Clinical trials: Esophageal Atresia
Atresia Esophagus
A Study of Patients Undergoing Surgical Treatment for Oesophageal Atresia
Oesophageal atresia (EA) is a rare congenital anomaly whose prevalence varies between 1 and 2 per 5000 live births in Europe. This condition is characterised by an interruption of the oesophagus often associated with the presence…
- Trial name
- NCT06286826
- Testing
- Postero-lateral thoracotomy, Minithoracotomy
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Meyer Children's Hospital IRCCS
Esophageal Atresia With Tracheoesophageal Fistula
Swallowing, Feeding and Eating in Children Born With Oesophageal Atresia/Trache-oesophageal Fistula (OA/TOF)
How does oesophageal atresia/trache-oesophageal fistula affect feeding and swallowing in the first year of life? Approximately 150 babies a year are born with oesophageal atresia and/or trache-oesophageal atresia.
- Trial name
- SaFE (NCT04183621)
- Testing
- high resolution impedance manometry
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Esophageal Varices
Wired Magnetically Assisted Capsule Endoscopy and Esophageal Varices
The goal of this clinical trial is to compare the safeness and effectiveness of traditional esophagogastroduodenoscope (EGD) and wired magnetically assisted capsule endoscopy (MACE) in the diagnosis of esophageal varices in…
- Trial name
- NCT06017102
- Testing
- wired magnetic assisted capsule endoscopy, esophagogastroduodenoscopy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Esophageal Atresia, Digestive System Abnormalities
Flourish™ Pediatric Esophageal Atresia
This study is continued evaluation of the safety and probable benefit of the Flourish Pediatric Esophageal Atresia device through the Humanitarian Device Exemption (HDE) pathway.
- Conditions
- Esophageal Atresia, Digestive System Abnormalities, Esophageal Disorders Congenital
- Trial name
- NCT03615495
- Testing
- Flourish Pediatric Esphogeal Atresia device
- Where
- 12 sites in United States, Canada
- Volunteers
- 21 people
- Sponsor
- Cook Research Incorporated
Esophageal Atresia
National Register of Oesophageal Atresia
The esophageal atresia is a group of birth defects including a break in continuity of the esophagus with or without persistent communication with the trachea (tracheoesophageal fistula), sometimes associated (from 50%) of other…
- Trial name
- REGATE (NCT02883725)
- Testing
- data collection
- Where
- 37 sites in France, Guadeloupe and 1 more
- Volunteers
- 1,460 people
- Sponsor
- University Hospital, Lille
One Lung Ventilation OLV, Esophageal Atresia
The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.
The children who will undergo OLV (one lung ventilation) through general anesthesia will be divided into two groups: The first will be intravenous infusion of dexmedetomidine at 0.4 mcg / kg / hour, and the second will be…
- Conditions
- One Lung Ventilation OLV, Esophageal Atresia, Hydrocystoma, Pneumonectomy
- Trial name
- RCT (NCT04932746)
- Testing
- Dexmedetomidine
- Where
- Syria
- Volunteers
- 110 people
- Sponsor
- Damascus University
Esophageal Atresia, Tracheoesophageal Fistula
Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair
This trial will compare the effectiveness of two common surgical practices for Type C esophageal atresia repair: esophageal atresia (EA) with distal tracheoesophageal fistula (TEF).
- Trial name
- TEF (NCT03730454)
- Testing
- Transanastomotic Tube (5FR), No Transanastomotic Tube
- Where
- 10 sites in United States
- Volunteers
- 142 people
- Sponsor
- Phoenix Children's Hospital
Esophageal Atresia
Endoscopic Ultrasound Findings in Esophageal Atresia Following Surgical Repair
Children with esophageal atresia who undergo surgical repair are at risk for anastomotic stricture following surgery. Esophageal stricture can be treated with serial endoscopic dilation but may ultimately need surgical resection…
- Trial name
- NCT04259528
- Testing
- Pediatric endoscopic ultrasound
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Esophageal Atresia
Omega 3 Fatty Acid Treatment for Pediatric Musculoskeletal Health
This is a randomized clinical trial comparing Omegaven® treatment with standard of care (soybean-based lipid formulation, Intralipid®) on bone health outcomes in infants with esophageal atresia (EA) undergoing surgical repair at…
- Trial name
- NCT03127345
- Testing
- Omegaven, Intralipid
- Sponsor
- Boston Children's Hospital
Antenatal Management of the Fetal Gastrointestinal Atresia
Prenatal Diagnosis of the Fetal Esophageal or Intestinal Atresia
Aim- to investigate how prenatal diagnosis of fetal esophageal or intestinal atresia impacts obstetric and neonatal outcomes. Methods- This was a retrospective cohort study at a single center.
- Trial name
- DANATRESIA (NCT05362604)
- Testing
- scheduled delivery at a tertiary center
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Poitiers University Hospital
Gastroesophageal Reflux, Esophageal Atresia
Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.
The purpose of this study is to compare the efficacy of oral and rectal omeprazole treatment in infants with gastroesophageal reflux due to esophageal atresia or congenital diaphragmatic hernia.
- Conditions
- Gastroesophageal Reflux, Esophageal Atresia, Hernia, Diaphragmatic
- Trial name
- NCT00226044
- Testing
- Omeprazole rectally 1mg/kg
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Rijnstate Hospital
Congenital Malformation
The Impact of the Birth of a Child With a Rare Abdomino-thoracic Malformation
Qualitative study in psychology whose main objective is to propose a grounded theory to report the dynamics of parental adjustment for the period from the announcement of the diagnosis to one year of the child affected by a rare…
- Trial name
- INEMAT (NCT03565822)
- Testing
- Interview
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Water-Electrolyte Imbalance, Intensive Care Units
Fluid Overload and Pulmonary Function
Esophageal atresia is a rare but severe malformation, and it requires early surgery. Coloesophagoplasty is surgical repair of the esophageal with an isoperistaltic transverse colon graft.
- Conditions
- Water-Electrolyte Imbalance, Intensive Care Units, Pediatric, Critical Illness
- Trial name
- NCT05129930
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Pirogov Russian National Research Medical University
Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus
Azygos Vein Preservation; Its Impact on Early Outcomes After Neonatal EA/TOF Repair
Azygos vein preservation revisited: impact on early outcomes after repair of Esophageal atresia/ Tracheo-Esophageal Fistula in newborns. A randomized controlled study.
- Conditions
- Azygos Vein Preservation Versus Disconnection, Tracheo-Esophageal Fistula With Atresia of Esophagus, Leak, Anastomotic, Stricture Esophagus
- Trial name
- EArAzygousvp (NCT05957562)
- Testing
- EA/TOF primary repair with Azygos vein preservation, EA/TOF primary repair with Azygos vein sacrifice (disconnection)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Esophageal Atresia
Cardiorespiratory Performance and Pulmonary Microbiome in Patients After Repair of Esophageal Atresia
The majority of the clinical research on esophageal atresia focuses on the upper gastrointestinal tract. However, the trachea and the lung are also affected in many of these children, so that a lifelong pulmonary impairment may…
- Trial name
- NCT03767673
- Testing
- Initial Spirometry, Final Spirometry, Pulmonary microbiome (16S rDNA profiling)
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Oesophageal Atresia, Dumping Syndrome
Dumping Syndrome After Operation of Esophageal Atresia Type III
The purpose of this study is to evaluate the prevalence at 3.5 months of age of dumping syndrome in children operated at birth for oesophageal atresia type III et IV.
- Trial name
- DUMPING (NCT02525705)
- Testing
- Oral Glucose
- Where
- 10 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Lille
Esophageal Atresia, Enhanced Recovery After Surgery
Application of Enhanced Recovery After Surgery for Congenital Esophageal Atresia During Perioperative Period
The purpose of this prospective cohort study is to evaluate the safety and effectiveness of enhanced recovery after surgery (ERAS) to perform routine thoracoscopic repair for elective esophageal atresia type C
- Trial name
- ERASforCEA (NCT04072419)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Gastroesophageal Reflux, Esophagus, Barrett
Esophageal Atresia: Metaplasia, Barrett
The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to…
- Trial name
- Oesophagix (NCT02495051)
- Testing
- esophageal biopsies
- Where
- 20 sites in Belgium, Canada and 2 more
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille
Tracheo Esophageal Fistula
Inverse Ratio Ventilation in Neonatal Open Repair of Tracheoesophageal Fistula.
Background and Objectives: Maintaining oxygenation during neonatal open repair of esophageal atresia is difficult. Inverse ratio ventilation can be used during one lung ventilation (OLV) to improve the oxygenation and lung…
- Trial name
- NCT05150600
- Testing
- Inverse Ratio Ventilation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Esophageal Atresia, Healthy Children
Symptoms, Pulmonary Function, Muscle Strength, Exercise Capacity, and Frailty in Esophageal Atresia vs. Healthy Peers
Esophageal atresia is the most common congenital anomaly of the esophagus and is caused by abnormal development of the esophagus during intrauterine life.
- Trial name
- NCT06975982
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University