Clinical trials: Epilepsy
Epilepsy, Cognitive Decline
Influence of Non-invasive Neurostimulation (Transcutaneous Vagus Nerve Stimulation) on 1. the Noradrenergic Release in the Brain and 2. a Neuropsychological Memory Task
The goal of this study is to investigate the influence of transcutaneous vagus nerve stimulation 1. on the noradrenergic system in the brain and 2. on memory, in healthy volunteers.
- Trial name
- NCT02409069
- Testing
- Transcutaneous vagus nerve stimulation (Nemos®, Cerbomed GmbH)
- Where
- Belgium
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Epilepsy, Drug Resistant
Drug Resistant Epilepsy: Clinical and Genetic Study
This study is to identify the clinical criteria of drug resistant epilepsy and to explore whether SCN1A c.3184 A/G (rs2298771) and ccl2(rs1024611) polymorphisms could serve as genetic based biomarkers to predict drug resistance…
- Trial name
- NCT04166305
- Testing
- Genetic study for SCN1A c.3184 A/G and CCL2-2518G>A polymorphism:
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Epilepsy
Non-Invasive Seizure Localization in Patients With Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings
This study will evaluate the magnetoencephalography (MEG) alone and together with electroencephalography (EEG) in non-invasive presurgical evaluation.
- Trial name
- NCT00071305
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Epilepsies, Partial
An Open-Label Extension Study of the Effectiveness and Safety of the Investigational Compound RWJ-333369 in Patients With Epilepsy
The purpose of this study is to evaluate the effectiveness and safety of the novel compound RWJ-333369 in reducing the frequency of seizures in patients with epilepsy.
- Trial name
- NCT00210522
- Testing
- RWJ 333369
- Volunteers
- 421 people
- Sponsor
- SK Life Science, Inc.
Epilepsy
Crossover Study to Evaluate the Pharmacokinetics of Ezogabine/Retigabine in Taiwanese Subjects
The purpose of this study is to investigate the pharmacokinetics of single oral doses of ezogabine/retigabine and the primary metabolite (NAMR) in healthy male and female Taiwanese volunteers.
- Trial name
- NCT01462669
- Testing
- 50mg Ezogabine/retigabine, 100mg Ezogabine/retigabine, 200mg Ezogabine/retigabine
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Epilepsy in Children, Coagulation and Hemorrhagic Disorders
The Prevalence and Risk Factors of Coagulopathy in Pediatric Epilepsy Surgery Patients
The hematologic consequences of novel Anti-seizure medications (ASMs) are rarely reported. Whether coagulation dysfunctions increase the risk of peri-operative bleeding remains controversial.
- Conditions
- Epilepsy in Children, Coagulation and Hemorrhagic Disorders, Epilepsy; Seizure, Antiepileptic Adverse Reaction
- Trial name
- NCT05675254
- Where
- China
- Volunteers
- 494 people
- Sponsor
- Children's Hospital of Fudan University
Convulsion, Non-Epileptic
Retraining and Control Therapy (ReACT) R33 Phase
The purpose of this study is to assess sense of control and catastrophic symptom expectations as targets for Retraining and Control Therapy (ReACT- an intervention focused on changing behaviors and thoughts) for treatment of…
- Trial name
- ReACT (NCT06007053)
- Testing
- ReACT, Supportive Therapy
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis, Epilepsy
Psychometric Evaluation in Patients With Brain Damage During Neuroinflammation
The presence of a damage to the central and / or peripheral nervous system resulting from diseases of a different nature (such as, Multiple Sclerosis, Parkinson's disease, dementia, head trauma, stroke, epilepsy or other…
- Conditions
- Multiple Sclerosis, Epilepsy, Parkinson Disease, Dementia
- Trial name
- NCT05450237
- Testing
- Psychometric Evaluations
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Neuromed IRCCS
Partial Epilepsy
Safety and Anticonvulsant Efficacy of Passiflora Incarnata Extract in Patients With Partial Epilepsy
The purpose of the Phase II clinical trial will be to see if a botanical extract from the plant Passiflora incarnata can improve seizure control and reduce anxiety in patients diagnosed with partial epilepsy.
- Trial name
- NCT00982787
- Testing
- Botanical extract from Passiflora incarnata
- Where
- United States
- Sponsor
- Oregon Health and Science University
Epilepsy, Anxiety Disorders and Symptoms
Pilot to Evaluate VR-Therapy on People With Epilepsy and Related Anxiety
Over 28% of people with epilepsy (PwE) struggle from at least one anxiety disorder, making anxiety the most common psychiatric comorbidity in this population.
- Trial name
- AnxEpiVR (NCT05296057)
- Testing
- Participants Receiving VR-Exposure Therapy Treatment
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University Health Network, Toronto
Partial Seizures (With or Without Secondary Generalized Seizures), Primary Generalized Tonic-clonic Seizures
Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic Seizures
The objective of this study is to identify the following in adolescent epilepsy participants with partial-onset seizures (with or without secondary generalized seizures) or primary generalized Tonic-clonic seizures who receive…
- Trial name
- FYC02T (NCT03059381)
- Testing
- Fycompa
- Where
- 2 sites in Japan
- Volunteers
- 519 people
- Sponsor
- Eisai Co., Ltd.
Alzheimer Disease
Levetiracetam for Alzheimer's Disease Neuropsychiatric Symptoms Related to Epilepsy Trial (LAPSE)
Patients with Alzheimer's disease (AD) are increasingly recognized to have seizures in addition to cognitive decline. Seizures may contribute to memory problems as well as other symptoms common in AD like agitation, depression…
- Trial name
- LAPSE (NCT04004702)
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Walter Reed National Military Medical Center
Epilepsy Intractable
Neural Computations of Goal-directed Decision-making
The purpose of this research is to better understand how the human brain accomplishes the cognitive task of making goal-directed decisions.
- Trial name
- NCT06489561
- Testing
- Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cedars-Sinai Medical Center
Epilepsy
Impact of SPEAC® System Data on Therapeutic Decisions Related to Convulsive Seizure Patients With a New Diagnosis
This is an open label, randomized, prospective study of the impact on healthcare utilization of a surface Electromyography (sEMG) based seizure monitoring and alerting system for Veterans with a history of motor seizures…
- Trial name
- NCT03742661
- Testing
- SPEAC System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brain Sentinel
Photosensitive Epilepsy
Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25).
Sunflower Syndrome (also referred to as Self-induced Photosensitive Epilepsy) is a rare epileptic disorder characterized by a distinctive seizure that manifests itself in a highly stereotyped physical behavior.
- Trial name
- NCT03790137
- Testing
- Fenfluramine Hydrochloride
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Elizabeth Anne Thiele
Spasms, Infantile
Cannabidiol Oral Solution for Treatment of Refractory Infantile Spasms
Infantile Spasms (IS) is a diagnosis described as a fairly rare and terrible form of epilepsy that usually strikes children in the first year of life. There is a great need for safe and effective therapies in the treatment of IS.
- Trial name
- NCT02551731
- Testing
- Cannabidiol Oral Solution
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- INSYS Therapeutics Inc
Epilepsies, Partial
Brain P-gp and Inflammation in People With Epilepsy
Background: The brain is protected by a barrier that keeps toxins in the blood from reaching the brain. However, this barrier can also keep useful medications from reaching the brain.
- Trial name
- NCT01663545
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
eValuation of the Efficacy and toleRability of Vimpat When Added to lEvetiracetam
The main purpose of this study is to evaluate the effectiveness of the study drug lacosamide (200-600 mg/day) when added to a stable dose of levetiracetam (1000-3000 mg/day) with withdrawal of the concomitant sodium channel…
- Trial name
- VERVE (NCT01484977)
- Testing
- Lacosamide
- Where
- 54 sites in United States, Australia and 7 more
- Volunteers
- 120 people
- Sponsor
- UCB Pharma
ALS, Autism Spectrum Disorder
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products
This is an observational study of medical marijuana manufactured and dispensed by Ilera and given as standard treatment for a variety of approved serious medical conditions as defined by individual state law.
- Conditions
- ALS, Autism Spectrum Disorder, Cancer, Spasticity, Muscle
- Trial name
- Ilera (NCT03886753)
- Testing
- Registry, PK microsampling of blood
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Epilepsy
Phenomenological Approach of Epilepsy in Patients With Epilepsy
Rationale : Persons with epilepsy have a greater risk of incurring accidental injury and a higher mortality risk than the general population.
- Trial name
- NCT02952456
- Testing
- interview with a psychologist
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier