Clinical trials: Esketamine
Major Depressive Disorder
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large…
- Trial name
- NCT05450432
- Testing
- Ketamine, Esketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Esketamine, Thoracoscopic Surgery
An Exploratory Study of Esketamine in Patients After Thoracoscopic Surgery
Thoracic surgery can produce severe postoperative acute pain, which can easily lead to cough weakness, atelectasis, respiratory restriction, pneumonia, hypoxemia, secretion retention, respiratory failure and other adverse events.
- Trial name
- NCT05458453
- Testing
- Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Postpartum Depression
Effects of Esketamine on Postpartum Depression
Different concentrations of Esketamine were used after cesarean section. Through the evaluation of postoperative psychological status and analgesic effect, the optimal dosage of Esketamine to exert the effects of depression and…
- Trial name
- EEPD (NCT05229913)
- Testing
- Esketamine is not added, Esketamine 0.2mg/kg, Esketamine 0.4mg/kg
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Qinghai University
Depressive Disorder, Treatment-Resistant
A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression
The purpose of this study is to assess the efficacy of intranasal esketamine plus an oral antidepressant compared with an oral antidepressant (active comparator) plus intranasal placebo in delaying relapse of depressive symptoms…
- Trial name
- SUSTAIN-1 (NCT02493868)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant)
- Where
- 155 sites in United States, Belgium and 13 more
- Volunteers
- 719 people
- Sponsor
- Janssen Research & Development, LLC
Behavior Problem
Effects of Esketamine on Postoperative Behavioral Changes in Children Undergoing Tonsillectomy and/or Adenoidectomy
The goal of this clinical trial is to learn the effect of intravenous esketamine in postoperative negative behavior changes in children compared to placebo (a look-alike substance that contains no drug).
- Trial name
- NCT06579937
- Testing
- Esketamine hydrochloride, normal saline
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Fujian Provincial Hospital
Adenotonsillectomy, Children
Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients
Postoperative pain after adenoid and tonsil surgery is significant, with approximately 75% of pediatric patients experiencing severe postoperative pain.
- Conditions
- Adenotonsillectomy, Children, Intranasal Administration, Dexmedetomidine
- Trial name
- NCT07479602
- Testing
- Intranasal dexmedetomidine-esketamine
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Peking University First Hospital
Esketamine, ECT
The Effectiveness and Safety of Esketamine in Modified Electroconvulsive Therapy
A multicenter, randomized, controlled, single blind clinical trial on the efficacy and safety of esmketamine injection in electroconvulsive therapy Objective to evaluate the efficacy and safety of esmketamine injection in the…
- Conditions
- Esketamine, ECT, Depression
- Trial name
- NCT04777110
- Testing
- Esketamine, Saline
- Volunteers
- 396 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Depressive Disorder, Major
54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide
The purpose of this study is to evaluate the efficacy of intranasal esketamine 84 milligram (mg) compared with intranasal placebo in addition to comprehensive standard of care in reducing the symptoms of Major Depressive Disorder…
- Trial name
- Aspire II (NCT03097133)
- Testing
- Esketamine, Standard of Care
- Where
- 61 sites in United States, Argentina and 10 more
- Volunteers
- 230 people
- Sponsor
- Janssen Research & Development, LLC
Spinal Surgery, Pain Intensity
Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP).
- Conditions
- Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine
- Trial name
- NCT07523321
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Peking University First Hospital
Fibromyalgia, Pregabalin
The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia
Fibromyalgia is a chronic pain syndrome where current medications have limited efficacy and a slow onset of action. Esketamine shows potential as a rapid-acting analgesic, but previous low-dose studies failed to demonstrate…
- Conditions
- Fibromyalgia, Pregabalin, Esketamine
- Trial name
- NCT07230171
- Testing
- Pregabalin and venlafaxine concomitant therapy, Esketamine plus pregabalin and venlafaxine concomitant therapy
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Beijing Tiantan Hospital
Sleep Wake Disorders, Esketamine and the Quality of Recovery
Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
The aim of this clinical trial is to understand the effects of dexmedetomidine and esketamine on postoperative sleep in patients undergoing cardiac surgery.
- Conditions
- Sleep Wake Disorders, Esketamine and the Quality of Recovery, Dexmedetomidine
- Trial name
- NCT06778811
- Testing
- Intraoperative infusion of dexmedetomidine, Intraoperative infusion of esketamine, Saline control
- Where
- 2 sites in China
- Volunteers
- 180 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Etomidate, Esketamine
Etomidate and Esketamine on Postoperative Pain After Tonsillectomy Undergoing Children
Objective: To explore the effect of etomidate and esketamine on postoperative pain after tonsillectomy in children. Methods: Investigators enrolled 64 children with American Society of Anesthesiologists (ASA) physical status I…
- Conditions
- Etomidate, Esketamine, Tonsillectomy, Children
- Trial name
- NCT07062601
- Testing
- Etomidate and fentanyl group, Etomidate and esketamine group
- Volunteers
- 64 people
- Sponsor
- Anqing Municipal Hospital
Biliary Tract Diseases, Procedural Sedation and Analgesia
Esketamine Versus Sufentanil for Sedation in Patients Undergoing ERCP
This study compares two anesthesia medications, esketamine and sufentanil, used together with propofol during ERCP procedures. The goal is to find out which combination provides better safety and comfort for people undergoing…
- Trial name
- ES-ERCP (NCT07702240)
- Testing
- Esketamine, Sufentanil
- Volunteers
- 530 people
- Sponsor
- Ren Da
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Treatment-resistant Depression
A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
The purpose of this study is to compare the efficacy and safety of switching treatment-resistant depression (TRD) participants from a prior antidepressant treatment (to which they have not responded) to either intranasal…
- Trial name
- TRANSFORM-1 (NCT02417064)
- Testing
- Esketamine, Duloxetine (Oral Antidepressant), Escitalopram (Oral antidepressant)
- Where
- 90 sites in United States, Belgium and 7 more
- Volunteers
- 346 people
- Sponsor
- Janssen Research & Development, LLC
Spinal Surgery, Pain Intensity
Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP).
- Conditions
- Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine
- Trial name
- NCT07525999
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Peking University First Hospital
Healthy
Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered Esketamine
The purpose of this study is to evaluate the pharmacokinetics of intranasally administered esketamine in healthy Han Chinese, Korean, Japanese, and Caucasian participants and to evaluate the effects of rifampin on the…
- Trial name
- NCT02846519
- Testing
- Esketamine, Rifampin
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Chronic Visceral Pain, Major Depressive Disorder
Esketamine Adjuvant Therapy for Patients With Chronic Visceral Pain Comorbid Major Depressive Disorder
Ketamine is a dissociative anesthetic and powerful analgesic. At low doses, ketamine can desensitize the central pain pathway and modulate opioid receptors.
- Trial name
- NCT04847245
- Testing
- Pregabalin 75mg tid + Duloxetine, Intravenous administration of esketamine 0.125 mg/kg+Duloxetine, Intravenous administration of esketamine 0.25 mg/kg +Duloxetine
- Volunteers
- 80 people
- Sponsor
- Peking University
Complex Regional Pain Syndromes, CRPS (Complex Regional Pain Syndromes)
Long-term Pain Modulation by Intravenous Esketamine in CRPS
Intravenous administration of esketamine is an effective recognized therapeutic option in refractory pain in CRPS, which sometimes in at least a part of the patients has a prolonged therapeutic effect.
- Trial name
- KetCRPS-2 (NCT05212571)
- Testing
- S-ketamine infusion inpatient setting, S-ketamine infusion outpatient setting
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Erasmus Medical Center