Clinical trials: Erythropoietin
Acute ST Elevation Myocardial Infarction
REVEAL: Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction
The purpose of this study is to evaluate whether erythropoietin can help limit the damage to the heart in patients with acute heart attacks.
- Trial name
- NCT00378352
- Testing
- Epoetin alfa
- Where
- 16 sites in United States
- Volunteers
- 223 people
- Sponsor
- National Institute on Aging (NIA)
Cognitive Impairment, Bipolar Disorder
Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions
The goal of this clinical trial is to investigate the effects of a three-week altitude-like cognition training intervention in healthy individuals (substudy 1) and symptomatically stable patients with mood disorders (depression…
- Conditions
- Cognitive Impairment, Bipolar Disorder, Depression
- Trial name
- ALTIBRAIN (NCT06121206)
- Testing
- Altitude-like hypoxia (12% O2), Normoxia (20% O2), Cognitive training
- Where
- Denmark
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Healthy
A Study of HM10760A (Long-acting Erythropoietin) in Healthy Adult Caucasian and Japanese Subjects
Study design: Phase I, first-in-human, randomized, double-blind, placebo-controlled, sequential dose escalation study of intravenously administered HM10760A in healthy adult Caucasian and Japanese subjects.
- Trial name
- EPO (NCT01030315)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hanmi Pharmaceutical Company Limited
Respiratory Failure
Hyperoxia, Erythropoiesis and Microcirculation in Critically Ill Patient
Prospective observational study in 40 adult critically ill patients. Patients were eligible if they were mechanically ventilated with an FiO2 ≤0.5 and PaO2/FiO2 ≥200 mmHg and hemodynamically stable with a hemoglobin ≥9 g/dL, no…
- Trial name
- NCT02481843
- Testing
- 2 hours of hyperoxia (FiO2 = 1)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Politecnica delle Marche
Anemia Renal
Erythropoietin Role in Acute Kidney Injury
The use of erythropoietin to treat anemia in acute kidney injury (AKI) is controversial. No previous clinical trial has assessed the possible reduction of transfusions when erythropoietin is started very early in a setting of…
- Trial name
- EAKI (NCT03401710)
- Testing
- Erythropoietin
- Where
- Lebanon
- Volunteers
- 134 people
- Sponsor
- Saint-Joseph University
Myelodysplastic Syndromes
A Study of NeoRecormon (Epoetin Beta), CellCept (Mycophenolate Mofetil) and Prednisone in Patients With Low or Intermediate Myelodysplastic Syndromes.
This single arm study will evaluate the efficacy and safety of a combination of NeoRecormon, CellCept and prednisone in patients with low or moderate risk myelodysplastic syndromes (MDS).
- Trial name
- NCT00551291
- Testing
- Mycophenolate mofetil, Prednisone, Erythropoietin Beta
- Where
- 8 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Hoffmann-La Roche
Sinus Lifting
Erythropoietin - Albumin Platelet-rich Fibrin in Transcrestal Sinus Lifting With Simultaneous Implant Placement
Background: Dental implant therapy in the posterior maxilla may be difficult owing to limited bone height after dental extraction with sinus pneumatization.
- Trial name
- NCT07150858
- Testing
- Erythropoietin and albumin PRF gel + implant placement, Albumin PRF gel +implant placement
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Healthy
Biosimilarity Study of Intravenous Recombinant Human Erythropoietin in Healthy Volunteers
Open label and monocentric Phase I Clinical Trial, to Determine the Pharmacokinetics and Pharmacodynamics of Recombinant Human Erythropoietin for Subcutaneous Use in an Adult Male Population
- Trial name
- RUBI (NCT04954989)
- Testing
- Experimental Erythropoietin subcutaneous injection single dose of 4,000 IU, Active comparator Erythropoietin subcutaneous injection single dose of 4,000 IU
- Where
- India
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Megalabs
Colorectal Cancer
The Effect of Darbepoetin Upon Rehabilitation for Colorectal Cancer Surgery
The study is investigating whether randomization to perioperative darbepoetin alfa treatment improves the rehabilitation following surgery for colonic and rectal cancer.
- Trial name
- NCT00122720
- Testing
- Darbepoetin Alfa
- Where
- 5 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Herning Hospital
Anemia, Neoplasms
A Safety Study of Epoetin Alfa in Patients With Cancer Who Have Chemotherapy-Related Anemia
The purpose of the study is to evaluate the safety of epoetin alfa in patients with cancer who have chemotherapy-related anemia.
- Trial name
- NCT01394991
- Testing
- Epoetin alfa 450 IU/kg once a week, Epoetin alfa 150 IU/kg 3 times a week, Epoetin alfa 450 IU/kg once a week (QW)
- Volunteers
- 504 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acquired Immunodeficiency Syndrome, Anemia
A Study to Evaluate the Safety and Efficacy of Epoetin Alfa Versus Placebo for the Treatment of Anemia in Patients With Acquired Immunodeficiency Syndrome (AIDS) Who Are Receiving Zidovudine (AZT) Therapy
The purpose of this study is to evaluate the effectiveness and safety of epoetin alfa in AIDS patients for the treatment of anemia that is a result of the disease and zidovudine (AZT) treatment.
- Trial name
- NCT00270283
- Testing
- epoetin alfa
- Volunteers
- 102 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Anemia, Breast Cancer
Epoetin Alfa in Treating Chemotherapy-Related Anemia in Women With Stage I, Stage II, or Stage III Breast Cancer
RATIONALE: Epoetin alfa may stimulate red blood cell production to treat patients who have anemia following chemotherapy. PURPOSE: Phase IV trial to study the effectiveness of epoetin alfa in treating chemotherapy-related anemia…
- Conditions
- Anemia, Breast Cancer, Fatigue
- Trial name
- NCT00022386
- Testing
- epoetin alfa, quality-of-life assessment
- Sponsor
- Jonsson Comprehensive Cancer Center
Peripheral Neuropathy, Chemotherapy-induced
A Study to Investigate the Neuroprotective Effect of PROCRIT (Epoetin Alfa) Versus Placebo in Cancer Patients Who Develop Chemotherapy-induced Peripheral Neuropathy
The purpose of this study is to evaluate the neuroprotective effect of PROCRIT (epoetin alfa, a glycoprotein that stimulates red blood cell production) versus placebo in patients with cancer who develop chemotherapy-induced…
- Trial name
- NCT00267007
- Testing
- PROCRIT 40,000 IU QW
- Where
- 28 sites in United States
- Volunteers
- 32 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hopeless Teeth
Xenograft with or Without Erythropoietin in Immediate Dental Implant
The aim of this study is to evaluate changes in buccal bone thickness after immediate implant placement with xenograft mixed with erythropoietin in the anterior maxilla with a thin buccal bone
- Trial name
- NCT06601400
- Testing
- Erythropoietin (EPO) with xenograft, Xenograft alone
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Chronic Kidney Disease, Blood Pressure
Mechanisms of EPO-induced Hypertension
The investigators hypothesize that compared to untreated controls, erythropoietin (EPO) therapy in anemic patients with chronic kidney disease will raise diastolic blood pressure (BP).
- Conditions
- Chronic Kidney Disease, Blood Pressure, Anemia
- Trial name
- EPIC (NCT03810911)
- Testing
- Darbepoetin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- VA Office of Research and Development
Kidney Failure, Chronic
The Clinical Evaluation of the Dose of Erythropoietins Trial
Anaemia is a risk factor for death, cardiac-cerebrovascular events and poor quality of life in patients with chronic kidney disease (CKD). Erythropoietin Stimulating Agents (ESAs) are the most used treatment option.
- Trial name
- CEDOSE (NCT00827021)
- Testing
- Erythropoiesis Stimulating Agents (ESAs): epoetin alfa, beta or any other epoetin in equivalent dose.
- Where
- 41 sites in Italy
- Volunteers
- 656 people
- Sponsor
- Giovanni FM Strippoli, MD
Anemia
Study of Epoetin Alfa to Treat Anemia After Kidney Transplantation
The primary purpose of this study is to determine the effect of Epoetin Alfa (Procrit) on the change in hemoglobin (red blood cell count) in anemic kidney transplant recipients.
- Trial name
- NCT01290328
- Testing
- Epoetin Alfa
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mehrotra, Anita, M.D.
Chronic Kidney Disease Stages 3-5
Effects of Ergocalciferol on Erythropoetin Stimulating Agent Dose
Hypothesis: The supplementation of Ergocalciferol (Vitamin D2) to those with Vitamin D deficiency in the Chronic Kidney Disease population requiring recombinant human erythropoietin for the treatment of anemia related to kidney…
- Trial name
- EASY (NCT01263028)
- Testing
- Ergocalciferol supplementation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kaiser Permanente
Anemia
A Study Comparing Maintenance of Hemoglobin Levels, Safety and Tolerability of Once Every 4 Weeks Mircera Versus Epoetin Beta in Dialysis Patients With Chronic Renal Anemia.
This two arm study will compare the maintenance of hemoglobin levels, safety and tolerability of once every 4 weeks subcutaneous administration of Mircera versus epoetin beta in dialysis patients with chronic renal anemia.
- Trial name
- NCT00773331
- Testing
- epoetin beta, methoxy polyethylene glycol-epoetin beta [Mircera]
- Where
- 13 sites in China
- Volunteers
- 281 people
- Sponsor
- Hoffmann-La Roche
Polycystic Ovary Syndrome (PCOS) Women
Effects of Metformin and Theory-Based Education in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common condition associated with metabolic abnormalities, including insulin resistance, impaired glucose regulation, and abnormal lipid levels.
- Trial name
- NCT07811856
- Testing
- MetFORMIN, Theory-Based Behavioral Educational Program
- Where
- Jordan
- Volunteers
- 900 people
- Sponsor
- Jerash Private University