Clinical trials: Esketamine
Autism Spectrum Disorder
Esketamine and Propofol for Children With Autism Spectrum Disorder Undergoing Colonoscopy
The purpose of this study is to examine the dose-response relationship of esketamine in combination with propofol for children with Autism Spectrum Disorder undering colonoscopy.
- Trial name
- NCT05951465
- Testing
- Esketamine, Propofol
- Where
- China
- Volunteers
- 46 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Adults, Major Noncardiac Surgery
Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia…
- Conditions
- Adults, Major Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06859892
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Peking University First Hospital
Postoperative Pain, Acute, Anaesthetic
Analgesic Effect of Intraoperative Intravenous S-Ketamine During Total Knee Arthroplasty Surgery
Severe acute pain after total knee arthroplasty surgery has multiple implications for hospitals and patients, monopolising resources and affecting the quality of life.
- Trial name
- NCT05289050
- Testing
- sodium chloride (NaCl; 0.9%), S-ketamine
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Ling Dong
Postoperative Pain, Adults
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
A multicenter, randomized, open-label, active controlled pragmatic clinical trial that evaluates the safety and efficacy of S (+) -ketamine for postoperative acute pain in adults in perioperative settings.
- Conditions
- Postoperative Pain, Adults, Anesthesia
- Trial name
- NCT04837170
- Testing
- Conventional therapy + S (+)-Ketamine, Conventional therapy
- Volunteers
- 12,000 people
- Sponsor
- Chinese PLA General Hospital
Electroencephalogram (EEG), Anesthesia
The Effects of Different Anesthetics on the Brain's Neural Networks
This study aims to analyze the electroencephalographic power spectrum and connectivity during unresponsive states induced by propofol, esketamine and dexmedetomidine, respectively.
- Trial name
- NCT07644663
- Testing
- propofol, Dexmeditomidine, Esketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fudan University
Total Abdominal Hysterectomy
S Ketamine Use in Total Abdominal Hysterectomy
This study investigates the effect of low dose S+ketamine compared to placebo on cumulative morphine consumption at 24 hours in women undergoing open abdominal hysterectomy with remifentanil-propofol target controlled infusion.
- Trial name
- SKET (NCT02543385)
- Testing
- S Ketamine
- Sponsor
- KK Women's and Children's Hospital
Depressive Disorder
Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly Patients
Phase III, open label, randomised, multicentre, blind for evaluators clinical trial to evaluate the efficacy of esketamine nasal spray at flexible dosis compared to aripiprazole in elderly participants (>60 years) who suffer from…
- Trial name
- CESAR (NCT07153406)
- Testing
- Experimental regimen, Control regimen
- Where
- 9 sites in Spain
- Volunteers
- 220 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Depressive Symptoms
Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy
Esketamine, as a powerful analgesic intravenous anesthetic, has a rapid onset and elimination effect, does not inhibit spontaneous respiration, and can slightly stimulate the circulatory system.
- Trial name
- EDSOP (NCT06199011)
- Testing
- Esketamine hydrochloride, Opioid
- Volunteers
- 400 people
- Sponsor
- The Second Hospital of Anhui Medical University
Adjunctive Treatment of Major Depressive Disorder
A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO Study
The clinical trial is a Phase 2, double-blind, randomized, placebo controlled study in Major Depressive Disorder (MDD) participants currently treated with antidepressant therapy.
- Trial name
- NCT04103892
- Testing
- CLE-100
- Where
- 46 sites in United States, Puerto Rico
- Volunteers
- 146 people
- Sponsor
- Clexio Biosciences Ltd.
Depressive Disorder
Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State
Ketamine is an anaesthetic used in low doses to treat depressive disorders. A related molecule, Esketamine, has recently been launched on the market for the treatment of resistant depression.
- Trial name
- EXPEDIE (NCT06133309)
- Testing
- Experiential Phenomenological Interview
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Sepsis, Acute Lung Injury
Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery
This study is a randomized, double-blinded, controlled design. In this study, low doses of S-ketamine were selected for surgury treatment in septic patients under general anesthesia , Meanwhile, activity of HO-1 protein …
- Trial name
- NCT04873479
- Testing
- S-ketamine, saline
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tianjin Nankai Hospital
Depressive Disorder, Treatment-Resistant
A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression
The purpose of this study is to assess the safety and tolerability of esketamine nasal spray in participants with treatment-resistant depression (TRD).
- Trial name
- SUSTAIN-3 (NCT02782104)
- Testing
- Esketamine Nasal Spray
- Where
- 173 sites in United States, Argentina and 24 more
- Volunteers
- 1,148 people
- Sponsor
- Janssen Research & Development, LLC
Laparoscopic Cholecystectomy, Alleviate Postoperative Fatigue Syndrome
Esketamine Combined With Magnesium Sulfate for Postoperative Fatigue Syndrome in Patients Undergoing Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy (LC), although minimally invasive, is frequently associated with postoperative fatigue syndrome (POFS), which can delay recovery and prolong convalescence.
- Trial name
- NCT07131033
- Testing
- Esketamine, Magnesium sulfate, Esketamine and Magnesium sulfate
- Where
- China
- Volunteers
- 128 people
- Sponsor
- The Second People's Hospital of Huai'an
Prolonged Disorders of Consciousness
Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDoC) are pathologies in which there is a loss of consciousness for more than 28 days. The number of patients with pDoC is increasing as the level of critical care treatment and monitoring…
- Trial name
- NCT06473285
- Testing
- Drug: Esketamine (Continuous infusion)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
General Anesthesia, Thoracic Surgery
Esketamine Anesthesia in Thoracic Surgery
Patients in the esketamine group was induced with esketamine 0.5 mg/kg, propofol 2 mg/kg, and rocuronium 0.9 mg/kg. Anesthesia is maintained with propofol 5 mg/kg/h and esketamine 0.5 mg/kg/h.
- Trial name
- NCT06310785
- Testing
- Esketamine, Sufentanil
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Hui Xu
Anesthesia
Comparison of the Effects of Esketamine, Sufentanil, or Lidocaine on Tussis Reflection During Upper Gastroscopy
the frequency of tussis, nausea and vomiting, and/or body movements observed at the insertion of the endoscope into the pharyngeal cavity or within 5 min of endoscope insertion.
- Trial name
- NCT05497492
- Testing
- propofol, propofol and sufentanil, propofol and esketamine
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Allergic Rhinitis
Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal Esketamine
The purpose of this study is to evaluate the effects of allergic rhinitis (group of symptoms affecting the nose) and co-administration of mometasone or oxymetazoline on the pharmacokinetics (explores what the body does to the…
- Trial name
- NCT02154334
- Testing
- Esketamine, Mometasone, Oxymetazoline
- Where
- Germany
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Treatment Resistant Major Depressive Disorder
Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant Depression
To examine the efficacy of Almond Therapy compared to Treatment as Usual when used in addition to an approved version of intranasal esketamine.
- Trial name
- ZYL-730-01 (NCT05323019)
- Testing
- Psychotherapy, Treatment as Usual, Intranasal Ketamine (esketamine)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Zylorion Health
Esketamine, Loop Electrosurgical Excision
Anesthesia for Loop Electrosurgical Excision Procedure (LEEP).
The goal of this prospective, randomized controlled study study is to investigate the efficacy and safety of propofol combined with different doses of esketamine (ESK) for anesthesia during loop electrosurgical excision procedure…
- Conditions
- Esketamine, Loop Electrosurgical Excision, Propofol
- Trial name
- ESK，LEEP (NCT06574945)
- Testing
- intravenous injection of propofol only, intravenous injection of propofol +esketamine
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Qian Wu
Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality
The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy
BACKGROUND: Some studies have revealed that intravenous dexmedetomidine and esketamine improve the quality of sleep after surgery.
- Trial name
- NCT06414941
- Testing
- Dexmedetomidine administration, Dexmedetomidine plus low-dose esketamine administration, Dexmedetomidine plus high-dose esketamine administration
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital