Clinical trials: Esophageal Variceal Bleeding
Esophageal and Gastric Varices, Gastrointestinal Hemorrhage
Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis for Variceal Bleeding
Prophylactic antibiotics have been routinely recommended for cirrhotic patients with upper gastrointestinal bleeding recently. However, the regimen and duration of its use remain an inconclusive issue.
- Trial name
- NCT00838864
- Testing
- ceftrioxone
- Where
- Taiwan
- Volunteers
- 79 people
- Sponsor
- Far Eastern Memorial Hospital
Liver Cirrhosis, Esophageal and Gastric Varices
The Effect of Carvedilol Vs Propranolol in Cirrhotic Patients With Variceal Bleeding
To compare the efficacy and safety of Carvedilol and Propranolol in patients with cirrhosis-related esophagogastric varices after multiple endoscopic treatments for secondary prophylaxis.
- Conditions
- Liver Cirrhosis, Esophageal and Gastric Varices, Hemorrhage
- Trial name
- NCT02385422
- Testing
- Carvedilol, Propranolol
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Zhongshan Hospital
EUS Guided Cyanoacrylate Injection, Endoscopic Variceal Band Ligation
EUS Glue vs Endoscopic Variceal Band Ligation for Prevention of Rebleeding in Patients With HCC and EV Bleeding: a Retrospective Comparative Study
SP by EUS-CYA improves clinical outcomes (eg, EV rebleeding) in patients with HCC and prior EV bleeding when compared with SP by EGD-VBL
- Conditions
- EUS Guided Cyanoacrylate Injection, Endoscopic Variceal Band Ligation, Hepatocelular Carcinoma, Esophageal Variceal Bleeding
- Trial name
- EUSgluevsVBL (NCT04918459)
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Gastric Varices
Primary Prophylaxis of Gastric Variceal Bleed
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the prevention of gastric variceal bleeding.
- Trial name
- NCT02468180
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Liver Cirrhosis, Esophageal Varices
Banding Versus Propranolol for Primary Prophylaxis of Variceal Bleeding
Whether beta-blockers or banding is the best therapy for primary prophylaxis of variceal bleeding is subject to debate. A randomized comparison between the two treatments was performed in candidates for liver transplantation.
- Trial name
- NCT00337740
- Testing
- endoscopic variceal banding, propranolol
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Padova
Variceal Bleeding, Ultrasonography
Ultrasound Prediction of Esophageal Variceal Bleeding Risk
This prospective observational study aims to evaluate the accuracy of using routine abdominal ultrasound to predict the risk of esophageal variceal bleeding in adult patients with liver cirrhosis.
- Conditions
- Variceal Bleeding, Ultrasonography, Esophageal Bleeding, Esophageal Varices
- Trial name
- NCT07571876
- Volunteers
- 165 people
- Sponsor
- Assiut University
Gastric Variceal Hemorrhage
N-Butyl-2-Cyanoacrylate Injection Versus Band Ligation for Gastric Variceal Hemorrhage
The purpose of this study was to test the hypothesis by comparing the efficacy of cyanoacrylate injection (GVO) and band ligation (GVL) in the treatment of acute GVH in liver cirrhotic patients with or without concomitant…
- Trial name
- NCT00292331
- Testing
- cyanoacrylate injection to treat gastric variceal hemorrhage
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Bleeding Esophageal
The Validation of Rockall Scoring System in Predicting Outcomes From Variceal Bleeding
Objective This study aims to evaluate the validation of the Rockall scoring system in predicting the outcomes of variceal bleeding among Sudanese patients.
- Trial name
- NCT06147115
- Testing
- Assessment tool to determine severity of GI bleeding
- Volunteers
- 150 people
- Sponsor
- National Center for Gastroentestinal and Liver Disease
Liver Cirrhosis, Esophageal and Gastric Varices
Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails
To observe and access the Effects and safety of terlipressin or high dose somatostatin/octreotide when usual dose somatostatin/octreotide fail to achieve hemostasis in patients with acute variceal bleeding.
- Conditions
- Liver Cirrhosis, Esophageal and Gastric Varices, Hemorrhage
- Trial name
- CER:T (NCT02311608)
- Testing
- Terlipressin, Usual Dose Somatostatin/Octreotide, High Dose Somatostatin/Octreotide
- Where
- China
- Volunteers
- 1,320 people
- Sponsor
- Shanghai Zhongshan Hospital
Porto-Sinusoidal Vascular Disease, Cirrhosis Due to Hepatitis B
TIPS for Platinum-Related Porto-Sinusoidal Vascular Disease With Variceal Bleeding
Platinum-based compounds are associated with several adverse effects, including Porto-Sinusoidal Vascular Disease (PSVD). Therapeutic strategies for platinum-related PSVD are based on the management of complications seen in…
- Conditions
- Porto-Sinusoidal Vascular Disease, Cirrhosis Due to Hepatitis B, Esophageal Variceal Rebleeding, Gastric Variceal Bleeding
- Trial name
- NCT06635122
- Testing
- Transjugular intrahepatic portosystemic shunt, Endoscopic treatment
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Air Force Military Medical University, China
Esophageal Varices
Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding
Carvedilol versus endoscopic band ligation for primary prophylaxis of oesophageal variceal bleeding in cirrhotic patients with arterial hypertension
- Trial name
- NCT04499898
- Testing
- Carvedilol, Endoscopic band ligation
- Where
- Egypt
- Volunteers
- 306 people
- Sponsor
- Sherief Abd-Elsalam
Cirrhosis, Hypertension, Portal
Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal Bleeding
This is a prospective, double blind controlled trial in which patients with esophagic variceal bleeding treated with standard therapy (endoscopic variceal ligation(EVL) + B-blockers), will be randomized to receive statins or…
- Conditions
- Cirrhosis, Hypertension, Portal, Bleeding Esophageal Varices, Portal Vein Thrombosis
- Trial name
- NCT01095185
- Testing
- Simvastatin
- Where
- 15 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Juan A. Arnaiz
Acute Bleeding Esophageal Varices
RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
The mortality rates from Acute Variceal Haemorrhage remain significant and first line therapy may fail in 15-25% of patients. The self-expandable metal stent has been described in case series as having a very high efficacy at…
- Trial name
- SOV (NCT01851564)
- Testing
- Self-expanding mesh-metal oesophageal stent (SEMS), Standard Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College, London
Variceal Bleeding, Endoscopic Variceal Ligation
Monthly Versus Biweekly Endoscopic Variceal Ligation for the Prevention of Esophageal Variceal Rebleeding
Endoscopic variceal ligation (EVL) has proved to be effective in the prevention of esophageal variceal rebleeding. However, the optimal interval of EVL remains unclear.
- Trial name
- NCT01809535
- Testing
- Wilson-Cook four shooter saeed multi-band ligator
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Acute Bleeding Esophageal Varices, Portal Hypertension
A Trial of Somatostatin With Endoscopic Variceal Ligation (EVL) in Control of Acute Variceal Bleeding
Background: Efficacy of endoscopic variceal sclerotherapy in achieving initial control of acute variceal bleeding and five-day haemostasis has been shown to significantly improve when vasoactive drug is added.
- Conditions
- Acute Bleeding Esophageal Varices, Portal Hypertension, Cirrhosis
- Trial name
- AVB-EVL+S (NCT01267669)
- Testing
- Somatostatin
- Where
- India
- Volunteers
- 61 people
- Sponsor
- Govind Ballabh Pant Hospital
Liver Cirrhoses, Variceal Hemorrhage
HVPG-Guided Therapy vs Carvedilol Plus Endotherapy for the Prevention of Esophageal Variceal Rebleeding in Cirrhotic Patients
Variceal bleeding is a major complication of cirrhosis, associated with a hospital mortality rate of 10%-20%. Surviving patients are at high risk for recurrent hemorrhage.
- Conditions
- Liver Cirrhoses, Variceal Hemorrhage, Esophageal Varices
- Trial name
- NCT04254822
- Testing
- Transjugular intrahepatic portosystemic shunt, Carvedilol, Endoscopic variceal ligation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Air Force Military Medical University, China
Esophageal and Gastric Varices
Comparison of Endoscopic Band Ligation Plus 24-hour Versus 72-hour Terlipressin Therapy
In the Western world, liver cirrhosis is a significant issue. Acute variceal bleeding (AVB) is a considerable complication of cirrhosis associated with high mortality.
- Trial name
- NCT05331768
- Testing
- banding ligation plus terlipressin infusion
- Where
- Mexico
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis
TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
To date, there is no treatment strategies for these patients according to American Association of the Study of Liver Disease (AASLD) practice guidelines and Baveno V consensus.
- Conditions
- Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis, Liver Cirrhosis, Bleeding Esophageal Varices
- Trial name
- NCT02853526
- Testing
- TIPS, Propranolol, Endoscopic therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zaibo Jiang
Acute Esophageal Variceal Hemorrhage
Life-2023-02 Esophagogastric Variceal Bleeding
Study on the efficacy of the growth inhibitors after endoscopic treatment of acute esophagogastric variceal bleeding
- Trial name
- NCT06011980
- Testing
- Growth Inhibitor
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Gastroesophageal Variceal Bleeding
Comparison of Early Vs Delayed Feeding on Rebleeding Following Endoscopic Ligation for Acute Esophageal Variceal Bleeding
Following endoscopic therapy of variceal bleeding, the issue of when to refeed these patients has rarely been investigated. This may imply that feeding is generally regarded as a negligible factor in the management of bleeding…
- Trial name
- EVLF (NCT03306095)
- Testing
- Early refeeding group, Delayed refeeding group
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Dayanand Medical College and Hospital