Clinical trials: Epilepsy Surgery
Epilepsy
Evaluation of the FYNA Research OPM MEG Device for Locating Epileptic Foci as Part of Pre-surgical Assessment of Epilepsy
The success of epilepsy surgery depends largely on the reliability of the preoperative localization of the epileptogenic zone. The conventional method for determining the area to be removed is based on a complex assessment…
- Trial name
- EPI-OPM (NCT07281222)
- Testing
- MEG OPM, MEG SQUID
- Where
- 3 sites in France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Epilepsy
Study for the Diagnosis and Treatment of Drug-resistant Focal Epilepsies
Epilepsy is a clinical condition that affects about fifty million people worldwide, with an estimated occurrence of 16-51 new cases per 100,000 people each year.
- Trial name
- EpiBesta (NCT06794606)
- Where
- Italy
- Volunteers
- 337 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Tuberous Sclerosis Complex, Epilepsy
The Effectiveness and Safety of Resective Epilepsy Surgery for TRE
A prospective cohort studies to identify clinical seizure control, cognitive changes, and safety in resective epilepsy surgery in patients with TSC-related drug-resistant epilepsy.
- Trial name
- NCT04198181
- Testing
- Surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Epilepsy
Impact of Thermocoagulation During Invasive EEG Monitoring in Children With Focal Drug-resistant Epilepsies
When focal epilepsies become drug-resistant, it could be eligible for cortical surgical resection. Therefore, an invasive EEG monitoring with depth electrodes is often needed during presurgical evaluation.
- Trial name
- COAG (NCT02886650)
- Testing
- Thermocoagulation
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Drug-resistant Epilepsy, Candidates for Surgical Treatment
MEG Versus EEG HR for the Localization of the Epileptogenic Zone as Part of the Pre-surgical Assessment of Epilepsy
Drug-resistant partial epilepsies are disabling diseases for which surgical treatment may be indicated. The determination of the area to be operated (or 'epileptogenic zone') is based on a bundle of clinical arguments and…
- Conditions
- Drug-resistant Epilepsy, Candidates for Surgical Treatment, Epilepsy
- Trial name
- EPIMEEG (NCT03893916)
- Testing
- MEG - EEG HR
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Cavernous Malformation, Cerebral, Cavernous Angioma
Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Cerebral cavernous malformation (CCM)-related epilepsy (CRE) impairs the quality of life in patients with CCM. Patients could not always achieve seizure freedom after surgical resection of the lesion, suggesting an inadequate…
- Conditions
- Cavernous Malformation, Cerebral, Cavernous Angioma, Cavernous Hemangioma, Cavernous Hemangioma of Brain
- Trial name
- CRESS (NCT04076449)
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- yuanli Zhao
Refractory Epilepsy, Focal Epilepsy
Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia
Focal Cortical Dysplasias (FCDs) are neurodevelopmental disorders that represent a major cause of early onset drug-resistant epilepsies with cognitive and behavioral impairments, carrying a lifelong perspective of disability and…
- Conditions
- Refractory Epilepsy, Focal Epilepsy, Focal Cortical Dysplasia
- Trial name
- SPREAD (NCT03321240)
- Testing
- visual and quantitative SEEG signal analysis, Resective epilepsy surgery procedure
- Where
- 11 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Strasbourg, France
Epilepsy in Children
Prognostic Value of High-resolution Electrical Source Imaging on the Success of Pediatric Focal Epilepsy Surgery
This study investigates the usefulness of high resolution electrical source imaging (HR-ESI) in the setting of presurgical evaluation of drug-resistant focal epilepsy in children.
- Trial name
- ISEPEE (NCT06271785)
- Testing
- HR-EEG recording
- Where
- 9 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Angers
Epilepsy
Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.
Epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population. Although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long…
- Trial name
- EPISTIM (NCT02844374)
- Testing
- Functional stereotaxic exploration
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Grenoble
Epilepsy
Study of Direct Brain Recording and Stimulation for Memory Enhancement
Background: Epilepsy is a seizure disorder. Sometimes it is treated with surgery. During surgery, electrodes are placed on or in the brain. Researchers want to learn more about memory and the brain.
- Trial name
- NCT04095026
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Partial Epilepsy
Multimodal Imaging in Pre-surgical Evaluation of Epilepsy
Epilepsy is the most common chronic neurological disorder in the world, affecting more than 50 million people worldwide. Approximately 35% of patients with epilepsy are refractory to all available antiepileptic drugs.
- Trial name
- EPIMAGE (NCT01735032)
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Electroencephalography, Refractory Epilepsy
Clinical Utility of ESI in Presurgical Evaluation of Patients With Epilepsy
This study evaluates to what extend electrical source imaging (ESI) provides nonredundant information in the evaluation of epilepsy surgery candidates.
- Conditions
- Electroencephalography, Refractory Epilepsy, Brain Imaging, Surgery
- Trial name
- CUESIPE (NCT03533530)
- Testing
- Low-density ESI (LD ESI), High-density ESI (HD ESI), No electrical source imaging (ESI)
- Where
- Denmark
- Volunteers
- 82 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Epilepsy, Epilepsy, Temporal Lobe
Surgery as a Treatment for Medically Intractable Epilepsy
Background: Drug resistant epilepsy is the term used to describe epilepsy that cannot be controlled by medication. Many people whose seizures do not respond to medication will respond to surgical treatment, relieving seizures…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Partial Epilepsy
- Trial name
- NCT01273129
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Temporal Lobe Epilepsy, Open Surgery
Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy
Temporal lobe epilepsy (TLE) is a chronically neurological disease characterized by progressive seizures. TLE is the most frequent subtype of refractory focal epilepsy in adults.
- Conditions
- Temporal Lobe Epilepsy, Open Surgery, Minimally Invasive Surgery
- Trial name
- MISET-TLE (NCT05019404)
- Testing
- Functional anterior temporal lobectomy (FATL), Anterior temporal lobectomy (ATL)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Drug Resistant Epilepsy
Lentiviral Gene Therapy for Epilepsy
This is a phase I/IIa clinical trial investigating the safety of a lentiviral epilepsy gene therapy using an engineered potassium channel in patients with refractory epilepsy.
- Trial name
- NCT04601974
- Testing
- lentiviral gene therapy
- Volunteers
- 10 people
- Sponsor
- University College, London
Dream Content
The Impact of Epilepsy Surgery on Dream Content
Prospective observational study on epilepsy patients undergoing partial brain resection surgery (i.e. anterior temporal lobectomy) to assess the change in dream content before and 3 months and 1 year after surgery using…
- Trial name
- NCT02731443
- Testing
- Epilepsy surgery, Depth electrodes insertion
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre
Electroencephalography, Refractory Epilepsy
Clinical Utility of Automated Electric Source Imaging in Presurgical Evaluation
Electrical source imaging is part of the presurgical evaluation of patients with drug-resistant focal epilepsy. The software packages that will be used in this study have Declaration of Conformity within the European Economic…
- Conditions
- Electroencephalography, Refractory Epilepsy, Brain Imaging, Surgery
- Trial name
- PROMAESIS (NCT04218812)
- Testing
- No electrical source imaging (ESI), Automated electrical source imaging (ESI)
- Where
- 12 sites in Austria, Czechia and 6 more
- Volunteers
- 250 people
- Sponsor
- Sándor Beniczky
Epilepsy
Allogenic Adipose-derived Mesenchymal Stem Cells(AMSCs) for Epilepsy During Deep Brain Stimulation(DBS) Surgery
This study is a non-randomized, open label, phase 1 clinical trial to evaluate the fesibility and safety of intrathalamic delivery of MSCs during standard of care DBS surgery for epilepsy.
- Trial name
- NCT06280092
- Testing
- AMSCs
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Epilepsies, Partial
Added Value of Automated Electrical Source Localization (EPILOG PreOp®) to Presurgical Evaluation of Refractory Epilepsy
Drug resistant epilepsy is best managed by surgery. The goal of presurgical evalution is to correctly identify the epileptogenic zone, defined by the extent of cortical tissue that needs to be removed is order to achieve seizure…
- Trial name
- EPILOG (NCT03882151)
- Testing
- electrical source imaging
- Where
- 2 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Seizures, Epilepsy
Efficacy of BGG492 in Individuals With Refractory Partial Seizures Undergoing Inpatient Evaluation for Epilepsy Surgery
This study will asses the safety and efficacy of BGG492 in reducing the seizure rate in therapy-refractory partial seizures.
- Trial name
- NCT00887861
- Testing
- Investigational new drug, company code: BGG492
- Where
- 6 sites in Germany
- Volunteers
- 37 people
- Sponsor
- Novartis