Clinical trials: Esophageal Dysmotility
Hiatal Hernia Large, Reflux, Gastroesophageal
Platelet Rich Plasma in Hiatal Hernia Repair
Rationale: Gastroesophageal reflux disease (GERD) is a common disease caused by a dysfunctional lower esophageal sphincter and an abnormal esophageal hiatus or hiatal hernia.
- Trial name
- PPR-HHR (NCT05023174)
- Testing
- Hiatal Hernia Repair with Platelet Rich Plasma, Hiatal Hernia Repair without Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Southern California
Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction
The Impact of Anesthetics on FLIP
To understand the impact of commonly used anesthetics on esophageal motility during FLIP topography.
- Conditions
- Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction, Spastic Esophageal Disorders
- Trial name
- NCT07458555
- Testing
- FLIP Imaging under various standard of care anesthetics in the context of endotracheal intubation.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Gastroesophageal Reflux Disease, Erosive Esophagitis
Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets
The purpose of this study is to measure the in-vivo disintegration time of a single dexlansoprazole delayed-release orally disintegrating (OD) tablet.
- Conditions
- Gastroesophageal Reflux Disease, Erosive Esophagitis, Heartburn
- Trial name
- NCT02096458
- Testing
- Dexlansoprazole
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Takeda
GERD, Non-erosive Reflux Disease
Comorbid Esophageal Disorders in IBS Patients
assess the incidence of the entire spectrum of esophageal disorders and possible theories for overlap in IBS patients using different diagnostic modalities.
- Conditions
- GERD, Non-erosive Reflux Disease, Functional Esophageal Disorders, Irritable Bowel Syndrome
- Trial name
- NCT04759378
- Testing
- Upper endoscopy, esophageal manometry, 24-hour pH monitoring
- Volunteers
- 50 people
- Sponsor
- Assiut University
GERD
Melanole, a Dietary Supplement, for the Treatment of Gastroesophageal Reflux Disease
Melanole, a Nigella sativa (Black Seed) extract , is studied for the treatment of GERD. Participants, who meet the inclusion criteria, will be divided into two arms.
- Trial name
- GERDMeDS (NCT02587910)
- Testing
- Melanole for GERD treatment
- Where
- 2 sites in Lebanon
- Volunteers
- 170 people
- Sponsor
- Lebanese American University
Gastroesophageal Reflux
Fexofenadine Use in Gastroesophageal Reflux Symptoms
The investigators wish to study the effectiveness of Fexofenadine (an over the counter allergy pill) for the treatment of gastroesophageal reflux symptoms in patients who still have symptoms despite being on a proton pump…
- Trial name
- NCT03425097
- Testing
- Fexofenadine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stanford University
Barrett Esophagus, Gastroesophageal Reflux
Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus
The purpose of this research study is to assess how safe, effective (how well it works), and tolerable (to put up with) the drug Zegerid is in reducing reflux episodes in patients who have both gastroesophageal reflux disease…
- Trial name
- NCT01129778
- Testing
- Zegerid (proton pump inhibitor), Bravo pH monitoring
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Stanford University
Refractory Gastroesophageal Reflux Disease
Anti-reflux Mucosectomy (ARMS) is a Useful Therapy for Refractory Gastroesophageal Reflux Disease (RGERD)
Anti-reflux mucosectomy (ARMS) may be a new therapy for refractory gastroesophageal reflux disease (RGERD). The aim of the present study is to explore the safety and efficacy of ARMS.
- Trial name
- NCT03259191
- Testing
- anti-reflux mucosectomy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruihua Shi
Gastroesophageal Reflux Disease, Obesity
Waist Circumference Versus Body Mass Index to Predict Severity of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a common and important disorder. Previous studies have demonstrated the association of obesity with GERD, and now obesity is regarded as a risk factor for GERD.
- Trial name
- NCT00698178
- Testing
- Anthropometric measurements
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Lotung Poh-Ai Hospital
Gastroesophageal Reflux Disease
Laparoscopic Antireflux Surgery Versus Endoscopic Full-thickness Gastroplication for Gastroesophageal Reflux Disease (GERD)
Endoscopic full thickness gastroplication (Plicator-Procedure) has the potential to be a safe and effective alternative to laparoscopic antireflux surgery (LARS)to improve symptoms of GERD.
- Trial name
- NCT01324791
- Testing
- anti-reflux surgery
- Where
- Austria
- Sponsor
- General Public Hospital Zell am See
Regurgitation, Gastric
Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant Formula
A randomised, controlled, double-blind trial to evaluate the tolerance and safety of a new partly fermented anti-regurgitation infant formula containing prebiotics and locust bean gum in infants with regurgitation.
- Trial name
- Leopard (NCT03371615)
- Testing
- Anti-regurgitation infant formula
- Where
- 2 sites in Poland
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Obesity, GERD
Pharmacokinetics of Pantoprazole and CYP2C19 Activity in Children and Adolescents With GERD: A Pilot Study
The World Health Organization has declared childhood obesity to be "one of the most serious public health challenges of the 21st century," (http://www.who.int/dietphysicalactivity/childhood).
- Trial name
- NCT01887743
- Testing
- Pantoprazole
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
GERD
A Study to Compare PK, PD and Safety of UI058 and UIC202004 in Healthy Subjects
A Study to compare pharmacokinetics, pharmacodynamics and safety of UI058 and UIC202004 in healthy subjects
- Trial name
- NCT05282914
- Testing
- administration of UI058, administration of UIC202004
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Gastroesophageal Reflux Disease
Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies.
- Trial name
- NCT02934152
- Testing
- H pylori eradication, H pylori eradication timing
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
GERD
Gastric Neuromuscular Function in GERD
Bodysurface gastric mapping (BSGM) will be used to assess gastric neuromuscular function in healthy controls and patients with medical refractory gastroesophageal reflux disease (GERD).
- Trial name
- NCT05719168
- Testing
- Body Surface Gastric Mapping
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Functional Gut Clinic
Gastroesophageal Reflux (GER), Infants
Polaprezinc (Zinc L-carnosine) in Infants With Gastroesophageal Reflux
The goal of this clinical trial is to evaluate efficacy and safety of Zinc-L carnosine/Polaprezinc in infants with GER. Researchers will compare Zinc-L carnosine/Polaprezinc to a placebo (a look-alike substance that contains no…
- Trial name
- GER (NCT06678997)
- Testing
- Zinc-L carnosine/Polaprezinc, Thickened formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Erosive Esophagitis
Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.
The aim of the study is to compare the safety and efficacy of two doses of Nexium in maintaining healing of erosive esophagitis in patients 1 to 11 years of age.
- Trial name
- EE (NCT05267613)
- Testing
- Nexium 20mg, Nexium 10mg
- Where
- 41 sites in United States, Argentina and 8 more
- Volunteers
- 53 people
- Sponsor
- AstraZeneca
GERD
Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients
Researchers are trying to determine if abdominal breathing exercises can reduce symptoms associated with GERD (Gastroesophageal reflux disease).
- Trial name
- NCT04120025
- Testing
- Diaphragm Training
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Mayo Clinic
Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive
Randomized Controlled Study of Optical 3D Navigated Repetitive Transcranial Magnetic Stimulation for Achalasia.
The goal of this clinical trial is to investigate the clinical efficacy of repetitive transcranial magnetic stimulation in the treatment of achalasia in patients diagnosed with achalasia by comprehensive evaluation of clinical…
- Conditions
- Esophageal Achalasia, Transcranial Magnetic Stimulation, Repetitive, Vagus Nerve Motor Disorder, Functional Magnetic Resonance Imaging
- Trial name
- NCT06027190
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhang Nina
Gastroesophageal Reflux
Diagnostic Tests in Supra-Esophageal Gastroesophageal Reflux Disease (SE-GERD)
After defining the manometric characteristics of UES incompetence associated with documented pharyngeal reflux, we will determine the reproducibility of manometric criteria for UES incompetence in prevention of pharyngeal reflux.
- Trial name
- SE-GERD (NCT05695846)
- Testing
- externally applied cricoid cartilage pressure
- Where
- United States
- Sponsor
- Medical College of Wisconsin
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