Clinical trials: Epilepsy Lobe Temporal
Epilepsy, Temporal Lobe
Hippocampal and Thalamic DBS for Bilateral Temporal Lobe Epilepsy
The study aims to compare the safety and effectiveness of deep brain stimulation of the hippocampus and the anterior nucleus of the thalamus for reducing the frequency of seizures in patients with bilateral temporal lobe epilepsy.
- Trial name
- NCT04164056
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy, Temporal Lobe
Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy
The goal is to provide a novel therapeutic option for temporal lobe epilepsy patients when focal impaired awareness seizures cannot be stopped by medications, surgical or laser ablation, or by neurostimulation.
- Trial name
- START (NCT04897776)
- Testing
- Central Thalamic Stimulation, Hippocampal Stimulation
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Temporal Lobe Epilepsy, Frontal Lobe Epilepsy
Changes in Attentional Control After a Focal Seizure.
Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI.
- Conditions
- Temporal Lobe Epilepsy, Frontal Lobe Epilepsy, Others Subtypes
- Trial name
- ATTENTIONEPIF (NCT06466681)
- Testing
- All included subjects
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Epilepsy, Temporal Lobe, MRI Scans
Structural Cartography of the Insula in Temporal Epilepsy Patients
The purpose of this study is to investigate insula structural connectivity in temporal epilepsy patients. Insula being at the interface of frontal, parietal, occipital and temporal lobes, its structural organization reflects the…
- Trial name
- CON-INSULA (NCT04871555)
- Testing
- MRI
- Where
- France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Epilepsy, Anomia
Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy
Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure.
- Conditions
- Epilepsy, Anomia, Temporal Lobe Epilepsy
- Trial name
- REPREO (NCT05609084)
- Testing
- Speech therapy, Speech therapy assessment
- Where
- 12 sites in France
- Volunteers
- 214 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Epilepsy, Epilepsy, Temporal Lobe
PRX-00023 Therapy in Localization-Related Epilepsy
Background: The brain chemical serotonin helps nerve cells communicate. Previous research suggests that serotonin activity may be lower in brain areas where seizures start, and that increasing activity at the serotonin receptor…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT01281956
- Testing
- PRX-00023
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy
A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures
Patients with medically refractory epilepsy will be treated by intracerebroventricular (ICV) delivery of valproate using an implantable drug pump system.
- Trial name
- NCT02899611
- Testing
- Valproate
- Where
- Australia
- Volunteers
- 6 people
- Sponsor
- Cerebral Therapeutics LLC
Temporal Lobe Epilepsy
Exercise for Brain Regeneration in Epilepsy
Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions.
- Trial name
- NCT05179083
- Testing
- High-Impact Aerobic Exercise, Low-Impact Aerobic Exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Tinnitus, Epilepsy, Temporal Lobe
Pathophysiology, Psycho-emotional and Cognitive Functioning Associated With Tinnitus
the investigators have recently shown that patients with drug-resistant temporal lobe epilepsy who have undergone brain surgery targeting the medial temporal lobe structures were more likely to develop tinnitus postoperatively.
- Trial name
- AudiCog (NCT04717388)
- Testing
- acoustics tests, Questionaries,, MRI
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epilepsy, Drug Resistant
Subiculum Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis(SESTB)
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Subiculum as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy with…
- Trial name
- NCT06436547
- Testing
- Subiculum-DBS ON
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, MTLE
Exploratory Study of UX-GIP001 Cell Therapy in Adult Patients With Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)
This is an exploratory clinical trial (Protocol: UX-GIP001-101) investigating UX-GIP001 Injection, a novel cell therapy product consisting of human GABAergic interneuron progenitor cells (GIP), for treating adult patients with…
- Trial name
- NCT07244328
- Testing
- UX-GIP001
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy
Human Thalamus in Propagation of Temporal Lobe Seizures and Memory Formation
The goal of the study is to examine how two key subregions of the human thalamus (ANT and PLV) are connected with other brain structures (Aim 1), how seizures involve the two thalamic subregions differently and how the map of…
- Trial name
- NCT07226908
- Testing
- Cognitive experiment, Electrical stimulation of the brain
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Epilepsy, Temporal Lobe
Language and Emotional Function in Patients With Temporal Lobe Epilepsy
This study uses functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to examine how the brain processes tasks involving language and emotion in normal volunteers and in patients with epilepsy.
- Trial name
- NCT00081432
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Temporal Lobe
Language Localization Using Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Epilepsy
Repetitive transcranial magnetic stimulation (rTMS) may be able to provide a moderately detailed localization of language functions in the brain.
- Trial name
- NCT00001672
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy, Hippocampal Sclerosis
Gene Expression Changes of Brain Tissue in Human Temporal Lobe Epilepsy With Hippocampal Sclerosis
Epilepsy is a common neurological disease, manifested in the sudden abnormal discharge of neurons leading to short-term brain dysfunction, has become the neurology after headache the second most common disease.
- Trial name
- NCT04917939
- Testing
- RNA sequencing
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Epilepsy
Study of Specimens Obtained During Epilepsy Surgery
This study will collect brain tissue samples for research purposes from patients undergoing surgery to treat epilepsy. The standard surgical procedure for medically intractable epilepsy i.e., epilepsy that cannot be controlled…
- Trial name
- NCT00025714
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Transcranial Electrical Stimulation, Temporal Lobe Epilepsy
Transcranial Electrical Stimulation Targeting the Cerebellum for the Treatment of Refractory Temporal Lobe Epilepsy
Study the therapeutic effect and potential neural mechanisms of transcranial electrical stimulation targeting the cerebellum for the treatment of refractory temporal lobe epilepsy through MRI and EEG.
- Conditions
- Transcranial Electrical Stimulation, Temporal Lobe Epilepsy, Magnetic Resonance Imaging, Electroencephalogram
- Trial name
- NCT06558890
- Testing
- Transcranial Alternating Current Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Epilepsy, Temporal Lobe
SEEG Guided RF-TC v.s. ATL for mTLE With HS
Mesial temporal lobe epilepsy (mTLE) is the most classical subtype of temporal lobe epilepsy, which is the indication of surgical intervention after evaluation.
- Trial name
- STARTS (NCT03941613)
- Testing
- SEEG guided RF-TC, Anterior temporal lobectomy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Temporal Lobe
Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation
The overall goal of this study is to open up the promising treatment of repetitive transcranial magnetic stimulation (rTMS), which has been shown to be effective against seizures in patients with surface neocortical foci, to a…
- Trial name
- NCT02339376
- Testing
- Low-frequency repetitive transcranial magnetic stimulation, High-frequency repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Beth Israel Deaconess Medical Center
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis