Clinical trials: Esketamine, open to volunteers
Major Depressive Disorder
Mitochondrial Function After Ketamine
The goal of this observational study is to learn about the role of mitochondria in response to S-ketamine. in individuals with Treatment-Resistant Depression. the Research Questions are 1.
- Trial name
- NCT07399756
- Testing
- S (+) Ketamine
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Autism Spectrum Disorder
The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavioral Changes in Children With Autism Spectrum Disorder
The goal of this clinical trial is to learn whether intranasal sedation given before anesthesia can lower negative postoperative behavioral changes in children with autism spectrum disorder who undergo elective surgery.
- Trial name
- NPOBCs (NCT07324057)
- Testing
- Intranasal dexmedetomidine, Intranasal Esketamine, saline control
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Fei
Suicide Prevention, Ketamine
Esketamine Versus Crisis Response Planning Versus Enhanced Treatment as Usual for Suicide Prevention: A Pragmatic Randomized Trial in a Brazilian Municipality (SAVE)
The SAVE study will test whether a single esketamine infusion or a single Crisis Response Planning session, each added to enhanced treatment as usual, reduces future suicide-related events compared with enhanced treatment as…
- Conditions
- Suicide Prevention, Ketamine, Crisis Response Plan
- Trial name
- SAVE (NCT07120477)
- Testing
- Intravenous Esketamine, Crisis Response Planning (CRP), Enhanced Treatment as Usual (eTAU)
- Where
- Brazil
- Volunteers
- 478 people
- Sponsor
- University of Sao Paulo
Endometriosis, Chronic Pelvic Pain Syndrome
Esketamine as Treatment for Chronic Pain Due to Endometriosis: a RCT Study
The goal of this randomized controlled trial is to investigate the effect of esketamine versus placebo on the NRS score for chronic pelvic pain.
- Trial name
- EASYlight (NCT06161805)
- Testing
- Esketamine hydrochloride
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Reinier de Graaf Groep
Adverse Respiratory Events, Hypoxemia
Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy
Gastroscopy is important for diagnosing and treating upper gastrointestinal diseases in children. To ensure the procedure is safe and smooth, most children require sedation.
- Conditions
- Adverse Respiratory Events, Hypoxemia, Children, Gastroscopy
- Trial name
- NCT07748884
- Testing
- Fentanyl and Propofol, Esketamine and remimazolam
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Major Depressive Disorder
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large…
- Trial name
- NCT05450432
- Testing
- Ketamine, Esketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Knee Osteoarthritis, Replacement, Knee
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
The goal of this clinical trial is to determine the appropriate Bispectral Index (BIS) range and propofol effect-site concentration required to maintain adequate anesthesia depth during total intravenous anesthesia (TIVA)…
- Conditions
- Knee Osteoarthritis, Replacement, Knee, Elective Surgical Patients, ASA Class I/II Patients
- Trial name
- NCT07736352
- Testing
- Propofol + Remifentanil +Midazolam, Propofol + Remifentanil + Dexmedetomidine, Propofol + Remifentanil + Esketamine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Depth of Anesthesia Monitoring, BIS-EEG
The Effects of Midazolam, Dexmedetomidine, and Esketamine on Bispectral Index and Raw Electroencephalogram in Patients Under Propofol-Remifentanil Baseline Anesthesia
This prospective, single-center, randomized interventional study aims to investigate the effects of commonly used adjunct anesthetic drugs on the Bispectral Index (BIS) and electroencephalographic (EEG) activity during total…
- Trial name
- NCT07699523
- Testing
- Midazolam, Dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Depression, Anxiety
Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression
A Dual-Center, Randomized, Controlled, Blinded, Prospective Study on the Effects of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients with Mild-to-Severe Depression
- Conditions
- Depression, Anxiety, S-ketamine, Breast Cancer
- Trial name
- NCT07374198
- Testing
- Esketamine 0.3mg/kg, normal saline
- Volunteers
- 142 people
- Sponsor
- Chinese PLA General Hospital
Senile Pruritus
The Effect of Intraoperative Esketamine Infusion on Pruritus in Elderly Surgical Patients
To explore the effect of intraoperative esketamine on pruritus in elderly patients undergoing elective general anesthesia for knee replacement surgery
- Trial name
- NCT07597486
- Testing
- Esketamine, Normal Saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Tianjin Medical University General Hospital
Urinary Catheter, Catheter-related Bladder Discomfort
Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort
Catheter-related bladder discomfort (CRBD) is common in patients awaking from general anesthesia with an urinary catheter. We suppose that that use of dexmedetomidine and/or esketamine during anesthesia may reduce the occurrence…
- Conditions
- Urinary Catheter, Catheter-related Bladder Discomfort, Dexmedetomidine, Esketamine
- Trial name
- NCT06399185
- Testing
- Normal saline, Dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 1,740 people
- Sponsor
- Peking University First Hospital
Cesarean Section (MeSH: D002585), Postoperative Pain After Cesarean Section
Esketamine Combined With Transcutaneous Electrical Acupoint Stimulation on Postoperative Recovery Quality After Elective Cesarean Section
This study is a prospective randomized controlled trial aimed at evaluating whether the combination of esketamine and transcutaneous electrical acupoint stimulation (TEAS) can improve the quality of postoperative recovery in…
- Conditions
- Cesarean Section (MeSH: D002585), Postoperative Pain After Cesarean Section, Enhanced Recovery After Surgery
- Trial name
- NCT07916051
- Testing
- Esketamine, Active TEAS, Normal Saline
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
Major Depressive Disorder
Positioning of Esketamine Treatment in the Real-world Management of Depression
The goal of this naturalistic, open label, single arm intervention study is to investigate the effects of Esketamine in treating depression.The main aims to answer are: to investigate whether Esketamine is effective when added to…
- Trial name
- PoET (NCT06103760)
- Testing
- Esketamine Nasal Spray [Spravato]
- Where
- Australia
- Volunteers
- 162 people
- Sponsor
- Royal North Shore Hospital
Chronic Pain, Postoperative
Effect of Low-Dose Esketamine Combined With Dexmedetomidine on the Incidence of Chronic Postsurgical Pain in Patients Undergoing Pancreatic Surgery
The goal of this clinical trial is to learn if low-dose esketamine combined with dexmedetomidine can reduce chronic pain after pancreatic surgery in adults. It will also learn about its safety.
- Trial name
- NCT07888413
- Testing
- Esketamine combined with dexmedetomidine
- Volunteers
- 450 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Postoperative Chronic Pain
Effect of Esketamine and Lidocaine on Postoperative Chronic Pain and Long-term Survival in Patients Undergoing Hepatectomy
This study is a further observation and follow-up of the patients enrolled in the registration number ChiCTR230007164430 to further evaluate the effect of long-term infusion of esketamine and lidocaine on postoperative chronic…
- Trial name
- NCT06778460
- Testing
- Esketamine-lidocaine group
- Where
- China
- Volunteers
- 304 people
- Sponsor
- West China Hospital
Postoperative Pain
Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT（ESSENCE）
This national, multi-center, randomized controlled study, through the study of intravenous injection of estaketamine in elderly patients undergoing surgery, is expected to explore whether estaketamine can improve the acute…
- Trial name
- NCT07063108
- Testing
- Esketamine hydrochloride, Saline
- Volunteers
- 276 people
- Sponsor
- Chinese PLA General Hospital
Hip Fractures
Effects of Esketamine Combined With Dexmedetomidine on Postoperative Sleep Quality
1. Eligible patients are randomly divided into experimental and control groups； 2. The experimental group is given esketamine combined with dexmedetomidine，while the control group is given normal saline； 3.
- Trial name
- NCT07002723
- Testing
- Esketamine combined with dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking University Shenzhen Hospital
MDD, Severe Depression
At-Home tDCS as Maintenance Therapy
The primary purpuse of this pilot study is to find out whether a home-based transcranial direct current stimulation (tDCS) program is feasible and well tolerated as maintenance therapy and whether there are early signs that it…
- Conditions
- MDD, Severe Depression, Major Depressive Episode
- Trial name
- MaintenanceDC (NCT07269964)
- Testing
- tDCS
- Where
- 2 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Thyroidectomy, Coughing Reflex
The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery
This study intends to conduct a prospective randomized controlled trial to implement esketamine-assisted anesthesia in patients undergoing open thyroidectomy, in order to observe the effect of esketamine on coughing during…
- Trial name
- NCT07625826
- Testing
- Esketamine, Normal Saline
- Where
- China
- Volunteers
- 136 people
- Sponsor
- The Second Hospital of Anhui Medical University
Depression and Quality of Life, Treatment Resistant Depression (TRD)
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
This observational study investigates the use of Esketamine Intranasal Spray in patients with Treatment-Resistant Depression in Real-World Settings.
- Conditions
- Depression and Quality of Life, Treatment Resistant Depression (TRD), Anhedonia, Apathy
- Trial name
- ESKPSY (NCT07146503)
- Testing
- Esketamine (Intranasal Spray)
- Where
- 5 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Riccardo Guglielmo