Clinical trials: Esrd
Chronic Kidney Disease
A Phase 1-2 Study of PRT-201 Administered in Chronic Kidney Disease (CKD) Patients
PRT-201 is a protein that causes long lasting dilation of blood vessels when applied to the outside surface of the blood vessel.
- Trial name
- NCT00679991
- Testing
- PRT-201
- Where
- 11 sites in United States
- Volunteers
- 66 people
- Sponsor
- Proteon Therapeutics
Chronic Kidney Disease (Stages 4 and 5), Health Related Quality of Life
Symptom Monitoring With Supported Feedback in Advanced Chronic Kidney Disease
Patient-reported outcome measures (PROMs) are validated tools to reliably measure outcomes highly prioritized by patients, such as health-related quality of life (HRQOL) and symptoms, but the current clinical impact of PROMs is…
- Trial name
- NCT07186218
- Testing
- Electronic patient-reported outcome measure (ePROM) for symptom monitoring
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Chronic Kidney Disease, Dialysis
A Study of MCI-196 in Chronic Kidney Disease Stage V Subjects on Dialysis With Hyperphosphatemia
This is a PIII multi-center, open-label, flexible dose, long-term safety study, that in conjunction with the E07(NCT00416520), E08(NCT00542386) and E09(NCT00451295) studies will allow exposure to MCI-196 for up to 52 weeks
- Conditions
- Chronic Kidney Disease, Dialysis, Hyperphosphatemia
- Trial name
- NCT00542815
- Testing
- MCI-196, Another Phosphate binder (Sevelamer)
- Where
- 115 sites in Austria, Czechia and 13 more
- Volunteers
- 632 people
- Sponsor
- Tanabe Pharma Corporation
Xerostomia Due to Hyposecretion of Salivary Gland
Chamomile Effect on Xerostomia Associated With End-stage Renal Disease in Elderly
Background and Objectives: Chronic hemodialysis causes changes in blood chemistry as well as dry mouth, due to removal of excess fluids. Dry mouth is due to hyposalivation or change in saliva composition.
- Trial name
- NCT06114797
- Testing
- Chamomile, Saline mouthwash
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Ain Shams University
Renal Impairment
Pharmacokinetic Profile of Glepaglutide After a Single Injection in Subjects With Varying Degrees of Renal Function
This is two stage design, open-label, multi-center, non-randomized trial evaluating the PK of a single, subcutaneous dose of 10 mg glepaglutide in subjects with varying degrees of renal function.
- Trial name
- NCT04178447
- Testing
- Glepaglutide
- Where
- 3 sites in Hungary, Poland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Zealand Pharma
Acute Kidney Injury, Liver Disease
Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant
To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters.
- Conditions
- Acute Kidney Injury, Liver Disease, Chronic Kidney Disease, End Stage Kidney Disease
- Trial name
- NCT01619449
- Testing
- Renal replacement therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Chicago
End Stage Renal Disease, Peritoneal Dialysis
Relationship Between Blood Pressure and Pulse Wave Velocity Measurements in Peritoneal Dialysis
This study evaluates the relationship between Ambulatory Aortic and Branchial blood pressure vs Office blood pressure measurements with the changes in arterial stiffness indices, in long-term Peritoneal Dialysis (PD) patients.
- Conditions
- End Stage Renal Disease, Peritoneal Dialysis, Arterial Sclerosis
- Trial name
- NCT03607747
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Kidney Transplantation, Acute Kidney Injury
Molecular Markers of Acute Kidney Injury in Elderly Deceased Donors
Scoring systems that combine donor clinical and morphological parameters to predict outcome of kidney transplantation lack enough specificity to be generally accepted.
- Trial name
- MoliDon (NCT06171438)
- Testing
- Urine Biomarkers, Gene expression profiling of donor kidneys by microarray, Gene expression profiling of recipient kidneys by microarray
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Renal Failure
Pilot Study of Wearable Artificial Kidney
This is a pilot study of a wearable type of kidney dialysis machine to treat patients with chronic kidney disease.
- Trial name
- WAK (NCT00454974)
- Testing
- Wearable artificial kidney
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Royal Free Hampstead NHS Trust
Kidney Injury
Prevention of Acute Kidney Injury in Cardiac Surgery Patients
Acute kidney injury (AKI) has no uniform criteria, but is commonly defined as an increase in serum creatinine concentration by at least 25% from baseline.
- Trial name
- NCT00921518
- Testing
- Sodium Bicarbonate
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Community Medical Center, Scranton, PA
Chronic Kidney Disease, Inflammation
Anti-Inflammatory Effects of Rosiglitazone in Patients With Stage 4 and 5 Chronic Kidney Disease
The purpose of this study in patients with stage 4 and 5 chronic kidney disease is to determine whether rosiglitazone can reduce inflammatory markers and to investigate its effect on intima media thickness, calcification and…
- Trial name
- Hercules (NCT00169923)
- Testing
- rosiglitazone
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Leiden University Medical Center
Secondary Hyperparathyroidism, Chronic Kidney Disease
Trial to Optimize Mineral Outcomes in Dialysis Patients
This trial is designed to determine if the use of a computer algorithm designed to optimize mineral outcomes in dialysis patients increases the number of patients achieving the desired target endpoints for calcium, phosphorus and…
- Trial name
- NCT01100723
- Testing
- Cinacalcet, active vitamin D analogue
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Colorado, Denver
Acute Kidney Injury
Renal Angina Index for Predicting Acute Kidney Injury in Adult ICU Patients
Acute kidney injury (AKI) is a frequent complication of critical illness and is associated with increased morbidity and mortality.
- Trial name
- NCT07863505
- Testing
- Renal Angina Index Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 324 people
- Sponsor
- Izmir Katip Celebi University
Contrast-induced Nephropathy, Acute Kidney Injury
Proenkephalin for Prediction of Contrast-Associated Kidney Events
Currently, contrast-induced kidney injury cannot be diagnosed on the day of cardiac catheterization. Recently, proenkephalin (penKid) was introduced as a new glomerular filtration marker.
- Conditions
- Contrast-induced Nephropathy, Acute Kidney Injury, Coronary Artery Disease
- Trial name
- PANCAKE (NCT03989505)
- Testing
- blood-draw for biomarker analyses
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Dr. med. Mahir Karakas
End-Stage Renal Disease, Gut Microbiome Dysbiosis
Gut Microbiome and p-Inulin in Hemodialysis
The Microbiome trial is a non-randomized, open-label, sequential, multi-center study of p-inulin for patients with hemodialysis-dependent end-stage renal disease.
- Trial name
- NCT02572882
- Testing
- p-inulin
- Where
- 4 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
End Stage Renal Disease
High-cutoff Hemodialyzer to Reduce Chronic Inflammation in Hemodialysis Patients
The purpose of this study is to test whether a dialyzer with a higher than usual permeability for proteins can eliminate proinflammatory proteins from the blood of patients on regular maintenance hemodialysis who have chronically…
- Trial name
- HCO1100 (NCT00974779)
- Testing
- HCO1100 dialyzer, regular dialysis polyamide
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Kidney Failure
Hepatitis C Virus (HCV) Positive Kidney Grafts in HCV Negative Recipients
To determine the efficacy and safety of transplanting HCV positive kidney allografts to HCV sero-negative patients who are on the waiting list.
- Trial name
- NCT04605679
- Testing
- Kidney Transplantation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Loma Linda University
End Stage Renal Failure, Hemodialysis
Exploring Predictors of Quality of Life in Older Adults With End-Stage Kidney Disease Receiving In-Center Hemodialysis
This cross-sectional observational study investigates the overall quality of life (QoL) in adults aged 65 and older receiving in-center hemodialysis.
- Trial name
- B670201837264 (NCT07129083)
- Testing
- Structured assessment interview
- Where
- Belgium
- Volunteers
- 111 people
- Sponsor
- University Ghent
Vitamin B12 Deficiency, Renal Failure , Chronic
Oral Versus Intravenous Vitamin B12 Replacement in Hemodialysis Patients
The goal of this clinical trial is to learn whether intravenous (IV) vitamin B12 works better than oral vitamin B12 to correct vitamin B12 deficiency in adults on maintenance hemodialysis.
- Conditions
- Vitamin B12 Deficiency, Renal Failure , Chronic, Renal Dialysis
- Trial name
- B12-HD-RCT (NCT07781020)
- Testing
- Mecobalamin IV Injection, Mecobalamin Tablets
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jinnah Hospital
Renal Insufficiency and Diabetes Mellitus
Prevention of Renal Failure in People Followed for Type 2 Diabetes in General Practice
This work will make it possible to identify the nephron loss of type 2 diabetic patients in the western region and to better define in general practice the impact of the elements put in place to reduce this loss and to raise…
- Trial name
- PENEDIAB (NCT05749679)
- Testing
- training and audit, Routine care
- Volunteers
- 360 people
- Sponsor
- University Hospital, Lille
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