Clinical trials: Esrd
ESRD, Peritoneal Dialysis
Evaluate Serious Illness Treatment Preferences and Outcomes in the Patients Receiving Peritoneal Dialysis
The goal of this clinical research study is to study the cardiopulmonary resuscitation (CPR) preferences of patients receiving peritoneal dialysis and how these preferences are associated with their responses to questions about…
- Trial name
- NCT05193474
- Testing
- integrated palliative care
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
End Stage Renal Disease (ESRD), Hemodialysis
Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis
Online hemodiafiltration confers a reduced mortality risk. However, it is not clear why HDF improved survival. To gain more insight in this issue, the effect of 4 dialysis techniques (differing in dialysate temperature and the…
- Conditions
- End Stage Renal Disease (ESRD), Hemodialysis, Hemodiafiltration, Intradialytic Hypotension
- Trial name
- HOLLANT (NCT03249532)
- Testing
- standard hemodialysis, cool hemodialysis, low volume hemodiafiltration
- Where
- 3 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus
Use of Closed Loop Insulin Delivery for Glucose Control in Patients With Insulin Dependent Diabetes Mellitus After Kidney Transplantation
This study will be a prospective, single center, randomized controlled parallel group open-label trial. Participants with insulin requiring diabetes mellitus who have been offered an organ for living or deceased donor kidney…
- Conditions
- Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus, End Stage Renal Disease (ESRD)
- Trial name
- NCT04189510
- Testing
- Artificial Pancreas, Multiple Daily Injections
- Sponsor
- University of Virginia
ESRD, Influenza Vaccine
Efficacy of Different Doses of Influenza Vaccine in Chronic Hemodialysis Patients
This study was a randomized controlled trial to investigate the immune response of influenza vaccines when doses were increased.
- Conditions
- ESRD, Influenza Vaccine, Seroprotection
- Trial name
- Enhance (NCT05070494)
- Testing
- Egg-derived standard dose trivalent influenza vaccine (surface antigen, inactivated)
- Where
- Thailand
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Mahidol University
ESRD
Interactive Videoconferencing in the Provision of Remote Peritoneal Dialysis
Home dialysis patients must be seen in a face to face visit on a monthly basis. For patients who live remotely these visits may impact their quality of life due to the amount of time needed to attend these visits.
- Trial name
- Telemedicine (NCT02428803)
- Testing
- Telemedicine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Alabama at Birmingham
ESRD, Hemodialysis
Evaluation of the Optimal Transition Program
This is an evaluation of a program developed by a team of nephrologists, operations experts and researchers. The goal is to provide CKD patients with a better way to transition to life on dialysis - one that emphasizes even more…
- Trial name
- NCT04263233
- Testing
- Analysis using descriptive statistics of patient clinical outcomes., Surveys with participants using validated survey tools., Evaluation of the program process including time, costs, referral rates, admission to the program and length of stay.
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Satellite Healthcare
Chronic Hemodialysis (ESRD)
Safety and Cardiovascular Efficacy of Hydralazine and Isosorbide Dinitrate in Dialysis-Dependent ESRD
This study is a pilot study designed to compare the safety and cardiovascular effects of 26 weeks of combination hydralazine/isorsorbide dinitrate therapy with placebo therapy in patients receiving chronic hemodialysis.
- Trial name
- HIDE (NCT02228408)
- Testing
- Hydralazine/Isorsorbide Dinitrate
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Diseases, Cardiovascular Abnormalities
Effect of SNF472 on Progression of Cardiovascular Calcification in End-Stage-Renal-Disease (ESRD) Patients on Hemodialysis (HD)
The primary objective is to assess the effect of 2 dose levels of SNF472 (300 mg and 600 mg) compared to placebo on the progression of coronary artery calcium volume score over a 12-month (52 weeks) period in ESRD patients on HD
- Conditions
- Cardiovascular Diseases, Cardiovascular Abnormalities, Calcifications, Vascular, Endstage Renal Disease
- Trial name
- NCT02966028
- Testing
- SNF472
- Where
- 75 sites in United States, Spain and 1 more
- Volunteers
- 274 people
- Sponsor
- Sanifit Therapeutics S. A.
End-stage Renal Disease (ESRD), Kidney Disease
Sympathetic Activity in Patients With End-stage Renal Disease on Peritoneal Dialysis
Hypothesis: Patients starting peritoneal dialysis with a glucose-based regimen have high sympathetic activity in response to an increase in leptin and insulin.
- Trial name
- SAPD (NCT01228279)
- Testing
- DIANEAL, EXTRANEAL
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Hyperphosphatemia, End Stage Renal Disease
Ferric Citrate for the Treatment of Hyperphosphatemia in Patients With Chronic Kidney Disease Undergoing Hemodialysis
To evaluate the efficacy and safety of ferric citrate capsules for the treatment of hyperphosphatemia in patients with chronic kidney disease undergoing hemodialysis
- Conditions
- Hyperphosphatemia, End Stage Renal Disease, ESRD
- Trial name
- NCT03984760
- Testing
- Ferric Citrate, Sevelamer Carbonate
- Where
- 24 sites in China
- Volunteers
- 240 people
- Sponsor
- Panion & BF Biotech Inc.
ESRD, Fabry Disease
Kidney Information Network for Disease Research and Education
In this study, Investigators will conduct a prospective cohort study of dialysis patients by collecting research-quality information on patient characteristics, comorbid diseases and laboratory markers used in routine practice…
- Conditions
- ESRD, Fabry Disease, Rare Diseases, Kidney Diseases
- Trial name
- KINDRED (NCT03321604)
- Where
- United States
- Volunteers
- 338 people
- Sponsor
- Massachusetts General Hospital
ESRD
Assessment of Gonadal Functions in Uremic Male Patients
1. Study the prevalence of sexual dysfunction in male patients on hemodialysis aged 18-60 years (sexually active male) . 2. Study the effect of hemodialysis on the male patients sexual functions by measurement of serum prolactin…
- Trial name
- NCT04710238
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hemodialysis Complication, ESRD
Individualized Incremental Hemodialysis Study
Thrice weekly hemodialysis has been the standard of care all-over the world for end-stage renal disease (ESRD) requiring renal replacement therapy (RRT).
- Conditions
- Hemodialysis Complication, ESRD, Renal Failure
- Trial name
- IIHD (NCT03352271)
- Testing
- Individualized Incremental hemodialysis, Conventional thrice weekly hemodialysis
- Where
- 2 sites in Egypt
- Volunteers
- 122 people
- Sponsor
- Alexandria University
ESRD
Effects of Postdilution Online Hemodiafiltration With AcEtate-free Citrate dialySis Fluid on Inflammation Markers
The aim of this study was to evaluate the effect and timing of action on the inflammatory state of a acetate-free containing citrate concentrate (Cit-, 1 mM Citrate) in online postidultion HDF with high volumes compared to…
- Trial name
- HEPHAESTUS (NCT02863016)
- Testing
- SelectBag One
- Where
- 3 sites in Italy
- Volunteers
- 66 people
- Sponsor
- Ospedale Santa Maria Annunziata
ESRD, T-Cell Dysfunction
T Cell Dysfunction in ESRD
Patients with end-stage renal disease (ESRD) suffer from high morbidity and mortality of cardiovascular and infectious disease and increased risk of all-cause mortality which is mainly attributed to the disturbed immune response.
- Trial name
- NCT04658069
- Testing
- no specific interventions
- Volunteers
- 400 people
- Sponsor
- Shanghai Zhongshan Hospital
End-Stage Renal Disease (ESRD)
Dose Ranging Study of Dialysate Containing Soluble Iron to Treat Subjects With End Stage Renal Disease (ESRD) Receiving Chronic Hemodialysis
The purpose of this study is to determine whether Dialysate containing soluble iron (Soluble Ferric Pyrophosphate) is safe and effective in maintaining physiological iron levels during chronic hemodialysis.
- Trial name
- NCT00548249
- Testing
- Standard Bicarbonate Solution, Soluble Ferric Pyrophosphate
- Where
- 28 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Rockwell Medical Technologies, Inc.
CKD, ESRD
Reducing Chronic Kidney Disease Burden in an Underserved Population
To evaluate a scalable population health strategy to 1) screen, 2) identify, and 3) intervene with individuals at high risk of CKD progression to ESRD that could be implemented in other high risk communities and health care…
- Trial name
- NCT03832166
- Testing
- Fruits and Vegetables, Cooking
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
ESRD
Dialysis mHealth Survey
This is a survey of dialysis patients and staff to determine both the readiness of ESRD patients to use mHealth as well as the Readiness of the dialysis center staff (healthcare technicians, nurses and administrative staff) to…
- Trial name
- NCT04177277
- Where
- United States
- Volunteers
- 949 people
- Sponsor
- Satellite Healthcare
COPD, ESRD
Randomized Evaluation of Default Access to Palliative Services
This is a large pragmatic, randomized controlled trial to test the real-world effectiveness of inpatient palliative care consultative services in improving a number of patient- and family-centered processes and outcomes of care…
- Conditions
- COPD, ESRD, Dementia
- Trial name
- REDAPS (NCT02505035)
- Testing
- Default ordering of palliative consult
- Where
- 11 sites in United States
- Volunteers
- 34,239 people
- Sponsor
- University of Pennsylvania
End Stage Renal Disease, Chronic Kidney Disease Stage 5
Pharmacodynamic Study of AZD1722 in End-stage Renal Disease Patients on Hemodialysis
The purpose of this study is to determine if the study drug is safe, tolerable and active in reducing fluid overload/weight gain between dialysis sessions for patients with End Stage Renal Disease on Hemodialysis.
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease Stage 5, ESRD
- Trial name
- NCT01764854
- Testing
- AZD1722 (in-patient), AZD1722 (out-patient)
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Ardelyx