Clinical trials: Esophageal Neoplasm
Colorectal Cancer, Esophageal Cancer
Clinical Study of CEA-targeted CAR-T Therapy for CEA-positive Advanced Malignant Solid Tumors
This trial is an open-label, single-arm clinical study. The main purpose is to verify the safety and efficacy of CAR-T cell preparations in the treatment of CEA-positive advanced malignant tumors, and to obtain the recommended…
- Conditions
- Colorectal Cancer, Esophageal Cancer, Stomach Cancer, Pancreatic Cancer
- Trial name
- NCT05415475
- Testing
- CEA CAR-T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Esophageal Cancer
Endoscopic Ultrasound Plus Submucosal Injection for Early Esophageal Cancer
Preoperative accurately staging T1a or T1b in early esophageal cancer is vital for the choices of treatment. At present, the main diagnostic method for early esophageal cancer is endoscopic ultrasound (EUS).
- Trial name
- NCT01555801
- Testing
- submucosal injection needle ; EUS, ordinary endosonography(EUS)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Carcinoma, Glioblastoma
MRinRT: Swansea University and SWWCC Collaboration Study.
The aim of this study is to learn whether using MRI (magnetic resonance imaging) scans to plan radiotherapy is better than using CT (computed tomography) scans alone.
- Conditions
- Carcinoma, Glioblastoma, Radiotherapy, MRI
- Trial name
- MRinRT (NCT07365124)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Esophagus Cancer, Esophagectomy
Comparison of Long-term Survival and Quality of Life After Minimally Invasive Esophagectomy Versus Open Esophagectomy
To analyze and compare the long-term recurrence-free survival rate, overall survival rate and quality of survival after minimally invasive esophagectomy and open esophagectomy, and to conduct subgroup analysis according to the…
- Conditions
- Esophagus Cancer, Esophagectomy, Quality of Life, Survival
- Trial name
- NCT06147180
- Where
- China
- Volunteers
- 1,474 people
- Sponsor
- Qilu Hospital of Shandong University
Esophageal Cancer
Study on the Design and Application of Special Semi Recumbent Cushion for Postoperative Patients With Esophageal Cancer
1. transform and produce the authorized utility model invention patent "a special cushion for semi recumbent position". 2. to verify the effect of using special semi recumbent cushion for postoperative patients with esophageal…
- Trial name
- NCT05542680
- Testing
- cushion
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Moderate Mitral Regurgitation
Moderate Mitral Regurgitation in CABG Patients
Background: The presence of a mild to moderate ischemic mitral regurgitation (IMR) results in a significantly reduced long-term survival and increased hospitalizations for heart-failure.
- Trial name
- MoMIC (NCT00613548)
- Testing
- CABG alone, CABG + Mitral repair
- Where
- Denmark
- Volunteers
- 550 people
- Sponsor
- University of Aarhus
Esophageal Squamous Cell Carcinoma
TPF Concurrent Chemo-radiotherapy Plus Immunotherapy for Local Advanced Esophageal Squamous Cell Carcinoma
The goal of this clinical trial is to learn if immune microenvironment modification could improve the effect of chemoradiotherapy for patients with local advanced esophageal squamous cell carcinoma.
- Trial name
- NCT06401447
- Testing
- Radiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fudan University
Non-Small-Cell Lung, Esophageal Cancer
Phase 1 Study of PF-08046033 in Advanced Solid Tumors
This is an early-stage (Phase 1) clinical study testing a new study medicine called PF-08046033. The goal of the study is to understand how safe the medicine is, how well people tolerate it, how it behaves in the body, and…
- Conditions
- Non-Small-Cell Lung, Esophageal Cancer, Cutaneous Melanoma
- Trial name
- NCT07519655
- Testing
- PF-08046033
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 250 people
- Sponsor
- Pfizer
Gastric Cancer, Esophageal Cancer
Magnetic Sentinel Lymph Node Mapping in Upper Gastro-Intestinal Cancer: A Feasibility Clinical Investigation
This is a multi-centre, partially blinded, side-by-side comparator study to assess the safety and tolerability, feasibility, and potential added diagnostic and clinical value of using the FerroTrace® and FerroMag Sentinel Lymph…
- Trial name
- MAGMAP (NCT05899985)
- Testing
- FerroTrace® and FerroMag Sentinel Lymph Node Mapping (SLNM) System
- Where
- 4 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Ferronova Pty Ltd
Lung Cancer
Prediction of Esophageal and Lung Toxicities After Radiation (Chemo) Therapy
(Chemo)-radiotherapy is the gold standard therapeutic treatment for patients with locally advanced lung cancer non accessible or ineligible for surgery.
- Trial name
- PTOP-RT (NCT04545658)
- Where
- France
- Volunteers
- 167 people
- Sponsor
- University Hospital, Brest
Esophageal Squamous Cell Carcinoma
Biomarker Based Neoadjuvant Strategies for Locally Advanced Resectable ESCC
This study aims to evaluate the impact of the neoadjuvant treatment strategy based on CPS score on the pathological complete response (pCR) rate in patients with resectable locally advanced esophageal cancer.
- Trial name
- ESCC (NCT06601309)
- Testing
- Serplulimab, Paclitaxel+Cisplatin (Neoadjuvant Chemotherapy), Paclitaxel+Cisplatin(Concurrent Chemoradiotherapy)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Neoplasms, Gastric Neoplasm
Prevalence of Sub-epithelial Lesions Among Patients Undergoing EGDs in Egypt
Subepithelial lesions (SEL) are incidentally observed in the stomach of about 0.3% of middle-aged men and women; half of these are neoplastic.
- Conditions
- Esophageal Neoplasms, Gastric Neoplasm, Duodenal Neoplasms
- Trial name
- NCT04622098
- Testing
- Endoscopic ultrasound
- Where
- Egypt
- Volunteers
- 2,000 people
- Sponsor
- Kafrelsheikh University
Esophageal Cancer
Total Intravenous Anesthesia and Recurrence Free Survival
The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or…
- Trial name
- NCT04513808
- Testing
- Propofol-based total intravenous anesthesia, Sevoflurane intravenous anesthesia
- Where
- China
- Volunteers
- 1,614 people
- Sponsor
- The Cleveland Clinic
Esophageal Adenocarcinoma, Esophagus SCC
Multiorgan Metabolic Imaging Response Assessment of Abemaciclib
Open-label, phase II, basket trial. This trial is a screening program for abemaciclib efficacy in multiple platinum-resistant tumour types by using metabolic imaging (PERCIST) and RECIST v1.1 criteria.
- Conditions
- Esophageal Adenocarcinoma, Esophagus SCC, Cholangiocarcinoma, Urothelial/Bladder Cancer, Nos
- Trial name
- MiMe-A (NCT03339843)
- Testing
- Abemaciclib
- Where
- 11 sites in Belgium, France
- Volunteers
- 85 people
- Sponsor
- Jules Bordet Institute
Stage I Adenoid Cystic Carcinoma of the Oral Cavity, Stage I Mucoepidermoid Carcinoma of the Oral Cavity
Esophagoscopy in Evaluating Treatment in Patients With Stage I-IV Head and Neck Cancer Who Are Undergoing Radiation Therapy and/or Chemotherapy
Brief Summary: RATIONALE: Comparing results of diagnostic procedures, such as esophagoscopy, done before and after radiation therapy and/or chemotherapy may help doctors predict a patient's response to treatment and help plan the…
- Conditions
- Stage I Adenoid Cystic Carcinoma of the Oral Cavity, Stage I Mucoepidermoid Carcinoma of the Oral Cavity, Stage I Squamous Cell Carcinoma of the Hypopharynx, Stage I Squamous Cell Carcinoma of the Larynx
- Trial name
- NCT01164566
- Testing
- endoscopic procedure, questionnaire administration
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wake Forest University Health Sciences
Esophageal Squamous Cell Carcinoma
Precision Medicine for Immunotherapy-Resistant Advanced Esophageal Cancer
This study is an open-label, biomarker-integrated umbrella trial designed to evaluate the clinical efficacy of molecular subtype- and genomic biomarker-guided precision therapies in patients with advanced esophageal cancer…
- Trial name
- ESCC-PT (NCT07653451)
- Testing
- Afatinib + Toripalimab, Dalpiciclib + Pyrotinib, Camrelizumab + Apatinib
- Volunteers
- 90 people
- Sponsor
- Peking University Cancer Hospital & Institute
Esophageal Squamous Cell Carcinoma (ESCC)
Neoadjuvant Immunotherapy Combined With Chemotherapy Sequenced With Endoscopic Resection for Esophageal Cancer (Endosurgery-02)
This single-center, prospective, single-arm study will evaluate whether giving neoadjuvant chemoimmunotherapy can safely shrink esophageal cancer and allow organ-preserving endoscopic removal in selected patients.
- Trial name
- Endosurgery-02 (NCT07317609)
- Testing
- Tislelizumab, Carboplatin, Nab-paclitaxel
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Zhongshan Hospital
Oesophageal Cancer
ROCS (Radiotherapy After Oesophageal Cancer Stenting) Study
The single most distressing symptom for more than 70% of patients with oesophageal cancer is difficulty in swallowing (dysphagia) caused by blockage of the gullet by a tumour.
- Trial name
- ROCS (NCT01915693)
- Testing
- Radiotherapy
- Where
- 17 sites in United Kingdom
- Volunteers
- 220 people
- Sponsor
- Lisette Nixon
Stage IV Esophageal Squamous Cell Carcinoma
Phase II Study of Maintenance Treatment of Nimotuzumab for Advanced Esophageal Carcinoma
There have been reports suggesting that anti-epidermal growth factor antibody nimotuzumab is advantageous for advanced esophageal cancer patients in combination with chemotherapy or radiotherapy.
- Trial name
- NCT02011594
- Testing
- Nimotuzumab
- Where
- 2 sites in China
- Sponsor
- Zhejiang University
Esophageal Squamous Cell Carcinoma
Paclitaxel Polymeric Micelles and Cisplatin Plus Sintilimab as Neoadjuvant Therapy for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma
Locally advanced Esophageal Squamous Cell Carcinoma (ESCC) has poor prognosis with standard therapies. Neoadjuvant immunochemotherapy improves pathological response rates, but optimal regimens remain undefined.
- Trial name
- NCT07799077
- Testing
- Paclitaxel polymer micelles for injection and cisplatin combined with sintilimab
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Hebei Medical University Fourth Hospital