Clinical trials: Esrd
Acute Kidney Injury, Chronic Kidney Disease
Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS-YA (NCT02599844)
- Testing
- Iodohippurate, 24 hour ambulatory Blood Pressure, Peripheral Arterial Tonometry
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Kidney Diseases
A Mass Balance Study of [14C]HRS-1780 in Healthy Adult Male Subjects
The study aims to evaluate the pharmacokinetics, mass balance recovery, metabolite profile and metabolite identification of [14C]HRS-1780 following an oral single dose in healthy adult male participants.
- Trial name
- NCT07557407
- Testing
- [14C]HRS-1780
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Acute Renal Injury
Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans
Implementation of an evidence-based and best practices acute RRT pathway aiming to decrease acute RRT program and healthcare systems costs while improving important patient-reported outcomes.
- Trial name
- NCT05186636
- Testing
- KPI reports, Prescriber reports
- Where
- 15 sites in Canada
- Volunteers
- 9,348 people
- Sponsor
- University of Alberta
Chronic Kidney Disease
Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and Diabetic Kidney Disease
The primary objective of this study was to demonstrate whether, in addition to standard of care, finerenone is superior to placebo in delaying the progression of kidney disease, as measured by the composite endpoint of time to…
- Trial name
- FIDELIO-DKD (NCT02540993)
- Testing
- Finerenone (BAY94-8862)
- Where
- 978 sites in United States, Argentina and 46 more
- Volunteers
- 5,734 people
- Sponsor
- Bayer
Acute Kidney Injury
Acute KIDnEy Injury in CoviD-19
This is a prospective observational parallel group cohort study that will aim to recruit 220 participants who were admitted to the hospital with COVID-19 between 1st March 2020 and 30th June 2020 (Group A - 110 participants who…
- Trial name
- AIDED (NCT04583293)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Hemodialysis
Cardiovascular Protective Effect of Spironolactone in Hemodialysis
The purpose of the present study is to determine if spironolactone is safe and effective in the treatment of cardiovascular complications in hemodialysis patients.
- Trial name
- NCT00277693
- Testing
- Spironolactone (drug)
- Where
- Chile
- Sponsor
- Universidad de los Andes, Chile
AKI - Acute Kidney Injury, Delirium, Postoperative
Metabolomics Analysis of Acute Kidney Injury and Delirium After Cardiac Surgery
Clinical evidence suggests that renal injury leads to changes in the structure of the cerebral cortex in patients, suggesting the existence of the renal brain axis.
- Trial name
- NCT06508593
- Testing
- Serum metabolic profile
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Multiple Myeloma, Renal Insufficiency
Study in Patients With Untreated Multiple Myeloma and Renal Insufficiency
The study will evaluate the effects of BHQ880 in patients with previously untreated multiple myeloma and renal insufficiency who are not considered candidates for bisphosphonate therapy.
- Trial name
- NCT01337752
- Testing
- BHQ880, bortezomib, dexamethasone
- Where
- 8 sites in United States, Spain and 1 more
- Volunteers
- 9 people
- Sponsor
- Novartis Pharmaceuticals
COVID-19
A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia
A new drug called azeliragon could be used to treat patients with COVID-19 or other pneumonia infections but the researchers don't know.
- Trial name
- NCT05815485
- Testing
- Azeliragon
- Where
- 3 sites in United States
- Volunteers
- 144 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Secondary Hyperparathyroidism
A Phase 4 Study to Determine Dosing of Hectorol® Capsules When Converting From Zemplar® Injection
Protocol HECT00306 aims to determine clinically appropriate doses of Hectorol (doxercalciferol capsules) when converting from Zemplar (paricalcitol injection) for the treatment of secondary hyperparathyroidism in Stage 5 chronic…
- Trial name
- NCT00463021
- Testing
- Hectorol (doxercalciferol capsules), Zemplar (paricalcitol injection)
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- Genzyme, a Sanofi Company
Renal Insufficiency, Chronic, Kidney Diseases
Validation of New Markers of Glomerular Filtration Rate: Dota Gadolinium and Calcium EDTA (MultiGFR)
The purpose of this study is to validate in comparison to a reference method (inuline) two novel non-radioactive biomarkers for glomerular filtration rate (GFR) measurement in chronic-kidney disease (CKD) patients and in healthy…
- Trial name
- MultiGFR (NCT02286258)
- Testing
- Calcium EDTA, Gd-DOTA
- Where
- 4 sites in France
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Failure, Paraproteinemias
The Effect of Daratumumab in Patients With Monoclonal Gammopathy of Renal Significance (MGRS) in Finland
The goal of this clinical trial is to learn if drug daratumumab works to treat kidney diseases other than AL-amyloidosis that fall under the category of monoclonal gammopathy of renal significance (MGRS).
- Conditions
- Kidney Failure, Paraproteinemias, Glomerulonephritis
- Trial name
- DAMOCLES (NCT06889948)
- Testing
- Daratumumab
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Helsinki University Central Hospital
Moderate to Severe Secondary Hyperparathyroidism, Stage 5 Chronic Kidney Diseases
A Pilot Clinical Study Evaluating the Effect of Parathyroid Hormone (PTH) Lowering On Erythropoietin Consumption in Calcitriol-Resistant Patients
To evaluate the effect of PTH lowering on erythropoietin consumption in calcitriol-resistant patients with stage 5 chronic kidney disease.
- Trial name
- NCT01506947
- Testing
- Paricalcitol, Darbepoetin alfa
- Volunteers
- 65 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Human Immunodeficiency Viruses, Kidney Failure
Impact of Drug Therapy and Co-Morbidities on the Development of Renal Impairment in HIV-Infected Patients
Tenofovir (TDF)-containing regimens may be associated with decreasing renal function in HIV-infected patients concurrently treated with boosted PI's and/or have co-morbid conditions including diabetes mellitus, hypertension…
- Conditions
- Human Immunodeficiency Viruses, Kidney Failure, HIV Infections
- Trial name
- NCT00551655
- Where
- United States
- Volunteers
- 684 people
- Sponsor
- AIDS Arms Inc.
Heart Failure, Acute Kidney Injury
Evaluation of VEXUS Score of Patients With Heart Failure in the Intensive Care Unit.
Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1).
- Trial name
- NCT06389708
- Volunteers
- 100 people
- Sponsor
- Inonu University
Kidney Disease, Chronic Kidney Disease (Stages 4 and 5)
The Adaptive Platform Trial for Kidney Disease
Background: Randomized clinical trials (RCTs) are essential for evaluating intervention effects but are often challenged by regulatory and logistical burdens, high costs, and extended timelines.
- Conditions
- Kidney Disease, Chronic Kidney Disease (Stages 4 and 5), End-Stage Kidney Disease (ESKD), Dialysis
- Trial name
- APT-KIDNEY (NCT07595952)
- Testing
- APT-KIDNEY platform participation
- Volunteers
- 5,000 people
- Sponsor
- Nicholas Carlson
Secondary Hyperparathyroidism, End Stage Renal Disease
A Study of an Investigational Medication for the Treatment of Secondary Hyperparathyroidism in Dialysis Patients
This 6 month long study will assess an investigational medication for patients on dialysis with secondary hyperparathyroidism. The study will look at the effects on parathyroid hormone, calcium and phosphorus levels.
- Trial name
- NCT00037635
- Testing
- AMG 073
- Volunteers
- 400 people
- Sponsor
- Amgen
Chronic Kidney Diseases, End Stage Renal Disease
Topical Magnesium and Muscle Cramps in Dialysis Patients.
Oral magnesium supplementation has been widely used in the treatment of muscle cramps. Muscle cramps are common in dialysis patients but are not satisfactorily prevented by oral magnesium.
- Conditions
- Chronic Kidney Diseases, End Stage Renal Disease, Dialysis Related Complications
- Trial name
- NCT03082625
- Testing
- Transdermal Magnesium
- Volunteers
- 40 people
- Sponsor
- Sir Charles Gairdner Hospital
End-stage Renal Disease
Evaluation of the Radial Artery Deviation And Reimplantation Technique for Primary Hemodialysis Access Creation
The Radial Artery Deviation And Reimplantation (RADAR) technique is a new approach for the construction of hemodialysis arteriovenous fistula.
- Trial name
- RADAR (NCT02728817)
- Testing
- End-cephalic vein to side-radial artery fistula creation, RADAR fistula creation
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Kidney Disease
Comparison of Effectiveness and Safety of Three Lock Solutions for Long-Term Central Venous Catheter for Hemodialysis
Background: Poor flow (PF) and catheter-related blood stream infections (CRBSI) are highly prevalent among CKD 5D patients with long-term central venous catheters.
- Trial name
- CLOCK (NCT02618317)
- Testing
- Heparin Lock Solution, Trissodium Citrate 30%, Minocycline-EDTA 30 mg/ml - 3 mg/ml
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- University of Sao Paulo
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