Clinical trials: Epilepsy, Temporal Lobe
Epilepsy Lobe Temporal, Healthy
Spatial Memory and Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) can cause memory disorders, including long-term forgetfulness due to a failure to consolidate verbal but also spatial information.
- Conditions
- Epilepsy Lobe Temporal, Healthy, Epilepsy
- Trial name
- EPINAVIG (NCT06847152)
- Testing
- spatial memory test
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Epilepsy, Epilepsy, Temporal Lobe
Early Surgical Intervention to Treat Epilepsy
The purpose of this trial is to compare the effectiveness of early surgical intervention for mesial temporal lobe epilepsy to continued treatment with antiepileptic drugs.
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Seizures
- Trial name
- ERSET (NCT00040326)
- Testing
- anteromesial temporal resection, antiepileptic drugs
- Where
- 12 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of California, Los Angeles
Low Intensity Ultrasound Pulsarions
Focused Ultrasound Neuromodulation for Treatment of Temporal Lobe Epilepsy
The aim of the proposed study is to assess the feasibility of using the BrainSonix BX Pulsar 1002 low-frequency and Low-Intensity Focused Ultrasound Pulsations (LIFUP) in human subjects suffering from intractable temporal lobe…
- Trial name
- LIFUP (NCT03657056)
- Testing
- BX Pulsar 1002
- Sponsor
- Massachusetts General Hospital
Epilepsy
Serum Profile of Inflammatory Factors, Immune and Angiogenic in Temporal Lobe Epilepsy
Epilepsy affects 0.7% of the general population and 15-20% of patients develop drug resistance. The temporal lobe epilepsy (TLE) is the most common symptomatic focal epilepsies with a particularly high rate of drug (about 20 to…
- Trial name
- NCT01563627
- Testing
- blood sampling for drug resistance biomarkers, Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Epilepsy, Temporal Lobe, Temporal Lobe
Light Scattering Spectroscopy to Determine Brain Tumors
This study will use light scattering spectroscopy (LSS) to analyze brain tissue removed from patients during brain surgery to determine if this new technology can be used to differentiate between normal and cancerous cells.
- Trial name
- NCT00067418
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
COMETE Study : COgnitive Rehabilitation of MEmory in Temporal Epilepsy
Studies on the cognitive function have highlighted promising results concerning attention. In contrast, in the field of memory, the single cohort study that has been carried out, has not been randomised, with non comparable…
- Trial name
- COMETE (NCT02589470)
- Testing
- COMETE
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Central Hospital, Nancy, France
Epilepsy, Temporal Lobe
The Utility of NIOM During LITT for Refractory MTLE
Mesial temporal lobe epilepsy (MTLE) is the most common cause of medication-resistant epilepsy in adults, and MRI-guided laser interstitial thermal therapy is a new approach to its surgical management; however, while LITT…
- Trial name
- NCT02913742
- Testing
- monitoring by depth electrode
- Where
- United States
- Sponsor
- Duke University
Mesial Temporal Lobe Epilepsy
Hippocampal Network Function in Epilepsy
The aim of this pilot study is to understand hippocampal network function in mesial temporal lobe epilepsy (MTLE) and to test whether transcranial magnetic stimulation (TMS) targeting the network of the hippocampus can change…
- Trial name
- NCT06521437
- Testing
- TMS targeting the hippocampus indirectly via its network
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Chicago
Epilepsy
Feasibility Study on LITT for Medical Refractory Epilepsy
Multicenter, open-label, prospective designed study to characterize the performance of brain laser interstitial thermal therapy (LITT) ablation using the Monteris NeuroBlate System for the treatment of drug-refractory medial…
- Trial name
- NCT02820740
- Testing
- NeuroBlate System
- Where
- 5 sites in United States
- Volunteers
- 4 people
- Sponsor
- Monteris Medical
Rolandic Epilepsy, Nocturnal Frontal Lobe Epilepsy
The Rolandic Epilepsy/ESES/Landau-Kleffner Syndrome and Correlation With Language Impairment Study
In clinical practice language impairment is frequently reported in association with nocturnal epileptiform activity. There is a spectrum of epileptic conditions that are characterized by nocturnal epileptiform activity.
- Conditions
- Rolandic Epilepsy, Nocturnal Frontal Lobe Epilepsy, Landau-Kleffner Syndrome, Electrical Status Epilepticus During Slow Wave Sleep
- Trial name
- REL (NCT01335425)
- Where
- Netherlands
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Epilepsy
Evaluation of the 24/7 EEG SubQ System for Ultra Long-Term Recording of Patients With Epilepsy Involving the Temporal Lobe Region.
The 24/7 EEG™ SubQ system will be compared to simultaneously recorded video-EEG in the Epilepsy Monitoring Unit (gold standard) and to self-reported seizure log books throughout 12 weeks of outpatient EEG recording.
- Trial name
- NCT04526418
- Testing
- 24/7 EEG™ SubQ system
- Where
- 12 sites in United States, Belgium and 1 more
- Volunteers
- 64 people
- Sponsor
- UNEEG Medical A/S
Epilepsy
Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy: A Case Study
Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure.
- Trial name
- REPREO SCED (NCT05325047)
- Testing
- Intensive speech rehabilitation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Temporal Lobe Epilepsy, Open Surgery
Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) is a chronically neurological disease characterized by progressive seizures. TLE is the most frequent subtype of refractory focal epilepsy in adults.
- Conditions
- Temporal Lobe Epilepsy, Open Surgery, Minimally Invasive Surgery
- Trial name
- MISET-TLE (NCT05019404)
- Testing
- Functional anterior temporal lobectomy (FATL), Anterior temporal lobectomy (ATL)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Temporal Lobe Epilepsy
Application of Diffusion Tensor Imaging and Tractography in Epilepsy Surgery
Using Synaptive Medical's BrightMatter™ products to better visualize and plan epilepsy surgeries by considering white matter tracts, and considering whether the technology results in improved clinical outcomes.
- Trial name
- NCT02590419
- Testing
- BrightMatter™ products
- Volunteers
- 40 people
- Sponsor
- Andrew Parrent
Temporal Lobe Epilepsy
A Multicenter Study of Hippocampal Electrical Stimulation (HS, in Mesial Temporal Lobe Epilepsy
The primary goal is to determine whether hippocampal electrical stimulation (HS) is safe and more effective than simply implanting an electrode in the hippocampus without electrical stimulation (HI), in patients with mesial…
- Trial name
- METTLE (NCT00717431)
- Testing
- Hippocampal Electrical Stimulation
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Calgary
Focal Epilepsy
Anti-Epilepsy Medication Valproate Administered Via ICV Route and Catheters and Pumps for CSF Infusion
This is a non-randomized open-label extension study for subjects having completed protocol DA071976 or CLN100P.01.
- Trial name
- NCT04529954
- Testing
- Valproic Acid delivered to ICV
- Where
- 8 sites in Australia, Israel
- Volunteers
- 20 people
- Sponsor
- Cerebral Therapeutics LLC
Depression, Epilepsy, Temporal Lobe
CBT Versus Selective Serotonin Reuptake Inhibitor For Treatment Of Depression In Temporal Lobe Epilepsy Patients
The aim of the study is to compare the effect of group-cognitive-behavioral therapy (CBT)versus treatment as usual with the selective serotonin reuptake inhibitor sertraline, in patients with diagnosis of temporal lobe epilepsy…
- Trial name
- CBTvsSSRI (NCT02262156)
- Testing
- Cognitive behavioral therapy, SSRI
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
Epilepsy
Evaluation of Stress Sensitivity and Hyperemotivity in Epilepsy Compared to and a Group of Healthy Volunteers
Recently, a possible subtype of temporal lobe epilepsy (TLE) has been proposed: this subtype presents ipsilateral amygdala enlargement (AE) without any other lesion.
- Trial name
- STELLA (NCT03464370)
- Testing
- Measure of emotional stressors
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy
Overnight TI in TLE
The goal of this clinical trial is to gauge whether overnight, non-invasive temporal interference (TI) stimulation aimed at the hippocampus can reduce abnormal brain activity linked to seizures and improve sleep in adults with…
- Conditions
- Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy, Sleep
- Trial name
- TI-HPC-TLE (NCT07434986)
- Testing
- Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Epilepsy, Temporal Lobe, Drug Resistant Epilepsy
Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy
The goal of this observational study is to understand heart rhythm changes in adults with epilepsy. It will also explore whether computer programs can use heart recordings to detect or predict seizures.
- Trial name
- EpHR-DP (NCT07835594)
- Testing
- Textile-based wearable electrocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Acibadem University