Clinical trials: Erythropoietin
Chronic Kidney Disease, End Stage Renal Disease
TARGTEPO Treatment for Anemia in Chronic Kidney Disease (CKD) Patients and End-Stage Renal Disease (ESRD)
The objectives of this study are to assess safety and to evaluate the biologic activity of TARGTEPO treatment.
- Trial name
- NCT02117427
- Testing
- MDGN201 TARGTEPO
- Where
- 5 sites in Israel
- Volunteers
- 11 people
- Sponsor
- Aevi Genomic Medicine, LLC, a Cerecor company
Anemia, Iron-Deficiency, Kidney Failure, Chronic
Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents
This study compares the effect of Ferrlecit® (a form of intravenous iron) to ferrous sulfate (a form of oral iron) in treating anemia and iron deficiency in chronic kidney disease patients who are receiving erythropoietic agents…
- Trial name
- NCT00224042
- Testing
- Sodium Ferric Gluconate complex in sucrose, Ferrous sulfate tablets
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 52 people
- Sponsor
- Watson Pharmaceuticals
Anemia, Surgery, Arthroscopy
PROCRIT and Short-Term Outcomes in Orthopedic Surgery
The purpose of this study is to compare the effect of perioperative administration of PROCRIT to that of autologous blood donation on post-operative rehabilitation outcomes in patients undergoing unilateral knee surgery.
- Trial name
- NCT00236405
- Testing
- epoetin alfa
- Volunteers
- 6 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Healthy, Coronary Artery Bypass Graft
Cardioprotective Effects of Increased Endogenous Erythropoietin After Normobaric Oxygen Breathing
Tissue hypoxia is the only accepted trigger for erythropoietin (EPO) production. However, in healthy subjects EPO concentrations have also increased after oxygen breathing. The aim of our study is to confirm these observations.
- Trial name
- NCT00824759
- Testing
- pure oxygen breathing versus air
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Delayed Graft Function
Effect of Procrit (Epoetin Alfa) on Preventing Delayed Graft Function After Deceased Donor Renal Transplantation
Delayed graft function (DGF) is a major complication following deceased donor renal transplantation. The surgical procedure of harvesting a kidney from a cadaveric donor and implanting the kidney into the recipient inevitably…
- Trial name
- NCT00425126
- Testing
- Epoetin Alfa
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- West Penn Allegheny Health System
Mood Disorders
Effects of Erythropoietin on Depressive Symptoms and Neurocognitive Deficits in Depression and Bipolar Disorder
Depression and bipolar disorder (mania and depression) may be related to problems with nerve cells not being regenerated as fast as normal and are accompanied by cognitive difficulties including memory, attention and planning…
- Trial name
- NCT00916552
- Testing
- Erythropoietin
- Where
- Denmark
- Volunteers
- 83 people
- Sponsor
- Lars Vedel Kessing, professor, MD, DMSc.
Vitamin B12 Deficiency
Impact of Vitamin B12 Replacement on Epogen Dosing and Improvement of Quality of Life in Hemodialysis Patients
Vitamin B12 has several important functions in the body, two of which are production of red blood cells and the maintenance of a healthy nervous system. When vitamin B12 is deficient, abnormal red blood cells form.
- Trial name
- NCT01876732
- Testing
- Vitamin B12
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Northwell Health
Anemia, Aortic Stenosis
Erythropoietin + Iron Therapy for Anemic Patients Undergoing Aortic Valve Replacement
The objective of the study is to evaluate the efficacy of Erythropoietin (EPO) (+ iron) in reducing the rate of red blood cell transfusion requirements in patients with aortic stenosis undergoing transcatheter aortic valve…
- Trial name
- EPICURE (NCT02390102)
- Testing
- Erythropoietin
- Where
- Canada
- Volunteers
- 117 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
HIV Infections, Neuropathy
Epoetin Alfa for HIV-Associated Neuropathy Trial
The purpose of this study is to evaluate the effect of epoetin alfa on HIV-associated neuropathy by measuring changes in nerve fiber density and pain ratings.
- Trial name
- NCT00528593
- Testing
- epoetin alfa
- Sponsor
- Washington University School of Medicine
Chemotherapy-induced Symptomatic Anaemia, Solid Tumours
Biosimilar Retacrit™ (Epoetin Zeta) in the Treatment of Chemotherapy-Induced Symptomatic Anaemia in Haematology and Oncology
The purpose of this study is to observe correction of haemoglobin (Hb) levels in patients receiving chemotherapy as a consequence of a solid tumour, a malignant lymphoma or a multiple myeloma and who are treated with Retacrit™.
- Conditions
- Chemotherapy-induced Symptomatic Anaemia, Solid Tumours, Malignant Lymphomas, Multiple Myeloma
- Trial name
- NCT01626547
- Where
- 39 sites in Germany
- Volunteers
- 291 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Chronic Renal Failure, Chronic Kidney Disease
Safety & Efficacy of Peginesatide for Maintenance Treatment of Anemia in Participants With Chronic Kidney Disease on Hemodialysis
The purpose of this study was to evaluate the safety and efficacy of peginesatide in the maintenance treatment of anemia in participants on dialysis.
- Conditions
- Chronic Renal Failure, Chronic Kidney Disease, Anemia
- Trial name
- EMERALD 2 (NCT00597584)
- Testing
- peginesatide, Epoetin alfa or Epoetin beta
- Where
- 84 sites in United States, Bulgaria and 7 more
- Volunteers
- 823 people
- Sponsor
- Affymax
Periodontal Disease, Chronic Kidney Disease
The Impact Of Periodontal Disease Treatment On The General Health Status In Chronic Haemodialyzed Patients
Several studies revealed a direct relationship between the severity of periodontal inflammation and CRP (NHANES III, Dumitriu HT et al, 1998).
- Trial name
- PAROHEM (NCT01785355)
- Testing
- Dental treatment
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Anemia Working Group Romania
Anemia
Study of the Efficacy and Safety of Ferrlecit in the Maintenance Dosing in Hemodialysis Patients.
This is a phase 4 clinical investigation of the efficacy and safety of Ferrlecit in the maintenance of iron stores and serum hemoglobin concentration in hemodialysis patients receiving Erythropoietin.
- Trial name
- NCT00223938
- Testing
- Oral Iron, sodium ferric gluconate
- Where
- 8 sites in United States
- Volunteers
- 112 people
- Sponsor
- Sanofi
Myelodysplastic Syndromes
Erythropoietin (EPO) and Granulocyte-Colony Stimulating Factor (G-CSF) for Low-Risk Myelodysplastic Syndromes (MDS)
Myelodysplastic syndromes (MDS) are acquired clonal disorders of the bone marrow. The clinical consequences of MDS are bone marrow failure and a predisposition to develop acute myeloid leukaemia (AML).
- Trial name
- NCT00234143
- Testing
- Darbepoetin and Filgrastim, Darbepoetin
- Where
- United Kingdom
- Volunteers
- 360 people
- Sponsor
- St. Bartholomew's Hospital
Traumatic Brain Injury
Erythropoietin Effects After Traumatic Brain Injury
To determine if the early administration of erythropoietin to patients sustaining traumatic brain injury will reduce secondary brain injury.
- Trial name
- NCT00260052
- Testing
- Erythropoietin administration
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Healthy
Relative Bioavailability of Two Formulations of AKB-6548 and the Food Effect of a New Tablet in Healthy Adult Subjects
The primary purpose of this study is to compare the PK parameters of a single dose of a test tablet formulation of AKB-6548 relative to a single dose of the reference AKB-6548 tablet formulation, both treatments administered…
- Trial name
- NCT02412449
- Testing
- AKB-6548 tablet, reference formulation given in the fasted state, AKB-6548 tablet, test formulation given in the fasted state., AKB-6548 tablet, test formulation given in the fed state
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Akebia Therapeutics
Anemia
Study for the Treatment of Anemia in Patients With Non-myeloid Malignancies Receiving Multicycle Chemotherapy.
Comparing two drugs to treat subjects with non-myeloid malignancies receiving multicycle chemotherapy.
- Trial name
- NCT00148421
- Testing
- Darbepoetin alfa and Epoetin alfa
- Sponsor
- Amgen
Anemia
A Study of Subcutaneous (sc) Mircera in Dialysis Patients With Chronic Renal Anemia.
This study will determine the appropriate dose and frequency of administration of sc Mircera maintenance therapy in dialysis patients with chronic renal anemia who were previously receiving sc epoetin alfa or beta.
- Trial name
- NCT00364832
- Testing
- methoxy polyethylene glycol-epoetin beta [Mircera]
- Where
- 23 sites in United States, Germany and 2 more
- Volunteers
- 137 people
- Sponsor
- Hoffmann-La Roche
HIV Infections, Cytopenias
A Study of Granulocyte Colony-Stimulating Factor Plus Recombinant Erythropoietin Plus Zidovudine in Patients With AIDS or AIDS-Related Complex
To evaluate the safety, tolerance and biological activity of filgrastim (granulocyte colony-stimulating factor; G-CSF) given by daily subcutaneous (SC) injection prior to and concomitantly with erythropoietin (EPO) and zidovudine…
- Trial name
- NCT00002281
- Testing
- Filgrastim, Epoetin alfa, Zidovudine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Amgen
Premature Infant
Erythropoietin Protects Very Preterm Infants Against Necrotizing Enterocolitis
This study evaluates the effect of repeated low-dose erythropoietin (EPO) treatment on necrotizing enterocolitis (NEC) in very preterm infants. Half of participants will receive EPO, while the other half will receive a placebo.
- Trial name
- NCT03919500
- Testing
- EPO, Normal saline
- Where
- China
- Volunteers
- 1,285 people
- Sponsor
- Zhengzhou University