Clinical trials: Esophageal Carcinoma
Esophageal Cancer, Reflux, Gastroesophageal
Evaluating Acid Reflux After Oesophageal Stenting Using Anti-reflux Stents
Incurable oesophageal cancer remains a global problem and in South Africa the vast majority of patients with oesophageal cancer have advanced disease at first presentation and are not curable.
- Trial name
- NCT05303298
- Testing
- Anti-reflux oesophageal stent, Conventional oesophageal stent
- Where
- South Africa
- Volunteers
- 72 people
- Sponsor
- University of Cape Town
Advanced Solid Tumours, Non-Small Cell Lung Cancer
BT1718 in Patients with Advanced Solid Tumours.
This clinical trial is looking at a drug called BT1718 in adult patients with advanced solid tumours. The main aim of the study is to find the maximum dose of BT1718 that can be given safely to patients; learn more about the…
- Conditions
- Advanced Solid Tumours, Non-Small Cell Lung Cancer, Non-Small Cell Lung Sarcoma, Oesophageal Cancer
- Trial name
- NCT03486730
- Testing
- BT1718
- Where
- 6 sites in United Kingdom
- Volunteers
- 72 people
- Sponsor
- Cancer Research UK
Cancer of the Esophagus
Phase I/II Study of Panitumumab, Capecitabine and Oxaliplatin w EBRT for Esophageal Cancer
The primary purpose of this trial is to define the maximum tolerated and/or recommended phase II dose of the combination of panitumumab, oxaliplatin and capecitabine in patients undergoing radiation therapy for carcinoma of the…
- Trial name
- POXX (NCT00578071)
- Testing
- Panitumumab, Capecitabine, Oxaliplatin
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Brian Czito
Lung Cancer, Esophageal Cancer
Investigating the Biomarkers in Tumor and Peripheral Blood to Evaluate the Efficacy of Cancer Immunotherapy in Chest Cancer Patients
This study aims to investigate the impact of immunotherapy on the immune status of tumor microenvironment and peripheral blood of chest cancer patients.
- Trial name
- NCT05789498
- Testing
- In vitro stimulation of Pbmc with tumor antigen nanoparticles
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhao Jun
Esophageal Cancer, Esophageal Carcinoma
Effect of Feeding Jejunostomy on Sarcopenia in Patients With Esophageal Cancer
Participants were diagnosed with esophageal cancer needing chemo- or radiochemotherapy before the potentially curing surgery consisting of esophagectomy.
- Conditions
- Esophageal Cancer, Esophageal Carcinoma, Sarcopenia, Feeding Tube
- Trial name
- NCT06712706
- Testing
- Feeding jejunostomy placement, Feeding jejunostomy placement at esophagectomy
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Stefan Gutknecht
Lung Cancer
Phase II Evaluation of Exhaled Nitric Oxide (NO)
The goal of this clinical research study is to learn if the level of nitric oxide you breathe out may relate to the amount of breathing complications that you may experience due to radiation treatment.
- Trial name
- NCT01392144
- Testing
- Nitric oxide breath test, Questionnaires
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- M.D. Anderson Cancer Center
Esophageal Squamous Cell Carcinoma
A Prospective Study of Apatinib Plus Concurrent Neoadjuvant Chemoradiotherapy in Patients With Esophageal Squamous Cell Carcinoma
The purpose of this study is to assess the efficacy and safety of apatinib plus concurrent neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma.
- Trial name
- NCT03857763
- Testing
- Apatinib,Paclitaxel,Cisplatin,RT
- Volunteers
- 40 people
- Sponsor
- Hebei Medical University Fourth Hospital
Oesophageal Cancer, Barrett Esophagus
Non-invasive Testing for Early oEesophageal Cancer and Dysplasia
This study aims to determine whether a breath test could be used for early detection of oesophageal cancer and Barrett's high grade dysplasia.
- Conditions
- Oesophageal Cancer, Barrett Esophagus, Barretts Esophagus With Dysplasia
- Trial name
- NEED (NCT04001478)
- Testing
- Breath test
- Where
- 12 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Metastatic Esophageal Cancer, Gastroesophageal Cancer
Phase II Study Using CHFR Methylation Status in Patients With Metastatic Esophageal, Gastroesophageal, Gastric Cancer.
To estimate and compare the response rates in patients treated with mDCF based on methylation status of CHFR.
- Conditions
- Metastatic Esophageal Cancer, Gastroesophageal Cancer, Gastric Cancer
- Trial name
- NCT01715233
- Testing
- Docetaxel, Leucovorin, Fluorouracil
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Oesophageal Squamous Cell Carcinoma, Oesophageal Adenocarcinoma
Breath Research Narrow Validation for Gastrointestinal Cancer Detection
The investigators of this study are developing a simple breath test to help detect gastrointestinal (gut) cancers earlier, including cancers of the oesophagus (food pipe), stomach, pancreas, liver and bowel.
- Conditions
- Oesophageal Squamous Cell Carcinoma, Oesophageal Adenocarcinoma, Gastric Adenocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC)
- Trial name
- BRAVE (NCT07714538)
- Where
- 6 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Esophageal Squamous Cell Carcinoma Stage II, Esophageal Squamous Cell Carcinoma Stage III
Toripalimab Adjuvant Therapy in Subjects With Resected Esophageal Squamous Cell Carcinoma Who Achieved Pathological Complete Response (pCR)
The goal of this clinical trial is to assess the 1-year DFS rate of toripalimab adjuvant therapy in participants with resected esophageal squamous cell carcinoma (ESCC) who achieved pCR.
- Trial name
- NCT06903871
- Testing
- TORIPALIMAB INJECTION(JS001 )
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Hebei Medical University Fourth Hospital
Neuromuscular Block, Esophageal Cancer
Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy
Rationale: Endoscopic (thoraco-laparoscopic) esophageal surgery is a high risk procedure where the use of deep neuromuscular block (NMB) may increase field visibility and anaesthesia conditions.
- Conditions
- Neuromuscular Block, Esophageal Cancer, Surgery
- Trial name
- DEPTH (NCT02320734)
- Testing
- Rocuronium
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Esophageal Squamous Cell Carcinoma
Sintilimab Plus NCT or NCRT Versus NCRT for ESCC
Comparative analysis of patients with resectable locally advanced esophageal squamous cell carcinoma treated with neoadjuvant chemotherapy or neoadjuvant chemoradiotherapy combined sintilimab versus neoadjuvant chemoradiotherapy.
- Trial name
- NCT05244798
- Testing
- Sintilimab, radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 420 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Gastro-entero-pancreatic Carcinoma, Esophageal Neuroendocrine Carcinoma
Octreotide LAR as Maintenance Treatment for Patients With NEC
This is phase II study on the efficacy of octreotide lar as maintenance treatment after first-line chemotherapy for patients with unresectable or metastatic gastro-entero-pancreatic or esophageal neuroendocrine carcinomas.
- Trial name
- NCT02409849
- Testing
- Octreotide lar
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Peking University
Esophageal Cancer
A Study With Peptide Vaccination in Treating Patients With Esophageal Cancer
The purpose of this study is to evaluate overall survival and immunological monitoring for peptide vaccination therapy using novel cancer testis antigens for locally advanced, recurrent, or metastatic esophageal squamous cell…
- Trial name
- NCT00995358
- Testing
- peptide
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- University of Yamanashi
ESCC
Immunotherapy Combined With Chemoradiotherapy for First-line Treatment of Esophageal Squamous Cell Carcinoma（ChinECR）
This trial aims to assess efficacy and safety of immunotherapy combined with chemoradiotherapy for first-line treatment of esophageal squamous cell carcinoma.
- Trial name
- NCT06478355
- Testing
- Immunotherapy, Chemotherapy drug, radiotherapy
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Hebei Medical University Fourth Hospital
Esophageal Cancer, Gastrointestinal Cancers
Single Dose Investigator Initiated Pilot Study to Investigate CYTALUX (Pafolacianine) for Intraoperative Detection of Malignant Tissue in Subjects Undergoing Surgical Resection for Cancer.
The goal of clinical trial is to test an FDA approved drug called Pafolacianine that attaches to cancer cells and lights up when seen through a special camera system in adults with a suspected primary diagnosis, or a high…
- Conditions
- Esophageal Cancer, Gastrointestinal Cancers, Gynecologic Cancers
- Trial name
- NCT07039526
- Testing
- CYTALUX™ (pafolacianine) injection preoperatively
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- John Waters
Esophagectomy, Esophageal Cancer
Outcomes After Esophagectomy With a Focus on Minimally Invasive Esophagectomy and Quality of Life
To assess short and long term outcomes after minimally invasive esophagectomy compared to open esophagectomy. To compare both standard outcome measures as well as patient derived outcome measures, in particular, quality of life…
- Trial name
- NCT00260559
- Testing
- Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 3,500 people
- Sponsor
- University of Pittsburgh
Breath Test, Oesophageal Cancer
Augmentation of Volatile Biomarkers of Oesophageal and Gastric Adenocarcinoma From the Tumour Lipidome
Nearly 10,000 people die each year in the United Kingdom from cancer of the lower gullet and stomach, known as known as oesophago- gastric adenocarcinoma (OGC).
- Conditions
- Breath Test, Oesophageal Cancer, Gastric Cancer, Augmentation
- Trial name
- AVOCADO (NCT05600608)
- Testing
- Oral Stimulant Drink
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Anuja Mitra
Cancer, Lung, Cancer of Esophagus
Radiogenomics in Aerodigestive Tract Cancers
Aerodigestive tract cancers are common malignancies. These cancers were ranked to be top-ten cancer-related deaths in Taiwan. Although many new target therapies and immunotherapies have emerged, many of the treatment eventually…
- Conditions
- Cancer, Lung, Cancer of Esophagus, Cancer of Head and Neck
- Trial name
- NCT04314349
- Where
- Taiwan
- Volunteers
- 139 people
- Sponsor
- Buddhist Tzu Chi General Hospital
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