Clinical trials: Epileptic Seizure
Epilepsy, Seizures
A Study of the Efficacy and Safety of Topiramate as "Add on" Treatment in Epilepsy Patients With Primary Generalized Tonic-clonic Seizures
The purpose of this study is to evaluate the effectiveness and safety of topiramate as an add-on therapy in epilepsy patients with uncontrolled primary generalized tonic-clonic seizures, who are taking 1 or 2 standard…
- Trial name
- NCT00236704
- Testing
- topiramate
- Volunteers
- 80 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Epilepsy; Paediatric Partial Onset Seizures
Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Study)
The purpose of this study is to compare the safety and efficacy of zonisamide with placebo.
- Trial name
- NCT00566254
- Testing
- Zonisamide
- Where
- 43 sites in Belgium, Estonia and 7 more
- Volunteers
- 207 people
- Sponsor
- Eisai Inc.
Focal-Onset Seizures
Prospective Study of Eslicarbazepine in Adults With Focal-Onset Seizures
This prospective multicenter observational study will evaluate the effectiveness, safety, tolerability, and impact on quality of life of eslicarbazepine in adults with focal-onset seizures in routine clinical practice.
- Trial name
- ENGAGE (NCT07793396)
- Testing
- Eslicarbazepine acetate
- Where
- Pakistan
- Volunteers
- 1,500 people
- Sponsor
- King Edward Medical University
Primary Generalized Tonic-Clonic Seizures
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the clinical efficacy, safety, and tolerability of XEN1101 administered as adjunctive treatment in primary generalized tonic-clonic…
- Trial name
- X-ACKT (NCT05667142)
- Testing
- XEN1101
- Where
- 138 sites in United States, Argentina and 18 more
- Volunteers
- 160 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Epilepsy
Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures
This study will evaluate the efficacy and safety of Brivaracetam to support the submission file in the indication of adjunctive treatment in adolescents and adults with partial onset seizures.
- Trial name
- NCT00464269
- Testing
- Brivaracetam 2.5 mg, Brivaracetam 10 mg, Brivaracetam 25 mg
- Where
- 69 sites in United States, Australia and 3 more
- Volunteers
- 400 people
- Sponsor
- UCB Pharma
Epilepsy, Drug Resistant
Clinical Trial : TROCC (Quick Oral Treatment of Cluster Epileptic Seizures)
This is a double blind, placebo controlled, add-on clinical trial, of levetiracetam efficacy and safety, in epilepsy cluster seizure. Efficacy is evaluated in the range of 2 to 24 hours after taking the tablet.
- Trial name
- NCT00376766
- Testing
- levetiracetam
- Where
- 10 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Grenoble
High-grade Glioma
Seizures During Radiotherapy for High-grade Gliomas
The primary objective of this trial is to evaluate the seizure frequency during a course of radiotherapy for high-grade (grade III or IV) gliomas. The patients keep a seizure diary during and up to 6 weeks following radiotherapy.
- Trial name
- SURF-ROGG (NCT04552756)
- Testing
- Seizure Diary
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- University Hospital Schleswig-Holstein
Neonatal Seizure
AI-assisted cEEG Diagnosis of Neonatal Seizures in Neonatal Intensive Care Unit
A diagnostic accuracy study on Artificial intelligence assisted continue EEG diagnostic tool is to carried out comparing with manually EEG interpretation as the golden standard for neonatal seizure.
- Trial name
- NCT04991779
- Testing
- AI-assisted cEEG detection tool
- Where
- 3 sites in China
- Sponsor
- Children's Hospital of Fudan University
Non Epileptic Seizures
Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical Trial
Open label intervention with a single dose of ayahuasca in patients with psychogenic non-epileptic seizures (PNES)
- Trial name
- NCT07747324
- Testing
- Ayahuasca
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- University of Sao Paulo
Lennox-Gastaut Syndrome
Safety and Effectiveness of Open-Label Clobazam in Subjects With Lennox-Gastaut Syndrome
The objective of this study is to evaluate the long-term safety and effectiveness of open-label clobazam in the treatment of drop seizures in subjects with LGS.
- Trial name
- LGS (NCT01160770)
- Testing
- Clobazam
- Volunteers
- 267 people
- Sponsor
- Lundbeck LLC
Seizures
Pregabalin In Partial Seizures Extension Study
To evaluate long-term efficacy and safety of pregabalin (150 to 600mg/day) as adjunctive treatment in patients with partial seizures.
- Trial name
- PREPS EXT (NCT00143130)
- Testing
- Pregabalin
- Where
- 47 sites in Belgium, Finland and 4 more
- Volunteers
- 227 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Antiepileptic Efficacy and Safety, Brain Injuries
Prophylactic Anti-epileptic Regimen in Traumatic Brain Injury
To evaluate the effectiveness and safety of anti-epileptic drugs in the prevention of early and late post-traumatic seizures among patients with trauma brain injury
- Trial name
- NCT07535736
- Testing
- Anti-Epileptic
- Volunteers
- 70 people
- Sponsor
- Assiut University
Epilepsy, Dravet Syndrome
An Open Label Extension Study of Cannabidiol (GWP42003-P) in Children and Adults With Dravet or Lennox-Gastaut Syndromes
To investigate the potential antiepileptic effects of cannabidiol (GWP42003-P) in children and adults with Dravet or Lennox-Gastaut syndromes.
- Conditions
- Epilepsy, Dravet Syndrome, Lennox-Gastaut Syndrome
- Trial name
- GWPCARE5 (NCT02224573)
- Testing
- GWP42003-P
- Volunteers
- 681 people
- Sponsor
- GW Research Ltd
SUDEP
Risk Factors for Sudden Unexplained Death in Epilepsy
The main purpose of this study is to develop a North American registry for SUDEP cases; requesting family members of epilepsy patients who died suddenly of unclear causes (SUDEP) to contact the study team.
- Trial name
- SUDEP (NCT01662453)
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Epilepsy, Generalized, Helicobacter Pylori Infection
Helicobacter Pylori Eradication Therapy for Epileptic Children
Helicobacter pylori (H. pylori) infection is associated with several health problems. The role of H. pylori infection in epilepsy has been investigated in a few studies.
- Trial name
- NCT05297695
- Testing
- Triple therapy for H. pylori infection
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Sohag University
Temporal Lobe Epilepsy
Exercise for Brain Regeneration in Epilepsy
Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions.
- Trial name
- NCT05179083
- Testing
- High-Impact Aerobic Exercise, Low-Impact Aerobic Exercise
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Epilepsy
CX-8998 for Absence Seizures
This is a Phase 2a, open-label study consisting of a screening period of up to 4 weeks and a 4-dose-titration treatment period to a dose of up to 10 mg twice daily (BID) of CX-8998, followed by a 1-week safety follow-up period…
- Trial name
- T-WAVE (NCT03406702)
- Testing
- CX-8998
- Where
- 7 sites in United States
- Volunteers
- 7 people
- Sponsor
- Jazz Pharmaceuticals
Epilepsy, Neurodevelopmental Disorders
The Biomarkers of Neurological Disease in Utero Study
Anti-epileptic drugs (AEDs) are potent teratogens associated with a spectrum of physical and neurodevelopmental anomalies to the exposed fetus.
- Conditions
- Epilepsy, Neurodevelopmental Disorders, Fetal Disease, Teratogenesis
- Trial name
- BONDING (NCT04043572)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Epilepsy, Temporal Lobe
Hippocampal and Thalamic DBS for Bilateral Temporal Lobe Epilepsy
The study aims to compare the safety and effectiveness of deep brain stimulation of the hippocampus and the anterior nucleus of the thalamus for reducing the frequency of seizures in patients with bilateral temporal lobe epilepsy.
- Trial name
- NCT04164056
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine