Clinical trials: Epilepsy, Refractory, open to volunteers
Epilepsy, Dravet Syndrome
A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome
Dravet Syndrome (DS) is a severe neurodevelopmental disease, which is predominantly caused by mutations of SCN1A, the gene coding for Nav1.1 voltage-gated sodium channels.
- Conditions
- Epilepsy, Dravet Syndrome, Drug Resistant Epilepsy, Healthy Controls
- Trial name
- DRAPETONINE (NCT07013331)
- Testing
- [18F]MPPF PET-MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Inborn Errors of Metabolism, Epilepsy (Treatment Refractory)
Metabolites in Blood and Breath in Metabolic Conditions
In patients with inborn errors of metabolism (IEM) and in those requiring a ketogenic diet for the treatment of medical conditions, relevant biochemical analytes are routinely and regularly measured in venous or capillary blood…
- Trial name
- NCT07704606
- Testing
- Observational Study
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Refractory Epilepsy
Effect of Blue Light on Vagus Nerve Stimulation in Patients With Refractory Epilepsy
Vagus nerve stimulation (VNS) is an adjunctive treatment for refractory epilepsy. Although widely used, there is still a substantial number of patients with insufficient response.
- Trial name
- BLUELIGHTVNS (NCT06304389)
- Testing
- electroencephalography, electrocardiogram, pupillometry, evoked potentials, light administration, transcutaneous vagus nerve stimulation, electroencephalography, pupillometry, electrocardiogram, light administration
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Epilepsy, Epilepsy Intractable
Localizing Epileptic Networks Using MRI and iEEG
Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes.
- Conditions
- Epilepsy, Epilepsy Intractable, Epilepsy, Temporal Lobe
- Trial name
- NCT04649008
- Testing
- 3T Magnetic Resonance Imaging, Intracranial electroencephalography recordings, 7T Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Epilepsy, Temporal Lobe, Drug Resistant Epilepsy
Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy
The goal of this observational study is to understand heart rhythm changes in adults with epilepsy. It will also explore whether computer programs can use heart recordings to detect or predict seizures.
- Trial name
- EpHR-DP (NCT07835594)
- Testing
- Textile-based wearable electrocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Epilepsy (Treatment Refractory), Epilepsy
Retinal OCT Changes and Biomarkers in Drug-Resistant Epilepsy
This prospective, longitudinal observational study investigates whether epilepsy involves a progressive neurodegenerative process.
- Trial name
- NCT07716930
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Kemal Tutkavul
Epilepsy, Drug Resistant Epilepsy
Evaluation of the Efficacy of Neurofeedback Technique Based on EEG Desynchronization in Epileptic Patients
A large proportion of patients (approximately 30%) with drug-resistant epilepsy are not eligible for surgical treatment. The alternatives that can be offered to reduce the frequency of seizures are neuromodulation (vagus nerve…
- Trial name
- EPIFEED (NCT07356661)
- Testing
- Neurofeedback
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Epilepsy
Caracterization of the Combined Alterations in Respiration and aROUSal in Patients With Drug-resistant EpiLepsy
30% of patients with epilepsy suffer from drug-resistant seizures and are at risk of epilepsy-related complications, from cognitive dysfunctions to premature mortality.
- Trial name
- CARROUSEL (NCT06545214)
- Testing
- Video-EEG monitoring, Respiratory monitoring and polysomnography, 1 Hypercapnic challenge while participant is awake
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Epilepsy, PET / MR
Multimodal PET Imaging With 18F-FDG/SV2A/TSPO for Resection Planning in Drug-Resistant Epilepsy
This study focuses on the application value of 18F-FDG, SV2A, and TSPO PET imaging in the preoperative localization of epileptogenic foci in epilepsy.
- Conditions
- Epilepsy, PET / MR, Synaptic Vesicle Proteins, Microglial Activation
- Trial name
- NCT07147309
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Weibing Miao, PhD
No Condition, Study Mental State in Healthy Populations and Drug-resistant Epilepsy Patients With Existing iEEG
Novel Multimodal Neural, Physiological, and Behavioral Sensing and Machine Learning for Mental States
In this program, the investigators will develop novel multimodal neural-behavioral-physiological monitoring tools (software and hardware), and machine learning models for mental states within social processes and beyond.
- Trial name
- NCT07110688
- Testing
- Virtual human social interaction, Cold pressor test
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Epilepsy, Sleep
Prospective Longitudinal Study of Sleep, Brain Activity, and Plasma Analyses in Patients Undergoing Epilepsy Surgery
The goal of this observational study is to understand how sleep and brain activity change after epilepsy surgery in adults with drug-resistant epilepsy.
- Conditions
- Epilepsy, Sleep, Drug Resistant Epilepsy, Epilepsy Sleep
- Trial name
- NCT07885826
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane