Clinical trials: Esophagectomy
Esophagectomy, Pneumonectomy
Stellate Ganglion Block
The purpose of this study is to determine if the addition of an ultrasound guided left sided stellate ganglion block with bupivacaine in patients undergoing esophagectomy, pneumonectomy, or lobectomy will result in lower rates of…
- Conditions
- Esophagectomy, Pneumonectomy, Lobectomy
- Trial name
- NCT06271707
- Testing
- 0.5% bupivacaine, Saline
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Minnesota
Esophageal Cancer, Adenocarcinoma, Esophageal
Preoperative Chemotherapy vs. Chemoradiation in Esophageal / GEJ Adenocarcinoma
The best treatment for resectable esophageal or gastroesophageal adenocarcinoma is unknown. Although an operation to remove the esophagus is the most common treatment, previous studies have shown that patients live longer when…
- Conditions
- Esophageal Cancer, Adenocarcinoma, Esophageal, Adenocarcinoma, Gastroesophageal Junction
- Trial name
- POWERRANGER (NCT01404156)
- Testing
- (Epirubicin Cisplatin 5-Fluorouracil / Xeloda) OR 5-Fluorouracil Leucovorin Oxaliplatin Docetaxel, Carboplatin paclitaxel plus concurrent radiotherapy
- Where
- 3 sites in Canada
- Volunteers
- 29 people
- Sponsor
- Dr. Gordon Buduhan
Esophageal Neoplasms, Lymph Node Metastases
Distribution of Lymph Node Metastases in Esophageal Carcinoma
Background: Lymph node status is an important prognostic parameter in esophageal carcinoma and an independent predictor of survival.
- Trial name
- TIGER (NCT03222895)
- Where
- 19 sites in United States, Brazil and 12 more
- Volunteers
- 5,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Esophageal Cancer
Open Versus Laparoscopically-assisted Esophagectomy for Cancer
To compare laparoscopically-assisted gastric mobilization versus open gastric mobilization in Ivor-Lewis esophagectomy for esophageal cancer, with open thoracic approach in the 2 arms.
- Trial name
- NCT00937456
- Testing
- Laparoscopically-assisted esophagectomy
- Where
- 11 sites in France
- Volunteers
- 207 people
- Sponsor
- University Hospital, Lille
Epidural Block, Oesophageal Cancer
The Hemodynamic Effect Between Two Types of Anesthesia in Esophageal Surgery
Continuous Paravertebral block (PVB) was reported to provide less episodes of hypotension than continuous thoracic epidural block (TEB).
- Conditions
- Epidural Block, Oesophageal Cancer, Oesophagectomy
- Trial name
- HEMOBLOC (NCT03185403)
- Testing
- paravertebral block, thoracic epidural block, ropivacaine
- Where
- France
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Sarcopenia, Malnutrition
Prognostic Value of CT-guided Sarcopenia for Surgical Outcomes in Esophagetomy and Total Gastrectomy Due to Neoplasia
The purpose of this study is to assess the degree of sarcopenia by CT and to analyze its association with morbidity and mortality after esophagectomy and / or total gastrectomy.
- Conditions
- Sarcopenia, Malnutrition, Gastrostomy, Esophagostomy Complication
- Trial name
- NCT05723783
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Barretos Cancer Hospital
Esophageal Neoplasms, Cancer of Esophagus
Mayo Clinic Upper Digestive Disease Survey
The Mayo Clinic Conduit Report Card Questionnaires have been created in order to have a consistent evaluation tools for patients undergoing esophageal reconstruction or treatment or patients that are experiencing an upper…
- Conditions
- Esophageal Neoplasms, Cancer of Esophagus, Cancer of the Esophagus, Esophageal Cancer
- Trial name
- UDD (NCT02530983)
- Testing
- Mayo Clinic Upper Digestive Disease Survey on Paper, Upper Digestive Disease (UDD Monitor) App
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mayo Clinic
Esophagus Cancer
Goal-directed Enteral Nutritional Perioperative Management
This clinical trial aims to determine whether perioperative goal-directed nutritional therapy can prevent postoperative pulmonary and other major complications in malnourished esophageal squamous cell cancer patients.
- Trial name
- GENTLEMAN (NCT06510543)
- Testing
- Goal-directed EN therapy, Conventional EN therapy
- Where
- 17 sites in China
- Volunteers
- 400 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Drug Safety ; Drug Specificity
Cetuximab - IRDye800 Intraoperative Fluorescence Imaging in Esophagectomy of Esophageal Cancer
The esophageal squamous cell carcinoma (ESCC) has high prevalence and mortality in China, which become a severe challenge for public health.
- Trial name
- NCT04161560
- Testing
- Cetuximab-IRDye800
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Esophageal Neoplasms
A Phase III Study of En Bloc Versus Non-En Bloc Esophagectomy in Esophageal Cancer
The purpose of this study is to test 2 different methods of surgery to remove cancer in the esophagus. This research is being done to see whether removing more tissue and lymph nodes surrounding the tumor in the esophagus (known…
- Trial name
- NCT00760604
- Testing
- Esophagectomy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Weill Medical College of Cornell University
Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction
FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma
This phase II trial studies how well oxaliplatin, leucovorin calcium, and fluorouracil followed by surgery and response based concurrent chemotherapy and radiation therapy works in treating patients with cancer of the esophagus…
- Conditions
- Adenocarcinoma of the Esophagus, Adenocarcinoma of the Gastroesophageal Junction, Adenocarcinoma of the Gastric Cardia, Stage IIIA Esophageal Cancer
- Trial name
- NCT02037048
- Testing
- oxaliplatin, leucovorin calcium, fluorouracil
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Case Comprehensive Cancer Center
Esophageal Cancer
Robotic Versus Thoracolaparoscopic Esophagectomy for Esophageal Cancer
Esophageal cancer is a debilitating condition. The treatment involved is complex requiring a combination of chemotherapy and surgery in most cases.
- Trial name
- NCT03727126
- Testing
- Robotic esophagectomy, Thoracolaparoscopic esophagectomy
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- GEM Hospital & Research Center
Esophageal Neoplasms, Constriction
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures.
- Conditions
- Esophageal Neoplasms, Constriction, Anastomotic Leak, Ischemia
- Trial name
- NCT02937389
- Testing
- Patients after esophagectomy
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Nagasaki University
Atrial Fibrillation, Esophagectomy
Prevention of Atrial Fibrillation Following Esophagectomy
The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following esophagectomy surgery.
- Trial name
- NCT00420017
- Testing
- Amiodarone, Control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Other Complications of Esophagostomy
Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy
The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response…
- Trial name
- PPV (NCT01933451)
- Testing
- Intraoperative fluid therapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- National Taiwan University Hospital
Esophageal Cancer
Assessment of a Modified Minimally Invasive Esophagectomy
This is a retrospective case series of a novel fully minimally invasive esophagectomy procedure for patients with primary esophageal cancer.
- Trial name
- NCT04219410
- Testing
- Fully minimally invasive esophagectomy
- Volunteers
- 142 people
- Sponsor
- Kaiser Permanente
Neuromuscular Block, Esophageal Cancer
Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy
Rationale: Endoscopic (thoraco-laparoscopic) esophageal surgery is a high risk procedure where the use of deep neuromuscular block (NMB) may increase field visibility and anaesthesia conditions.
- Conditions
- Neuromuscular Block, Esophageal Cancer, Surgery
- Trial name
- DEPTH (NCT02320734)
- Testing
- Rocuronium
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Minimally Invasive Surgery
Learning Curve for Minimally Invasive Oesophagectomy and Contrast With Open Procedure
Minimally invasive oesophagectomy is a technically demanding procedure; thus, the learning curve of this procedure should be explored.
- Trial name
- NCT04206696
- Volunteers
- 384 people
- Sponsor
- The Second Hospital of Shandong University
Esophageal Cancer
Early Oral Feeding Following Thoracolaparoscopic Oesophagectomy in Patients With Esophageal Cancer
The purpose of this study is to determine the feasibility of early oral food intake postoperatively in patients with thoracolaparoscopic esophagectomy.
- Trial name
- NCT01998230
- Testing
- early oral feeding
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Yin Li
Esophageal Carcinoma
Perioperative Outcomes and Survival of Inflatable Video-Assisted Mediastinoscopic Transhiatal Esophagectomy for Selected Esophageal Cancer
Perioperative and oncologic benefits of inflatable video-assisted mediastinoscopic transhiatal esophagectomy (IVMTE) are unclear.
- Trial name
- NCT07182266
- Where
- China
- Volunteers
- 1,661 people
- Sponsor
- Shanghai Zhongshan Hospital