Clinical trials: Epigenetics
Aging
The Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And Epigenetics
The goal of this clinical trial is to assure the safety of long term therapeutic plasma exchange (TPE) with and without Intravenous Immunoglobulin (IVIG) and its effects on biomarkers and epigenetic biologic clocks in forty…
- Trial name
- NCT06534450
- Testing
- Therapeutic Plasma Exchange, IVIG
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dobri Kiprov
Vagina Disease, Diagnosis
Feasibility of the Oricol™ Sampling Device to Retrieve Vagina Mucus (Wall) Samples for Genomic & Epigenetic Analysis.
Primary Objective The primary objective is to explore the feasibility of collecting a vaginal sample using the OriCol™ Sampling Device. Secondary Objectives The study has secondary objectives to assess: 1.
- Trial name
- Ellele-01 (NCT05709119)
- Testing
- Quantification of human DNA retrieved and DNA fragmentation profile.
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Origin Sciences
Biological Aging
The Translational Initiative to Map Epigenetics in Aging (TIME-A)
The Translational Initiative to Map Epigenetics in Aging (TIME-A) study aims to advance our understanding of the connections between epigenetics, lifestyle, demographics, and health and aging.
- Trial name
- TIME-A (NCT05760547)
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Elysium Health
Aging
AC-11 Supplement and Biological Aging
This is a prospective non-randomized clinical study of 24 patients to evaluate the effects of the AC-11®. The study will evaluate the effectiveness of the supplement's ability to reverse epigenetic markers of biological age.
- Trial name
- NCT05310123
- Testing
- AC-11
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Bowel Cancer, Bowel Disease
Exploratory Study of Rectal Mucus for Diagnosing Disease
The identification of patients with colorectal cancer is challenging as they present with a variable symptom profile and require invasive tests (colonoscopy) for diagnosis (through histological analysis of biopsies) and…
- Conditions
- Bowel Cancer, Bowel Disease, Genomic, Epigenetic Disorder
- Trial name
- ORI-EGI-02 (NCT04659590)
- Where
- 4 sites in United Kingdom
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Origin Sciences
Healthy
Natural Product System and Lifestyle Modification
The goal of this clinical trial is to learn whether four dietary supplements and lifestyle changes can affect gene expression and blood markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT06931977
- Testing
- Supplement system + copaiba softgels
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- dōTERRA International
Malaria, Bacterial Co-infection
Host Immunity, Plasmodium and Pathogens Co-Infections
Few studies have focused on malaria co-infections, mainly caused by Plasmodium falciparum, occurring mainly in children under 5 years of age in sub-Saharan Africa.
- Trial name
- HIPPI (NCT06769815)
- Testing
- Blood sample, Urine sample, oropharyngeal sample
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Healthy
Metabolic and Epigenetic Impact of FAAH Inhibitors and OEA
The goal of this clinical trial is to learn whether a dietary supplement can affect gene expression and serum protein markers in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT07127445
- Testing
- OEA supplement
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nicole Stevens, PhD
Arthritis, Rheumatoid
Identification of Epigenetic Biomarkers for Early Detection of Rheumatic Disease
Given the cost and risk associated with biologic disease modifying anti-rheumatic drugs (bDMARDs), selection of the optimal medication is imperative.
- Trial name
- NCT02742337
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arthritis Northwest PLLC
Lung Cancer, Non-Small Cell
Novel Epigenetic Mapping in Cell-Free DNA for the Detection of Lung Cancer
This trial is a multicenter, open-label, non-interventional controlled study to identify and characterize epigenetic signatures of lung cancer.
- Trial name
- LumenDx (NCT06963307)
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- JaxBio Ltd
Mild Cognitive Impairment, Metabolic Syndrome
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
The study explores whether selective memory complaints (SMC), mild cognitive impairment (MCI) and the comorbidity of Metabolic Syndrome symptomatic of peripheral and cerebral hypo-metabolism with corresponding epigenetic shifts…
- Trial name
- NCT03319173
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Bristlecone Health, Inc.
Aging
Safety & Efficacy of Extended Longevity Protocol
The purpose of this study is to quantifiably determine if the Extended Longevity Protocol has a significant clinical effect on epigenetic age.
- Trial name
- NCT05296993
- Testing
- Extracts found in the Extended Longevity supplements
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Immunity Disorders, Aging
The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
This is a prospective, interventional, single-arm, open-label pilot study of 50 patients to evaluate the effect of a polyphenol-rich nutritional supplement on epigenetic and cellular markers of immune age.
- Conditions
- Immunity Disorders, Aging, Inflammation
- Trial name
- NCT05234203
- Testing
- HTB Rejuvenate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Big Bold Health, PBC
Aging
The Impact of a Human Breast Milk Supplement on Epigenetic and Cellular Markers
This is a trial to assess the effects of the Trulacta supplement on biological age, sleep quality, immune system and wellness markers.
- Trial name
- NCT05297097
- Testing
- Trulacta breastmilk supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Depression, Post Traumatic Stress Disorder
Ketamine and Epigenetic Aging
This is a prospective, clinical pilot study (n=20) to evaluate the impact of a ketamine treatment for Major Depressive Disorder (MDD) or Post Traumatic Stress Disorder (PTSD) on epigenetic aging by the TruAge epigenetic age…
- Trial name
- NCT05294835
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Healthy Female Volunteer
Relationship Between Skin Microbiome, Epigenetic Age, and Facial Features in Aging
The goal of this observational study is to evaluate the effect of age on skin microbiome.
- Trial name
- NCT07431203
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lesaffre International
Fetal Origin of Adult Diseases
Maternal Transcriptomic Regulation of the Preimplantation Embryo
The aim of this study is to understand the epigenetic and transcriptomic mechanisms that regulate the fetal origin of adult diseases (FOAD), either for the presence of metabolic disorders in the future mothers, such as obesity or…
- Trial name
- NCT02813746
- Testing
- Fitness program, Stop smoking, Endometrial fluid collection
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Igenomix
Aging
A Dosing Study of Hyperbaric Oxygen Therapy (HBOT) on Epigenetic Aging
This study aims to assess the impact of hyperbaric oxygen therapy on a number of outcomes, including epigenetic aging, inflammation, and cellular health.
- Trial name
- HBOT (NCT05297019)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Skin Ageing, Healthy Ageing
Effects of a Multi-Targeted Oral Supplement on Skin, Hair, Sleep, Energy, Cognition, Libido and Epigenetic Biological Clock Age
This study evaluated the effects of a daily oral supplement regimen (Advanced ID Brain, Heart and Eye Omega Gel Capsules taken with Advanced ID Longevity and Collagen Complex Powder) on measures of skin condition, hair, sleep…
- Conditions
- Skin Ageing, Healthy Ageing, Effect of Oral Nutritional Supplementation on Skin, Hair, Sleep, Energy, Cognition and Sexual Wellbeing in Healthy Adults, Longevity
- Trial name
- IDF-AID-1 (NCT07827651)
- Testing
- Advanced ID
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- IDI Skincare Limited
Biological Aging
Translational Initiative to Map Epigenetics in Sleep
The primary aim of TIME-ZZZ is to explore the relationship between chronotype, incidence of depression and biological age, and whether individuals working "out-of-phase" with their chronotype are more likely to exhibit signs of…
- Trial name
- TIME-ZZZ (NCT06333301)
- Testing
- Surveys
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Elysium Health