Clinical trials: Epilepsy, Drug Resistant
Drug Resistant Epilepsy
The Role of Vitamin D in Neuroinflammatory on Drug Resistant Epilepsy
The incident of epilepsy still very high in Indonesia, thus many patients become drug resistant epilepsy. As vitamin D has some anticonvulsant effect, the investigators want to study if an additional dose of vitamin D can help…
- Trial name
- NCT06053281
- Testing
- Cholecalciferol
- Where
- Indonesia
- Volunteers
- 70 people
- Sponsor
- DINA KEUMALA SARI
Epilepsy
IMPACT of AspireSR® for VNS Therapy on Healthcare Resource Utilisation and Clinical Outcomes.
This is a retrospective non-interventional study to describe the HCRU and clinical outcomes before and after AspireSR® device implantation in subjects with drug resistant epilepsy at the Queen Elizabeth Hospital, Birmingham…
- Trial name
- IMPACT (NCT05975931)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- LivaNova
Epilepsy, Drug-resistant Focal Epilepsy
Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity
Despite the continuous development of new antiseizure medications over the past 25 years, 30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, like cognitive…
- Conditions
- Epilepsy, Drug-resistant Focal Epilepsy, Healthy Controls
- Trial name
- BRAVE (NCT07249034)
- Testing
- 1 Hypercapnic challenge while participant is awake, PET/MRI acquisition
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy, Cardiovascular Disease
Impact of Ketogenic Diet on Lipoproteins in Refractory Epilepsy
The ketogenic diet is a non-pharmacological treatment prescribed especially for children and indicated in most specialized centers for patients with refractory epilepsy.
- Conditions
- Epilepsy, Cardiovascular Disease, Non-alcoholic Fatty Liver Disease, Quality of Life
- Trial name
- Ketonutri (NCT02644239)
- Testing
- ketogenic diet
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Drug Resistant Epilepsy, Autism Spectrum Disorder
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients
The goal of this observational study is to learn about the clinical and nutritional effectiveness of ketogenic diet (KD) in pediatric patients with genetic, neurological or metabolic conditions requiring KD.
- Conditions
- Drug Resistant Epilepsy, Autism Spectrum Disorder, Chronic Migraine, Brain Tumor, Pediatric
- Trial name
- NCT06309251
- Testing
- ketogenic diet (as per clinical practice)
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Danone Nutricia SpA Società Benefit
Refractory Epilepsy
A Study to Evaluate fMRI of Active DBS Stimulation in Epilepsy
The purpose of this study is to use functional imaging to study the mechanisms of the anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS).
- Trial name
- NCT04753983
- Testing
- Functional magnetic resonance imaging (fMRI)
- Sponsor
- Mayo Clinic
Epilepsies
VNS Algorithm for Advanced Dosing
The goal of this clinical trial is to compare the standard programming of the VNS device (Control) to a modified programming (Augusta Way) in adults with epilepsy.
- Trial name
- NCT07725601
- Testing
- Rapid Titration VNS programming, Standard VNS programming
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fernando Vale
Epilepsy, Focal Epilepsy
Cognitive Impairment in Drug-resistant and Drug-responsive Focal Cryptogenic Epilepsy
This is a national monocentric (San Raffaele Hospital - OSR, Via Olgettina, 60, 20132 Milan, Italy) observational low-risk-intervention study, prospective and multiparametric (clinical, EEG, neuropsychological evaluations) study.
- Trial name
- NCT06210022
- Testing
- Neuropsychological Assessment
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- IRCCS San Raffaele
Drug Resistant Partial Onset Seizure
A Two-year Open-label Extension Study of Ganaxolone in Patients With Drug-resistant Partial-onset Seizures
A follow-on, two-year open-label extension study of ganaxolone as add-on therapy in adult patients with drug-resistant partial-onset seizures
- Trial name
- NCT02519439
- Testing
- ganaxolone
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Marinus Pharmaceuticals
Refractory Epilepsy
Effect of Short-term Theta Frequency Stimulation of the Vagus Nerve on Cognition in Patients With Refractory Epilepsy
The purpose of this investigation is data pilot study of the effect of theta frequency stimulation of the vagus nerve on cognitive performance in patients with refractory epilepsy.
- Trial name
- NCT03331939
- Testing
- no stimulation, beta (25-30 Hz), Theta (5 Hz)
- Volunteers
- 2 people
- Sponsor
- University of California, Davis
Epilepsy
Modified Atkins Diet in Children and Adolescents With Drug-resistant Epilepsy
The purpose of the study is to evaluate the effect of the Modified Atkins Diet in children and adolescents with drug-resistant epilepsy regarding seizure control, and to create a protocol for the use of the Modified Atkins Diet…
- Trial name
- NCT01278966
- Testing
- The Modified Atkins Diet
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- Oslo University Hospital
Refractory Epilepsy
Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization
This is a Phase 2 double-blind, randomized, placebo-controlled study to assess the safety and efficacy of ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC) in subjects with focal…
- Trial name
- NCT04153175
- Testing
- ICV delivery of CT-010 via an implantable pump and a cranial port and dual lumen catheter (CIC)
- Where
- 11 sites in Australia, Israel
- Volunteers
- 30 people
- Sponsor
- Cerebral Therapeutics LLC
Refractory Epilepsy
Feasibility of HOBSCOTCH Telehealth Intervention in Refractory Epilepsy
The purpose of this study is to see whether a phone-intervention called HOBSCOTCH will improve health, daily functioning and quality of life among patients with refractory epilepsy.
- Trial name
- HOBSCOTCH (NCT04240977)
- Testing
- HOBSCOTCH: "Home-Based Self-Management and Cognitive Training Changes Lives"
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Drug Resistant Epilepsy, Healthy
Investigating Surprise Signals in the Anterior Insula
The investigators propose a behavioral experiment with SEEG recording and stimulation, to both confirm the role of a brain region known as the anterior insula in identifying surprise, and disambiguate between competing principles…
- Trial name
- NCT05997758
- Testing
- SEEG stimulation, Adaptation task
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Intractable Epilepsy
EXPRESON-IN : Intracerebral Recordings of P3a Responses to Expressive Own-names
Neurophysiologic evaluation of disorders of consciousness (DOC) patients in intensive care unit include late auditory evoked potentials.
- Trial name
- EXPRESON-IN (NCT04810832)
- Testing
- Evoked related potentials
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier St Anne
Epilepsy
A Phase I Clinical Trial of UX-GIP001 in the Treatment of Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
This is a phase I study (Protocol: UX-GIP001-102) investigating UX-GIP001 Injection, a novel cell therapy product consisting of human GABAergic interneuron progenitor cells (GIP), for treating adult patients with drug-resistant…
- Trial name
- NCT07572812
- Testing
- UX-GIP001
- Where
- 3 sites in China
- Volunteers
- 12 people
- Sponsor
- Shanghai UniXell Biotechnology Co., Ltd
Focal Epilepsy, Generalized Seizure
Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables
Mayo Clinic is conducting a research study to test a new approach to managing seizures in people with epilepsy whose seizures have not been fully controlled with regular medications.
- Conditions
- Focal Epilepsy, Generalized Seizure, Drug Refractory Epilepsy
- Trial name
- FORESITE (NCT07012148)
- Testing
- UNEEG SubQ device, seizure forecasts, nasal diazepam, Preventative Medication (PM)
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Drug Resistant Epilepsy, Temporal Lobe Epilepsy
The GABAergic Inhibitory System in Drug Resistant Epilepsy
This study aims to investigate the effect of lovastatin on neurotransmission and neuroinflammation in patients with temporal lobe onset drug resistant epilepsy.
- Trial name
- NCT06789497
- Testing
- Lovastatin 60 MG
- Where
- Portugal
- Volunteers
- 5 people
- Sponsor
- University of Coimbra
Epilepsy
Non-interventional Study Describing Healthcare Resource Utilisation and Clinical Outcomes Associated With VNS Therapy in UK.
This is a UK, multi-center, non-interventional study based on the use of health service administrative and medical records (paper-based and/or electronic, as applicable) along with the use of prospectively collected…
- Trial name
- DANTE (NCT04779814)
- Where
- 5 sites in United Kingdom
- Volunteers
- 97 people
- Sponsor
- LivaNova
Transcranial Magnetic Stimulation, Drug Resistant Epilepsy
The Mechanism of cTBS Targeting Dentate Nucleus for DRE
In our previous cross-over study--the continuous θ burst stimulation (cTBS) targeting cerebellum dentate nucleus of 44 drug-refractory epilepsy (DRE) patients, a significant reduction in seizure frequency was observed.
- Conditions
- Transcranial Magnetic Stimulation, Drug Resistant Epilepsy, Cerebellum
- Trial name
- NCT05809349
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital