxel in Patients With Chemotherapy naïve Metastatic Melanoma
A phase 2, open-label randomized, multicenter trial to compare CC-486 in combination with Abraxane administered weekly with respect to overall survival, objective tumor response rate and Progression-Free Survival (PFS) in…
- Trial name
- NCT01933061
- Testing
- Abraxane
- Sponsor
- Celgene Corporation
Traumatic Brain Injury, PTSD
An Investigation of the Biological and Neuronal Mechanisms of Post Traumatic Stress Disorder, Depression and Post-Concussive Syndrome Onset Following a Traumatic Brain Injury
Background: A traumatic brain injury (TBI) could mean a person is at high risk for other long-lasting problems. These problems could include post-traumatic stress disorder (PTSD), depression, and post-concussive syndrome (PCS).
- Conditions
- Traumatic Brain Injury, PTSD, Depression
- Trial name
- NCT02019654
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Institute of Nursing Research (NINR)
Type 2 Diabetes
The Impact of Diabetes Remission on Aging
This study is a real-world, prospective clinical cohort study. It will enroll Chinese patients with type 2 diabetes. The aim is to assess the changes in aging biomarkers, primarily DunedinPACE, from baseline to post-remission…
- Trial name
- NCT07736040
- Testing
- Comprehensive Lifestyle Intervention
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine