Clinical trials: Epithelial Neoplasms, Malignant
Renal Cell Carcinoma
Dynamic Contrast Enhancement Computed Tomography for Evaluating Tumor Perfusion in Patients With Metastatic Renal Cell Carcinoma Receiving Targeted Therapies: Renal Cell Carcinoma (RCC) Scramble
This is a companion protocol to MD Anderson Cancer Center study 2010-0085 (Sequential Therapy in Advanced Renal Cell Carcinoma Therapy: The "START" Trial).
- Trial name
- NCT01224288
- Testing
- Perfusion CT scan
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer
Stereotactic Body Radiation Therapy in Treating Patients With Stage I or Stage II Non-Small Cell Lung Cancer That Can Be Removed By Surgery
RATIONALE: Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue near the tumor.
- Trial name
- NCT00551369
- Testing
- SBRT
- Where
- 19 sites in United States
- Volunteers
- 33 people
- Sponsor
- Radiation Therapy Oncology Group
Glioblastoma Multiforme
TTFields Together With Temozolomide and Radiotherapy in Patients With Newly Diagnosed GBM
The study is a prospective, single arm open label study, designed to test the to evaluate the tolerability and safety outcome of newly diagnosed GBM patients treated with NovoTTF-200A concomitant to Radiotherapy/Temozolomide…
- Trial name
- NCT03780569
- Testing
- NovoTTF-200A, Radiotherapy, Temozolomide
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- NovoCure Ltd.
Papillary Thyroid Cancer
Radiofrequency Ablation of Papillary Thyroid Microcarcinoma
Traditionally, surgery has been the standard recommendation for treating papillary thyroid cancer. The risk of surgery including permanent hoarseness, permanent hypocalcemia, a mid-cervical scar, and the potential for permanent…
- Trial name
- NCT05132205
- Testing
- Radiofrequency Ablation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Liver Tumor
National Polish Registry of Minimally Invasive Liver Surgery
After the two consensus meetings on laparoscopic liver resection in Louisville (2008) and in Morioka (2014) minimally invasive approach for liver resection was finally widely established in liver surgery practice.
- Trial name
- PL-MILS (NCT05516394)
- Testing
- Laparoscopic liver resection
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Warsaw
IPMN, Pancreatic, Pancreatic Cancer, Resected
Venous Resection in Patients Undergoing Pancreatic Surgery
Pancreatic surgery is the only treatment in the multimodality approach to pancreatic cancer sine qua non long-term survival cannot be achieved.
- Conditions
- IPMN, Pancreatic, Pancreatic Cancer, Resected, Pancreatic Cancer Borderline, Chronic Pancreatitis
- Trial name
- VENUS (NCT07621029)
- Where
- 2 sites in Netherlands, Sweden
- Volunteers
- 1,000 people
- Sponsor
- Sahlgrenska University Hospital
Ovarian Cancer
Clinical Study of Apatinib in the Treatment of Platinum Resistant Recurrent Ovarian Cancer
For patients with "Platinum-resistant recurrent ovarian cancer" after second-line chemotherapy failure Using apatinib as a single drug Clinical efficacy observation Single study no control
- Trial name
- NCT03587129
- Testing
- Apatinib
- Where
- China
- Volunteers
- 1 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Metastatic Cancer
Molecularly Targeted Theranostic Approach for the Detection and Treatment of Metastatic Carcinomas
This is a Phase I study to evaluate the safety and efficacy of the [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G theranostics pair in patients with metastatic cancer.
- Trial name
- NCT06389123
- Testing
- [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Davis
Pancreatic Cancer
Cabozantinib and Pembrolizumab in Metastatic Pancreas
This study aims to evaluate cabozantinib and pembrolizumab for the treatment of metastatic pancreatic adenocarcinoma.
- Trial name
- NCT05052723
- Testing
- Cabozantinib, Pembrolizumab
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Joseph Kim
Head and Neck Cancer, Oropharynx Cancer
Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110)
This is a phase II, non-randomized, therapeutic trial with the primary objective to determine the efficacy of reduced contralateral (C/L) elective nodal treatment volumes in preventing C/L recurrences at 2 years in patients with…
- Conditions
- Head and Neck Cancer, Oropharynx Cancer, Oropharyngeal Squamous Cell Carcinoma
- Trial name
- SAVER (NCT04609280)
- Testing
- Intensity modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) or Pencil beam proton therapy (PBPT)
- Where
- 6 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Maryland, Baltimore
Spinal Cord Tumors
MRE Evaluation for Spinal Cord Tumor Surgery: Stiffness and Adhesion Assessment
In spinal cord tumors requiring surgical intervention, the resection difficulty is determined by two significant factors: tumor stiffness and adhesion to surrounding tissue.
- Trial name
- NCT05957679
- Testing
- Magnetic Resonance Elastography, Assessment and Recording
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Psychosocial
Effects of Cancer Symptoms on Caregivers
The primary objectives are to: 1.1 identify and compare the experiences of minority and nonminority caregivers, including the prevalence and severity of physical (fatigue, sleep disturbance) and psychologic (depression, anxiety…
- Trial name
- NCT00351988
- Testing
- Phenomenological Interviews, Quantitative Interviews
- Where
- 4 sites in United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Gastric Adenocarcinoma
S1+ Paclitaxel (IV&IP) + Bevacizumab (IP) Versus S1+Oxaliplatin as First-line Treatment in Gastric Cancer With Malignant Ascites
The purpose of this study is to compare the efficacy of S1 plus paclitaxel (intravenous injection \& intraperitoneal injection) plus bevacizumab (intraperitoneal injection) vs.
- Trial name
- NCT03990103
- Testing
- S1, Paclitaxel, Bevacizumab
- Where
- China
- Volunteers
- 66 people
- Sponsor
- China Medical University, China
Glioblastoma Multiforme, Anaplastic Astrocytoma
IL13-PE38QQR Infusion After Tumor Resection, Followed by Radiation Therapy With or Without Temozolomide in Patients With Newly Diagnosed Malignant Glioma
This Phase 1 study in patients with newly diagnosed malignant glioma is designed to determine the highest dose of IL13-PE38QQR that can be safely administered by Convection Enhanced Delivery (CED) to the area around the tumor…
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Oligoastrocytoma
- Trial name
- NCT00089427
- Testing
- IL13-PE38QQR, Surgery for placement, Radiation therapy
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- INSYS Therapeutics Inc
Carcinoma, Transitional Cell
Gemcitabine and Platinol Followed by Pemetrexed and Gemcitabine in Patients With Advanced or Metastatic Bladder Cancer
The purposes of this study are: To determine the maximum tolerated dose of Gemcitabine and Platinol followed by Pemetrexed and Gemcitabine in patients with advanced or metastatic transitional cell carcinoma of the urothelium; To…
- Trial name
- NCT00101842
- Testing
- Pemetrexed, Gemcitabine, Platinol
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Eli Lilly and Company
Brain Cancer
Phase I/II Cabazitaxel for Recurrent Malignant Glioma
The goal of Part 1 of this clinical research study is to find the highest tolerable dose of cabazitaxel that can be given to patients with glioblastoma.
- Trial name
- NCT01740570
- Testing
- Cabazitaxel
- Sponsor
- M.D. Anderson Cancer Center
Carcinoma, Non-Small-Cell Lung
Study in Patients With Advanced Non-Small Cell Lung Cancer Treated With Pemetrexed and Carboplatin Plus or Minus Sorafenib
The majority of patients with advanced NSCLC treated with standard platinum based chemotherapy regimens ultimately develop disease progression. Active therapies with improved toxicity profiles are clearly needed in this setting.
- Trial name
- PECASO (NCT00473486)
- Testing
- pemetrexed, carboplatin, sorafenib
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Hospital Muenster
Recurrent Glioma
Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma
The primary objective of step 1 is the rate of adverse events of minocycline and bevacizumab during reirradiation and of step 2 is the response rate to bevacizumab, reirradiation, and minocycline.
- Trial name
- RAMBO (NCT01580969)
- Testing
- Bevacizumab, Minocycline, Radiation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah
Gastric Cancer, Renal Cell Carcinoma
A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors
The purpose of this study is to test the safety and tolerability of HFB200301 as a single agent and in combination with tislelizumab in patients with advanced cancers. There are two parts in this study.
- Conditions
- Gastric Cancer, Renal Cell Carcinoma, Melanoma, Sarcoma
- Trial name
- NCT05238883
- Testing
- HFB200301, Tislelizumab
- Where
- 10 sites in United States, Spain
- Volunteers
- 72 people
- Sponsor
- HiFiBiO Therapeutics
Advanced Solid Tumor, Locally Advanced Solid Tumor
A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors
TransCon TLR7/8 Agonist is an investigational drug being developed for treatment of locally advanced or metastatic solid tumors.
- Conditions
- Advanced Solid Tumor, Locally Advanced Solid Tumor, Metastatic Solid Tumor, Head and Neck Squamous Cell Carcinoma HNSCC
- Trial name
- NCT04799054
- Testing
- TransCon TLR7/8 Agonist, Pembrolizumab
- Where
- 49 sites in United States, Australia and 4 more
- Volunteers
- 188 people
- Sponsor
- Ascendis Pharma Oncology Division A/S
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